胃癌组织中干细胞标志物 Sox2、OCT4、CD44、β-catenin 表达与胃癌术后复发转移关系.

Objective To analyze the relationship between the expression of stem cell markers Sox2，OCT4，CD44 andβ-catenin in gastric cancer tissue and the recurrence and metastasis after operation，in order to provide reference for the risk assessment and prediction of gastric cancer.Methods 132 cases of gastric cancer admitted to central hospital of Chongq- ing Three Gorges from March 2011 to March 2014 were selected as research subjects.The expression of Sox2，OCT4，CD44 and β-catenin in gastric cancer specimens were detected，and the effects of these stem cell markers on postoperative recurrence and metastasis of gastric cancer were analyzed. Results In the 132 specimens，74 cases were positive for Sox2（56.06%），58 cases were positive for OCT4（43.94%），78 cases were positive for CD44（59.09%），and 70 cases were positive for β - catenin （53.03%）.The positive rate of Sox2 in gastric cancer tissues of patients with different age，lymph node metastasis and degree of differentiation was statistically significant（P<0.05）.The positive rate of OCT4 in gastric cancer tissues of patients with different TNM stages was statistically significant（P<0.05）.The positive rate of CD44 in gastric cancer tissues of patients with different histological grade，tumor diameter，vascular infiltration，lymph node metastasis and TNM stages was statistically significant（P< 0.05）.The positive rate of β-catenin in gastric cancer tissues of patients with different lymph node metastasis and TNM stages was statistically significant（P<0.05）.During the follow-up period，105 of 132 cases had recurrence and metastasis，and the inci- dence was 79.55%.With the increase of the positive rate of stem cell markers in patients with gastric cancer，the incidence of re- currence and metastasis gradually increased ，and the difference was statistically significant（P<0.05）.Conclusion The mark- ers of stem cells in gastric cancer are related to the clinicopathological features of the patients.Early detection of stem cell mark- ers in gastric cancer tissue is expected to provide reference for the risk assessment of recurrence and metastasis. [ABSTRACT FROM AUTHOR]