Clinical symptoms of SARS-CoV-2 breakthrough infection during the Omicron period in relation to baseline immune status and booster vaccination-A prospective multicentre cohort of health professionals (SURPRISE study).

Authors :: Kohler P
Babouee Flury B
Güsewell S
Egger T
Leal O
Brucher A
Lemmenmeier E
Meier Kleeb D
Möller JC
Ortner M
Rieder P
Ruetti M
Schmid HR
Stocker R
Vuichard-Gysin D
Speer O
Wiggli B
Besold U
McGeer A
Risch L
Friedl A
Schlegel M
Vernazza P
Kahlert CR
Kuster SP
Source :: Influenza and other respiratory viruses [Influenza Other Respir Viruses] 2023 Jun 19; Vol. 17 (6), pp. e13167. Date of Electronic Publication: 2023 Jun 19 (Print Publication: 2023).
Publication Year :: 2023
Abstract: The effects of different types of pre-existing immunity on the frequency of clinical symptoms caused by the SARS-CoV-2 breakthrough infection were prospectively assessed in healthcare workers during the Omicron period. Among 518 participants, hybrid immunity was associated with symptom reduction for dizziness, muscle or limb pain and headache as compared to vaccination only. Moreover, the frequencies of dizziness, cough and muscle or limb pain were lower in participants who had received a booster vaccine dose. Thus, hybrid immunity appeared to be superior in preventing specific symptoms during breakthrough infection compared to vaccination alone. A booster vaccine dose conferred additional symptom reduction.<br />Competing Interests: No conflict of interest was declared.<br /> (© 2023 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.)

Subjects :: Humans
SARS-CoV-2
Breakthrough Infections
Dizziness
Prospective Studies
Vaccination
Health Personnel
Pain
COVID-19 prevention & control
Vaccines

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