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In the study, Tichoderma afroharzianum Tr35 obtained in the early stage was selected as the research object. Trichoderma agent and Trichoderma microbial fertilizer were prepared through carrier screening. By measuring the plant height, root length and fresh weight of Trichoderma agent and Trichoderma microbial fertilizer with different contents, the treatments with obvious growth promotion effect were screened, and the control effect of Trichoderma agent and Trichoderma microbial fertilizer on stalk rot of maize seedling was evaluated through indoor pot experiment. The results showed that maize stalk powder had the advantages of strong water absorption, non-toxic to Tr35 and high release rate. and co-fermented with Tr35 to prepare Trichoderma agent, had a significant growth promoting effect when the soil to fertilizer was 5 ∶ 1, and achieved 51. 77% prevention effect on maize seedling stalk rot. The best growth promotion effect was achieved when the agent soil was 7 ∶ 1 with rotted sheep manure, Trichoderma microbial fertilizer was prepared in this proportion and the prevention effect of stalk rot on maize seedling reached 61. 31%. The results provided a preliminary basis for the application and development of Tr35 agent and microbial fertilizer. [ABSTRACT FROM AUTHOR]

Objectives：Trajectory subsegment matching is an important part of trajectory pattern mining. Its applications span many scenarios, such as user recommendation, abnormal movement detection and prevention of infectious diseases. Traditional trajectory matching methods are mainly based on classical distances or similarity measures, which are of high complexity and the accuracy is seriously affected by data noise.Methods: We firstly propose a multi-level trajectory code tree structure that integrates adaptive Hilbert geographic grid coding. A hierarchical organizational form and sub-segment subordinate relationship expression structure are formed from the entire segment of the trajectory to the smallest segment. Then a sub-segment similarity matching algorithm is designed based on the trajectory segment code tree to transform complex spatial calculation into string matching operation, which greatly reduces the computational complexity of similar matching of sub-segments.Results: Experiments on actual trajectory data show that the efficiency of the proposed method achieved more than an order of magnitude improvement over the classical distance-based similarity measurement method without affecting accuracy.Conclusions: We proposed trajectory subsegment matching method greatly reduce the computational complexity with acceptable accuracy, which has high application value in the field of multi-granulate trajectory pattern mining and similarity analysis. [ABSTRACT FROM AUTHOR]

目的：本次研究主要剖析骨科护理安全隐患及人性化护理。方法：本次研究主要选择我院接诊的90例骨 外科患者作为本次研究的主体，2020年7月-2021年7月为患者住院治疗时间，本次研究选用分组研究方式，开展基础 护理的45例患者称为对照组，开展人性化护理且进行安全隐患风险研究的45例患者称为观察组。结果：观察组的患者 满意度是93.33%，对照组患者住院开展基础护理后满意度是77.78%，两组之间数据信息P < 0.05，具备统计学意义。 结论：骨科护理通过人性化护理的与此同时进行安全隐患风险研究，可消除相关的安全隐患，将总体满意度提高。 [ABSTRACT FROM AUTHOR]

目的: 讨论剖析快速康复护理理念在骨科患者围手术期的运用效果. 方法: 选择2021年3月～2022年7月 在本院骨科接纳手术70例骨科患者做为此次的研究主体, 任意分成2组, 各35例. 对照组在围手术期选用基础护理, 研究组在围手术期选用快速康复护理理念开展医护, 统计分析2组患者的恢复状况、病发症产生状况. 结果: 研究 组术后疼痛、下肢静脉血栓、褥疮、严重便秘发病率远远低于对照组, 二者病发症发病率比较差别有统计学意义P < 0.05; 研究组均值卧床不起时长、下地练习时间、住院天数均显著小于对照组, 差别有统计学意义P < 0.05; 研究组患 者医护满意率高过对照组, 差别有统计学意义P < 0.05. 结论: 在骨科患者围手术期中运用快速康复护理理念开展医 护, 可以有效加速患者的功能恢复, 减少患者的住院天数、第一次下地时间及第一次锻炼时间, 减少患者产生病发症 的几率. 因而, 快速康复护理理念还可以在骨科患者围手术期的临床实践上全面推广. [ABSTRACT FROM AUTHOR]

[Objective] The study aimed to reveal ant diversity regularity in Yunnan Province. [Method] Ant communities of southwest Yunnan Province were surveyed through plot-sampling method. [Result] Totally 188 species belonging to 65 genera and 10 subfamilies were recognized on the 5 vertical zones in the area. Nylanderia birmana (Forel) and Pheidole noda Smith were dominant species. The main indexes of ant communities from different sample-plots were as follows: species numbers 3 - 55 (average 28. 6), individual densities 4.0 - 4089. 4 heads·m-2 (average 594. 6 heads·m-2), diversity indexes 0. 2619 -2. 6397 (average 1. 6870), evenness indexes 0. 0924 -0. 7766 (average 0. 5283), dominant indexes 0. 0924 - 0. 7766 (average 0. 3310); similarity coefficients between ant communities 0. 4113 - 0. 4806 (average 0. 4503), which represented moderately dissimilar level. [Conclusion] Along with altitude increasing, species numbers, individual densities, diversity indexes and evenness indexes of the ant communities generally expressed mid-domain effect phenomenon, the main reasons were vegetation on the low potion of the vertical zones changed by human being and the effect of dry hot valley. Meanwhile, the indexes of ant communities express decreased multi-domain effect phenomenon, the reasons were distinct species assemblages in different vegetation types and the difference of micro-habitat at different altitude. Ant communities from the 5 vertical zones had significant difference and distinct value in biodiversity conservation. [ABSTRACT FROM AUTHOR]

Most of the traditional video caption generation models adopt encoder-decoder framework.In the encoder stage,the convolutional neural networks are used to deal with the video.In the decoder stage,the LSTM are used to generate the caption of video.Based on the temporal correlation and multi-modality of video,this paper proposed a hybrid model,which was a multimodal video caption generation model based on hard attention.In the encoder stage,it utilized the model of multi-modal fusion,which could make the two kinds of characteristics resonated to generated the final feature outputs.It used LSTM with hard attention mechanism in the decoder state to generate a description of video.The machine translation index obtained by this hybrid model on MSR-VTT is 0.2% ～3.8% higher than the basic model.Experimental results show that the multi-modal fusion based on hard attention mechanism can generate accurate description captions of video. [ABSTRACT FROM AUTHOR]

