22 results on '"Besold, Ulrike"'
Search Results
2. Non-occupational and occupational factors associated with specific SARS-CoV-2 antibodies among hospital workers – A multicentre cross-sectional study
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Kahlert, Christian R., Persi, Raphael, Güsewell, Sabine, Egger, Thomas, Leal-Neto, Onicio B., Sumer, Johannes, Flury, Domenica, Brucher, Angela, Lemmenmeier, Eva, Möller, J. Carsten, Rieder, Philip, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Albrich, Werner C., Babouee Flury, Baharak, Besold, Ulrike, Fehr, Jan, Kuster, Stefan P., McGeer, Allison, Risch, Lorenz, Schlegel, Matthias, Friedl, Andrée, Vernazza, Pietro, and Kohler, Philipp
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- 2021
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3. SARS‐CoV‐2 Vaccination is Not Associated With Involuntary Childlessness in Female Healthcare Workers: A Multicenter Cohort Study.
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Dörr, Tamara, Güsewell, Sabine, Cusini, Alexia, Brucher, Angela, Goppel, Stephan, Grässli, Fabian, Betschon, Elsbeth, Möller, J. Carsten, Ortner, Manuela, Ruetti, Markus, Stocker, Reto, Vuichard‐Gysin, Danielle, Besold, Ulrike, Risch, Lorenz, von Kietzell, Matthias, Schlegel, Matthias, Kuster, Stefan P., Kahlert, Christian R., and Kohler, Philipp
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MEDICAL personnel ,SARS-CoV-2 ,VACCINE hesitancy ,INFERTILITY ,VACCINATION ,COHORT analysis - Abstract
Background: There is debate about the causes of the recent birth rate decline in high‐income countries worldwide. During the pandemic, concern about the effects on reproductive health has caused vaccine hesitancy. We investigated the association of SARS‐CoV‐2 vaccination and infection with involuntary childlessness. Methods: Females in fertility age within a prospective multicenter cohort of healthcare workers (HCW) were followed since August 2020. Data on baseline health, SARS‐CoV‐2‐infection, and vaccination were obtained and regularly updated, in which serum samples were collected repetitively and screened for anti‐nucleocapsid and anti‐spike antibodies. In October 2023, participants indicated the presence of involuntary childlessness with onset during the pandemic, whereas those indicating an onset before the pandemic were excluded. The association of involuntary childlessness and SARS‐CoV‐2‐vaccination and infection was investigated using univariable and multivariable analysis. Sensitivity analysis was performed to compare those reporting involuntary childlessness with those birthing a child since 2020. Results: Of 798 participants, 26 (3.2%) reported involuntary childlessness starting since the pandemic. Of the involuntary childless women, 73.1% (19/26) were vaccinated compared to 86.0% (664/772) without involuntary childlessness (p = 0.73). SARS‐CoV‐2 infection was reported by 76.9% (20/26) compared to 72.4% (559/772) of controls (p = 0.64). Neither SARS‐CoV‐2 vaccination (aOR 0.91 per dose, 95%CI 0.67–1.26) nor infection (aOR per infection 1.05, 95%CI 0.62–1.71) was associated with involuntary childlessness. Sensitivity analysis confirmed these results. Conclusions: Among female HCW of fertility age, 3.2% indicated involuntary childlessness, which is comparable to pre‐pandemic data. No association between involuntary childlessness and SARS‐CoV‐2 vaccination or infection was found. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent COVID-19—a prospective multicenter cohort study
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Kohler, Philipp, Güsewell, Sabine, Seneghini, Marco, Egger, Thomas, Leal, Onicio, Brucher, Angela, Lemmenmeier, Eva, Möller, J. Carsten, Rieder, Philip, Ruetti, Markus, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Besold, Ulrike, Kuster, Stefan P., McGeer, Allison, Risch, Lorenz, Friedl, Andrée, Schlegel, Matthias, Vernazza, Pietro, and Kahlert, Christian R.
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- 2021
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5. Clinical symptoms of SARS-CoV-2 breakthrough infection during the Omicron period in relation to baseline immune status and booster vaccination-A prospective multicentre cohort of health professionals (SURPRISE study)
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Kohler, Philipp, Babouee Flury, Baharak, Güsewell, Sabine, Egger, Thomas, Leal, Onicio, Brucher, Angela, Lemmenmeier, Eva, Meier Kleeb, Dorette, Möller, J Carsten, Ortner, Manuela, Rieder, Philip, Ruetti, Markus, Schmid, Hans-Ruedi, Stocker, Reto, Vuichard-Gysin, Danielle, Speer, Oliver, Wiggli, Benedikt, Besold, Ulrike, McGeer, Allison, Risch, Lorenz, Friedl, Andrée, Schlegel, Matthias, Vernazza, Pietro, Kahlert, Christian R, and Kuster, Stefan P
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610 Medicine & health - Abstract
The effects of different types of pre-existing immunity on the frequency of clinical symptoms caused by the SARS-CoV-2 breakthrough infection were prospectively assessed in healthcare workers during the Omicron period. Among 518 participants, hybrid immunity was associated with symptom reduction for dizziness, muscle or limb pain and headache as compared to vaccination only. Moreover, the frequencies of dizziness, cough and muscle or limb pain were lower in participants who had received a booster vaccine dose. Thus, hybrid immunity appeared to be superior in preventing specific symptoms during breakthrough infection compared to vaccination alone. A booster vaccine dose conferred additional symptom reduction.
