251 results on '"Bach, Jean-Marie"'
Search Results
2. Spontaneous Akt2 deficiency in a colony of NOD mice exhibiting early diabetes
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Hervé, Julie, Haurogné, Karine, Allard, Marie, Sourice, Sophie, Lindenbaum, Pierre, Bach, Jean-Marie, and Lieubeau, Blandine
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- 2024
- Full Text
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3. Optimization of an O2-balanced bioartificial pancreas for type 1 diabetes using statistical design of experiment
- Author
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Mouré, Anne, Bekir, Sawsen, Bacou, Elodie, Pruvost, Quentin, Haurogné, Karine, Allard, Marie, De Beaurepaire, Laurence, Bosch, Steffi, Riochet, David, Gauthier, Olivier, Blancho, Gilles, Soulillou, Jean-Paul, Poncelet, Denis, Mignot, Grégoire, Courcoux, Philippe, Jegou, Dominique, Bach, Jean-Marie, and Mosser, Mathilde
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- 2022
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4. Pathogen exposure influences immune parameters around weaning in pigs reared in commercial farms
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Hervé, Julie, Haurogné, Karine, Buchet, Arnaud, Bacou, Elodie, Mignot, Grégoire, Allard, Marie, Leblanc-Maridor, Mily, Gavaud, Solenn, Lehébel, Anne, Terenina, Elena, Mormède, Pierre, Merlot, Elodie, Belloc, Catherine, Bach, Jean-Marie, and Lieubeau, Blandine
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- 2022
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5. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
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Théry, Clotilde, Witwer, Kenneth W, Aikawa, Elena, Alcaraz, Maria Jose, Anderson, Johnathon D, Andriantsitohaina, Ramaroson, Antoniou, Anna, Arab, Tanina, Archer, Fabienne, Atkin‐Smith, Georgia K, Ayre, D Craig, Bach, Jean‐Marie, Bachurski, Daniel, Baharvand, Hossein, Balaj, Leonora, Baldacchino, Shawn, Bauer, Natalie N, Baxter, Amy A, Bebawy, Mary, Beckham, Carla, Zavec, Apolonija Bedina, Benmoussa, Abderrahim, Berardi, Anna C, Bergese, Paolo, Bielska, Ewa, Blenkiron, Cherie, Bobis‐Wozowicz, Sylwia, Boilard, Eric, Boireau, Wilfrid, Bongiovanni, Antonella, Borràs, Francesc E, Bosch, Steffi, Boulanger, Chantal M, Breakefield, Xandra, Breglio, Andrew M, Brennan, Meadhbh Á, Brigstock, David R, Brisson, Alain, Broekman, Marike LD, Bromberg, Jacqueline F, Bryl‐Górecka, Paulina, Buch, Shilpa, Buck, Amy H, Burger, Dylan, Busatto, Sara, Buschmann, Dominik, Bussolati, Benedetta, Buzás, Edit I, Byrd, James Bryan, Camussi, Giovanni, Carter, David RF, Caruso, Sarah, Chamley, Lawrence W, Chang, Yu‐Ting, Chen, Chihchen, Chen, Shuai, Cheng, Lesley, Chin, Andrew R, Clayton, Aled, Clerici, Stefano P, Cocks, Alex, Cocucci, Emanuele, Coffey, Robert J, Cordeiro‐da‐Silva, Anabela, Couch, Yvonne, Coumans, Frank AW, Coyle, Beth, Crescitelli, Rossella, Criado, Miria Ferreira, D'Souza‐Schorey, Crislyn, Das, Saumya, Chaudhuri, Amrita Datta, de Candia, Paola, De Santana, Eliezer F, De Wever, Olivier, del Portillo, Hernando A, Demaret, Tanguy, Deville, Sarah, Devitt, Andrew, Dhondt, Bert, Di Vizio, Dolores, Dieterich, Lothar C, Dolo, Vincenza, Rubio, Ana Paula Dominguez, Dominici, Massimo, Dourado, Mauricio R, Driedonks, Tom AP, Duarte, Filipe V, Duncan, Heather M, Eichenberger, Ramon M, Ekström, Karin, Andaloussi, Samir EL, Elie‐Caille, Celine, Erdbrügger, Uta, Falcón‐Pérez, Juan M, Fatima, Farah, Fish, Jason E, Flores‐Bellver, Miguel, Försönits, András, and Frelet‐Barrand, Annie
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Biochemistry and Cell Biology ,Biological Sciences ,extracellular vesicles ,exosomes ,ectosomes ,microvesicles ,minimal information requirements ,guidelines ,standardization ,microparticles ,rigor ,reproducibility ,Biochemistry and cell biology - Abstract
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. We now update these "MISEV2014" guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
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- 2018
6. Can we extrapolate from a Cmah −/− Ldlr −/− mouse model a susceptibility for atherosclerosis in humans?
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Soulillou, Jean-Paul, Cozzi, Emanuele, Galli, Cesare, and Bach, Jean-Marie
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- 2020
7. LIS1, a glyco-humanized swine polyclonal anti-lymphocyte globulin, as a novel induction treatment in solid organ transplantation
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Rousse, Juliette, primary, Royer, Pierre-Joseph, additional, Evanno, Gwénaëlle, additional, Lheriteau, Elsa, additional, Ciron, Carine, additional, Salama, Apolline, additional, Shneiker, Françoise, additional, Duchi, Roberto, additional, Perota, Andrea, additional, Galli, Cesare, additional, Cozzi, Emmanuele, additional, Blancho, Gilles, additional, Duvaux, Odile, additional, Brouard, Sophie, additional, Soulillou, Jean-Paul, additional, Bach, Jean-Marie, additional, and Vanhove, Bernard, additional
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- 2023
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8. β2-adrenergic stimulation of dendritic cells favors IL-10 secretion by CD4+ T cells
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Hervé, Julie, Haurogné, Karine, Bacou, Elodie, Pogu, Sylvie, Allard, Marie, Mignot, Grégoire, Bach, Jean-Marie, and Lieubeau, Blandine
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- 2017
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9. Effects of divergent selection upon adrenocortical activity on immune traits in pig
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Hervé, Julie, Terenina, Elena, Haurogné, Karine, Bacou, Elodie, Kulikova, Elizaveta, Allard, Marie, Billon, Yvon, Bach, Jean-Marie, Mormède, Pierre, and Lieubeau, Blandine
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- 2019
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10. LIS1, a glyco-humanized swine polyclonal anti-lymphocyte globulin, as a novel induction treatment in solid organ transplantation
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Rousse, Juliette, primary, Royer, Pierre-Joseph, additional, Evanno, Gwenaëlle, additional, Lheriteau, Elsa, additional, Ciron, Carine, additional, Salama, Apolline, additional, Shneiker, Françoise, additional, Duchi, Roberto, additional, Perota, Andrea, additional, Galli, Cesare, additional, Cozzi, Emmanuele, additional, Blancho, Gilles, additional, Duvaux, Odile, additional, Brouard, Sophie, additional, Soulillou, Jean-Paul, additional, Bach, Jean-Marie, additional, and Vanhove, Bernard, additional
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- 2022
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11. β2-adrenoreceptor stimulation dampens the LPS-induced M1 polarization in pig macrophages
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Bacou, Elodie, Haurogné, Karine, Allard, Marie, Mignot, Grégoire, Bach, Jean-Marie, Hervé, Julie, and Lieubeau, Blandine
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- 2017
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12. Anti-Gal and Anti-Neu5Gc Responses in Nonimmunosuppressed Patients After Treatment With Rabbit Antithymocyte Polyclonal IgGs
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Salama, Apolline, Evanno, Gwénaëlle, Lim, Noha, Rousse, Juliette, Le Berre, Ludmilla, Nicot, Arnaud, Bach, Jean-Marie, Brouard, Sophie, Harris, Kristina M., Ehlers, Mario R., Gitelman, Stephen E., and Soulillou, Jean-Paul
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- 2017
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13. Rabbit antithymocyte globulin-induced serum sickness disease and human kidney graft survival
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Couvrat-Desvergnes, Gregoire, Salama, Apolline, Berre, Ludmilla Le, Evanno, Gwenaelle, Viklicky, Ondrej, Hruba, Petra, Vesely, Pavel, Guerif, Pierrick, Dejoie, Thomas, Rousse, Juliette, Nicot, Arnaud, Bach, Jean-Marie, Ang, Evelyn, Foucher, Yohann, Brouard, Sophie, Castagnet, Stephanie, Giral, Magali, Harb, Jean, Perreault, Helene, Charreau, Beatrice, Lorent, Marine, and Soulillou, Jean-Paul
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Kidneys -- Transplantation ,Organic acids -- Analysis -- Research ,Health care industry - Abstract
BACKGROUND. Rabbit-generated antithymocyte globulins (ATGs), which target human T cells, are widely used as immunosuppressive agents during treatment of kidney allograft recipients. However, ATGs can induce immune complex diseases, including serum sickness disease (SSD). Rabbit and human IgGs have various antigenic differences, including expression of the sialic acid Neu5Gc and α-1-3-Gal (Gal), which are not synthesized by human beings. Moreover, anti-Neu5Gc antibodies have been shown to preexist and be elicited by immunization in human subjects. This study aimed to assess the effect of SSD on long-term kidney allograft outcome and to compare the immunization status of grafted patients presenting with SSD following ATG induction treatment. METHODS. We analyzed data from a cohort of 889 first kidney graft recipients with ATG induction (86 with SSD [[SSD.sup.+]] and 803 without SSD [[SSD.sup.-]]) from the Donnees Informatisees et Validees en Transplantation data bank. Two subgroups of [SSD.sup.+] and [SSD.sup.-] patients that had received ATG induction treatment were then assessed for total anti-ATG, anti-Neu5Gc, and anti-Gal antibodies using ELISA assays on sera before and after transplantation. RESULTS. SSD was significantly associated with long-term graft loss (>10 years, P = 0.02). Moreover, [SSD.sup.+] patients exhibited significantly elevated titers of anti-ATG (P = 0.043) and anti-Neu5Gc (P = 0.007) IgGs in late post-graft samples compared with [SSD.sup.-] recipients. CONCLUSION. In conclusion, our data indicate that SSD is a major contributing factor of late graft loss following ATG induction and that anti-Neu5Gc antibodies increase over time in [SSD.sup.+] patients. FUNDING. This study was funded by Societe d'Acceleration du Transfert de Technologies Ouest Valorisation, the European FP7 'Translink' research program, the French National Agency of Research, Labex Transplantex, the Natural Science and Engineering Research Council of Canada, and the Canadian Foundation for Innovation., Introduction Polyclonal anti-human T lymphocyte IgGs (antithymocyte globulins [ATGs]) from various animal sources have been used since the very beginning of allotransplantation (1, 2). ATGs are administered either immediately following [...]
