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Pretreatment AKR1B10 expression predicts the risk of hepatocellular carcinoma development after hepatitis C virus eradication
- Source :
- World Journal of Gastroenterology
- Publication Year :
- 2016
- Publisher :
- Baishideng Publishing Group Inc, 2016.
-
Abstract
- AIM To clarify the association between aldo-keto reductase family 1 member B10 (AKR1B10) expression and hepatocarcinogenesis after hepatitis C virus eradication. METHODS In this study, we enrolled 303 chronic hepatitis C patients who had achieved sustained virological response (SVR) through interferon-based antiviral therapy. Pretreatment AKR1B10 expression in the liver was immunohistochemically assessed and quantified as a percentage of positive staining area by using image-analysis software. A multivariate Cox analysis was used to estimate the hazard ratios (HRs) of AKR1B10 expression for hepatocellular carcinoma (HCC) development after achieving SVR. The cumulative incidences of HCC development were evaluated using Kaplan-Meier analysis and the log-rank test. RESULTS Of the 303 chronic hepatitis C patients, 153 (50.5%) showed scarce hepatic AKR1B10 expression, quantified as 0%, which was similar to the expression in control normal liver tissues. However, the remaining 150 patients (49.5%) exhibited various degrees of AKR1B10 expression in the liver, with a maximal AKR1B10 expression of 73%. During the median follow-up time of 3.6 years (range 1.0-10.0 years), 8/303 patients developed HCC. Multivariate analysis revealed that only high AKR1B10 expression (≥ 8%) was an independent risk factor for HCC development (HR = 15.4, 95%CI: 1.8-132.5, P = 0.012). The 5-year cumulative incidences of HCC development were 13.7% and 0.5% in patients with high and low AKR1B10 expression, respectively (P < 0.001). During the follow-up period after viral eradication, patients expressing high levels of AKR1B10 expressed markedly higher levels of alanine aminotransferase and α-fetoprotein than did patients exhibiting low AKR1B10 expression. CONCLUSION Chronic hepatitis C patients expressing high levels of hepatic AKR1B10 had an increased risk of HCC development even after SVR.
- Subjects :
- Male
Hepatocellular carcinoma
viruses
Hepacivirus
Treatment outcome
Aldo-Keto Reductases
medicine.disease_cause
Chronic hepatitis C
0302 clinical medicine
Risk Factors
Medicine
Aged, 80 and over
biology
Liver Neoplasms
Gastroenterology
General Medicine
Hepatitis C
Middle Aged
Immunohistochemistry
Gene Expression Regulation, Neoplastic
Sustained virological response
Treatment Outcome
030220 oncology & carcinogenesis
Human AKR1B10 protein
030211 gastroenterology & hepatology
Female
Adult
Carcinoma, Hepatocellular
Genotype
Hepatitis C virus
macromolecular substances
03 medical and health sciences
Young Adult
Retrospective Study
Aldehyde Reductase
Carcinoma
Humans
Risk factor
Aged
Retrospective Studies
business.industry
Hepatitis C, Chronic
medicine.disease
biology.organism_classification
digestive system diseases
Cancer research
business
Subjects
Details
- Language :
- English
- ISSN :
- 22192840 and 10079327
- Volume :
- 22
- Issue :
- 33
- Database :
- OpenAIRE
- Journal :
- World Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....7bd899eed8828e5310b3f15ed4cfca1c