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- 2023
6. SARS-CoV-2 risk in household contacts of healthcare workers: a prospective cohort study.
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Kohler, Philipp, Dörr, Tamara, Friedl, Andrée, Stocker, Reto, Vuichard, Danielle, Kuster, Stefan P., Kahlert, Christian R., the SURPRISE Study Group, Besold, Ulrike, Betschon, Elsbeth, Brucher, Angela, Cusini, Alexia, Goppel, Stephan, Grässli, Fabian, Keller, Joelle, Kessler, Simone, Leal, Onicio, Lemmenmeier, Eva, McGeer, Allison, and Kleeb, Dorette Meier
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MEDICAL personnel ,SARS-CoV-2 ,COVID-19 ,HOUSEHOLDS ,COHORT analysis - Abstract
Background: Few studies have assessed whether the increased SARS-CoV-2 risk of healthcare workers (HCW) is carried on to their household contacts. Within a prospective HCW cohort, we assessed the SARS-CoV-2 risk of household contacts of HCW depending on the HCWs cumulative exposure to COVID-19 patients and identified factors influencing this association. Methods: HCW aged ≥ 16 years from nine Swiss healthcare networks participated. HCW without any household contacts were excluded. For HCW, cumulative patient exposure (number of COVID-19 patient contacts times average contact duration during a 12-month follow-up) was calculated. During follow-up, HCW reported SARS-CoV-2 nasopharyngeal swab results and positive swab results of their household contacts. We used multivariable logistic regression to identify variables associated with SARS-CoV-2 household positivity. Results: Of 2406 HCW, 466 (19%) reported ≥ 1 SARS-CoV-2 positive household. In multivariable analysis, patient exposure of HCW (adjusted OR [aOR] 1.08 per category, 95% CI 1.04–1.12), household size (aOR 1.53 per household member, 95% CI 1.35–1.73) and having children (aOR 0.70, 95% CI 0.53–0.94) remained associated with household positivity. Vaccinated HCW had a lower risk (aOR 0.54, 95% CI 0.38–0.77) of reporting a positive contact, as were those using respirator masks in contact with COVID-19 patients (aOR 0.65, 95% CI 0.49–0.86). Among vaccinated HCW, delayed first vaccination was associated with increased household SARS-CoV-2 positivity (aOR 1.14 per month, 95% CI 1.08–1.21). Conclusions: SARS-CoV-2 positivity in household contacts of HCW increases with higher cumulative COVID-19 patient exposure of HCWs. Measures reducing the SARS-CoV-2 risk in HCW might indirectly reduce the infection risk of their households. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Post-acute sequelae after SARS-CoV-2 infection by viral variant and vaccination status: a multicenter cross-sectional study
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Kahlert, Christian R, Strahm, Carol, Güsewell, Sabine, Cusini, Alexia, Brucher, Angela, Goppel, Stephan, Möller, Elisabeth, Möller, J Carsten, Ortner, Manuela, Ruetti, Markus, Stocker, Reto, Vuichard-Gysin, Danielle, Besold, Ulrike, McGeer, Allison, Risch, Lorenz, Friedl, Andrée, Schlegel, Matthias, Vernazza, Pietro, Kuster, Stefan P, and Kohler, Philipp
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610 Medicine & health - Abstract
BACKGROUND Disentangling the effects of SARS-CoV-2 variants and vaccination on the occurrence of post-acute sequelae of SARS-CoV-2 (PASC) is crucial to estimate and reduce the burden of PASC. METHODS We performed a cross-sectional analysis (May/June 2022) within a prospective multicenter healthcare worker (HCW) cohort in North-Eastern Switzerland. HCW were stratified by viral variant and vaccination status at time of their first positive SARS-CoV-2 nasopharyngeal swab. HCW without positive swab and with negative serology served as controls. The sum of eighteen self-reported PASC symptoms was modeled with univariable and multivariable negative-binomial regression to analyse the association of mean symptom number with viral variant and vaccination status. RESULTS Among 2'912 participants (median age 44 years, 81.3% female), PASC symptoms were significantly more frequent after wild-type infection (estimated mean symptom number 1.12, p
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- 2023
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8. Post-Acute Sequelae After Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Viral Variant and Vaccination Status: A Multicenter Cross-Sectional Study.