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- 2015
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14. Development of extracellular vesicle-based medicinal products: A position paper of the group “Extracellular Vesicle translatiOn to clinicaL perspectiVEs – EVOLVE France”
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Silva, Amanda K.A., primary, Morille, Marie, additional, Piffoux, Max, additional, Arumugam, Surendar, additional, Mauduit, Phlippe, additional, Larghero, Jérôme, additional, Bianchi, Arnaud, additional, Aubertin, Kelly, additional, Blanc-Brude, Olivier, additional, Noël, Danièle, additional, Velot, Emilie, additional, Ravel, Célia, additional, Elie-Caille, Céline, additional, Sebbagh, Anna, additional, Boulanger, Chantal, additional, Wilhelm, Claire, additional, Rahmi, Gabriel, additional, Raymond-Letron, Isabelle, additional, Cherukula, Kondareddy, additional, Montier, Tristan, additional, Martinaud, Christophe, additional, Bach, Jean-Marie, additional, Favre-Bulle, Olivier, additional, Spadavecchia, Jolanda, additional, Jorgensen, Christian, additional, Menasché, Philippe, additional, Aussel, Clotilde, additional, Chopineau, Joël, additional, Mosser, Mathilde, additional, Ullah, Matti, additional, Sailliet, Nicolas, additional, Luciani, Nathalie, additional, Mathieu, Noëlle, additional, Rautou, Pierre-Emmanuel, additional, Brouard, Sophie, additional, Boireau, Wilfrid, additional, Jauliac, Sébastien, additional, Dedier, Marianne, additional, Trouvin, Jean-Hugues, additional, Gazeau, Florence, additional, Trouillas, Marina, additional, Peltzer, Juliette, additional, Monsel, Antoine, additional, and Banzet, Sébastien, additional
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- 2021
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15. Molecular and functional signatures of distinct subpopulations of extracellular vesicles provide a rationale for beta-cell mediated immune disease
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MIGNOT, Grégoire, Giri, Khem Raj, De Beaurepaire, Laurence, Jegou, Dominique, Lavy, Margot, Mosser, Mathilde, Dupont, Aurelien, Fleurisson, Romain, Dubreil, Laurence, Pichon, Julien, van Endert, Peter Van, Bach, Jean-Marie, Bosch, Steffi, Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), Université de Nantes (UN)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Microscopie de Rennes (MRic), Université de Rennes (UR)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Expertise en Anatomie Pathologique (APEX), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Paris Descartes - Paris 5 (UPD5), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)
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[SDV]Life Sciences [q-bio] ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2021
16. Optimization of An O2-Balanced Bioartificial Pancreas for Type 1 Diabetes Using Statistical Design of Experiment.
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Mouré, Anne, primary, Bekir, Sawsen, additional, Bacou, Elodie, additional, Haurogne, Karine, additional, Allard, Marie, additional, De Beaurepaire, Laurence, additional, Bosch, Steffi, additional, Riochet, David, additional, Gauthier, Olivier, additional, Blancho, Gilles, additional, Soulillou, Jean-Paul, additional, Poncelet, Denis, additional, Mignot, Grégoire, additional, Courcoux, Philippe, additional, Jegou, Dominique, additional, Bach, Jean-Marie, additional, and Mosser, Mathilde, additional
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- 2021
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17. hCTLA4-Ig transgene expression in keratocytes modulates rejection of corneal xenografts in a pig to non-human primate anterior lamellar keratoplasty model
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Vabres, Bertrand, Le Bas-Bernardet, Stéphanie, Riochet, David, Chérel, Yan, Minault, David, Hervouet, Jérémy, Ducournau, Yvette, Moreau, Anne, Daguin, Véronique, Coulon, Flora, Pallier, Annaïck, Brouard, Sophie, Robson, Simon C., Nottle, Mark B., Cowan, Peter J., Venturi, Eric, Mermillod, Pascal, Brachet, Philippe, Galli, Cesare, Lagutina, Irina, Duchi, Roberto, Bach, Jean-Marie, Blancho, Gilles, Soulillou, Jean-Paul, and Vanhove, Bernard
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- 2014
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18. Nonhypoalbuminemic Inflammatory Bowel Disease in Dogs as Disease Model
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Hernandez, Juan, primary, Rouillé, Elodie, additional, Chocteau, Florian, additional, Allard, Marie, additional, Haurogné, Karine, additional, Lezin, Florence, additional, Hervé, Julie M, additional, Bach, Jean-Marie, additional, Abadie, Jérôme, additional, and Lieubeau, Blandine, additional
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- 2021
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19. High neutralizing potency of swine glyco‐humanized polyclonal antibodies against SARS‐CoV‐2
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Vanhove, Bernard, primary, Duvaux, Odile, additional, Rousse, Juliette, additional, Royer, Pierre‐Joseph, additional, Evanno, Gwénaëlle, additional, Ciron, Carine, additional, Lheriteau, Elsa, additional, Vacher, Laurent, additional, Gervois, Nadine, additional, Oger, Romain, additional, Jacques, Yannick, additional, Conchon, Sophie, additional, Salama, Apolline, additional, Duchi, Roberto, additional, Lagutina, Irina, additional, Perota, Andrea, additional, Delahaut, Philippe, additional, Ledure, Matthieu, additional, Paulus, Melody, additional, So, Ray T., additional, Mok, Chris Ka‐Pun, additional, Bruzzone, Roberto, additional, Bouillet, Marc, additional, Brouard, Sophie, additional, Cozzi, Emanuele, additional, Galli, Cesare, additional, Blanchard, Dominique, additional, Bach, Jean‐Marie, additional, and Soulillou, Jean‐Paul, additional
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- 2021
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20. Optimization of an O2-balanced bioartificial pancreas for type 1 diabetes using statistical design of experiment.
