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Objective: To observe the effects of acetylcysteine nebulization combined with alveolar lavage on inflammatory absorption time, levels of serum C-reactive protein(CRP), lactate dehydrogenase(LDH) and D-dimer(D-D) in children with lobar pneumonia. Methods: A total of 80 children with lobar pneumonia admitted to the hospital were enrolled between January 2021 and December2022. According to random number table method, they were divided into control group(n=40) and combination group(n=40). The control group was treated with alveolar lavage, while combination group was additionally treated with acetylcysteine nebulization. The clinical curative effect, improvement of clinical symptoms, lung function [forced expiratory volume in 1 second(FEV1), forced vital capacity(FVC), peak expiratory flow(PEF)] and serological indexes in the two groups were compared before and after treatment. Results: After treatment, total response rate of clinical curative effect in combination group was significantly higher than that in control group(92.50%vs 75.00%, P＜0.05), absorption time of lung inflammation, relief time of cough and antipyretic time were significantly shorter than those in control group(P＜0.05). After treatment, FEV1, FVC and PEF in both groups were increased, which were higher in combination group than control group(P＜0.05), while levels of CRP, LDH and D-D were decreased, which were lower in combination group than control group(P＜0.05). Conclusion: The curative effect of acetylcysteine nebulization combined with alveolar lavage is significant on children with lobar pneumonia, which can significantly relieve clinical symptoms, shorten inflammatory absorption time, significantly improve lung function and reduce levels of serum inflammatory factors. [ABSTRACT FROM AUTHOR]

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目的:探讨牛肺磷脂注射液联合呼吸机鼻塞式持续正压通气治疗新生儿呼吸窘迫综合征的疗效。方法:98例呼吸窘迫综合征新生儿为研究对象,随机数字法分为两组。对照组应用呼吸机鼻塞式持续正压通气治疗,研究组应用牛肺磷脂注射液联合治疗。结果:研究组有效率高于对照组（P<0.05）;治疗前两组患儿的动脉血气指标无明显差异,治疗后,研究组12 h及24 h后的PaO2、血pH水平高于对照组,PaCO2水平低于对照组,两组差异有统计学意义（P<0.05）;治疗前两组患儿的胸部X线情况对比无明显差异,治疗后,研究组胸部X线各项情况的改善均优于对照组,两组差异有统计学意义（P<0.05）;研究组用机时间、住院时间均短于对照组（P<0.05）;研究组并发症的发生率低于对照组,两组差异有统计学意义（P<0.05）。结论:牛肺磷脂注射液联合呼吸机鼻塞式持续正压通气治疗新生儿呼吸窘迫综合征效果理想,能够改善患儿的动脉血气指标,提高治疗的效果,缩短患儿的用机及住院时间。 [ABSTRACT FROM AUTHOR]

目的观察脓毒血症患儿静脉血培养分离的412株病原菌的菌种及耐药情况,为临床合理使用抗菌药物提供依据。方法 1 280例脓毒血症患儿,共培养分离出病原菌412株,采用VITEK2 compact全自动微生物鉴定及药敏分析仪进行菌种鉴定和药敏分析试验。结果 412株病原菌中,革兰氏阳性菌184株,革兰氏阴性菌225株,真菌3株。前6位病原菌分别为凝固酶阴性葡萄球菌(CNS,150株)、嗜麦芽窄食单胞菌(61株)、假单胞菌(38株)、伯克霍尔德菌(26株)、粘质沙雷菌(25株)、产碱杆菌(21株)。178株革兰氏阳性球菌对苯唑西林、青霉素、克林霉素、红霉素等耐药率较高,对利福平、万古霉素、利奈唑胺、替加环素等敏感; 199株革兰氏阴性杆菌对氨曲南、多粘菌素B等耐药率较高,对头孢他啶、头孢吡肟、复方新诺明、米诺环素、头孢哌酮、亚胺培南等敏感。结论脓毒血症患儿血培养阳性的412株病原菌中,主要为CNS、嗜麦芽窄食单胞菌、假单胞菌、伯克霍尔德菌、粘质沙雷菌、产碱杆菌等,种类较多、耐药情况差异较大,对利福平、万古霉素、替加环素、头孢他啶、头孢吡肟、亚胺培南及复方新诺明等敏感。 [ABSTRACT FROM AUTHOR]