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Kahlert, Christian R, Strahm, Carol, Güsewell, Sabine, Cusini, Alexia, Brucher, Angela, Goppel, Stephan, Möller, Elisabeth, Möller, J Carsten, Ortner, Manuela, Ruetti, Markus, Stocker, Reto, Vuichard-Gysin, Danielle, Besold, Ulrike, McGeer, Allison, Risch, Lorenz, Friedl, Andrée, Schlegel, Matthias, Vernazza, Pietro, Kuster, Stefan P, and Kohler, Philipp
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RESEARCH ,COVID-19 ,CONFIDENCE intervals ,POST-acute COVID-19 syndrome ,SICK people ,COVID-19 vaccines ,CROSS-sectional method ,SELF-evaluation ,MEDICAL personnel ,REGRESSION analysis ,VACCINE effectiveness ,RISK assessment ,RESEARCH funding ,DESCRIPTIVE statistics ,VACCINATION status ,ODDS ratio ,LONGITUDINAL method ,DISEASE risk factors ,SYMPTOMS ,EVALUATION - Abstract
Background Disentangling the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and vaccination on the occurrence of post-acute sequelae of SARS-CoV-2 (PASC) is crucial to estimate and reduce the burden of PASC. Methods We performed a cross-sectional analysis (May/June 2022) within a prospective multicenter healthcare worker (HCW) cohort in north-eastern Switzerland. HCWs were stratified by viral variant and vaccination status at time of their first positive SARS-CoV-2 nasopharyngeal swab. HCWs without positive swab and with negative serology served as controls. The sum of 18 self-reported PASC symptoms was modeled with univariable and multivariable negative-binomial regression to analyze the association of mean symptom number with viral variant and vaccination status. Results Among 2912 participants (median age: 44 years; 81.3% female), PASC symptoms were significantly more frequent after wild-type infection (estimated mean symptom number: 1.12; P <.001; median time since infection: 18.3 months), after Alpha/Delta infection (0.67 symptoms; P <.001; 6.5 months), and after Omicron BA.1 infections (0.52 symptoms; P =.005; 3.1 months) versus uninfected controls (0.39 symptoms). After Omicron BA.1 infection, the estimated mean symptom number was 0.36 for unvaccinated individuals versus 0.71 with 1–2 vaccinations (P =.028) and 0.49 with ≥3 prior vaccinations (P =.30). Adjusting for confounders, only wild-type (adjusted rate ratio [aRR]: 2.81; 95% confidence interval [CI]: 2.08–3.83) and Alpha/Delta infections (aRR: 1.93; 95% CI: 1.10–3.46) were significantly associated with the outcome. Conclusions Previous infection with pre-Omicron variants was the strongest risk factor for PASC symptoms among our HCWs. Vaccination before Omicron BA.1 infection was not associated with a clear protective effect against PASC symptoms in this population. [ABSTRACT FROM AUTHOR]
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- 2023
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9. Risk and symptoms of COVID-19 in health professionals according to baseline immune status and booster vaccination during the Delta and Omicron waves in Switzerland-A multicentre cohort study
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Babouee Flury, Baharak, Güsewell, Sabine, Egger, Thomas, Leal, Onicio, Brucher, Angela, Lemmenmeier, Eva, Meier Kleeb, Dorette, Möller, J Carsten, Rieder, Philip, Rütti, Markus, Schmid, Hans-Ruedi, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Besold, Ulrike, McGeer, Allison, Risch, Lorenz, Friedl, Andrée, Schlegel, Matthias, Kuster, Stefan P, Kahlert, Christian R, and Kohler, Philipp
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SARS-CoV-2 ,Vaccination ,Humans ,COVID-19 ,610 Medicine & health ,Viral Vaccines ,Prospective Studies ,610 Medizin und Gesundheit ,Switzerland - Abstract
BACKGROUND Knowledge about protection conferred by previous Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and/or vaccination against emerging viral variants allows clinicians, epidemiologists, and health authorities to predict and reduce the future Coronavirus Disease 2019 (COVID-19) burden. We investigated the risk and symptoms of SARS-CoV-2 (re)infection and vaccine breakthrough infection during the Delta and Omicron waves, depending on baseline immune status and subsequent vaccinations. METHODS AND FINDINGS In this prospective, multicentre cohort performed between August 2020 and March 2022, we recruited hospital employees from ten acute/nonacute healthcare networks in Eastern/Northern Switzerland. We determined immune