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Constitutive model of stone masonry is an important foundation and prerequisite for physical calculation and finite element numerical simulation of stone masonry. In order to further study the constitutive relationship of stone masonry under uniaxial compression, based on the theory of damage mechanics, the two-parameter Weibull distribution function was applied to reflect the damage variable, and its parameters were determined according to the characteristic conditions of the whole process of the stress-strain curve of stone masonry under uniaxial compression. The uniaxial compression damage constitutive model of stone masonry was derived and established, and the correctness of the constitutive model was verified by the existing test data. The constitutive model was compared with the typical masonry constitutive model. Finally, the finite element analysis of the existing stone masonry arch bridge test was carried out to verify the applicability of the constitutive model. The results show that the model is in good agreement with the uniaxial compression test results of existing stone masonry. The established model verifies the general law of masonry damage evolution and accords with the general trend of typical masonry constitutive model. The model can be applied to the finite element analysis and calculation of masonry structure with good applicability. [ABSTRACT FROM AUTHOR]

In order to investigate the residual degradation of pyrazolin in pears and provide theoretical basis for safe drug use in production, field experiments were conducted in Shandong, Hebei, Hubei, Gansu and Anhui provinces in 2020 to investigate the residual degradation of pyrazolin in pears. The results showed that the dissipation equations of pyraclostrobin in pear samples fit the first-order kinetics equation. The half-lives in pear was 9. 9 d. The pyraclostrobin was sprayed by dilution of 1 000 times and 500 times on pear for 2-6 times and samples were collected 7, 14 and 21 d after the last application. The final residue of pyraclostrobin in the pear was 0. 001-3. 601 mg/ kg. After applying high concentration, samples from 6 regions had exceeded the standard in some cases. After low-concentration application, except the samples collected at 7 and 14 days, the samples at 21 days exceed the standard. It was suggested that pesticide labeling requirements such as pesticide concentration, application times and pre-harvest interval should be strictly controlled when applying pesticide on pears, and the application times should not be blindly increased to avoid excessive standard. [ABSTRACT FROM AUTHOR]

Presently, the practical teaching system for chemistry and chemical engineering students faces challenges such as a weak theoretical foundation, a disconnect between theory and practice, and a mismatch between knowledge and innovative skill application. To address these issues, a binary combination strategy integrating theory-engineering and research-teaching is proposed, aligning with emerging engineering education paradigms. This approach allows for a more comprehensive and reinforced knowledge system, achieved by merging theory with practice. Both real and virtual training methods are employed to enhance experimental skills. Furthermore, amalgamating scientific research with industry-focused education elevates the practical proficiency of students. Investigating this holistic approach to practical education, tailored to societal demands and talent growth, offers a more robust method for cultivating innovative and skilled graduates in the fields of chemistry and chemical engineering. [ABSTRACT FROM AUTHOR]

Buckwheat is the major food crop in high altitude areas such as Liangshan district, Sichuan province, China. In order to explore the cold resistance of buckwheat and screen excellent buckwheat germplasm resources adapted to Liangshan district, 5 common buckwheat (Fagopyrum esculentum Moench.) and 13 Tartary buckwheat [Fagopyrum tataricum (L.) Gaertn. ], the most extensive varieties and landrace, were used to evaluate the cold resistance during seed germination stage at 4℃(low temperature condition) and 22℃(control condition). Seven indices related to germination and growth were measured, including radicle length, germination rate and germination potential. Comprehensive cold resistance was reflected by subordinate function analysis, principal component analysis and cluster analysis. The results showed that under low temperature conditions, the seed germination of all buckwheat materials was delayed and the germination rate was retarded. Compared with Tartary buckwheat, seven germination and growth indexes of common buckwheat maintained a higher level, indicating that common buckwheat was more tolerant under low temperature environment. The comprehensive evaluation of the membership function results suggested that Jiuzhaigou common buckwheat had the strongest low temperature tolerance ability at the germination stage, followed by Pintian No.3, whereas Xiqiao No.6 was the most sensitive to low temperature. [ABSTRACT FROM AUTHOR]