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Mouré, Anne, Bekir, Sawsen, Bacou, Elodie, Pruvost, Quentin, Haurogné, Karine, Allard, Marie, De Beaurepaire, Laurence, Bosch, Steffi, Riochet, David, Gauthier, Olivier, Blancho, Gilles, Soulillou, Jean-Paul, Poncelet, Denis, Mignot, Grégoire, Courcoux, Philippe, Jegou, Dominique, Bach, Jean-Marie, and Mosser, Mathilde
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TYPE 1 diabetes ,ISLANDS of Langerhans ,EXPERIMENTAL design ,ARTIFICIAL pancreases ,RESPONSE surfaces (Statistics) ,PANCREAS ,ISLANDS - Abstract
A bioartificial pancreas (BAP) encapsulating high pancreatic islets concentration is a promising alternative for type 1 diabetes therapy. However, the main limitation of this approach is O
2 supply, especially until graft neovascularization. Here, we described a methodology to design an optimal O2 -balanced BAP using statistical design of experiment (DoE). A full factorial DoE was first performed to screen two O2 -technologies on their ability to preserve pseudo-islet viability and function under hypoxia and normoxia. Then, response surface methodology was used to define the optimal O2 -carrier and islet seeding concentrations to maximize the number of viable pseudo-islets in the BAP containing an O2 -generator under hypoxia. Monitoring of viability, function and maturation of neonatal pig islets for 15 days in vitro demonstrated the efficiency of the optimal O2 -balanced BAP. The findings should allow the design of a more realistic BAP for humans with high islets concentration by maintaining the O2 balance in the device. [ABSTRACT FROM AUTHOR]- Published
- 2022
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21. Easy and rapid method of zygosity determination in transgenic mice by SYBR® Green real-time quantitative PCR with a simple data analysis
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Haurogné, Karine, Bach, Jean-Marie, and Lieubeau, Blandine
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- 2007
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22. Can We Extrapolate From a Cmah -/- Ldlr -/- Mouse Model a Susceptibility for Atherosclerosis in Humans?
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Soulillou, Jean-Paul, Cozzi, Emanuele, Galli, Cesare, Bach, Jean-Marie, Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Institut de transplantation urologie-néphrologie (ITUN), Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), University Hospital of Padua, Avantea Laboratory of Reproductive Technologies [Cremona, Italy], Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes, Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Le Bihan, Sylvie, Azienda Ospedale Università di Padova = Hospital-University of Padua (AOUP), and Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
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[SDV] Life Sciences [q-bio] ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,[SDV]Life Sciences [q-bio] ,Models, Animal ,Animals ,Humans ,Neuraminic Acids ,Letters ,Atherosclerosis ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,ComputingMilieux_MISCELLANEOUS ,Mixed Function Oxygenases - Abstract
International audience
- Published
- 2020
23. Generation of fertile cloned bull knock out for galactose-alpha 1,3-galactose and N-glycolylneuraminic acid antigens
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Perota, Andrea, Lagutina, Irina, Duchi, Roberto, Zanfrini, Elisa, Lazzari, Giovanna, Judor, Jean Paul, Conchon, Sophie, Bach, Jean-Marie, Bottio, Tomaso, Gerosa, Gino, Costa, Cristina, Galiñanes, Manuel, Roussel, Jean Christian, Padler-Karavani, Vered, Cozzi, Emanuele, Soulillou, Jean Paul, Galli, Cesare, Avantea Laboratory of Reproductive Technologies, Fondazione Avantea [Cremona, Italy], Centre hospitalier universitaire de Nantes (CHU Nantes), Université de Nantes (UN), Immuno-Endocrinologie Cellulaire et Moléculaire, Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Universita di Padova, IDIBELL--Hospital Universitari de Bellvitge, Vall d'Hebron University Hospital [Barcelona], Tel Aviv University [Tel Aviv], Transplant Immunology Unit, Universita degli Studi di Padova, European Project: 603049,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,TRANSLINK(2013), ProdInra, Migration, Defining the role of xeno-directed and autoimmune events in patients receiving animal-derived bioprosthetic heart valves - TRANSLINK - - EC:FP7:HEALTH2013-09-01 - 2017-08-31 - 603049 - VALID, Institut National de la Recherche Agronomique (INRA)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Università degli Studi di Padova = University of Padua (Unipd), and Tel Aviv University (TAU)
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[SDV] Life Sciences [q-bio] ,[SDV]Life Sciences [q-bio] ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2019
24. CD8 + T lymphocytes specific for glutamic acid decarboxylase 90–98 epitope mediate diabetes in NOD SCID mouse
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Sévère, Sabine, Gauvrit, Anne, Vu, Anh-Tuan, and Bach, Jean-Marie
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- 2007
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25. Epigenetic Mechanisms in Immune Disease: The Significance of Toll-Like Receptor-Binding Extracellular Vesicle-Encapsulated microRNA
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Bosch, Steffi, primary, Young, Nicholas A., additional, Mignot, Grégoire, additional, and Bach, Jean-Marie, additional
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- 2020
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26. Molecular and Functional Diversity of Distinct Subpopulations of the Stressed Insulin-Secreting Cell's Vesiculome
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Giri, Khem Raj, primary, de Beaurepaire, Laurence, additional, Jegou, Dominique, additional, Lavy, Margot, additional, Mosser, Mathilde, additional, Dupont, Aurelien, additional, Fleurisson, Romain, additional, Dubreil, Laurence, additional, Collot, Mayeul, additional, Van Endert, Peter, additional, Bach, Jean-Marie, additional, Mignot, Gregoire, additional, and Bosch, Steffi, additional
- Published
- 2020
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27. Analysis of major repetitive DNA sequences in the dog (Canis familiaris) genome
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Bentolila, Simone, Bach, Jean-Marie, Kessler, Jean-Louis, Bordelais, Isabelle, Cruaud, Corinne, Weissenbach, Jean, and Panthier, Jean-Jacques
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- 1999
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28. High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2
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Vanhove, Bernard, primary, Duvaux, Odile, additional, Rousse, Juliette, additional, Royer, Pierre-Joseph, additional, Evanno, Gwénaëlle, additional, Ciron, Carine, additional, Lheriteau, Elsa, additional, Vacher, Laurent, additional, Gervois, Nadine, additional, Oger, Romain, additional, Jacques, Yannick, additional, Conchon, Sophie, additional, Salama, Apolline, additional, Duchi, Roberto, additional, Lagutina, Irina, additional, Perota, Andrea, additional, Delahaut, Philippe, additional, Ledure, Matthieu, additional, Paulus, Melody, additional, So, Ray T., additional, Mok, Chris Ka-Pun, additional, Bruzzone, Roberto, additional, Bouillet, Marc, additional, Brouard, Sophie, additional, Cozzi, Emanuele, additional, Galli, Cesare, additional, Blanchard, Dominique, additional, Bach, Jean-Marie, additional, and Soulillou, Jean-Paul, additional
- Published
- 2020
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29. Challenging the Role of Diet-Induced Anti-Neu5Gc Antibodies in Human Pathologies
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Soulillou, Jean-Paul, primary, Cozzi, Emanuele, additional, and Bach, Jean-Marie, additional
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- 2020
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30. The Possible Role of Anti-Neu5Gc as an Obstacle in Xenotransplantation
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Tector, Alfred Joseph, primary, Mosser, Mathilde, additional, Tector, Matthew, additional, and Bach, Jean-Marie, additional
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- 2020
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31. Molecular and functional diversity of distinct subpopulations of extracellular vesicles from stressed pancreatic beta cells: implications for autoimmunity
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Giri, Khem Raj, primary, de Beaurepaire, Laurence, additional, Jegou, Dominique, additional, Lavy, Margot, additional, Mosser, Mathilde, additional, Dupont, Aurelien, additional, Fleurisson, Romain, additional, Dubreil, Laurence, additional, Collot, Mayeul, additional, Van Endert, Peter, additional, Bach, Jean-Marie, additional, Mignot, Gregoire, additional, and Bosch, Steffi, additional
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- 2020
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32. Can we extrapolate from a Cmah−/−Ldlr−/−mouse model a susceptibility for atherosclerosis in humans?