status in September 2021 based on serology and previous SARS-CoV-2 infections/vaccinations: Group N (no immunity); Group V (twice vaccinated, uninfected); Group I (infected, unvaccinated); Group H (hybrid: infected and ≥1 vaccination). Date and symptoms of (re)infections and subsequent (booster) vaccinations were recorded until March 2022. We compared the time to positive SARS-CoV-2 swab and number of symptoms according to immune status, viral variant (i.e., Delta-dominant before December 27, 2021; Omicron-dominant on/after this date), and subsequent vaccinations, adjusting for exposure/behavior variables. Among 2,595 participants (median follow-up 171 days), we observed 764 (29%) (re)infections, thereof 591 during the Omicron period. Compared to group N, the hazard ratio (HR) for (re)infection was 0.33 (95% confidence interval [CI] 0.22 to 0.50, p < 0.001) for V, 0.25 (95% CI 0.11 to 0.57, p = 0.001) for I, and 0.04 (95% CI 0.02 to 0.10, p < 0.001) for H in the Delta period. HRs substantially increased during the Omicron period for all groups; in multivariable analyses, only belonging to group H was associated with protection (adjusted HR [aHR] 0.52, 95% CI 0.35 to 0.77, p = 0.001); booster vaccination was associated with reduction of breakthrough infection risk in groups V (aHR 0.68, 95% CI 0.54 to 0.85, p = 0.001) and H (aHR 0.67, 95% CI 0.45 to 1.00, p = 0.048), largely observed in the early Omicron period. Group H (versus N, risk ratio (RR) 0.80, 95% CI 0.66 to 0.97, p = 0.021) and participants with booster vaccination (versus nonboosted, RR 0.79, 95% CI 0.71 to 0.88, p < 0.001) reported less symptoms during infection. Important limitations are that SARS-CoV-2 swab results were self-reported and that results on viral variants were inferred from the predominating strain circulating in the community at that time, rather than sequencing. CONCLUSIONS Our data suggest that hybrid immunity and booster vaccination are associated with a reduced risk and reduced symptom number of SARS-CoV-2 infection during Delta- and Omicron-dominant periods. For previously noninfected individuals, booster vaccination might reduce the risk of symptomatic Omicron infection, although this benefit seems to wane over time.
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- 2022
10. Additional file 1 of Impact of respirator versus surgical masks on SARS-CoV-2 acquisition in healthcare workers: a prospective multicentre cohort
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Haller, Sabine, G��sewell, Sabine, Egger, Thomas, Scanferla, Giulia, Thoma, Reto, Leal-Neto, Onicio B., Flury, Domenica, Brucher, Angela, Lemmenmeier, Eva, M��ller, J. Carsten, Rieder, Philip, R��tti, Markus, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Besold, Ulrike, Kuster, Stefan P., McGeer, Allison, Risch, Lorenz, Schlegel, Matthias, Friedl, Andr��e, Vernazza, Pietro, Kahlert, Christian R., and Kohler, Philipp
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body regions ,fungi ,skin and connective tissue diseases - Abstract
Additional file 1. Table S1. List of participating health care institutions with local mask policies (FFP2 or surgical masks), self-reported global adherence, number of healthcare workers (HCW) participating in the study, self-reported FFP2 use in contact with COVID-19 patients, and SARS-CoV-2 seroprevalence among healthcare workers. Table S2. Description and categorization of variables used in analyses. Table S3. Multivariable Cox regression analysis (full model and sensitivity analyses) with outcome ���Time to first SARS-CoV-2- positive nasopharyngeal PCR/rapid antigen test���. Table S4. Complete case analysis excluding observations with missing values: A) Cox regression (outcome time to first SARS-CoV-2 positive swab); B) multivariable logistic regression (outcome SARS-CoV-2 seroconversion). Table S5. Results of multivariable logistic regression analysis (full model and sensitivity analyses) regarding outcome ���SARS-CoV-2 seroconversion���. Table S6. Subgroup analysis of HCW with frequent COVID-19 exposure vs. HCW with less frequent COVID-19 exposure; A) Cox regression (outcome SARS-CoV-2 positive swab); B) multivariable logistic regression (outcome SARS-CoV-2 seroconversion). Table S7. Subgroup analysis of HCW performing AGP: A) Cox regression (outcome SARS-CoV-2 positive swab); B) multivariable logistic regression (outcome SARS-CoV-2 seroconversion).