Objective To analyze the serological markers and surgical indicators associated with biliary complications after orthotopic liver transplantation, explore their influencing factors and predictive indicators. Methods A retrospective analysis was performed for the clinical data of 101 patients who underwent orthotopic liver transplantation in Renmin Hospital of Wuhan University from January 2016 to June 2022, according to the presence or absence of biliary complication (BC) at 6 months after surgery, they were divided into BC group with 21 patients and non-BC group with 80 patients.The t-test or the Mann-Whitney U test was used for comparison of continuous data between groups, and the chi-square test was used for comparison of categorical data between groups.Univariate and multivariate Logistic regression analyses were performed, and the receiver operating characteristic (ROC) curve was used to evaluate the predictive performance of combined indicators. Results Among the 101 patients, 21(20.8%) experienced BC.The multivariate Logistic regression analysis showed that MELD score (odds ratio[OR]=0.134, 95% confidence interval[CI]: 0.031-0.590, P=0.008), SⅡ/Alb (OR=1.415, 95%CI: 1.181-1.696, P=0.001), and plasma transfusion volume (OR=1.001, 95%CI: 1.000-1.002, P=0.032) were independent risk factors for the development of BC in patients after liver transplantation.MELD score, SⅡ/Alb, plasma transfusion volume, MELD+SⅡ/Alb, and MELD+SⅡ/Alb+plasma transfusion volume had an area under the ROC curve of 0.712, 0.870, 0.712, 0.900, and 0.918, respectively, in predicting BC after liver transplantation. Conclusion SⅡ/Alb, plasma transfusion volume and MELD score are independent risk fators for BC after liver transplantation.The combination of three indicators has good predictive value and clinical guiding significance for BC after liver transplantation. [ABSTRACT FROM AUTHOR]

Gaomiao site is an important agricultural site of the middle and late Neolithic Age in Yuanjiang River basin, Hunan Province. Since 1991, Gaomiao site has been excavated three times and a lot of agricultural remains have been unearthed, which is the key to revealing the origin of prehistoric civilization and the evolution of agriculture in the Yuanjiang River basin, including four stages of embryonic, foundation, development and mature period. The historical, artistic, scientific, social, and cultural values of this site have provided the important prerequisite and foundation for scientific planning and construction of archaeological parks, as well as for the protection of large sites and heritage tourism. [ABSTRACT FROM AUTHOR]

An accurate and rapid identification of species is one of the most important parts of freshwater fish pre-treatment. However, deep learning-based freshwater fish classification cannot quantitatively describe the feature parameters of fish, due to the complicated feature extraction. This study aims to propose a deep learning-based fish feature point detection and freshwater fish classification. Firstly, an image acquisition device was built to acquire the images of five freshwater fish species: bream, bighead carp, grass carp, silver carp, and common carp. Secondly, the data enhancement was performed on the original images. LabelMe software was also used to label 20 feature points of the fish body, in order to construct a freshwater fish feature point detection dataset. The feature point of freshwater fish was detected using an improved AlexNet feature point detection model with the convolutional neural networks (CNN). The improved AlexNet model also adjusted the network structure of the traditional model, in order to accommodate the feature point detection task by the modified convolutional kernel size, the removal of the local response normalization layer, the addition of batch normalization layer, and the replacement of the loss function. The Euclidean distance between feature points was extracted as the feature value using the coordinates of the feature points. Feature vectors were constructed. Fisher discriminant analysis was used to identify the species of freshwater fish. A series of ablation experiments were conducted on the improved AlexNet model to clarify the impact of different improvement schemes on model performance. The results showed that the improved schemes were beneficial to improve the training efficiency and performance of the model. The average value of normalized mean error (NME) of the improved AlexNet model on the test set was 0.0099, the failure rate (FR) at thresholds of 0.02 and 0.03 were 2.50% and 0.83%, and the average detection time was 0.037 s, indicating the better accuracy and error distribution. The number of parameters and floating-point operations per second (FLOPs) of the improved AlexNet model were smaller than those of the VGG16 model. The test set detection was also better than that of the VGG16 model, compared with different feature extraction models. Although the number of parameters and FLOPs of the improved AlexNet model was larger, the average NME and the FR were lower than that of the MobileNetV2 model. The recognition accuracy of 98.0% was achieved in the freshwater fish species recognition using the model and Fisher discriminant analysis for five freshwater fish species. The average recognition time of a single image was 0.368s. The feature point detection model can be expected to detect the feature points of five species of freshwater fish with high accuracy. The finding can also facilitate freshwater fish species identification, size detection, and fish segmentation. The freshwater fish species identification using feature point detection and Fisher's discriminant analysis can lay the foundation for the development of an automated freshwater fish classification device. [ABSTRACT FROM AUTHOR]