心血管疾病是21世纪成胁人类健康的重大公共卫生问题,全世界人民均需密切关注心血管的预防和诊治问题, 心血管成病具有高患病率、高致我率、高复发率和高死亡率的特点,给经济发展及社会进步带来了极大的负担,心血管疾病也括 高血压,冠心病和动脉粥样硬化等,在动物模型和人类研究中的研究已经阐明了许多遗传因素的作用,包括非编 RNA。 非编 马 RNA 是未翻译成蛋白廣的 RNA,在转录后参与基因表达调控,与心血管疾病有关,其中主安包括 circRNAs 和 mieroRNAs. circRNAs 是由前信使RNA 的反向剪接产生的,其与心血管疾病的关系一直未得到充分的证实, circRNA 可以作为人类疾病的 生物标志物,它们可以从全血,血裝、唔液和精液中提取,circRNAS 最近被认为与各种疾病过程有关,其中包括高血压和心血管 我病。 [ABSTRACT FROM AUTHOR]

To investigate the incidence of acute myocardial injury in patients with novel coronavirus pneumonia (new coronary pneumonia) and analyze its risk factors. Methods The study was a retrospective cross-sectional study. A total of 150 confirmed cases of new coronary pneumonia admitted to Wuhan Huangpi District People's Hospital and Huangpi Fangcai Hospital from January to February 2020 were included. Collect the general information, vital signs, myocardial enzyme spectrum and imaging data of all patients, compare and analyze the characteristics of patients with acute myocardial injury with new coronary pneumonia, and apply multivariate logistic regression analysis to analyze the risk factors of acute myocardial injury. Draw a receiver operating characteristic curve (ROC curve) to evaluate the effectiveness of the regression equation on acute myocardial injury in patients with new coronary pneumonia. Results Comparing patients with new coronary pneumonia with acute myocardial injury and patients without acute myocardial injury, age, breathing frequency, blood oxygen saturation, white blood cell count, neutrophil percentage, lymphocyte percentage, lymphocyte count, urea nitrogen, liver function, Signs of myocardial injury, N-terminal pro-B-type natriuretic peptide (NT-proBNP), clinical classification, the proportion of diabetes, the proportion of arrhythmia, the proportion of colic, the proportion of cerebrovascular disease, and the mortality rate were statistically different Significance (P <0.05). Logistic regression analysis showed that the number of white blood cells, clinical classification and angina pectoris were risk factors for acute myocardial injury in patients with new coronary pneumonia (P<0.05). The regression equation evaluated the maximum Youden index of acute myocardial injury in patients with new coronary pneumonia as 0.784, the area under the curve was 0.943, the sensitivity was 0.913, and the specificity was 0.881. Conclusion The number of white blood cells, clinical classification and angina pectoris are risk factors for acute myocardial injury in patients with new coronary pneumonia. [ABSTRACT FROM AUTHOR]

Objective To investigate the incidence of acute myocardial injury in patients with COVID-19 and analyze its risk factors. Methods The study was a retrospective cross sectional study, a total of 150 patients with COVID-19 were included in the Huangpi District People's Hospital of Wuhan and Wuhan Fang Cabin Hospital from January to February 2020. General information.vital signs. myocardial enzymes and imaging data of all patients were collected, The characteristics of COVID-19 patients with acute myocardial injury were compared and analyzed. The risk factors of acute myocardial injury were analyzed by multivariate logistie regression analysis. The receiver operating characteristic curve (ROC curve) was drawn to evaluate the efficacy of the regression equation for acute myocardial injury in patients with COVID-19, Results Compared with the patients without acute myocardial injury, there were statistically significant differences in age.breathing.blood oxygen saturation. percentage of white cell count neutrophils percentage.lymphocytes percentage.lymphocyte count, urea nitrogen. liver function.myocardial injury markers. N terminal pro-B-type natriuretic peptide (NT-proBNP). clinical classification. the proportion of diabetes, the combining arrhythmia rates pro portion of arrhythmia proportion of angina pectoris and cerebrovascular disease and mortality between COVID-19 patients with a- cute myocardial injury and without acute myocardial injury (P<0. 05). Logistic regression analysis showed that white cell count. clinical classification and with and without coronary heart disease were the risk factors of acute myocardial injury in patients with COVID-19 (P<0, 05): The maximum Youden index and area under curve of COVID-19 patients with acute myocardial injury were 0.781.0,013 and the sensitivity and specificity were 0.913.0.881.respectively. Conclusion White cell count.clinical classification and with and without coronary heart disease are risk factors for acute myocardial injury in patients with COVID-19. [ABSTRACT FROM AUTHOR]

糖尿病酮症酸中毒（DKA）时发生腹痛者并不少见，但如不及时鉴别腹痛原因，会延误诊治。该文报道1例并发急性肠系膜上动脉栓塞（ASMAE）的DKA患者。ASMAE在发病早期可有急性腹痛病史，但缺乏特异性症状，难以与其他急腹症区别，通常在晚期被诊断。在临床诊治中，临床医生应警惕在DKA诊治期间血栓形成的风险，提高对ASMAE的认识。快速、准确地对ASMAE患者做出病情判断，及时完成相关辅助检查，对患者的生存和预后至关重要。 [ABSTRACT FROM AUTHOR]

The geometric parameters of CCD camera and TOF camera system is need to know first in color target 3D reconstruction based on time-of-fiight (TOF) camera, this paper proposed a calibration method based on planar pattern, after researching ihe calibration algorithm of color image and TOF depth image existed. Il look color images and amplitude images from different angles of the checkerboard pattern, which fixed on a flat calibration template, improved Harris corner extraction algorithm. Il established ihe model of camera calibration system according to ihe conjugate relation between the corner point and ihe virtual image point and used Levenberg-Marquardt algorithm to solve, then carried out calibration experiments. Obtaining the internal parameters of the TOF and CCD cameras, il estimated ihe relative attitude of ihe two camera coordinate system by using ihe pose relation between image planes. Finally, il performed joint optimization and obtained ihe rotation matrix and ihe translation vector between ihe cameras. Results show that ihe proposed algorithm optimizes ihe solving process, improves ihe efficiency of calibration, and obtaines higher accuracy. [ABSTRACT FROM AUTHOR]