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- 2022
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11. Symptoms Compatible With Long Coronavirus Disease (COVID) in Healthcare Workers With and Without Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection—Results of a Prospective Multicenter Cohort
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Strahm, Carol, primary, Seneghini, Marco, additional, Güsewell, Sabine, additional, Egger, Thomas, additional, Leal-Neto, Onicio, additional, Brucher, Angela, additional, Lemmenmeier, Eva, additional, Meier Kleeb, Dorette, additional, Möller, J Carsten, additional, Rieder, Philip, additional, Ruetti, Markus, additional, Rutz, Remus, additional, Schmid, Hans Ruedi, additional, Stocker, Reto, additional, Vuichard-Gysin, Danielle, additional, Wiggli, Benedikt, additional, Besold, Ulrike, additional, Kuster, Stefan P, additional, McGeer, Allison, additional, Risch, Lorenz, additional, Friedl, Andrée, additional, Schlegel, Matthias, additional, Schmid, Dagmar, additional, Vernazza, Pietro, additional, Kahlert, Christian R, additional, and Kohler, Philipp, additional
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- 2022
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12. Impact of respirator versus surgical masks on SARS-CoV-2 acquisition in healthcare workers: a prospective multicentre cohort
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Haller, Sabine, Güsewell, Sabine, Egger, Thomas, Scanferla, Giulia, Thoma, Reto, Leal-Neto, Onicio B, Flury, Domenica, Brucher, Angela, Lemmenmeier, Eva, Möller, J Carsten, Rieder, Philip, Rütti, Markus, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Besold, Ulrike, Kuster, Stefan P, McGeer, Allison, Risch, Lorenz, Schlegel, Matthias, Friedl, Andrée, Vernazza, Pietro, Kahlert, Christian R, and Kohler, Philipp
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Adult ,Male ,Adolescent ,Health Personnel ,610 Medicine & health ,Infectious and parasitic diseases ,RC109-216 ,Kaplan-Meier Estimate ,Young Adult ,Surgical mask ,Healthcare workers ,Humans ,Prospective Studies ,Respiratory Protective Devices ,Aerosol ,Aged ,Aerosols ,Infection Control ,Research ,Masks ,COVID-19 ,Middle Aged ,Logistic Models ,Seroconversion ,Female ,Respirator ,Switzerland - Abstract
Background There is insufficient evidence regarding the role of respirators in the prevention of SARS-CoV-2 infection. We analysed the impact of filtering facepiece class 2 (FFP2) versus surgical masks on the risk of SARS-CoV-2 acquisition among Swiss healthcare workers (HCW). Methods Our prospective multicentre cohort enrolled HCW from June to August 2020. Participants were asked about COVID-19 risk exposures/behaviours, including preferentially worn mask type when caring for COVID-19 patients outside of aerosol-generating procedures. The impact of FFP2 on (1) self-reported SARS-CoV-2-positive nasopharyngeal PCR/rapid antigen tests captured during weekly surveys, and (2) SARS-CoV-2 seroconversion between baseline and January/February 2021 was assessed. Results We enrolled 3259 participants from nine healthcare institutions, whereof 716 (22%) preferentially used FFP2. Among these, 81/716 (11%) reported a SARS-CoV-2-positive swab, compared to 352/2543 (14%) surgical mask users; seroconversion was documented in 85/656 (13%) FFP2 and 426/2255 (19%) surgical mask users. Adjusted for baseline characteristics, COVID-19 exposure, and risk behaviour, FFP2 use was non-significantly associated with decreased risk for SARS-CoV-2-positive swab (adjusted hazard ratio [aHR] 0.8, 95% CI 0.6–1.0) and seroconversion (adjusted odds ratio [aOR] 0.7, 95% CI 0.5–1.0); household exposure was the strongest risk factor (aHR 10.1, 95% CI 7.5–13.5; aOR 5.0, 95% CI 3.9–6.5). In subgroup analysis, FFP2 use was clearly protective among those with frequent (> 20 patients) COVID-19 exposure (aHR 0.7 for positive swab, 95% CI 0.5–0.8; aOR 0.6 for seroconversion, 95% CI 0.4–1.0). Conclusions Respirators compared to surgical masks may convey additional protection from SARS-CoV-2 for HCW with frequent exposure to COVID-19 patients. Supplementary Information The online version contains supplementary material available at 10.1186/s13756-022-01070-6.
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- 2021
13. Symptoms compatible with long-COVID in healthcare workers with and without SARS-CoV-2 infection – results of a prospective multicenter cohort
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Strahm, Carol, primary, Seneghini, Marco, additional, Güsewell, Sabine, additional, Egger, Thomas, additional, Leal, Onicio, additional, Brucher, Angela, additional, Lemmenmeier, Eva, additional, Kleeb, Dorette Meier, additional, Möller, J. Carsten, additional, Rieder, Philip, additional, Ruetti, Markus, additional, Rutz, Remus, additional, Schmid, Hans-Ruedi, additional, Stocker, Reto, additional, Vuichard-Gysin, Danielle, additional, Wiggli, Benedikt, additional, Besold, Ulrike, additional, Kuster, Stefan P., additional, McGeer, Allison, additional, Risch, Lorenz, additional, Friedl, Andrée, additional, Schlegel, Matthias, additional, Schmid, Dagmar, additional, Vernazza, Pietro, additional, Kahlert, Christian R., additional, and Kohler, Philipp, additional