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Soulillou, Jean-Paul, primary, Cozzi, Emanuele, additional, Galli, Cesare, additional, and Bach, Jean-Marie, additional
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- 2020
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33. The Frequency and Immunodominance of Islet-Specific CD8+ T-cell Responses Change after Type 1 Diabetes Diagnosis and Treatment
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Martinuzzi, Emanuela, Novelli, Giulia, Scotto, Matthieu, Blancou, Philippe, Bach, Jean-Marie, Chaillous, Lucy, Bruno, Graziella, Chatenoud, Lucienne, van Endert, Peter, and Mallone, Roberto
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- 2008
34. Generation of cattle knockout for galactose‐α1,3‐galactose and N‐glycolylneuraminic acid antigens
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Perota, Andrea, Lagutina, Irina, Duchi, Roberto, Zanfrini, Elisa, Lazzari, Giovanna, Judor, Jean Paul, Conchon, Sophie, Bach, Jean Marie, Bottio, Tomaso, Gerosa, Gino, Costa Farré, Cristina, Galiñanes, Manuel, Roussel, Jean Christian, Padler-Karavani, Vered, Cozzi, Emanuele, Soulillou, Jean Paul, Galli, Cesare, Universitat Autònoma de Barcelona, Avantea Laboratory of Reproductive Technologies [Cremona, Italy], Fondazione Avantea [Cremona, Italy], Institut de transplantation urologie-néphrologie (ITUN), Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), Immunoregulation And Immunointervention in Transplantation and Autoimmunity (Team 4 - U1064 Inserm - CRTI), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Immuno-Endocrinologie Cellulaire et Moléculaire [Nantes] (IECM), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Department of Cardiac, Thoracic and Vascular Sciences and Public Health [Padova, Italy] (Cardiac Surgery Unit), Padova University School of Medicine [Padova, Italy] -Consorzio per la Ricerca Sanitaria - CORIS [Padova, Italy], Infectious Diseases and Transplantation Division [Barcelona, Spain], L’Hospitalet de Llobregat [Barcelona, Spain]-Bellvitge Biomedical Research Institute IDIBELL [Barcelona, Spain], Department of Cardiac Surgery & Reparative Therapy of the Heart [Barcelona, Spain], Vall d’Hebron Institute of Research [Barcelona, Spain]-Hospital Universitari Vall d'Hebron [Barcelona, Spain], Département de chirurgie thoracique et cardiovasculaire [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Department of Cell Research and Immunology, Tel Aviv University [Tel Aviv], Transplantation Immunology Unit [Padua, Italy] (Department of Transfusion Medicine), University of Padua–Ospedale Giustinianeo [Padua, Italy], Le Bihan, Sylvie, Defining the role of xeno-directed and autoimmune events in patients receiving animal-derived bioprosthetic heart valves - TRANSLINK - - EC:FP7:HEALTH2013-09-01 - 2017-08-31 - 603049 - VALID, Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Università degli Studi di Padova = University of Padua (Unipd)-Consorzio per la Ricerca Sanitaria - CORIS [Padova, Italy], Vall d'Hebron University Hospital [Barcelona]-Vall d’Hebron Research Institute (VHIR), Tel Aviv University (TAU), Università degli Studi di Padova = University of Padua (Unipd), and European Project: 603049,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,TRANSLINK(2013)
- Subjects
Male ,0301 basic medicine ,knockout ,Neu5Gc ,030230 surgery ,Epitope ,Mixed Function Oxygenases ,law.invention ,Animals, Genetically Modified ,Gene Knockout Techniques ,chemistry.chemical_compound ,0302 clinical medicine ,Carn de boví ,N-Glycolylneuraminic acid ,law ,xenotransplantation ,Polymerase chain reaction ,2. Zero hunger ,Sanger sequencing ,Heart valves ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Immunogenicity ,Galactosyltransferases ,Vàlvules cardíaques ,Heart Valve Prosthesis ,symbols ,bioprosthetic Heart Valve (BHV) ,Somatic cell nuclear transfer ,Xenotransplantation ,Female ,Original Article ,Beef ,cattle ,CMAH ,GGTA1 ,αGal ,Food Hypersensitivity ,Knockout ,Transplantation, Heterologous ,Immunology ,Biology ,03 medical and health sciences ,symbols.namesake ,Antigens, Heterophile ,Cytidine Monophosphate ,Animals ,Humans ,Gene ,Bioprosthesis ,Galactosyltransferase ,Transplantation ,Galactose ,Original Articles ,Fibroblasts ,Bioprosthetic Heart Valve (BHV) ,Molecular biology ,030104 developmental biology ,chemistry ,Cattle ,Neuraminic Acids ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
International audience; Two well-characterized carbohydrate epitopes are absent in humans but present in other mammals. These are galactose-α1,3-galactose (αGal) and N-glycolylneuraminic acid (Neu5Gc) which are introduced by the activities of two enzymes including α(1,3) galactosyltransferase (encoded by the GGTA1 gene) and CMP-Neu5Gc hydroxylase (encoded by the CMAH gene) that are inactive in humans but present in cattle. Hence, bovine-derived products are antigenic in humans who receive bioprosthetic heart valves (BHVs) or those that suffer from red meat syndrome. Using programmable nucleases, we disrupted (knockout, KO) GGTA1 and CMAH genes encoding for the enzymes that catalyse the synthesis of αGal and Neu5Gc, respectively, in both male and female bovine fibroblasts. The KO in clonally selected fibroblasts was detected by polymerase chain reaction (PCR) and confirmed by Sanger sequencing. Selected fibroblasts colonies were used for somatic cell nuclear transfer (SCNT) to produce cloned embryos that were implanted in surrogate recipient heifers. Fifty-three embryos were implanted in 33 recipients heifers; 3 pregnancies were carried to term and delivered 3 live calves. Primary cell cultures were established from the 3 calves and following molecular analyses confirmed the genetic deletions. FACS analysis showed the double-KO phenotype for both antigens confirming the mutated genotypes. Availability of such cattle double-KO model lacking both αGal and Neu5Gc offers a unique opportunity to study the functionality of BHV manufactured with tissues of potentially lower immunogenicity, as well as a possible new clinical approaches to help patients with red meat allergy syndrome due to the presence of these xenoantigens in the diet.
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- 2019
35. Additional file 2: of Effects of divergent selection upon adrenocortical activity on immune traits in pig
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HervÊ, Julie, Terenina, Elena, HaurognÊ, Karine, Bacou, Elodie, Kulikova, Elizaveta, Allard, Marie, Billon, Yvon, Bach, Jean-Marie, MormèDe, Pierre, and Lieubeau, Blandine
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Table S1. Variableâ s contributions to the first two dimensions of the PCA. Variables that contributed to more than 10% to one axis are underlined. (PDF 35 kb)
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- 2019
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36. Additional file 1: of Effects of divergent selection upon adrenocortical activity on immune traits in pig
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Hervé, Julie, Terenina, Elena, Haurogné, Karine, Bacou, Elodie, Kulikova, Elizaveta, Allard, Marie, Billon, Yvon, Bach, Jean-Marie, Mormède, Pierre, and Lieubeau, Blandine
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Figure S1. PCA variables’ correlogram. Correlations of each variable to the first two dimensions of the PCA are shown. CTL, CD8αhi cytotoxic T lymphocytes. (PDF 129 kb)
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- 2019
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37. Expression and distribution of Toll-Like Receptor (TLR)2, TLR4, TLR5 and TLR9 in the colonic mucosa of dogs with Inflammatory Bowel Disease
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Hernandez, Juan, Chocteau, Florian, Rouillé, Elodie, Hervé, Julie, Bach, Jean-Marie, Lieubeau, Blandine, and Abadie, Jérôme
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- 2019
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38. CD8+ T lymphocytes specific for glutamic acid decarboxylase 90–98 epitope mediate diabetes in NODSCID mouse
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Sévère, Sabine, Gauvrit, Anne, Vu, Anh-Tuan, and Bach, Jean-Marie
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- 2007
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39. CD8+ T-Cell Responses Identify β-Cell Autoimmunity in Human Type 1 Diabetes