Objective: To study the effect of Kangfuxin liquid combined with topical application of thymopentin on the oral ulcer and the serum TNF-α, IL-6, SOD, SIgA and IgG levels. Methods: 86 cases with oral ulcer from December 2014 to December 2016 were selected and divided into the Kangfuxin Liquid group(n=39) and the combination therapy group( n=39) according to the random number table. Kangfuxin Liquid group was treated by Kangfuxin Liquid, ewhile combination therapy group was given thymopentin topical on the basis of Kangfuxin Liquid. The clinical effect, improvement of symptoms, relief time of pain and ulcer healing time, serum TNF-α,IL-6, SOD levels, SIgA and IgG levels and the incidence of adverse reactions and relapse were compared between two groups. Results:At 72 h after treatment, compared with before treatment, the pain levels of both groups were significantly improved, ulcer diameters were significantly reduced, total scores were significantly decreased, the total score drop index were significantly decreased(P<0.05). The relief time of pain and ulcer healing time of Kangfuxin Liquid group were longer than those of the combined treatment group(P<0.05); the serum TNF-α and IL-6 levels were significantly decreased, serum SOD levels were significantly increased(P<0.05). Compared with the Kangfuxin Liquid group, the total effective rate of combined treatment group was significantly higher(P<0.05), the improvement of pain level, ulcer diameter, total score and total score drop index were better(P<0.05), the levels of serum TNF-α and IL-6 were significantly decreased and the level of serum SOD was significantly increased(P<0.05); the SIgA levels in both groups were significantly higher than those before treatment, the levels of IgG were significantly decreased than those before treatment, which were improved significantly better in the combined treatment group than those of the Kangfuxin Liquid group(P<0.05); The recurrence rate was significantly lower in the combined treatment group(P<0.05). Conclusion: The combination of Kangfuxin liquid and thymopentin was more effective than Kangfuxin liquid single used in the treatment of oral ulcer, it could effectively relieving the pain and symptoms, accelerat the healing,which might be related to the decrease of serum TNF-α, IL-6 levels and increase of serum SOD levels. [ABSTRACT FROM AUTHOR]

Unmanned aerial vehicle (UAV) aeromagnetic measurement, as an efficient, convenient and low-cost geophysical exploration method, has been widely used in geological survey, mineral resources exploration, and engineering prospecting. First, we outline the historical process of UAV aeromagnetic measurement systems in the past two decades. The domestic and international progress of research and development, and the application of UAV aeromagnetic measurement are summarized. We compare the advantages and disadvantages of three main types of UAV flight platforms and their application scenarios in the field of aeromagnetic measurement. The types and characteristics of UAV aerial magnetometers are analyzed. Second, we carefully discuss the interference problem of aeromagnetic measurement. The principle of aeromagnetic compensation is mathematically described. The applications of various aeromagnetic measurement compensation methods are discussed. The characteristics of UAV electromagnetic interference and related suppression methods are summarized. The relevant ways to further improve the accuracy of UAV aeromagnetic measurement on the basis of traditional magnetic compensation are pointed out. Finally, the typical application cases of UAV aeromagnetic measurement technology are shown and the challenges and developments of UAV aeromagnetic measurement technology are foreseen. [ABSTRACT FROM AUTHOR]

BACKGROUND: Coping with osteoporosis is an important part of China's response to population aging. Early prevention, early detection and early intervention of osteoporosis were considered to play a very important role in improving prognosis. OBJECTIVE: To analyze the relevant factors affecting the difference in bone mineral density of bilateral proximal femur and to explore the methods to improve the diagnostic performance of dual-energy X-ray absorptiometry. METHODS: The clinical data of 207 subjects who underwent dual-energy X-ray absorptiometry bone mineral density examination in Department of Nuclear Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University from January to July 2021 were retrospectively analyzed. After grouping, differences between groups and related factors leading to differences were analyzed. Multivariate Logistic Regression Equation was utilized for correction. Receiver operating characteristic curve was used to predict performance. RESULTS AND CONCLUSION: (1) There was no significant correlation between the differences in the bone mineral density of the bilateral femoral necks (higher than the least significant change) and left-right handedness, sleep orientation preference (all P > 0.05). (2) For postmenopausal women and men over the age of 50 years, when the left femoral neck T value was -0.9 or -1.0 (the difference between the bone mineral density value and the bone mineral density value when the T value was -1.1 was greater than the least significant change), the right-side examination could significantly improve the diagnosis rate of osteopenia (P < 0.001). Multivariate logistic regression analysis showed that it was an independent influencing factor after correcting traditional factors, OR=0.001, 95%CI (0.000-0.326), P=0.03; receiver operating characteristic curve predicted its efficacy in altering the diagnosis: area under the curve=0.765, 95%CI (0.536- 0.993), P=0.018. (3) It is concluded that for postmenopausal women and men over 50 years old, when the T value of the left femoral neck was -0.9 or -1.0 (the difference between the bone mineral density value and the bone mineral density value when the T value was -1.1 was greater than the least significant change), the dual-energy X-ray absorptiometry bone density test of the lumbar spine and bilateral proximal femur could significantly improve the diagnosis rate of bone loss compared with the lumbar and left side examination. [ABSTRACT FROM AUTHOR]

BACKGROUND: Coping with osteoporosis is an important part of China's response to population aging. Early prevention, early detection and early intervention of osteoporosis were considered to play a very important role in improving prognosis. OBJECTIVE: To analyze the relevant factors affecting the difference in bone mineral density of bilateral proximal femur and to explore the methods to improve the diagnostic performance of dual-energy X-ray absorptiometry. METHODS: The clinical data of 207 subjects who underwent dual-energy X-ray absorptiometry bone mineral density examination in Department of Nuclear Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University from January to July 2021 were retrospectively analyzed. After grouping, differences between groups and related factors leading to differences were analyzed. Multivariate Logistic Regression Equation was utilized for correction. Receiver operating characteristic curve was used to predict performance. RESULTS AND CONCLUSION: (1) There was no significant correlation between the differences in the bone mineral density of the bilateral femoral necks (higher than the least significant change) and left-right handedness, sleep orientation preference (all P > 0.05). (2) For postmenopausal women and men over the age of 50 years, when the left femoral neck T value was -0.9 or -1.0 (the difference between the bone mineral density value and the bone mineral density value when the T value was -1.1 was greater than the least significant change), the right-side examination could significantly improve the diagnosis rate of osteopenia (P < 0.001). Multivariate logistic regression analysis showed that it was an independent influencing factor after correcting traditional factors, OR=0.001, 95%CI (0.000-0.326), P=0.03; receiver operating characteristic curve predicted its efficacy in altering the diagnosis: area under the curve=0.765, 95%CI (0.536- 0.993), P=0.018. (3) It is concluded that for postmenopausal women and men over 50 years old, when the T value of the left femoral neck was -0.9 or -1.0 (the difference between the bone mineral density value and the bone mineral density value when the T value was -1.1 was greater than the least significant change), the dual-energy X-ray absorptiometry bone density test of the lumbar spine and bilateral proximal femur could significantly improve the diagnosis rate of bone loss compared with the lumbar and left side examination [ABSTRACT FROM AUTHOR]