Rural tourism is a vigorous drive force to the development of rural economy, and an important power to lead the rural revitalization strategy in China as well. After the Pandemic of COVID-19, the demand for rural tourism products and quality continues to expand. However, during the rapid development, rural tourism showed mismatch between supply and demand. This paper took the case of Kunshan City in Jiangsu Province, based on the data of tourist market investment, using the IPA analytical method and the gap model of service quality, tried to find out the problems and countermeasures in re-matching of supply and demand in Kunshan's rural tourism industry, especially from the supply-side. This paper constructed the logical frame‐ work of supply-demand matching governance policy of rural tourism based on China's Rural Re‐ vitalization strategy. The research result can provide reference to the promotion of the quality for China's rural tourism development. [ABSTRACT FROM AUTHOR]

The experiment was to screen the shared DEGs of important brain tissues related to heat stress in broilers and explore their molecular mechanisms. Two sets of gene chip data sets of chicken brain and hypothalamus processed by heat stress were obtained from GEO database, and bioinformatics data were mined again. The results showed that 32 DEGs shared by important brain tissues related to heat stress were screened, including 27 significantly up-regulated genes and five significantly down-regulated genes. Through the analysis of GO and KEGG, the above genes are mainly involved in seveen biological processes and three KEGG pathways. Used STRING database and Cytoscape software to construct protein interaction network, there were 16 nodes and 102 proteins interacting. The first to seventh genes were screened as differentially expressed up-regulated genes due to GC, FGG, FGA, FGB, PLG, APOB and FABP1. The study indicates that sharing DEGs may be related to damage and pathogenesis of different tissues or organs in broilers during heat stress. [ABSTRACT FROM AUTHOR]

Objective To investigate the risk factors of infection after hepatectomy for liver cancer, and to establish and validate a risk prediction model. Methods The clinical data of 167 patients with primary liver cancer who underwent hepatectomy in People's Hospital of Wuhan University from January 2020 to March 2022 were retrospectively collected. All patients were divided into postoperative infection group (n=28) and non-infection group (n=139) according to whether postoperative infection complications occurred. The t-test or Mann-Whitney U test was used for comparison of continuous data between two groups and the chi-square test was used for comparison of categorical data between two groups. Univariate analysis and logistic regression analysis were used to screen the risk factors of infection after hepatectomy for hepatocellular carcinoma, and a nomogram risk prediction model for postoperative infection was established. All patients were randomly divided into training cohort (n=119) and the validation cohort (n=48) according to the ratio of 7∶ 3, the Bootstrap method was used for internal validation of the model, and the model calibration curve and ROC curve were used to evaluate the calibration and discrimination of the nomogram model. Results Postoperative infection occurred in 28 of 167 patients (16.8%). Logistic regression analysis showed that diabetes, CONUT score ≥4 points, preoperative NLR, operation time, intraoperative blood loss, and drainage tube placement time > 7 d were independent risk factors for infection after hepatectomy for liver cancer (all P < 0.05). Based on the nomogram constructed from the above six risk factors, the area under the ROC curve of the training cohort and the validation cohort was 0.848, and 0.853, respectively. The calibration curve of the nomogram model shows that the predicted value is basically consistent with the actual observed value, indicating that the accuracy of the nomogram model prediction is better. Conclusion The individualized nomogram risk prediction model based on diabetes, CONUT score ≥4 points, preoperative NLR, operation time, intraoperative blood loss, and drainage tube placement time > 7 d has good predictive performance and has high predictive value for high-risk patients. [ABSTRACT FROM AUTHOR]