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Mallone, Roberto, Martinuzzi, Emanuela, Blancou, Philippe, Novelli, Giulia, Afonso, Georgia, Dolz, Manuel, Bruno, Graziella, Chaillous, Lucy, Chatenoud, Lucienne, Bach, Jean-Marie, and van Endert, Peter
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- 2007
40. Minimal information for studies of extracellular vesicles 2018 (MISEV2018):a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
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Théry, Clotilde, Witwer, Kenneth W, Aikawa, Elena, Alcaraz, Maria Jose, Anderson, Johnathon D, Andriantsitohaina, Ramaroson, Antoniou, Anna, Arab, Tanina, Archer, Fabienne, Atkin-Smith, Georgia K, Ayre, D Craig, Bach, Jean-Marie, Bachurski, Daniel, Baharvand, Hossein, Balaj, Leonora, Baldacchino, Shawn, Bauer, Natalie N, Baxter, Amy A, Bebawy, Mary, Beckham, Carla, Bedina Zavec, Apolonija, Benmoussa, Abderrahim, Berardi, Anna C, Bergese, Paolo, Bielska, Ewa, Blenkiron, Cherie, Bobis-Wozowicz, Sylwia, Boilard, Eric, Boireau, Wilfrid, Bongiovanni, Antonella, Borràs, Francesc E, Bosch, Steffi, Boulanger, Chantal M, Breakefield, Xandra, Breglio, Andrew M, Brennan, Meadhbh Á, Brigstock, David R, Brisson, Alain, Broekman, Marike Ld, Bromberg, Jacqueline F, Bryl-Górecka, Paulina, Buch, Shilpa, Buck, Amy H, Burger, Dylan, Busatto, Sara, Buschmann, Dominik, Bussolati, Benedetta, Buzás, Edit I, Byrd, James Bryan, Camussi, Giovanni, Carter, David Rf, Caruso, Sarah, Chamley, Lawrence W, Chang, Yu-Ting, Chen, Chihchen, Chen, Shuai, Cheng, Lesley, Chin, Andrew R, Clayton, Aled, Clerici, Stefano P, Cocks, Alex, Cocucci, Emanuele, Coffey, Robert J, Cordeiro-da-Silva, Anabela, Couch, Yvonne, Coumans, Frank Aw, Coyle, Beth, Crescitelli, Rossella, Criado, Miria Ferreira, D'Souza-Schorey, Crislyn, Das, Saumya, Datta Chaudhuri, Amrita, de Candia, Paola, De Santana, Eliezer F, De Wever, Olivier, Del Portillo, Hernando A, Demaret, Tanguy, Deville, Sarah, Devitt, Andrew, Dhondt, Bert, Di Vizio, Dolores, Dieterich, Lothar C, Dolo, Vincenza, Dominguez Rubio, Ana Paula, Dominici, Massimo, Dourado, Mauricio R, Driedonks, Tom Ap, Duarte, Filipe V, Duncan, Heather M, Eichenberger, Ramon M, Ekström, Karin, El Andaloussi, Samir, Elie-Caille, Celine, Erdbrügger, Uta, Falcón-Pérez, Juan M, Fatima, Farah, Fish, Jason E, Flores-Bellver, Miguel, Försönits, András, Frelet-Barrand, Annie, Fricke, Fabia, Fuhrmann, Gregor, Gabrielsson, Susanne, Gámez-Valero, Ana, Gardiner, Chris, Gärtner, Kathrin, Gaudin, Raphael, Gho, Yong Song, Giebel, Bernd, Gilbert, Caroline, Gimona, Mario, Giusti, Ilaria, Goberdhan, Deborah Ci, Görgens, André, Gorski, Sharon M, Greening, David W, Gross, Julia Christina, Gualerzi, Alice, Gupta, Gopal N, Gustafson, Dakota, Handberg, Aase, Haraszti, Reka A, Harrison, Paul, Hegyesi, Hargita, Hendrix, An, Hill, Andrew F, Hochberg, Fred H, Hoffmann, Karl F, Holder, Beth, Holthofer, Harry, Hosseinkhani, Baharak, Hu, Guoku, Huang, Yiyao, Huber, Veronica, Hunt, Stuart, Ibrahim, Ahmed Gamal-Eldin, Ikezu, Tsuneya, Inal, Jameel M, Isin, Mustafa, Ivanova, Alena, Jackson, Hannah K, Jacobsen, Soren, Jay, Steven M, Jayachandran, Muthuvel, Jenster, Guido, Jiang, Lanzhou, Johnson, Suzanne M, Jones, Jennifer C, Jong, Ambrose, Jovanovic-Talisman, Tijana, Jung, Stephanie, Kalluri, Raghu, Kano, Shin-Ichi, Kaur, Sukhbir, Kawamura, Yumi, Keller, Evan T, Khamari, Delaram, Khomyakova, Elena, Khvorova, Anastasia, Kierulf, Peter, Kim, Kwang Pyo, Kislinger, Thomas, Klingeborn, Mikael, Klinke, David J, Kornek, Miroslaw, Kosanović, Maja M, Kovács, Árpád Ferenc, Krämer-Albers, Eva-Maria, Krasemann, Susanne, Krause, Mirja, Kurochkin, Igor V, Kusuma, Gina D, Kuypers, Sören, Laitinen, Saara, Langevin, Scott M, Languino, Lucia R, Lannigan, Joanne, Lässer, Cecilia, Laurent, Louise C, Lavieu, Gregory, Lázaro-Ibáñez, Elisa, Le Lay, Soazig, Lee, Myung-Shin, Lee, Yi Xin Fiona, Lemos, Debora S, Lenassi, Metka, Leszczynska, Aleksandra, Li, Isaac Ts, Liao, Ke, Libregts, Sten F, Ligeti, Erzsebet, Lim, Rebecca, Lim, Sai Kiang, Linē, Aija, Linnemannstöns, Karen, Llorente, Alicia, Lombard, Catherine A, Lorenowicz, Magdalena J, Lörincz, Ákos M, Lötvall, Jan, Lovett, Jason, Lowry, Michelle C, Loyer, Xavier, Lu, Quan, Lukomska, Barbara, Lunavat, Taral R, Maas, Sybren Ln, Malhi, Harmeet, Marcilla, Antonio, Mariani, Jacopo, Mariscal, Javier, Martens-Uzunova, Elena S, Martin-Jaular, Lorena, Martinez, M Carmen, Martins, Vilma Regina, Mathieu, Mathilde, Mathivanan, Suresh, Maugeri, Marco, McGinnis, Lynda K, McVey, Mark J, Meckes, David G, Meehan, Katie L, Mertens, Inge, Minciacchi, Valentina R, Möller, Andreas, Møller Jørgensen, Malene, Morales-Kastresana, Aizea, Morhayim, Jess, Mullier, François, Muraca, Maurizio, Musante, Luca, Mussack, Veronika, Muth, Dillon C, Myburgh, Kathryn H, Najrana, Tanbir, Nawaz, Muhammad, Nazarenko, Irina, Nejsum, Peter, Neri, Christian, Neri, Tommaso, Nieuwland, Rienk, Nimrichter, Leonardo, Nolan, John P, Nolte-'t Hoen, Esther NM, Noren Hooten, Nicole, O'Driscoll, Lorraine, O'Grady, Tina, O'Loghlen, Ana, Ochiya, Takahiro, Olivier, Martin, Ortiz, Alberto, Ortiz, Luis A, Osteikoetxea, Xabier, Østergaard, Ole, Ostrowski, Matias, Park, Jaesung, Pegtel, D Michiel, Peinado, Hector, Perut, Francesca, Pfaffl, Michael W, Phinney, Donald G, Pieters, Bartijn Ch, Pink, Ryan C, Pisetsky, David S, Pogge von Strandmann, Elke, Polakovicova, Iva, Poon, Ivan Kh, Powell, Bonita H, Prada, Ilaria, Pulliam, Lynn, Quesenberry, Peter, Radeghieri, Annalisa, Raffai, Robert L, Raimondo, Stefania, Rak, Janusz, Ramirez, Marcel I, Raposo, Graça, Rayyan, Morsi S, Regev-Rudzki, Neta, Ricklefs, Franz L, Robbins, Paul D, Roberts, David D, Rodrigues, Silvia C, Rohde, Eva, Rome, Sophie, Rouschop, Kasper Ma, Rughetti, Aurelia, Russell, Ashley E, Saá, Paula, Sahoo, Susmita, Salas-Huenuleo, Edison, Sánchez, Catherine, Saugstad, Julie A, Saul, Meike J, Schiffelers, Raymond M, Schneider, Raphael, Schøyen, Tine Hiorth, Scott, Aaron, Shahaj, Eriomina, Sharma, Shivani, Shatnyeva, Olga, Shekari, Faezeh, Shelke, Ganesh Vilas, Shetty, Ashok K, Shiba, Kiyotaka, Siljander, Pia R-M, Silva, Andreia M, Skowronek, Agata, Snyder, Orman L, Soares, Rodrigo Pedro, Sódar, Barbara W, Soekmadji, Carolina, Sotillo, Javier, Stahl, Philip D, Stoorvogel, Willem, Stott, Shannon L, Strasser, Erwin F, Swift, Simon, Tahara, Hidetoshi, Tewari, Muneesh, Timms, Kate, Tiwari, Swasti, Tixeira, Rochelle, Tkach, Mercedes, Toh, Wei Seong, Tomasini, Richard, Torrecilhas, Ana Claudia, Tosar, Juan Pablo, Toxavidis, Vasilis, Urbanelli, Lorena, Vader, Pieter, van Balkom, Bas Wm, van der Grein, Susanne G, Van Deun, Jan, van Herwijnen, Martijn Jc, Van Keuren-Jensen, Kendall, van Niel, Guillaume, van Royen, Martin E, van Wijnen, Andre J, Vasconcelos, M Helena, Vechetti, Ivan J, Veit, Tiago D, Vella, Laura J, Velot, Émilie, Verweij, Frederik J, Vestad, Beate, Viñas, Jose L, Visnovitz, Tamás, Vukman, Krisztina V, Wahlgren, Jessica, Watson, Dionysios C, Wauben, Marca Hm, Weaver, Alissa, Webber, Jason P, Weber, Viktoria, Wehman, Ann M, Weiss, Daniel J, Welsh, Joshua A, Wendt, Sebastian, Wheelock, Asa M, Wiener, Zoltán, Witte, Leonie, Wolfram, Joy, Xagorari, Angeliki, Xander, Patricia, Xu, Jing, Yan, Xiaomei, Yáñez-Mó, María, Yin, Hang, Yuana, Yuana, Zappulli, Valentina, Zarubova, Jana, Žėkas, Vytautas, Zhang, Jian-Ye, Zhao, Zezhou, Zheng, Lei, Zheutlin, Alexander R, Zickler, Antje M, Zimmermann, Pascale, Zivkovic, Angela M, Zocco, Davide, Zuba-Surma, Ewa K, dB&C I&I, LS Celbiologie-Algemeen, Celbiologie, Afd Pharmaceutics, Sub General Pharmaceutics, Sub Biomol.Mass Spect. and Proteomics, Afd Pharmacology, Urology, Pathology, Medical Oncology, Immunité et cancer, Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Johns Hopkins University School of Medicine [Baltimore], Stress Oxydant et Pathologies Métaboliques (SOPAM), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 (PRISM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Infections Virales et Pathologie Comparée - UMR 754 (IVPC), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Immuno-Endocrinologie Cellulaire et Moléculaire [Nantes] (IECM), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Department for Molecular Biology and Nanobiotechnology, National Institute of chemitry, Slovenia, Biologie, génétique et thérapies ostéoarticulaires et respiratoires (BIOTARGEN), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes, Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Imagerie Moléculaire et Nanobiotechnologies - Institut Européen de Chimie et Biologie (IECB), Université Sciences et Technologies - Bordeaux 1-Centre National de la Recherche Scientifique (CNRS), Molecular Biotechnology Center, Università degli studi di Torino = University of Turin (UNITO), Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Centre for Sustainable Tropical Fisheries and Aquaculture, James Cook University (JCU), Department of Oncology - Pathology, Cancer Center Karolinska [Karolinska Institutet] (CCK), Karolinska Institutet [Stockholm]-Karolinska Institutet [Stockholm], Departamento de Ciências Biológicas, Universidade do Porto = University of Porto, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Cancer Research Institute Ghent (CRIG), Universiteit Gent = Ghent University [Belgium] (UGENT), Department of Medical and Surgical Sciences for Children and Adults [Modena, Italy] (Laboratory of Cellular Therapy), Università degli Studi di Modena e Reggio Emilia (UNIMORE), Clinical Research Center, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Huddinge, Sweden, Karolinska Institutet [Stockholm]-Karolinska University Hospital [Stockholm], Center for Cooperative Research in Biosciences (CIC bioGUNE), Partner site Munich, German Centre for Infection Research (DZIF), Institute for Transfusion Medicine, University Hospital Essen, Universität Duisburg-Essen [Essen], Mécanismes Adaptatifs et Evolution (MECADEV), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Psychiatry, Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, Department of Bacteriology and Immunology [Helsinki], Haartman Institute [Helsinki], Faculty of Medecine [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Faculty of Medecine [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Rigshospitalet [Copenhagen], Copenhagen University Hospital, Dalhousie University [Halifax], Department of Biology, Molecular Cell Biology, University of Mainz, Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Glycobiologie et signalisation cellulaire, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, University of Gothenburg (GU), Universidad de Alicante, École supérieure du professorat et de l'éducation - Académie de Créteil (UPEC ESPE Créteil), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), University of Antwerp (UA), Université Catholique de Louvain = Catholic University of Louvain (UCL), Research Institute, IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Department of Veterinary Disease Biology [Copenhagen], Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Biologie et Pathologie du Neurone (Brain-C), Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing (B2A), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of Mathematics and Statistics, American University, University of Pretoria [South Africa], Ecole des Ingénieurs de la Ville de Paris (EIVP), Universitat Pompeu Fabra [Barcelona] (UPF), Instituto de Investigaciones Biomedicas, Universidad Nacional Autónoma de México (UNAM), Istituto Ortopedico Rizzoli, Department of Molecular Therapeutics, The Scripps Research Institute, Laboratoire d'Informatique de Grenoble (LIG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Montreal Children's Hospital, McGill University Health Center [Montreal] (MUHC), Compartimentation et dynamique cellulaires (CDC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Curie [Paris]-Centre National de la Recherche Scientifique (CNRS), National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cardiovascular Research Center, Massachusetts General Hospital [Boston], University Medical Center [Utrecht], University of Toronto, Fiocruz Minas - René Rachou Research Center / Instituto René Rachou [Belo Horizonte, Brésil], Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Federal University of Sao Paulo (Unifesp), Functional Genomics / Genómica Funcional [Montevideo], Institut Pasteur de Montevideo, Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia (UNIPG), Hospital Santa Cristina Instituto de Investigación Sanitaria Princesa C, Unidad de Investigación, Institut Curie [Paris]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Department of Physiology, University of California [San Francisco] (UCSF), University of California-University of California, University of Vermont [Burlington], Peking University [Beijing], Shandong Agricultural University (SDAU), State Key Laboratory of Quality Research in Chinese Medicine Taipa, Macau SAR, (Institute of Chinese Medical Sciences), Human Genetics, Universität Ulm - Ulm University [Ulm, Allemagne], INSERM, Institut Curie, INCa [INCA-11548], French National Research Agency [ANR-10-IDEX-0001-02 PSL*, ANR-11-LABX-0043], SIDACTION [17-1-AAE-1138], Fondation ARC [PGA1 RF20180206962, PJA 20171206453], NIDA [DA040385, DA047807], Ministry of Education, NIA [AG057430], NIMH [MH118164], Institut National de la Recherche Agronomique (INRA)-École Pratique des Hautes Études (EPHE), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN), Université Sciences et Technologies - Bordeaux 1 (UB)-Centre National de la Recherche Scientifique (CNRS), Universiteit Gent = Ghent University (UGENT), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Biotechnology and Biological Sciences Research Council (BBSRC)-Aberystwyth University, University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), The Scripps Research Institute [La Jolla, San Diego], Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Università degli Studi di Perugia = University of Perugia (UNIPG), Instituto de Investigacion Sanitaria del Hospital de la Princesa, Hospital Universitario de La Princesa, University of California [San Francisco] (UC San Francisco), University of California (UC)-University of California (UC), ANR-17-CE09-0025,MADNESS,Une approche microfluidique générique pour la qualification des nanoparticules biologiques(2017), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE)-Université Claude Bernard Lyon 1 (UCBL), Biomedical Engineering and Physics, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, Laboratory Specialized Diagnostics & Research, Radiotherapie, RS: GROW - R2 - Basic and Translational Cancer Biology, Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Université Nice Sophia Antipolis (... - 2019) (UNS), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Vétérinaire de Nantes-Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), Università degli studi di Torino (UNITO), Universidade do Porto, University of Helsinki-University of Helsinki-Faculty of Medecine [Helsinki], University of Helsinki-University of Helsinki, Johannes Gutenberg - Universität Mainz (JGU), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Université Pierre et Marie Curie - Paris 6 (UPMC), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Université de Toronto [Canada], Institut Curie-Institut National de la Santé et de la Recherche Médicale (INSERM), Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192 (PRISM), Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université de Franche-Comté (UFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidade do Porto [Porto], Ghent University [Belgium] (UGENT), FEMTO-ST Institute, Université de Technologie de Belfort-Montbeliard (UTBM)-Université de Franche-Comté (UFC)-CNRS : UMR6174, Mécanismes adaptatifs : des organismes aux communautés (MECADEV), Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN), Johannes Gutenberg - University of Mainz (JGU), Université Catholique de Louvain (UCL), Universitat Pompeu Fabra [Barcelona], Laboratoire d'Informatique de Grenoble (LIG), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre National de la Recherche Scientifique (CNRS)-Institut Curie-Université Pierre et Marie Curie - Paris 6 (UPMC), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Laboratoire Réactions et Génie des Procédés (LRGP), Fiocruz Minas - René Rachou Research Center / Instituto René Rachou, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Functional Genomics Unit, Institut Curie-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), University of Vermont College of Medicine [Burlington, VT, USA], Extracellular Vesicles, Molecular and Integrative Biosciences Research