In order to analyze the accumulation characteristics of amino acid components from different origins of foxtail millet germplasms, evaluate quality of core germplasms of foxtail millet, and provide a reference for breeding for excellent quality cultivars of foxtail millet. In this study, 154 core germplasms of foxtail millet were selected as materials. The contents of 17 different amino acids in grains of foxtail millet were determined by near-infrared spectroscopy in 2019 and 2020, respectively. The accumulation characteristics were studied based on the coefficient of variation, correlation of amino acid, the effects of different germplasm origins on amino acid content. Furthermore, principal component analysis and cluster analysis were used to screen the excellent germplasms with abundance of amino acids. The results revealed that the contents of Glu, Ala, and Ile were the highest (>1%), the contents of Thr, His, Lys, and Cys were the lowest (<0.4%) in grains of foxtail millet. There were significant differences in accumulation characteristics of the 15 amino acids between years, except His and Val. Moreover, the average total content of amino acids from Heilongjiang province, Gansu province and other regions presented the highest (>13%). Additionally, the contents of 13 amino acids in grains in spring-sown millet class were significantly higher than the contents in summer-sown millet class. The correlation analysis results showed that there were significant correlations among different amino acids. A significantly negative correlation existed among the 10 amino acids such as Phe, His and so on. The 154core germplasms of foxtail millet could be divided into 4 subgroups through principal component analysis and cluster analysis. The amino acid content of grains in the first subgroup was significantly higher than that in the other three subgroups. The cultivars with high amino acid content were screened, they were Longsu 2, Longgu 5, and Longgu 10 from Gansu, Nenxuan 11from Heilongjiang, Datonghuang and Baimaolianggu from Shanxi, Erbaigu from Xinjiang. The cultivars with high Lys content were screened, such as Longgu 10 from Gansu, Xiangyanggu from Shanxi. [ABSTRACT FROM AUTHOR]

The objective is to acquire non-transgenic Brassica campestris mutants via CRISPR/Cas9 gene editing system，for achieving the application of CRISPR/Cas9 in B. campestris in planta transformation method and providing reference for application of marker-free gene editing technique. Using‘49 Caixin’as plant material and dehydrogenase gene（PDS）as target gene，total of 25 plants were transformed by in planta transformation via vacuum-infiltration method. The results showed that 3 of the 2 032 transformed seedlings were identified to have PDS gene editing，one of which was detected to have exogenous vector insertion and heterozygous editing of PDS gene，and the phenotype was consistent with that of the wild type. The other two seedlings had a dwarf，albino phenotype，and there was no insertion of foreign vector in their genomes. Different types of targeted mutagenesis of PDS gene were detected in these two seedlings compared with the wild type. In conclusion， gene editing can be achieved in B. campestris by CRISPR/Cas9 through in planta tissue culture-independent transformation，and particularly non-transgenic editing mutants without exogenous insertion can be obtained directly. [ABSTRACT FROM AUTHOR]

Compared to other high power electric propulsion, Hall thruster has significant advantages in Thruster power ratio and Specific impulse.However, the increase in power brings many complex physical problems.Therefore, aiming at the key difficulties of high-power Hall thruster, such as the difficulty of working stably under strong thermal load and the difficulty ofadjusting the wide discharge voltage range and efficient electromagnetic regulation, Lanzhou Institute of Physics (LIP) and Harbin Institute of Technology (HIT) had jointly launched the over-10 kW high power Hall thruster.The thermal analysis and design were carried out, and the thermal simulation model was established to calculate the steady-state temperature of the key components.The results showed that the temperature of each part met the design requirements.The PIC simulation model was established synchronously, and the ionization characteristics were analyzed under different voltages at fixed flow rate of 80 mg/s.The results showed that low current would reduce the utilization rate of working medium and lead to low efficiency of thruster under the condition of large discharge cavity diameter.Further, the performance analysis was carried out to obtain the working condition of 600 V anode efficiency lower than 500 V,which was caused by insufficient ionization and wall energy loss.In addition, based on the experimental prototype, experimental research under 30 kw power was carried out and the result suggests that corresponding design has a good effect.The thermal and laser interference measurement method was adopted to obtain the thrust of 1.33 N,which deviates from the simulation data 1.38 N by an error within 5%. Therefore, the thruster design in this paper was reasonable and effective. [ABSTRACT FROM AUTHOR]

A freeze-dried gel containing sodium alginate loaded grape seed extract was prepared and its antibacterial and hemostatic properties were investigated. The freeze-dried gel SA/GSE/Fe3+(SGF (0.75)) was obtained with the mixture of grape seed extract (GSE), sodium alginate (SA) and Fe3+ by being freeze-dried twice. Then the porosity, water absorption, photothermal properties, antibacterial properties, biocompatibility and hemostatic properties of SGF(0.75) freeze-dried gel were investigated through in vitro experiments. The prepared SGF(0.75) freeze-dried gel has a porosity of about 37% and a water absorption rate of about 1500%. Under near-infrared laser irradiation, SGF(0.75) freeze-dried gel can kill nearly 90% of Staphylococcus aureus and 91% of Escherichia coli. The hemostatic performance experiment shows that SGF(0.75) freeze dried gel reduces blood loss and hemostatic time by 31% and 66%, respectively, in comparism with gauze. The prepared SGF(0.75) freeze-dried gel has strong hemostatic ability, good antibacterial effect, good biocompatibility, high safety, and can promote wound tissue healing. It has great application prospects in future clinical research. [ABSTRACT FROM AUTHOR]

Aim To investigate the relationship between the triglyceride-glucose (TyG) index and major adverse cardiovascular and cerebrovascular events (MACCE) in the acute coronary syndrome(ACS) patients underwent emergency percutaneous coronary intervention (PCI) with drug-eluting stents. Methods Overall, 2 249 patients with ACS underwent emergency PCI were enrolled in this study. The patients were divided into high TyG index group and low TyG index group according to the median TyG index. The incidence of endpoint events as follows: all-cause death, non-fatal myocardial infarction ( MI ), non-fatal ischemia stroke, and ischemia-driven revascularization were determined and compared between two groups. Unitivariate and multivariate Cox analysis were used to evaluate the predictive value of the TyG index for MACCE. Subgroup analysis was used to evaluate the consistency of the predictive value of the TyG index for MACCE. Results Overall, 299 (13. 3% ) endpoint events were documented during a 66-month follow-up. Compared with the low TyG index group, the high TyG index group had a significantly higher incidence of MACCE (17. 1% vs. 9. 5%, P<0. 001), all-cause death (6. 2% vs. 3. 7%, P= 0. 007), cardiac death (4. 4% vs. 2. 1%, P= 0. 002), non-fatal MI (1. 0% vs. 0. 3%, P= 0. 001), non-fatal ischemia stroke (2. 0% vs. 1. 0%, P = 0. 039) and is chemia-driven revascularization ( 7. 8% vs. 4. 8%, P = 0. 001 ). The multivariable Cox regression analysis further revealed that the TyG index was an independent predictor of MACCE (hazard ratio (HR)1. 710, 95% confidence interval (CI) 1. 304 ~ 2. 242,P<0. 001). The results of subgroup analysis showed that the predictive effect of TyG index on MACCE still existed in different subgroups. Conclusion The TyG index might be an independent predictor of MACCE in patients with ACS underwent emergency PCI with drug-eluting stents. [ABSTRACT FROM AUTHOR]