To study the clinical efficacy of acetylcysteine adjuvant therapy mycoplasma pneumonia in the treatment of children and its effect on the content of CD molecular. 90 children with mycoplasma pneumonia who received therapy from January 2019 to December 2019 in our hospital were selected, according to the random number table, they were divided into the observation group and the control group, each group had 45 cases. The control group was given routine treatment, on the basis of the control group, the observation group was combined with acetylcysteine solution inhalation, they were treated for 5 days. The clinical efficacy, symptoms disappear time, hospital stay, the changes of the white blood cell count (WBC), C reactive protein (CRP), CD3+, CD4+ and CD4+/CD8+ before and after treatment, and the occurrence of adverse reactions were compared between the two groups. After treatment, the total effective rate in the observation group was 93.33%, which was significantly higher than that of the control group 77.78%(P＜0.05); the disappearance time of cough, pulmonary rales and hospital stay in the observation group were significantly shorter than that of the control group[(5.24± 1.07)d vs (6.59± 1.16)d, (5.53± 0.76)d vs (6.75± 1.04)d, (7.01± 1.40)d vs (8.11± 1.36)d](P＜ 0.05); the leukocyte count (WBC), C-reactive protein (CRP) in the observation group were significantly lower than that of the control group[(5.06± 0.72)× 109/L vs (7.34± 1.30)× 109/L, (1.86± 0.20)mg/L vs (4.63± 0.61)mg/L], the CD3+, CD4+ and CD4+/CD8+were significantly higher than that of the control group[(64.81± 5.63)% vs (58.03± 4.27)%,(36.86± 3.09)% vs (29.17± 2.64)%, (1.32± 0.18)% vs (1.20± 0.12)%](P＜0.05). There were no obvious adverse reactions in the two groups during the treatment. Acetylcysteine adjuvant therapy is effective for mycoplasma pneumonia in children, it can promote disease recovery with high safety, the internal mechanismmay be related to the regulation of CD molecular content, repair of the immune function and so on. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the clinical effect of extensively hydrolyzed formula (eHPF) on the early feeding of different weight premature infants. Methods: Premature infants treated in our hospital's neonatal ward from September 2017 to December 2018 were studied, including 62 very low birth weight (weight between 1000- 1500g) and 100 low birth weight (weight between 1500-2000g). They were randomly divided into two groups: extensively hydrolyzed formula group (observed group) and preterm formula (control group), and concretely very low birth weight were started feeding after 12 hours and changed to preterm formula after 2 weeks and very low birth weight were feeding 12 hours and changed to preterm formula after 1 weeks. The clinical effect were compared between different weight premature infants early feeding. The recovery time to birth weight, weight growth, retention time to stomach tube, time to reach full enteral nutrition, hospitalization days, feeding tolerance, the incidence of extrauterine growth retardation(EUGR) and ureanitrogon, alkaline phosphatase were observed and compared between two groups. Results: Compared with the control group, the recovery time to birth weight, full enteral feeding, retention time to stomach tube and hospitalization day of treatment group were markedly shorter, (P<0.05). The weight growth of observed group was superior to that of the preterm formula group, the feeding tolerance and the incidence of extrauterine growth retardation(EUGR) were lower than control group(P<0.05). There was no difference in the ureanitrogon, alkaline phosphatase between two groups (P>0.05). Conclusion: Extensively hydrolyzed formula is obviously better than that of preterm formula in the early feeding of premature infants with different body weights, which is more conducive to the growth and development of premature infants. [ABSTRACT FROM AUTHOR]

Objective: To analyze the clinical characteristics, treatment methods and cause of death of aluminium phosphide poisoning in children. Methods: The clinical data of 55 cases of children with accidental inhalation of aluminum phosphide poisoning in our hospital from 2014 to 2018 (31 cases of mild poisoning and 14 cases of severe poisoning ) were analyzed, including the age, gender, onset seasons, poisoning inhalation time, visit time and examination results. Results: In the 55 cases, 10 cases died. The average inhalation time of mild poisoning was 25.1 hours, of which the severe poisoning was 185.4 hours, and the average visit time were 14.6 hours and 38.5 hours separately. The clinical manifestations were nausea and vomiting in 55 cases (100%), dizziness and pale in 14 cases (25%), palpitation in 16 cases (29%), respiratory failure in 14 cases (25%), severe arrhythmia in 8 cases (14.5%), hypotension and cardiogenic shock in 10 cases (18%). Electrocardiogram examination were analyzed: 1 case of supraventricular tachycardia, 4 cases of ventricular tachycardia, 1 case of grade 2 II atrioventricular block, 5 cases of sinus arrhythmia, and 26 cases of sinus tachycardia. Laboratory results followed: myocardial enzymes were elevated in 19 cases (34.5%), liver function were abnormal in 12 cases (21.8%), 6 cases (10.9%) had abnormal renal function and 14 cases (25%) had metabolic acidosis. Treatment is mainly symptomatic support treatment. All of them were severe poisoned and died from circulatory failure. Conclusion: The mortality of aluminium phosphide poisoning is very high and the cause of death is circulatory failure. There are no special detoxification drugs now, so it is important to diagnose early and treatment comprehensively. [ABSTRACT FROM AUTHOR]