Aiming at the problems of low calculation accuracy by using traditional bolt connection model and parameter identification of bolt structure dynamic model, the six parameter Iwan model was introduced to numerically solve the force displacement relationship equation and draw the nonlinear force displacement relationship curve of Iwan model. The universal testing machine tensile test and vibration experiment platform excitation test were combined to identify the parameters of the model and realize the model construction. The experimental results show that with the increase of bolt diameter, the macro sliding residual stiffness increases, and the energy dissipation of the model decreases. The research results can provide a reference for the design, analysis and calculation of bolt structure. [ABSTRACT FROM AUTHOR]

Tumor microenvironment is composed of tumor cells and their internal and external environment, and the components vary slightly between different types of tumor. Liver cancer microenvironment is a tumor-promoting microenvironment constructed by hepatoma cells and immune cells and can lead to the development, invasion, and metastasis of liver cancer by recruiting inflammatory cells, inhibiting antitumor immune response, promoting angiogenesis, and promoting drug resistance. This article discusses the characteristics of liver cancer microenvironment, the composition and role of liver cancer microenvironment, and the new advances in microenvironment-targeting therapy for liver cancer. [ABSTRACT FROM AUTHOR]

Objective To investigate the predictive value of heart rate-corrected QT (QTc) and heart rate-corrected Tp-Te (Tp-Tec) intervals combined with serum complement 1q/tumor necrosis factor-related protein 9 (CTRP9) levels for the development of ventricular arrhythmias (VA) after acute myocardial infarction (AMI). Methods A total of 156 patients with AMI were selected, VA occurred in 61 cases during hospitalization (VA group), and 95 cases (non-VA group) did not have VA. The QT and Tp-Te intervals were recorded on admission using a 12-lead ECG machine, and the QTc and Tp-Tec intervals were calculated. On the next day of admission, early morning fasting elbow venous blood was collected, centrifuged and serum was retained, and serum CTRP9 was measured by ELISA. We compared the general clinical data［including gender, age, BMI, smoking history, underlying diseases (hypertension, diabetes, hyperlipidemia)], disease-related data［including Killip classification on admission, left ventricular ejection fraction (LVEF) within 6 h after admission], laboratory examination data [including the four lipid items (TC, TG, HDL-C, LDL-C), blood creatinine (Scr), blood uric acid (UA), fasting plasma glucose (FPG) and serum CTRP9 level on the day after admission] and ECG examination data (including QTc, Tp-Tec interval) between the two groups. A multi-factor Logistic regression model was used to analyze the factors influencing the development of VA after AMI. Receiver operating characteristic (ROC) curves were used to analyze the predictive value of QTc, Tp-Tec intervals and serum CTRP9 levels in the development of VA after AMI. Results Compared with the non-VA group, the QTc and Tp-Tec intervals were significantly prolonged and serum CTRP9 levels were significantly lower in the VA group (all P<0. 05). No significant differences were found in the general clinical data and blood lipid, FPG, or Scr between the two groups (all P>0. 05). The ratio of Killip grade >Ⅱ in the VA group was higher than that in the non-VA group, while the LVEF was lower than that in the non-VA group (both P<0. 05). UA was higher in the VA group than in the non-VA group (P<0. 05). Multi-factor Logistic regression analysis showed that UA, QTc interval and Tp-Tec interval were all independent risk factors for the development of VA after AMI, while CTRP9 was an independent protective factor (all P<0. 05). ROC curve analysis showed that the area under the curve (AUC) for QTc and Tp-Tec intervals combined with serum CTRP9 levels in predicting VA after AMI was significantly higher than that of QTc interval, Tp-Tec interval, QTc interval + Tp-Tec interval, and CTRP9 in predicting VA after AMI (all P<0. 01). Conclusions Patients with VA after AMI had significantly longer QTc and Tp-Tec intervals and significantly lower serum CTRP9 levels. QTc and Tp-Tec intervals were independent risk factors for the development of VA after AMI, while CTRP9 was its independent protective factor. QTc, Tp-Tec intervals and serum CTRP9 levels all had some predictive value for the development of VA after AMI, but QTc and Tp-Tec intervals combined with serum CTRP9 levels had significantly higher predictive value for the development of VA after AMI. [ABSTRACT FROM AUTHOR]