Objective To analyze the relationship between the expression of stem cell markers Sox2，OCT4，CD44 andβ-catenin in gastric cancer tissue and the recurrence and metastasis after operation，in order to provide reference for the risk assessment and prediction of gastric cancer.Methods 132 cases of gastric cancer admitted to central hospital of Chongq- ing Three Gorges from March 2011 to March 2014 were selected as research subjects.The expression of Sox2，OCT4，CD44 and β-catenin in gastric cancer specimens were detected，and the effects of these stem cell markers on postoperative recurrence and metastasis of gastric cancer were analyzed. Results In the 132 specimens，74 cases were positive for Sox2（56.06%），58 cases were positive for OCT4（43.94%），78 cases were positive for CD44（59.09%），and 70 cases were positive for β - catenin （53.03%）.The positive rate of Sox2 in gastric cancer tissues of patients with different age，lymph node metastasis and degree of differentiation was statistically significant（P<0.05）.The positive rate of OCT4 in gastric cancer tissues of patients with different TNM stages was statistically significant（P<0.05）.The positive rate of CD44 in gastric cancer tissues of patients with different histological grade，tumor diameter，vascular infiltration，lymph node metastasis and TNM stages was statistically significant（P< 0.05）.The positive rate of β-catenin in gastric cancer tissues of patients with different lymph node metastasis and TNM stages was statistically significant（P<0.05）.During the follow-up period，105 of 132 cases had recurrence and metastasis，and the inci- dence was 79.55%.With the increase of the positive rate of stem cell markers in patients with gastric cancer，the incidence of re- currence and metastasis gradually increased ，and the difference was statistically significant（P<0.05）.Conclusion The mark- ers of stem cells in gastric cancer are related to the clinicopathological features of the patients.Early detection of stem cell mark- ers in gastric cancer tissue is expected to provide reference for the risk assessment of recurrence and metastasis. [ABSTRACT FROM AUTHOR]

The open operation of experimental teaching center is an important measure adapting to the reform of higher education and cultivating college students'practical and innovation ability. This paper analyzed the significance of the open operation of experiment teaching center from the aspects of deepening the reform of practical teaching, cultivating students' practical ability and innovative spirit and maximizing the effectiveness of experimental teaching resources. Combining with the building practice of experiment teaching demonstration center of agricultural biotechnology, the beneficial explorations about open running of experimental center have been made in operation mode, management mechanism and condition guarantee, to provide services for cultivating students' comprehensive quality and innovation ability. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical characteristics of type 2 diabetes mellitus (T2DM) patients complicated with nonalcoholic fatty liver disease (NAFLD) and to analyze its relationship with chronic diabetic complications. Methods: A total of 245 patients with T2DM, who were treated in Cangzhou Central Hospital of Hebei Province from January 2016 to January 2017, were chosen as subjects. According to the results of hepatobiliary ultrasound and biochemical examination, 105 patients with T2DM only were taken as control group, 140 patients with T2DM combined with NAFLD. as observation group. The general situation and biochemical indexes of the two groups were compared: univariate and multivariate Logistic regr ession analysis were used to analyze the relationship between T2DM complicated with NAFLD and macrovascular clironic diseases. Results: Compared with the control group, the observation group had a shorter course of disease, HDL-C level was lower. BMI. SBP, TC, TG, LDL-C. ALT. AST. HbAlc, FINS, INS-120. HOMA-IR. FPG, 21iPG. fasting C peptide and postprandial 2 h C peptide were higher (P<0.05). The incidence of macrovascular disease in the observation group was significantly higher than that in the control group (P<0.05). Logistic regression analysis showed that the risk factors of T2DM complicated with NAFLD patients with macrovascular chronic disease were as follows: BMI. HOMA-IR. SBP. LDL-C, HbAlc, TG. Conclusion: The incidence of diabetic macrovascular chronic disease significantly increased in T2DM patients with NAFLD. and the influencing factors of complicating with NAFLD are BMI. HOMA-IR. SBP. LDL-C. HbAlc. and TG. [ABSTRACT FROM AUTHOR]

The "Structure and Mechanical Properties of the 3rd Generation Advanced High Strength Steel ( AHSS)" is taken as a project to apply for college students' innovative training project. The authors all joined the project. In the process, the authors' theoretical knowledge and basic skills were improved; the approaches and means of scientific research were extended ； several research papers have been published. With the knowledge, ability and attitude enhanced on all fronts to our teammates, it has important significance for us in the future study, research or work. Eventually we won the national excellent project, and the importance of innovative training project has been proved by the harvests and experience in the process. [ABSTRACT FROM AUTHOR]

[13:00] Yadaiah Adla Objective To explore the diagnostic value of synthetic magnetic resonance imaging (syMRI) quantitative parameters for benign and malignant breast lesions. Methods From September 2018 to March 2019, a total of 43 cases of breast lesions which were confirmed by surgery and pathology in Cancer Hospital, Chinese Academy of Medical Sciences were enrolled in this study. All patients underwent syMRI sequence scans before and after enhancement except for conventional T2WI, DWI, and enhancement scans. GE AW4.7 workstation was used to generate syMRI parameter maps (T1, T2, proton density mappings), and ITK-SNAP software was used to delineate the volume of interest. The T1, T2, PD values before and after dynamic contrast enhanced (DCE) were obtained, and the change values of each parameter were calculated. Meanwhile, the apparent diffusion coefficient (ADC) and time intensity curve (TIC) of the lesions were measured. The differences of each parameter value were compared between benign and malignant breast lesions, and the receiver operating characteristic (ROC) curve was used to analyze the diagnostic performance of each parameter. Results Among the 43 enrolled cases, 13 were benign and 30 were malignant. Among the syMRI parameters, the pre-enhancement parameters including TIpre (median 1 663.07 ms), T2pre (median 103.33 ms), post-enhancement parameters ATI (median 1 022.68 ms) and AT2 (median 27.67 ms) of benign group, significantly higher than those of the malignant group (the medians were 1 141.74, 92.53, 664.95, and 16.19 ms, respectively. P<0.05). The ADC value of the benign group (median 1.66x 10-3 mm²/s) was significantly higher than that of the malignant group (median 1.00×10-3 mm/s, P<0.05). The benign group included 6 cases of TIC curve type I, 5 cases of type II, and 2 cases of type III. The malignant group included 2 cases of TIC curve type I, 17 cases of type II, and 11 cases of type II. The difference between the two groups was statistically significant (P<0.05). The area under the ROC curve (AUC) of T1 pre before DCE was 0.869, higher than 0.806 of ADC and 0.697 of TIC. When the best cut-off value of 1 282.94 ms was chosen, the sensitivity and specificity of diagnosis were 76.9% and 93.3%, respectively. The combination of T1pre and T2pre can further improve the diagnostic performance (AUC=0.908). Conclusions Among the syMRI quantitative parameters, Tipre, T2pre, ΔT1 and ΔT2 have good value for the differential diagnosis of benign and malignant breast lesions. T1pre has the best diagnostic performance, and the combination of T1pre and T2pre can further improve the diagnostic performance. [ABSTRACT FROM AUTHOR]

