[Objective] The changes of rhizosphere soil characteristics and yield of waxy sorghum with different bandwidth configurations and sorghum-soybean intercropping pattern were studied, so as to provide a scientific basis for high quality, high yield and sustainable production of waxy sorghum. [Method] The field experiments were conducted in 2021 and 2022 by using a completely randomized block design with sole cropping waxy sorghum as CK. The nutrient content of rhizosphere soil, enzyme activity and yield of waxy sorghum were studied with setting four bandwidth configurations (T1: 120 cm of bandwidth with 40 cm of narrow row spacing for waxy sorghum, 80 cm of wide row spacing for waxy sorghum, and 40 cm of spacing between waxy sorghum and soybean; T2: 130 cm of bandwidth with 50 cm of narrow row spacing for waxy sorghum, 80 cm of wide row spacing for waxy sorghum, and 40 cm of spacing between waxy sorghum and soybean; T3: 140 cm of bandwidth with 40 cm of narrow row spacing for waxy sorghum, 100 cm of wide row spacing for waxy sorghum, and 50 cm of spacing between waxy sorghum and soybean; T4: 150 cm of bandwidth with 50 cm of narrow row spacing for waxy sorghum, 100 cm of wide row spacing for waxy sorghum, and 50 cm of spacing between waxy sorghum and soybean) based on 2 rows of waxy sorghum intercropped with 1 row of soybean. [Result] Different bandwidth configurations of waxy sorghum intercropped with soybean had significant effects on the rhizosphere soil characteristics and yield of waxy sorghum. The rhizosphere soil nutrient contents, enzyme activities and yield of waxy sorghum under different strip width configurations were significantly higher than those under sole cropping waxy sorghum, and the T3 treatment showed the best performance. In 2021 and 2022, the waxy sorghum organic matter, total N, total P, total K, available N, available P and available K contents of rhizosphere soil under the T3 treatment were 69.85 and 61. 12 g/kg, 0.84 and 1.08 g/kg, 0.39 and 0.51 g/kg, 44.61 and 46.92 g/ kg, 344.58 and 266.63 mg/kg, 25.79 and 26. 16 mg/kg, and 16. 32 and 23.60 mg/kg, respectively, with a two-year average increase of 18.47%, 13.36%, 26.00%, 12.18%, 60.85%, 43.47% and 49.24%, respectively, compared with CK. The urease, polyphenol oxidase, sucrase, nitrate reductase, and catalase activities were 207.94 and 180.27 U/g, 53.43 and 70.90 U/g, 150.09 and 208.64 U/g, 0.43 and 0.40 U/g, and 48.06 and 51.38 U/g, respectively, with a two-year average increase of 49.37%, 45.61%, 76.10%, 55.81% and 18.89%, respectively, compared with CK. The yield were 6199. 18 and 6467.28 kg/hm², respectively, with a two-year average increase of 22.68% compared with CK. [Conclusion] Under the experimental conditions, the optimal bandwidth configurations of waxy sorghum intercropped with soybean was 140 cm of bandwidth with 40 cm of narrow row spacing for waxy sorghum, 100 cm of wide row spacing for waxy sorghum, and 50 cm of spacing between waxy sorghum and soybean. [ABSTRACT FROM AUTHOR]