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- 2021
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14. Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent Covid-19 – a prospective multicentre cohort study
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Kohler, Philipp, primary, Güsewell, Sabine, additional, Seneghini, Marco, additional, Egger, Thomas, additional, Leal, Onicio, additional, Brucher, Angela, additional, Lemmenmeier, Eva, additional, Möller, J. Carsten, additional, Rieder, Philip, additional, Ruetti, Markus, additional, Stocker, Reto, additional, Vuichard-Gysin, Danielle, additional, Wiggli, Benedikt, additional, Besold, Ulrike, additional, Kuster, Stefan P., additional, McGeer, Allison, additional, Risch, Lorenz, additional, Friedl, Andrée, additional, Vernazza, Pietro, additional, and Kahlert, Christian R., additional
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- 2021
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15. Use of respirator vs. surgical masks in healthcare personnel and its impact on SARS-CoV-2 acquisition – a prospective multicentre cohort study
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Haller, Sabine, primary, Güsewell, Sabine, additional, Egger, Thomas, additional, Scanferla, Giulia, additional, Thoma, Reto, additional, Leal-Neto, Onicio B., additional, Flury, Domenica, additional, Brucher, Angela, additional, Lemmenmeier, Eva, additional, Möller, J. Carsten, additional, Rieder, Philip, additional, Ruetti, Markus, additional, Stocker, Reto, additional, Vuichard-Gysin, Danielle, additional, Wiggli, Benedikt, additional, Besold, Ulrike, additional, Kuster, Stefan P., additional, McGeer, Allison, additional, Risch, Lorenz, additional, Schlegel, Matthias, additional, Friedl, Andrée, additional, Vernazza, Pietro, additional, Kahlert, Christian R., additional, and Kohler, Philipp, additional
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- 2021
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16. Non-occupational and occupational factors associated with specific SARS-CoV-2 antibodies among hospital workers - A multicentre cross-sectional study
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Kahlert, Christian R, Persi, Raphael, Güsewell, Sabine, Egger, Thomas, Leal-Neto, Onicio B; https://orcid.org/0000-0001-5785-1867, Sumer, Johannes, Flury, Domenica, Brucher, Angela, Lemmenmeier, Eva, Möller, J Carsten, Rieder, Philip, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Albrich, Werner C, Babouee Flury, Baharak, Besold, Ulrike, Fehr, Jan, Kuster, Stefan P, McGeer, Allison, Risch, Lorenz, Schlegel, Matthias, Friedl, Andrée, Vernazza, Pietro, Kohler, Philipp, Kahlert, Christian R, Persi, Raphael, Güsewell, Sabine, Egger, Thomas, Leal-Neto, Onicio B; https://orcid.org/0000-0001-5785-1867, Sumer, Johannes, Flury, Domenica, Brucher, Angela, Lemmenmeier, Eva, Möller, J Carsten, Rieder, Philip, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Albrich, Werner C, Babouee Flury, Baharak, Besold, Ulrike, Fehr, Jan, Kuster, Stefan P, McGeer, Allison, Risch, Lorenz, Schlegel, Matthias, Friedl, Andrée, Vernazza, Pietro, and Kohler, Philipp
- Abstract
OBJECTIVES Protecting healthcare workers (HCWs) from coronavirus disease-19 (COVID-19) is critical to preserve the functioning of healthcare systems. We therefore assessed seroprevalence and identified risk factors for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) seropositivity in this population. METHODS Between 22 June 22 and 15 August 2020, HCWs from institutions in northern/eastern Switzerland were screened for SARS-CoV-2 antibodies. We recorded baseline characteristics, non-occupational and occupational risk factors. We used pairwise tests of associations and multivariable logistic regression to identify factors associated with seropositivity. RESULTS Among 4664 HCWs from 23 healthcare facilities, 139 (3%) were seropositive. Non-occupational exposures independently associated with seropositivity were contact with a COVID-19-positive household (adjusted OR 59, 95% CI 33-106), stay in a COVID-19 hotspot (aOR 2.3, 95% CI 1.2-4.2) and male sex (aOR 1.9, 95% CI 1.1-3.1). Blood group 0 vs. non-0 (aOR 0.5, 95% CI 0.3-0.8), active smoking (aOR 0.4, 95% CI 0.2-0.7), living with children <12 years (aOR 0.3, 95% CI 0.2-0.6) and being a physician (aOR 0.2, 95% CI 0.1-0.5) were associated with decreased risk. Other occupational risk factors were close contact to COVID-19 patients (aOR 2.7, 95% CI 1.4-5.4), exposure to COVID-19-positive co-workers (aOR 1.9, 95% CI 1.1-2.9), poor knowledge of standard hygiene precautions (aOR 1.9, 95% CI 1.2-2.9) and frequent visits to the hospital canteen (aOR 2.3, 95% CI 1.4-3.8). DISCUSSION Living with COVID-19-positive households showed the strongest association with SARS-CoV-2 seropositivity. We identified several potentially modifiable work-related risk factors, which might allow mitigation of the COVID-19 risk among HCWs. The lower risk among those living with children, even after correction for multiple confounders, is remarkable and merits further study.