Objective To observe the correlation between the anti-atherosclerosis mechanism of dissipating phlegm and removing blood stasis method and the effect on the input protein oc3/NF-kB signaling pathway through the regulation of microribonucleic acid 181 (miR-181). Methods In vitro experiments, vascular endothelial cell injury model was established with oxidized low-density lipoprotein (ox-LDL). According to different intervention methods, cells were randomly divided into four groups: model group (blank serum)，miR-181 mimic group，miR -181 inhibitor group，phlegm-resolving and blood stasis-eliminating TCM serum group (TCM serum group). After intervention，the cell activity of each group was detected. RT-PCR and Western blot were used to detect the mRNA and protein expression levels of miR-181，input protein oc3 and NF-kB. In vivo experiments, 60 ApoE ' mice were randomly divided into 5 groups: model group，miR-181 inhibitor group，miR-181 mimic group，highdose and low-dose phlegm-resolving and blood stasis-eliminating TCM serum group (TCM high-dose serum group，and TCM low-dose serum group respectively) (n = 12). After continuous intervention for 8 weeks，the plasma and aorta were collected for testing. The levels of IL-6，VCAM-1 and E-selectin in the peripheral plasma were tested by ELISA. The expression of microRNA-181，input protein a3 and NF-kB in the aortic wall of each group was tested by RT-PCR, and the pathological changes were observed. Results In vitro experiments，the cell activity of the TCM serum group and the miR-181 mimic group was significantly increased (P <0. 05)，and the expression of a3 and NF-kB mRNA were significantly down-regulated (P <0- 05). In vivo experiments, compared with the model group，the plasma levels of IL-6，VCAM-1 and E-selectin in the TCM high-dose and low-dose serum groups and miR-181 mimic group were significantly lower，compared with the model group (P <0. 05) ； compared with the inhibitor group，the levels of peripheral plasma IL-6，VCAM-1 and E-selectin in the TCM serum group were lower (jP <0. 05), Compared with the model group，the mRNA expression of aortic miR-181 in the TCM highdose and low-dose serum groups and miR-181 mimic group was significantly increased (P <0. 05), and the expression level of a3 and NF-kB significantly down-regulated (jP <0. 05). There was no significant difference in the indexes between the TCM high-dose and low-dose serum groups (P >0. 05). Conclusion The anti-atherosclerosis mechanism of resolving phlegm and eliminating blood stasis may be related to the targeted regulation of miR-181 to affect the input protein «3/NF-kB signaling pathway， which could possibly reduce the levels of inflammatory mediators such as IL-6，VCAM-1 and E-selectin? thus reducing the damage of vascular endothelial cells. [ABSTRACT FROM AUTHOR]

Objective To investigate the underlying mechanisms and intracellular signaling of up-regulating adenosine triphosphate binding cassette transporter A1 (ABCA1) by interleukin-17A (IL-17) in macrophages. Methods Mouse RAW264.7 cells were treated with 20ng/mL of IL-17A. The protein expressions of ABCA1 and p-p38MAPK were detected using Western blot. The ubiquitination level of ABCA1 was detected using Coimmunoprecipitation. Results IL-17A increased the expression of ABCA1 at the protein level, but not at the mRNA level. IL-17A reduced the degradation of ABCA1 protein. IL-17A attenuated binding of ABCA1 to ubiquitin. SB203580, p38MAPK inhibitor, reversed the decrease of ubiquitination and increased expression of ABCA1 protein induced by IL-17A in macrophages. Conclusion IL-17A increases the expression of ABCA1 protein by inhibiting its degradation through p38MAPK pathway in macrophages. [ABSTRACT FROM AUTHOR]

Objective: To explore the clinical effect of laser combined with conbercept on the diabetic retinopathy with macular edema and its possible mechanis. Methods: From January 2017 to December 2017, 92 cases of patients with diabetic retinopathy and macular edema were selected as the research subjects, and they were randomly divided into the observation group (46 eyes) and the control group (46 eyes). Patients in the control group were treated with laser treatment, and the observation group was treated with laser therapy after 1 week of conbercept injection. The clinical efficacy of two groups after treatment was compared, and the changes of best corrected visual acuity (BCVA), central macular thickness (CMT) and vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1) and erythropoietin (EPO) level were compared between the two groups before and after treatment. Results: After treatment, the total effective rate of observation group was 91.30%, which was significantly higher than that of the control group (69.57%) (P<0.05). The BCVA of both groups were significantly higher than those before treatment (P<0.05), CMT were lower than those before treatment (P<0.05), but BCVA of observation group was higher than that of control group, CMT was lower than control group(P<0.05). After treatment, the serum VEGF, IGF-1 and EPO of both groups were significantly decreased than those before treatment, and which were lower in the observation group than those of the control group (P<0.05). Conclusion: The clinical effect of laser combined with Compassix in the treatment of diabetic retinopathy with macular edema is significantly better than that of laser alone, and it can effectively improve the levels of vascular endothelial growth factor, IGF-1 and EPO, which may contribute to the anti-angiogenic effect. [ABSTRACT FROM AUTHOR]