Currently, multiple difficulties exist in clinical liver transplantation, such as shortage of donor liver, increasing quantity of patients waiting for liver transplantation and lack of matching donors, etc. Some children and adult patients have little chance of undergoing liver transplantation, which also limits the development of liver transplantation. In this context, split liver transplantation emerges, in which 1 donor liver can be applied to 2 or even more recipients. It may effectively increase the utilization rate of donor liver and alleviate the shortage of donor liver. With the development of split liver transplantation, the survival rate of split liver transplantation is comparable to that of total liver transplantation. Multiple transplantation centers have routinely adopted split liver transplantation. In this article, the development of split liver transplantation, the selection and matching of donors and recipients, the split and reconstruction techniques of donor liver and postoperative complications were reviewed, aiming to provide reference for subsequent development of split liver transplantation in clinical practice and increase the chance of liver transplantation for more patients diagnosed with end-stage liver diseases. [ABSTRACT FROM AUTHOR]

Feeding has been one of the most cost sources in fish farming so far. Artificial and mechanized feeding has been the most two widely-applied approaches to fish feeding in China. However, both feeding cannot be cost saving, due mainly to the amount of feed always depends on the experience rather than the real hunger situation of fish. Once the feed is superfluous, it is likely to the water contamination in many cases. It is necessary to appropriately adjust the amount of feed, according to the timely feeding information. As a result, a more flexible feeding has been a high demand to control the feed amount, according to the changes in fish behavior, in order to effectively reduce costs for more benefits. Intelligent feeding has been partially realized, whether via the detected information from the feeding process through various sensors, or via the developed predicting models as a feeding guideline for the decision-making. However, there are still great challenges to realizing completely intelligent feeding. However, the predicted information depends mainly on the complex farming environment and uncertain fish behavior. In this review, the most technical applications were categorized in the fish intelligent feeding over the recent decades, including fish feeding behavior, visually intelligent feed detection, acoustics, sensor, and biological model technology. Several types of commonly-used fish feeders were determined, including the gravity drop, pneumatic conveying, centrifugal throwing, and hydraulic conveying types. A better performance was achieved to avoid the labor costs and feed wasting, if the feeder was precisely selected to fit well the actual breeding operation, according to the various fish types or breeding modes. Some aspects of the feeder still need to be improved for the goal of complete intelligence. More advanced techniques can be required to meet the future requirements of the feeder in the long-distance precise transmission for large-scale fish farming, specifically including average feeding and wide-range feeding. By contrast, an accurate and reliable feeding can be achieved for the feeder in the factory intensive farming mode, with emphasis on the small-size design and technical revolution. Furthermore, there is also some change from the timer and quantitative feeding to intelligent feeding in machines. Finally, a systematic investigation was made to summarize the national and international research on the specific application scenarios and basic components of intelligent feeding systems. It indicated that the signal transmission and control system were dominated in the most intelligent machines of fish feeding, where the input data was generally collected from the farming environment and fish behavior in practice. The document analysis on intelligent feeding demonstrated that the instant behavior of fish was usually identified to guide the feeding operation under the experimental condition in fish farming. Yet, there was still something to do better: 1) Some exogenous factors can pose some elusive impacts on the actual feeding operation, such as the environmental fluctuations or human activities; 2) The feeding decision-making models can be required to upgrade or modify for the wide universality suitable for the more types of scenarios and fish; 3) The computing equipment can be more powerful to promote more reliable data sampling. In conclusion, the main purpose of an intelligent feeding system can be to fit much better with the various feeding situations, whether different fish types or different breeding modes. As such, a much more accurate judgment can be achieved to take more variables into the comprehensive consideration. Therefore, it is a promising potential way to combine more available disciplines like Aquaculture, Engineering, and Computer Science, or incorporate more accessible information, such as images, sounds, growth patterns, and biological characteristics. The multidisciplinary or multimedia fusing entity can greatly contribute to the fish feeding system for fully complete intelligence in the near future. [ABSTRACT FROM AUTHOR]