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- 2021
17. Non-occupational and occupational factors associated with specific SARS-CoV-2 antibodies among Hospital Workers – a multicentre cross-sectional study
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Kahlert, Christian R., primary, Persi, Raphael, additional, Güsewell, Sabine, additional, Egger, Thomas, additional, Leal-Neto, Onicio B., additional, Sumer, Johannes, additional, Flury, Domenica, additional, Brucher, Angela, additional, Lemmenmeier, Eva, additional, Möller, J. Carsten, additional, Rieder, Philip, additional, Stocker, Reto, additional, Vuichard-Gysin, Danielle, additional, Wiggli, Benedikt, additional, Albrich, Werner C., additional, Flury, Baharak Babouee, additional, Besold, Ulrike, additional, Fehr, Jan, additional, Kuster, Stefan P., additional, McGeer, Allison, additional, Risch, Lorenz, additional, Schlegel, Matthias, additional, Friedl, Andrée, additional, Vernazza, Pietro, additional, and Kohler, Philipp, additional
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- 2020
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18. Additional file 3 of Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent COVID-19—a prospective multicenter cohort study
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Kohler, Philipp, Güsewell, Sabine, Seneghini, Marco, Egger, Thomas, Leal, Onicio, Brucher, Angela, Lemmenmeier, Eva, Möller, J. Carsten, Rieder, Philip, Ruetti, Markus, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Besold, Ulrike, Kuster, Stefan P., McGeer, Allison, Risch, Lorenz, Friedl, Andrée, Schlegel, Matthias, Vernazza, Pietro, and Kahlert, Christian R.
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Data_FILES ,3. Good health - Abstract
Additional file 3.
19. Additional file 3 of Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent COVID-19—a prospective multicenter cohort study
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Kohler, Philipp, Güsewell, Sabine, Seneghini, Marco, Egger, Thomas, Leal, Onicio, Brucher, Angela, Lemmenmeier, Eva, Möller, J. Carsten, Rieder, Philip, Ruetti, Markus, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Besold, Ulrike, Kuster, Stefan P., McGeer, Allison, Risch, Lorenz, Friedl, Andrée, Schlegel, Matthias, Vernazza, Pietro, and Kahlert, Christian R.
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Data_FILES ,3. Good health - Abstract
Additional file 3.
20. Colonization with resistant bacteria in hospital employees: an epidemiological surveillance and typing study.
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Badinski T, Seiffert SN, Grässli F, Babouee Flury B, Besold U, Betschon E, Biggel M, Brucher A, Cusini A, Dörr T, Egli A, Goppel S, Güsewell S, Keller J, von Kietzell M, Möller JC, Nolte O, Ortner M, Roloff T, Ruetti M, Schlegel M, Seth-Smith HMB, Stephan R, Stocker R, Vuichard-Gysin D, Willi B, Kuster SP, Kahlert CR, and Kohler P
- Abstract
The objective of this study was to determine the prevalence, molecular epidemiology, and risk factors for gut colonization with extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E), carbapenemase-producing Enterobacterales (CPE), and vancomycin-resistant enterococci (VRE) in healthcare workers (HCWs). In September/October 2022, we performed a cross-sectional study among HCW from 14 institutions in Northeastern Switzerland. HCWs reported risk factors for antimicrobial resistance (covering the last 12-24 months) and provided rectal swabs. Swabs were screened for ESBL-E, CPE, and VRE; whole-genome sequencing (WGS) was performed to assess the genetic relatedness. Logistic regression was used to identify occupational and non-occupational risk factors. Among approximately 22,500 employees, 1,209 participated (median age 46 years, 82% female). Prevalences of ESBL-E ( n = 65) and CPE ( n = 1) were 5.4% [95% confidence interval (CI) 4.2-6.8] and 0.1% (95% CI 0.0-0.5), respectively; no VREs were detected. In the multivariable analysis, non-European ethnicity [adjusted odds ratio (aOR) 7.0, 95% CI 1.4-27.3], travel to high-risk countries (aOR 4.9, 95% CI 2.5-9.3), systemic antibiotics (aOR 2.1, 95% CI 1.1-3.7), antibiotic eye drops (aOR 4.7, 95% CI 1.7-11.9), and monthly sushi consumption (aOR 2.4, 95% CI 1.4-4.3) were positively associated with ESBL-E colonization, whereas alcohol consumption (aOR 0.5 per glass/week, 95% CI 0.3-0.9) was negatively associated with ESBL-E colonization. Occupational factors showed no association. Among ESBL- Escherichia coli , ST131 (15 of 61, 25%) and bla
CTX-M-15 (37/61; 61%) were most common; one isolate co-harbored blaOXA-244 . WGS data did not show relevant clustering. Occupational exposure is not associated with ESBL-E colonization in HCW. Given the potential public health and antibiotic stewardship implications, the role of sushi consumption and antibiotic eye drops as risk factors should be further elucidated.- Published
- 2024
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21. SARS-CoV-2 immunity and reasons for non-vaccination among healthcare workers from eastern and northern Switzerland: results from a nested multicentre cross-sectional study.