Objcclive To investigate the effects of different concentrations of pilocarpine on the spontaneous movement and anxiety-related behaviors of zebrafish juveniles under different light conditions. Methods Different concentrations of pilocarpine were used to treat the 5 days post-fertilization (5dpf) and 7 days post-fertilization (7dpf) zebrafish of AB strains.and their spontaneous and tactile behaviors were observed under continuous illumination and alternating light and dark environment. Results The locomotor activity of 5dpf zebrafish was enhanced under continuous light (except for the groups with a concentration of 0. 1 mmol/L and 0. 3 mmol/L) * while the locomotor activity of 7dpf zebrafish increased with increasing drug concentration ( reduced in the 10 mmol/L concentration group). Group 7dpf zebrafish in the concentration of 3 mmol/L and 10 mmol/L had significant increase of thigmotactic behavior. In the light-dark alternating phase. 10 mmol. L pilocarpine completely abolished the effect of dark stimulation on the of locomotor activity zebrafish juveniles; its thigmotactic ibehavior increased with increasing of drug concentration. Occlusions Low-dose pilocarpine inhibited the locomotor activity of 5dpf zebrafish in continuous light; high-dose pilocarpine inhibited the locomotor activity of 7dpf zebrafish and increased its anxiety behavior. At the phase of alternating light and dark, the anxiety behavior of zebrafish juveniles was positively correlated with their age and pilocarpine concentration. [ABSTRACT FROM AUTHOR]

Objective To observe the regulation of miRNA-126 and its downstream signal expression in mouse aorta and vascular endothelial cells by observation of phlegm and blood stasis method to study the mechanism of Chinese medicine in inhibiting atherosclerosis. Methods In the cell experiment, the vascular endothelial cells were randomly divided into 4 groups: control group, model group, high-dose Chinese medicine-containing serum group, and low-dose Chinese medicine-containing serum group. Different groups of vascular endothelial cells were treated with different drug-containing serum to observe cell proliferation and apoptosis. RT-PCR and Western-blot assay were used to detect miRNA-126, RGS16,CXCL12, CXCR4, VCAM-1, mRNA and protein expression in vascular endothelial cells. The aortic cross-sectional pathological damage was evaluated with HE staining in vivo. The aortic miRNA-126, RGS16, CXCL12, CXCR4, VCAM-1 mRNA and protein expression were measured with RT-PCR and Western-blot methods. Results The results of in vitro experiments showed that the apoptosis rates of VEC in the model group, high-dose group and low-dose group were significantly higher than that in the control group (P < 0.05), and the proliferation rate was significantly decreased (P < 0. 05). Compared with the model group, the apoptotic rate of VEC was significantly decreased in the high-dose group and the low-dose Chinese medicine-containing serum group (P < 0. 05), and the proliferation rate was significantly increased. Compared with the high-dose group, there was no significant difference in apoptotic rate and proliferation rate (P > 0. 0 5). After intervention, the expressions of miR-126 mRNA in the VEC of the model group, the high-dose group and the low-dose group were significantly lower than that of the control group (P < 0.05). Compared with the model group, the expression of the miR-126 mRNA in the VEC of the high-dose group and the low-dose group was significantly increased (P < 0. 05). Compared with the high-dose group, there was no significant difference in the expression of miR-126 mRNA in the low-dose group (P > 0. 05). After intervention, the expressions of RGS16, CXCL12, CXCR4, VCAM-1 mRNA and protein in the VEC of the model group, high-dose group and low-dose group were significantly higher than those of the control group (P < 0.05). Compared with the model group, the expressions of RGS16, CXCL12, CXCR4, VCAM-1 mRNA and protein were significantly decreased in high-dose group and low-dose group (P < 0. 05). Compared with high-dose group, there was no significant difference in RGS16, CXCL12, CXCR4, VCAM-1 mRNA and protein expression in low dose group VEC (P > 0. 05). The results of in vivo experiments showed that through HE staining, in the control group, the aortic vessels were even, the endometrium smooth and flat, and there was no atherosclerotic lesion; In the model group, the aortic vessels were uneven, plaque formed, and the thickness of the blood vessels and the cross-sectional area of the AS plaque were significantly larger than those of the other groups; In the high-dose group and the low-dose group, the aortic layers were normal, the inflammatory cells infiltrated lightly with mild lesions; the AS plaques were small and the lesion was significantly lighter than the model group. After intervention, the expressions of miR-126 mRNA in the arteries of the model group, high-dose group and low-dose group were significantly lower than that of the control group (P < 0.05). Compared with the model group, the expression of miR-126 mRNA in the arteries was significantly increased (P < 0.05). Compared with the high-dose group, there was no significant difference in the expression of miR-126 mRNA in the arteries of the low-dose group (P > 0. 0 5). After intervention, the expressions of RGS16, CXCL12, CXCR4, VCAM-1 mRNA and protein in the arteries of the model group, high-dose group and low-dose group were significantly increased compared with the control group (P < 0.05). Compared with the model group, the expressions of RGS16, CXCL12, CXCR4 and VCAM-1 mRNA and protein in the arteries of the high-dose group and the low-dose group were significantly decreased (P < 0. 05). Compared with the high-dose group, there was no significant difference in the RGS16 and CXCL12 CXCR4 and VCAM-1 mRNA and protein expression in the arteries of the low-dose group. (P > 0. 05). Conclusion The mechanism of action in inhibiting the formation of atherosclerotic plaque may be related to the regulation of miRNA-126 affecting the expression of downstream signals GRS16, CXCL12, CXCR4 and VCAM-1. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation between postoperative pleural effusion and pulmonary infection, pleural glucosamine(Glu) level in patients with spontaneous pneumothorax, and to provide reference for the diagnosis and treatment of postoperative pleural effusion in patients with spontaneous pneumothorax. Methods: A total of 96 patients with spontaneous pneumothorax who underwent thoracoscopic surgery from June 2016 to March 2018 in our hospital were selected as the study subjects. They were divided into a control group and an observation group according to whether or not they had pleural effusion after operation, there were 56 patients in the control group and no postoperative complications. There were 40 patients in the observation group and postoperative pleural effusion. Single factor analysis was used to analyze the general data of the two groups of patients, and the correlation analysis was performed on the above data by Pearson analysis. The distribution of pathogenic bacteria and the composition ratio of patients with postoperative pulmonary infection were analyzed to observe the changes of inflammatory factors in peripheral blood before and after surgery. Results:In the observation group, the infection rate, length of stay, postoperative recovery time, and pleural Glu level were significantly higher than those in the control group. The difference was statistically significant(P<0.05); Pearson analysis of the general data with significant differences indicated that there was a positive correlation between pulmonary infection and postoperative pleural effusion in patients with SP, and there was a negative correlation between pleural effusion and postoperative pleural effusion in SP patients(P<0.05). Of the 17 infections, 11 were Gram-negative bacteria, 64.71% of the constituents were Gram-negative bacteria, 6 were Gram-positive bacteria,35.29% of the constituents were Gram-positive bacteria, and no fungal infection occurred. The levels of inflammatory cytokines before treatment in the two groups were not statistically significant and comparable(P>0.05); the levels of Calcitonin(PCT), interleukin-6(IL-6),interleukin-8(IL-8) and interleukin-10(IL-10) were significantly increased after treatment in both groups, the above indicators in the observation group increased more significantly, the difference was statistically significant(P<0.05). Conclusion: Postoperative pleural effusion in patients with spontaneous pneumothorax is negatively correlated with Glu and pleural effusion levels. It is positively correlated with lung infections. Gram-negative bacteria are more common in patients with pulmonary infections, it can be used as a reference for the clinical diagnosis and treatment of postoperative pleural effusion in patients with spontaneous pneumothorax. [ABSTRACT FROM AUTHOR]