Programme, Thery, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin-Smith, G. K., Ayre, D. C., Bach, J. -M., Bachurski, D., Baharvand, H., Balaj, L., Baldacchino, S., Bauer, N. N., Baxter, A. A., Bebawy, M., Beckham, C., Bedina Zavec, A., Benmoussa, A., Berardi, A. C., Bergese, P., Bielska, E., Blenkiron, C., Bobis-Wozowicz, S., Boilard, E., Boireau, W., Bongiovanni, A., Borras, F. E., Bosch, S., Boulanger, C. M., Breakefield, X., Breglio, A. M., Brennan, M. A., Brigstock, D. R., Brisson, A., Broekman, M. L. D., Bromberg, J. F., Bryl-Gorecka, P., Buch, S., Buck, A. H., Burger, D., Busatto, S., Buschmann, D., Bussolati, B., Buzas, E. I., Byrd, J. B., Camussi, G., Carter, D. R. F., Caruso, S., Chamley, L. W., Chang, Y. -T., Chaudhuri, A. D., Chen, C., Chen, S., Cheng, L., Chin, A. R., Clayton, A., Clerici, S. P., Cocks, A., Cocucci, E., Coffey, R. J., Cordeiro-da-Silva, A., Couch, Y., Coumans, F. A. W., Coyle, B., Crescitelli, R., Criado, M. F., D'Souza-Schorey, C., Das, S., de Candia, P., De Santana, E. F., De Wever, O., del Portillo, H. A., Demaret, T., Deville, S., Devitt, A., Dhondt, B., Di Vizio, D., Dieterich, L. C., Dolo, V., Dominguez Rubio, A. P., Dominici, M., Dourado, M. R., Driedonks, T. A. P., Duarte, F. V., Duncan, H. M., Eichenberger, R. M., Ekstrom, K., EL Andaloussi, S., Elie-Caille, C., Erdbrugger, U., Falcon-Perez, J. M., Fatima, F., Fish, J. E., Flores-Bellver, M., Forsonits, A., Frelet-Barrand, A., Fricke, F., Fuhrmann, G., Gabrielsson, S., Gamez-Valero, A., Gardiner, C., Gartner, K., Gaudin, R., Gho, Y. S., Giebel, B., Gilbert, C., Gimona, M., Giusti, I., Goberdhan, D. C. I., Gorgens, A., Gorski, S. M., Greening, D. W., Gross, J. C., Gualerzi, A., Gupta, G. N., Gustafson, D., Handberg, A., Haraszti, R. A., Harrison, P., Hegyesi, H., Hendrix, A., Hill, A. F., Hochberg, F. H., Hoffmann, K. F., Holder, B., Holthofer, H., Hosseinkhani, B., Hu, G., Huang, Y., Huber, V., Hunt, S., Ibrahim, A. G. -E., Ikezu, T., Inal, J. M., Isin, M., Ivanova, A., Jackson, H. K., Jacobsen, S., Jay, S. M., Jayachandran, M., Jenster, G., Jiang, L., Johnson, S. M., Jones, J. C., Jong, A., Jovanovic-Talisman, T., Jung, S., Kalluri, R., Kano, S. -I., Kaur, S., Kawamura, Y., Keller, E. T., Khamari, D., Khomyakova, E., Khvorova, A., Kierulf, P., Kim, K. P., Kislinger, T., Klingeborn, M., Klinke, D. J., Kornek, M., Kosanovic, M. M., Kovacs, A. F., Kramer-Albers, E. -M., Krasemann, S., Krause, M., Kurochkin, I. V., Kusuma, G. D., Kuypers, S., Laitinen, S., Langevin, S. M., Languino, L. R., Lannigan, J., Lasser, C., Laurent, L. C., Lavieu, G., Lazaro-Ibanez, E., Le Lay, S., Lee, M. -S., Lee, Y. X. F., Lemos, D. S., Lenassi, M., Leszczynska, A., Li, I. T. S., Liao, K., Libregts, S. F., Ligeti, E., Lim, R., Lim, S. K., Line, A., Linnemannstons, K., Llorente, A., Lombard, C. A., Lorenowicz, M. J., Lorincz, A. M., Lotvall, J., Lovett, J., Lowry, M. C., Loyer, X., Lu, Q., Lukomska, B., Lunavat, T. R., Maas, S. L. N., Malhi, H., Marcilla, A., Mariani, J., Mariscal, J., Martens-Uzunova, E. S., Martin-Jaular, L., Martinez, M. C., Martins, V. R., Mathieu, M., Mathivanan, S., Maugeri, M., Mcginnis, L. K., Mcvey, M. J., Meckes, D. G., Meehan, K. L., Mertens, I., Minciacchi, V. R., Moller, A., Moller Jorgensen, M., Morales-Kastresana, A., Morhayim, J., Mullier, F., Muraca, M., Musante, L., Mussack, V., Muth, D. C., Myburgh, K. H., Najrana, T., Nawaz, M., Nazarenko, I., Nejsum, P., Neri, C., Neri, T., Nieuwland, R., Nimrichter, L., Nolan, J. P., Nolte-'t Hoen, E. N. M., Noren Hooten, N., O'Driscoll, L., O'Grady, T., O'Loghlen, A., Ochiya, T., Olivier, M., Ortiz, A., Ortiz, L. A., Osteikoetxea, X., Ostegaard, O., Ostrowski, M., Park, J., Pegtel, D. M., Peinado, H., Perut, F., Pfaffl, M. W., Phinney, D. G., Pieters, B. C. H., Pink, R. C., Pisetsky, D. S., Pogge von Strandmann, E., Polakovicova, I., Poon, I. K. H., Powell, B. H., Prada, I., Pulliam, L., Quesenberry, P., Radeghieri, A., Raffai, R. L., Raimondo, S., Rak, J., Ramirez, M. I., Raposo, G., Rayyan, M. S., Regev-Rudzki, N., Ricklefs, F. L., Robbins, P. D., Roberts, D. D., Rodrigues, S. C., Rohde, E., Rome, S., Rouschop, K. M. A., Rughetti, A., Russell, A. E., Saa, P., Sahoo, S., Salas-Huenuleo, E., Sanchez, C., Saugstad, J. A., Saul, M. J., Schiffelers, R. M., Schneider, R., Schoyen, T. H., Scott, A., Shahaj, E., Sharma, S., Shatnyeva, O., Shekari, F., Shelke, G. V., Shetty, A. K., Shiba, K., Siljander, P. R. -M., Silva, A. M., Skowronek, A., Snyder, O. L., Soares, R. P., Sodar, B. W., Soekmadji, C., Sotillo, J., Stahl, P. D., Stoorvogel, W., Stott, S. L., Strasser, E. F., Swift, S., Tahara, H., Tewari, M., Timms, K., Tiwari, S., Tixeira, R., Tkach, M., Toh, W. S., Tomasini, R., Torrecilhas, A. C., Tosar, J. P., Toxavidis, V., Urbanelli, L., Vader, P., van Balkom, B. W. M., van der Grein, S. G., Van Deun, J., van Herwijnen, M. J. C., Van Keuren-Jensen, K., van Niel, G., van Royen, M. E., van Wijnen, A. J., Vasconcelos, M. H., Vechetti, I. J., Veit, T. D., Vella, L. J., Velot, E., Verweij, F. J., Vestad, B., Vinas, J. L., Visnovitz, T., Vukman, K. V., Wahlgren, J., Watson, D. C., Wauben, M. H. M., Weaver, A., Webber, J. P., Weber, V., Wehman, A. M., Weiss, D. J., Welsh, J. A., Wendt, S., Wheelock, A. M., Wiener, Z., Witte, L., Wolfram, J., Xagorari, A., Xander, P., Xu, J., Yan, X., Yanez-Mo, M., Yin, H., Yuana, Y., Zappulli, V., Zarubova, J., Zekas, V., Zhang, J. -Y., Zhao, Z., Zheng, L., Zheutlin, A. R., Zickler, A. M., Zimmermann, P., Zivkovic, A. M., Zocco, D., Zuba-Surma, E. K., dB&C I&I, LS Celbiologie-Algemeen, Celbiologie, Afd Pharmaceutics, Sub General Pharmaceutics, Sub Biomol.Mass Spect. and Proteomics, Afd Pharmacology, CCA - Imaging and biomarkers, Amsterdam Neuroscience - Neuroinfection & -inflammation, and Amsterdam Neuroscience - Cellular & Molecular Mechanisms
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ectosome ,ectosomes ,exosomes ,extracellular vesicles ,guidelines ,microparticles ,microvesicles ,minimal information requirements ,reproducibility ,rigor ,standardization ,Histology ,Cell Biology ,[SDV]Life Sciences [q-bio] ,size-exclusion ,Medicine and Health Sciences ,CELL-DERIVED MICROPARTICLES ,FIELD-FLOW FRACTIONATION ,requirements ,circulating ,ComputingMilieux_MISCELLANEOUS ,Manchester Cancer Research Centre ,lcsh:Cytology ,PROSTATE-CANCER ,microparticle ,Cell interaction ,microvesicle ,chromatography ,Position Paper ,guideline ,Life Sciences & Biomedicine ,ectosomes, exosomes, extracellular vesicles, guidelines, microparticles, microvesicles, minimal information requirements, reproducibility, rigor, standardization ,MEMBRANE-VESICLES ,FETAL BOVINE ,Ectosomes ,Exosomes ,Extracellular Vesicles ,Guidelines ,Microparticles ,Microvesicles ,Minimal Information Requirements ,Reproducibility ,Rigor ,Standardization ,CIRCULATING MICROPARTICLES ,[SDV.BC]Life Sciences [q-bio]/Cellular Biology ,ddc:570 ,exosome ,SURFACE-PLASMON RESONANCE ,ddc:610 ,lcsh:QH573-671 ,Biology ,Interacció cel·lular ,Science & Technology ,ResearchInstitutes_Networks_Beacons/mcrc ,Cell membranes ,HUMAN URINARY EXOSOMES ,PREANALYTICAL PARAMETERS ,minimal information requirement ,SIZE-EXCLUSION CHROMATOGRAPHY ,1182 Biochemistry, cell and molecular biology ,extracellular vesicle ,Human medicine ,Membranes cel·lulars - Abstract
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. We now update these "MISEV2014" guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
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- 2018
41. HLA Class I Epitope Discovery in Type 1 Diabetes
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VAN ENDERT, PETER, HASSAINYA, YOUSRA, LINDO, VIVIAN, BACH, JEAN-MARIE, BLANCOU, PHILIPPE, LEMONNIER, FRANÇOIS, and MALLONE, ROBERTO
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- 2006
42. Gene-Gun Biolistic Immunization Encoding Glutamic Acid Decarboxylase: A Model for Studying Langerhans Cell Abnormalities and Mimicry in the Nonobese Diabetic Mouse
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JOUSSEMET, BÉATRICE, VU, ANH-TUAN, SAI, PIERRE, and BACH, JEAN-MARIE
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- 2005
43. The elusive case for a role of mimicry in autoimmune diseases
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Fourneau, Jean-Marie, Bach, Jean-Marie, van Endert, Peter M, and Bach, Jean-François
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- 2004
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44. Assignation of highly polymorphic markers on a canine purebred pedigree