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Albrecht S, Grässli F, Cusini A, Brucher A, Goppel S, Betschon E, Möller JC, Ortner M, Ruetti M, Stocker R, Vuichard-Gysin D, Besold U, Risch L, Von Kietzell M, Schlegel M, Vernazza P, Kuster SP, Kahlert CR, and Kohler P
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- Humans, Switzerland, Cross-Sectional Studies, Female, Male, Adult, Middle Aged, Antibodies, Viral blood, Vaccination statistics & numerical data, Young Adult, Adolescent, Immunity, Humoral, Surveys and Questionnaires, Aged, COVID-19 prevention & control, COVID-19 immunology, Health Personnel statistics & numerical data, COVID-19 Vaccines immunology, SARS-CoV-2 immunology
- Abstract
Aims of the Study: We aimed to assess the extent of SARS-CoV-2 humoral immunity elicited by previous infections and/or vaccination among healthcare workers, and to identify reasons why healthcare workers decided against vaccination., Methods: This nested cross-sectional study included volunteer healthcare workers from 14 healthcare institutions in German-speaking Switzerland. In January 2021, SARS-CoV-2 vaccines were available for healthcare workers. In May and June 2022, participants answered electronic questionnaires regarding baseline characteristics including SARS-CoV-2 vaccination status (with one or more vaccine doses defined as vaccinated) and previous SARS-CoV-2 infections. Unvaccinated participants indicated their reasons for non-vaccination. Participants underwent testing for SARS-CoV-2 anti-spike (anti-S) and anti-nucleocapsid (anti-N) antibodies. Antibody prevalence was described across age groups. In addition, we performed multivariable logistic regression to identify baseline characteristics independently associated with non-vaccination and described reasons for non-vaccination., Results: Among 22,438 eligible employees, 3,436 (15%) participated; the median age was 43.7 years (range 16-73), 2,794 (81.3%) were female, and 1,407 (47.7%) identified as nurses; 3,414 (99.4%) underwent serology testing, among whom 3,383 (99.0%) had detectable anti-S (3,357, 98.3%) antibodies, anti-N (2,396, 70.1%) antibodies, or both (2,370, 69.4%). A total of 296 (8.6%) healthcare workers were unvaccinated, whereas 3,140 (91.4%) were vaccinated. In multivariable analysis, age (adjusted OR [aOR] 1.02 per year, 95% CI 1.01-1.03), being a physician (aOR 3.22, 95% CI 1.75-5.92) or administrator (aOR 1.88, 95% CI 1.27-2.80), and having higher education (aOR 2.23, 95% CI 1.09-4.57) were positively associated with vaccine uptake, whereas working in non-acute care (aOR 0.58, 95% CI 0.34-0.97), active smoking (aOR 0.68, 95% CI 0.51-0.91), and taking prophylactic home remedies against SARS-CoV-2 (aOR 0.42, 95% CI 0.31-0.56) were negatively associated. Important reasons for non-vaccination were a belief that the vaccine might not have long-lasting immunity (267/291, 92.1%) and a preference for gaining naturally acquired instead of vaccine-induced immunity (241/289, 83.4%)., Conclusions: Almost all healthcare workers in our cohort had specific antibodies against SARS-CoV-2 from natural infection and/or from vaccination. Young healthcare workers and those working in non-acute settings were less likely to be vaccinated, whereas physicians and administrative staff showed higher vaccination uptake. Presumed ineffectiveness of the vaccine is an important reason for non-vaccination.
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- 2024
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22. Clinical symptoms of SARS-CoV-2 breakthrough infection during the Omicron period in relation to baseline immune status and booster vaccination-A prospective multicentre cohort of health professionals (SURPRISE study).
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Kohler P, Babouee Flury B, Güsewell S, Egger T, Leal O, Brucher A, Lemmenmeier E, Meier Kleeb D, Möller JC, Ortner M, Rieder P, Ruetti M, Schmid HR, Stocker R, Vuichard-Gysin D, Speer O, Wiggli B, Besold U, McGeer A, Risch L, Friedl A, Schlegel M, Vernazza P, Kahlert CR, and Kuster SP
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- Humans, SARS-CoV-2, Breakthrough Infections, Dizziness, Prospective Studies, Vaccination, Health Personnel, Pain, COVID-19 prevention & control, Vaccines
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The effects of different types of pre-existing immunity on the frequency of clinical symptoms caused by the SARS-CoV-2 breakthrough infection were prospectively assessed in healthcare workers during the Omicron period. Among 518 participants, hybrid immunity was associated with symptom reduction for dizziness, muscle or limb pain and headache as compared to vaccination only. Moreover, the frequencies of dizziness, cough and muscle or limb pain were lower in participants who had received a booster vaccine dose. Thus, hybrid immunity appeared to be superior in preventing specific symptoms during breakthrough infection compared to vaccination alone. A booster vaccine dose conferred additional symptom reduction., Competing Interests: No conflict of interest was declared., (© 2023 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.)
- Published
- 2023
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