Auxin response factor (ARF) is an important transcription factor that can specifically bind auxin responsive gene promoter in plants,and influences the plant growth and development. To better understand the type and quantity of ARF gene families in Gossypium arboretum, we used the method of bioinformatics to analyze the structure types physical mapping of genes and conserved motifs of genome in Gossypium arboretum. The results show that 29 ARF genes,named GaARF were identified in the genome of Gossypium arboretum. All chromosomes contain the ARF gene except the 2,3,5 and 11 by analyzing the position of genes. In addition,there is a gene cluster on chromosome 10. Phylogenetic analysis showed that some ARF proteins and proteins with known function in Arabidopsis were clustered together. Expression profile analysis indicated the expression of ARF genes were diverse in different tissues. [ABSTRACT FROM AUTHOR]

Objective To investigate the relationship between serum bilirubin level and left ventricular diastolic function in patients with type 2 diabetic nephropathy ( DKD) combined with renal failure. Methods Totally 103 eases of patients with type 2 DKD and renal failure were selected as the observation group. According to the level of urinary albumin/ creatinine ratio (UACR), the patients were divided into the normal albuminuria group ( NA group, n = 34 ), microalbuminuria group (MA group, n =39) and maeroalbuminuria group ( OA group, n = 30 ). On the basis of diagnostic criteria of left ventricular diastolic dysfunction (LVDD), patients were divided into patients with LVDD ( LVDD group, n =43) and patients without LVDD (non-LVDD group, n =60). In addition, 58 eases of health volunteers were taken as the control group. The levels of serum total bilirubin (TBIL), direct bilirubin (DBIL), and indirect bilirubin (IBIL) in each group were analyzed by Automatic biochemical analyzer. Meanwhile, the left ventricular mass index (LVMI), end-diastolic ventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT) , left ventricular end-diastolic diameter ( LVEDD ), left ventricular ejection fraction ( LVEF), and left ventricular end-diastolic volume ( LVEDV) , and early diastolic blood flow velocity E peak/diastolic late A peak (E/A) were measured by color Doppler ultrasonography. Then , we analyzed the correlation between serum TBIL, DBIL, IBIL levels and left ventricular diastolic function. Results Compared with the control group, the levels of serum TBIL, DBIL and IBIL of the observation group significantly decreased (all P < 0.05 ). Compared with the NA group, the levels of serum bilirubin of MA group and OA group were significantly lower (P <0.05 ) , the level of serum bilirubin in the OA group was lower than that of the MA group (all P <0.05) , and the level of serum bilirubin in the LVDD group was lower than that of the non-LVDD group (P <0.05 ). The levels of LVMI, LVP-WT, LVEDD and I VST of the observation group were significantly higher than those of the control group (all P <0.05 ), while the levels of LVEF, LVEDV and E/A were significantly lower than those of the control group (all P <0.05 ). The serum TBIL level was negatively correlated with I VST, LVEF and E/A of patients with DKD (r = -0. 708, -0.716, -0.703 , respectively; all P < 0.05 ), and was positively correlated with LVMI, LVPWT, and LVEDD ( r = 0.727, 0.729,0.732, respectively; all P <0.05 ). Serum DBIL level was negatively correlated with I VST and E/A (r = - 0.721, - 0.719; both P <0.05 ), and was positively correlated with LVMI and LVPWT (r = 0.706,0. 698 ; both P <0.05 ). Serum IBIL level was negatively correlated with I VST, LVEF and E/A (r= -0.705, -0.702, -0.651 , respectively; all P <0.05 ) , and was positively correlated with LVMI, LVPWT and LVEDD (r = 0.713 ,0.719,0.723 , respectively; all P < 0.05 ). Conclusion The level of serum bilirubin could reflect the state of disease in type 2 DKD patients with renal failure, which is closely related to left ventricular diastolic function. [ABSTRACT FROM AUTHOR]

Transmission capacity is one of the important performance indicators in wireless sensor networks. This paper applied stochastic geometry theory to establish the network model under regular hexagon，and according to the nodes distribution， it calculated the cumulative distribution function and the probability density function. Meanwhile，this paper studied the system outage probability and transmission capacity in CSMA protocol based on power control. The simulation results show that the system outage probability is lower and transmission capacity is larger in regular hexagon. Furthermore，the space packet density，coding efficiency，backoff times and retransmission times determine transmission capacity. These provide theoretical bases for future research of transmission performance of wireless sensor network. [ABSTRACT FROM AUTHOR]

Objective To observe the effect of curcumin on RAW264.7 macrophages induced with LPS and IFNγ (M1) and the mechanisms involved. Methods Curcumin of different concentrations (6.25μmol/L, 12.5μmol/L and 25μmol/L) was used to treat RAW264.7 macrophages induced with LPS and IFNγ (M1) for 12h, and RAW264.7 macrophages induced with LPS and IFNγ (M1) were incubated with 20μmol/L GW9662 and 25μmol/L curcumin for 12h. Using Real-time PCR, ELISA and Western blotting analysis, we examined the expressions of IL-1β, IL-6, PPARγ and phenotype markers M2 (KLF4, FIZZ1, and MGL1) and the expressions of KLF4 and FIZZ1 when PPARγ was inhibited. Results Curcumin of different concentrations all could inhibit the expressions of IL-1β and IL-6 in RAW264.7 macrophages induced with LPS and IFNγ (M1). Curcumin of different concentrations could upregulate the expression of M2 markers (KLF4, FIZZ1 and MGL1) and PPARγ in RAW264.7 macrophages induced with LPS and IFNγ (M1). When M1 macrophages were incubated with curcumin and GW9662, the expression of the M2 phenotype markers was reduced. Conclusion Curcumin polarized the M1 phenotype macrophages derived from RAW264.7 macrophages to become M2 phenotype through activating PPARγ. [ABSTRACT FROM AUTHOR]