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Tiret, Laurent, Kessler, Jean-Louis, Bentolila, Simone, Fauré, Sabine, Bach, Jean-Marie, Weissenbach, Jean, and Panthier, Jean-Jacques
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- 2000
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45. Divergent selection on adrenocortical activity modulates immune traits in pig
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Lieubeau, Blandine, Hervé, Julie, Haurogné, Karine, Bacou, Elodie, Allard, Marie, Billon, Yvon, Terenina, Elena, Bach, Jean-Marie, Mormède, Pierre, Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), and Ecole Nationale Vétérinaire de Nantes-Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA)
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[SDV]Life Sciences [q-bio] ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
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- 2018
46. Quantitative and qualitative changes in anti‐Neu5Gc antibody response following rabbit anti‐thymocyte IgG induction in kidney allograft recipients
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Rousse, Juliette, primary, Salama, Apolline, additional, Leviatan Ben‐Arye, Shani, additional, Hruba, Petra, additional, Slatinska, Janka, additional, Evanno, Gwénaëlle, additional, Duvaux, Odile, additional, Blanchard, Dominique, additional, Yu, Hai, additional, Chen, Xi, additional, Bach, Jean‐Marie, additional, Padler‐Karavani, Vered, additional, Viklicky, Ondrej, additional, and Soulillou, Jean‐Paul, additional
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- 2019
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- View/download PDF
47. Extracellular hemoglobin combined with an O2‐generating material overcomes O2 limitation in the bioartificial pancreas
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Mouré, Anne, primary, Bacou, Elodie, additional, Bosch, Steffi, additional, Jegou, Dominique, additional, Salama, Apolline, additional, Riochet, David, additional, Gauthier, Olivier, additional, Blancho, Gilles, additional, Soulillou, Jean‐Paul, additional, Poncelet, Denis, additional, Olmos, Eric, additional, Bach, Jean‐Marie, additional, and Mosser, Mathilde, additional
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- 2019
- Full Text
- View/download PDF
48. Pdx-1 or Pdx-1-VP16 protein transduction induces β-cell gene expression in liver-stem WB cells
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Dubreil Laurence, Martignat Lionel, Delisle Juliette, Saï Pierre, Bach Jean-Marie, Louzier Vanessa, and Bösch Steffi
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Medicine ,Biology (General) ,QH301-705.5 ,Science (General) ,Q1-390 - Abstract
Abstract Background Pancreatic duodenal homeobox-1 (Pdx-1) or Pdx-1-VP16 gene transfer has been shown to induce in vitro rat liver-stem WB cell conversion into pancreatic endocrine precursor cells. High glucose conditions were necessary for further differentiation into functional insulin-producing cells. Pdx-1 has the ability to permeate different cell types due to an inherent protein transduction domain (PTD). In this study, we evaluated liver-to-pancreas conversion of WB cells following Pdx-1 or Pdx-1-VP16 protein transduction. Findings WB cells were grown in high glucose medium containing Pdx-1 or Pdx-1-VP16 recombinant proteins for two weeks. β-like cell commitment was analysed by RT-PCR of pancreatic endocrine genes. We found that WB cells in high glucose culture spontaneously express pancreatic endocrine genes (Pdx-1, Ngn3, Nkx2.2, Kir6.2). Their further differentiation into β-like cells expressing genes related to endocrine pancreas development (Ngn3, NeuroD, Pax4, Nkx2.2, Nkx6.1, Pdx-1) and β-cell function (Glut-2, Kir6.2, insulin) was achieved only in the presence of Pdx-1(-VP16) protein. Conclusion These results demonstrate that Pdx-1(-VP16) protein transduction is instrumental for in vitro liver-to-pancreas conversion and is an alternative to gene therapy for β-cell engineering for diabetes cell therapy.
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- 2009
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49. Bipotential mouse embryonic liver (BMEL) cells spontaneously express Pdx1 and Ngn3 but do not undergo further pancreatic differentiation upon Hes1 down-regulation
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Martignat Lionel, Delisle Juliette, Bach Jean-Marie, Bösch Steffi, and Louzier Vanessa
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Medicine ,Biology (General) ,QH301-705.5 ,Science (General) ,Q1-390 - Abstract
Abstract Background Liver-to-pancreas conversion offers new possibilities for β-cell engineering for type 1 diabetes therapy. Among conceivable sources of liver cells, we focused on BMEL cells. These untransformed mouse embryonic liver cells have been reproducibly isolated from different inbred mice strains and have the potential to differentiate into hepatocytes and cholangiocytes in vitro and in vivo. Findings Strikingly, we find here that adherent BMEL cells display functional similarities with multipotent pancreatic precursor cells, namely Pdx1 and Ngn3 expression, and further express Hnf6 in floating aggregate culture. Hes1, a direct repressor of Ngn3 and pancreatic endocrine commitment, is expressed in adherent BMEL cells and decreases with time in aggregate culture. However, Hes1 decrease fails to initiate activation of late-stage pancreatic endocrine transcription factors. Conclusion Here we report that BMEL cells present features of pancreatic endocrine progenitor cells. In the field of diabetes research, BMEL cells are of potential interest for the study of inductive signals critical for in vitro β-cell maturation in-liver-to-pancreas conversion.
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- 2008
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50. Anti-gal and anti-neu5gc responses in non-immunosuppressed patients following treatment with anti-thymocyte globulin
- Author
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Salama, Apolline, Evanno, Gwénaëlle, Lim, Noha, Rousselot, Juliette, Le Berre, Ludmilla, Nicot, Arnaud, Bach, Jean-Marie, Brouard, Sophie, Harris, Kristina M., Ehlers, Mario R., Gitelman, Stephen E., Soulillou, Jean-Paul, Université de Nantes (UN), Xenothera [Nantes, France], Immune Tolerance Network, Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes, Division of Pediatric Endocrinology and Diabetes, and Duke University [Durham]
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[SDV]Life Sciences [q-bio] - Abstract
International audience; Background Polyclonal antihuman thymocyte rabbit IgGs (antithymocyte globulin [ATG]) are popular immunosuppressive drugs used to prevent or treat organ or bone-marrow allograft rejection, graft versus host disease, and autoimmune diseases. However, animal-derived glycoproteins are also strongly immunogenic and rabbit ATG induces serum sickness disease in almost all patients without additional immunosuppressive drugs, as seen in the Study of Thymoglobulin to arrest Type 1 Diabetes (START) trial of ATG therapy in new-onset type 1 diabetes. Methods Using enzyme-linked immunosorbent assay, we analyzed serial sera from the START study to decipher the various anti-ATG specificities developed by the patients in this study: antitotal ATG, but also antigalactose-α1-3-galactose (Gal) and anti-Neu5Gc antibodies, 2 xenocarbohydrate epitopes present on rabbit IgG glycans and lacking in humans. Results We show that diabetic patients have substantial levels of preexisting antibodies of the 3 specificities, before infusion, but of similar levels as healthy individuals. ATG treatment resulted in highly significant increases of both IgM (for anti-ATG and anti-Neu5Gc) and IgG (for anti-ATG, -Gal, and -Neu5Gc), peaking at 1 month and still detectable 1 year postinfusion. Conclusions Treatment with rabbit polyclonal IgGs in the absence of additional immunosuppression results in a vigorous response against Gal and Neu5Gc epitopes, contributing to an inflammatory environment that may compromise the efficacy of ATG therapy. The results also suggest using IgGs lacking these major xenoantigens may improve safety and efficacy of ATG treatment.
- Published
- 2017
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