1. Hypertension and diabetes mellitus are associated with high FIB-4 index in a health checkup examination cohort without known liver disease
- Author
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Shunsuke Sato, Hidehiko Kawai, Sho Sato, Hirohiko Iwasaki, Masashi Omori, Yuji Kita, Yuji Ikeda, Takahito Awatsu, Ayato Murata, Gentaro Taniguchi, Yuji Shimada, and Takuya Genda
- Subjects
Diabetes mellitus ,Fibrosis-4 index ,health check-up examination ,Hypertension ,Liver fibrosis ,Non-alcoholic fatty liver disease ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Background Non-alcoholic fatty liver disease (NAFLD) is usually asymptomatic and lacks a specific biomarker; therefore, many individuals might remain undiagnosed even with advanced liver fibrosis. The aim of this study was to clarify the prevalence and clinical features of subjects with a high risk of advanced liver fibrosis in the general population, using the Fibrosis-4 (FIB-4) index. Methods We retrospectively investigated 6,087 subjects without known liver disease who had participated in an annual health checkup examination. We analyzed the factors associated with high FIB-4 index (≥ 2.67) using a logistic regression analysis. Results Among the 6,087 subjects, 76 (1.2%) had high FIB-4 index. Multivariate analysis identified hypertension (odds ratio [OR]; 9.040; 95% confidence interval [CI], 4.081–20.024; P
- Published
- 2022
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