For improving the classification accuracy of high-resolution remote sensing imagery, an accurate and automatic land cover classification convolutional neural network (LCC-CNN) for high resolution remote sensing imagery based on deep learning is proposed. The training dataset is constructed by GF-2 and BJ-2 image. The LCCCNN is designed with different sizes of dilated convolution in extracting multiscale features from remote sensing imagery. A novel loss function is designed for distinguishing the fuzzy boundary among different land cover classification regions. With the structure of encoder-decoder, LCC-CNN export pixel-level classification result, the experiments show that the overall classification accuracy, IOU, and Kappa coefficient of LCC-CNN are 87. 17%, 0. 773 2, and 0. 829 1. Compared with the existing approaches, such as SVM and decision tree, the accuracy, IOU, and Kappa coefficient are improved by 8%, 10%, and 11%. The experiments also prove that LCC-CNN has strong applicability for high-resolution image classification without designing classification features and parameters. [ABSTRACT FROM AUTHOR]

Sustainable agricultural mechanization has been one of the most important strategies for the decision-making and operations in the management of crop production. An accurate and rapid evaluation can greatly contribute to promoting the quality of sustainable agricultural mechanization in China. However, many complex and changing factors are confined to the sustainable agricultural mechanization in recent years. Generally, four dimensions can be maintained for agricultural mechanization: the social and economic benefits, the operation level, the impact on the resources and environment, and the level of the agricultural engineering industry. In this study, a systematic evaluation was made on the influencing factors in the sustainable agricultural mechanization in Hubei Province of China using the combination of Decision-Making Trial and Evaluation Laboratory (DEMATEL) and Interpretive Structure Modeling (ISM). An evaluation index system was constructed to determine 13 indicators of sustainable agricultural mechanization, four parts of which were pressure (including the positive and negative factors), state, influence, and response, according to the hierarchical connections. A comparison was also made on the specific data of the 13 secondary indicators in the study area from 2004 to 2020. The quantitative data showed that the fuzzy DEMATEL-ISM performed better to integrate the subjective and objective opinions of influence indicators, further to determine the main influencing factors of sustainable agricultural mechanization. A pressure-state-impact-response model was selected to assess the index system of t sustainable agricultural mechanization. It was found that the pressure factors were the most significant driving factors in agricultural mechanization, accounting for more than 40% of the weights in the evaluation index system, followed by the State, and the lowest were Impact and Response. The results show that the economic factors were the most important development factors, while, the environmental factors dramatically increased to be the influencing factors. Furthermore, the input-output, scientific and technological factors of agricultural mechanization were also comprehensively evaluated in the index system. More importantly, the evaluation result showed that the sustainable agricultural mechanization in the study area was positive and orderly developed as a whole over the past ten years. Among them, the positive driving factors of the pressure and state-related indicators increased significantly, such as the economics, the agricultural engineering industry, as well as agricultural science and technology. The maximum contribution rate was attributed to the economic benefits and capacity development in sustainable agriculture manufacturing. The pressure part was remained basically stable, indicating the impact of labor reduction on agricultural mechanization. The agricultural machinery cost factors were basically maintained a small range of fluctuations. The adverse factors of the energy environment posed a great effect on income, output growth, and agricultural mechanization. At the first time, the response part was much higher than the pressure and impact parts, indicating the ever-increasing investment in the control of sustainable development. Much attention can be paid to the concept of sustainable development for the decision-making on the increasing investment, further offering greater opportunities and challenges for the sustainable agricultural mechanization in the end, some recommendations were also proposed for the future development of agricultural mechanization. [ABSTRACT FROM AUTHOR]

作为近年来快速发展的一种新的起搏治疗方法,希浦系统起搏相比传统的右心室起 搏,更符合生理性起搏的定义。 本文报告 1 例房颤伴三度房室阻滞患者植入单腔起搏器治疗, 术中发现并夺获右束支电位;将起搏器电极置于右束支区域起搏后,QRS 波时限为 90 ms,达 峰时间 37 ms,较术前无明显改变。 此例经右束支选择性起搏 QRS 波时限几乎正常,有利于维 持心电活动的同步性、保护左心功能。 [ABSTRACT FROM AUTHOR]

[Objective] The extraction and change monitoring of cultivated land information is one of the hotspots of remote sensing application research. Northern Guangdong is the main grain base of Guangdong Province, and is the key area of cultivated land change monitoring by business management departments.[Method] In the present paper, using GF-2 and Sentinel-2 remote sensing images, combined with the phenological period of late rice in the study area, the vegetation index, humidity index, brightness index, color index and texture features were extracted for multi-scale segmentation, and the multi-scale image of paddy field extraction was constructed. The index difference image and time series multi feature difference image were classified to extract the paddy field area and evaluate the results.[Result]（i) The highest extraction accuracy of paddy field in time series multi feature difference image was 0.98,and the minimum difference between paddy field area and late rice sowing area was 240.05 hm2,and the best paddy field extraction effect was based on time series multi feature difference image;（ii）The difference of index feature needed to use the key phenological characteristics of crops and combine with multi-scale segmentation of image to improve the accuracy of paddy field extraction;（iii）The machine forest method has faster operation speed and higher classification accuracy in data classification with high dimensional features. [Conclusion] The research of the paper is to explore the method of high-resolution remote sensing in rapid and accurate updating of cultivated land information, which can provide support for the application of cultivated land management business. [ABSTRACT FROM AUTHOR]

In order to improve the accuracy rate of state diagnosis of rolling bearing based on time domain signals, a novel diagnosis system which combined significance sequence of vibration signals and machine learning was proposed. Firstly, the residual spectral of the signal was obtained by subtracting the logarithmic amplitude spectrum from the mean logarithmic amplitude spectrum which was acquired by analyzing the normalized vibration signals in frequency domain. Then, the spectral residual of the vibration signals was mapped back to the time domain by inverse Fourier transform to obtain the significance sequence. Finally, the state diagnosis model was used to classify the significance sequence to achieve fault detection of the bearing state. The experiment results indicate that the significant sequence can effectively improve the classification accuracy rate comparing with the original vibration signal, especially for the vibration signal mixed with the different signal noise ratio (SNR) of Gaussian white noise, such as mixed with white Gaussian noise of-6 dB, using support vector machine (SVM) or convolution neural network (CNN) as the state diagnosis model respectively, the significance sequence can respectively improve the accuracy rate of state diagnosis by 9% and 10.75%. What’s more, this method can also effectively shorten the training time of the network model. [ABSTRACT FROM AUTHOR]

The fracture mechanics for thermoelectric materials with equilateral triangle holes subjected to uniform electric current densities and uniform energy fluxes at infinity was studied by means of the complex variable method. The analytic expressions of temperature fields and stress fields were obtained under the boundary conditions of electric insulation and thermal insulation. Effects of the triangle size, the applied electric current density and the energy flux on the thermoelectric material were analyzed. The results show that, the variations of the current density and the triangle size have obvious influences on the annular energy flux, the annular stress and the annular heat flux. [ABSTRACT FROM AUTHOR]

Objective To elucidate the role of miR-490-3p in regulating HMGA2 expression and affecting epithelial-mesenchymal transition (EMT) of SW1990 cells. Methods miR-490-3p expression was measured in HPDE and SW1990 cell lines by Real-time PCR. SW1990 cell lines were cultured in vitro and divided into four groups, including inhibitor-Negative control (inhibitor-NC), miR-490-3p inhibitor, mimic- Negative control (mimic-NC) and miR-490-3p mimic group, and the transfection efficiency was verified by RT-qPCR. After 48 h of transfection, CCK8 assay, wound healing assay, Transwell invasion assay andflow cytometric were used to detect the effects of malignant biological characteristics such as proliferation, migration, invasion and apoptosis of SW1990 cell linerespectively. Western blot was used to detect the expression of E-cadherin and N-cadherin. Meanwhile, database predicted the target genes of miR-490-3p, and dual luciferase assay confirmed the targeted relationship between miR-490-3p and HMGA2, western blot was used to detect the expression of HMGA2. Results 1) The expression of miR-490-3p was downregulated in SW1990 cells (P = 0.215). 2) Overexpression of miR-490-3p significantly inhibited the proliferation (P < 0.0001), migration (P < 0.0001) and invasion (P < 0.0001) of SW1990 cell line and prompted apoptosis (P < 0.0001); In contrast, downregulation of miR-490-3p significantly promoted the proliferation (P < 0.0001), migration (P < 0.0001) and invasion (P < 0.0001) of SW1990 cell line and inhibited apoptosis (P < 0.0001). 3) Upregulation of miR-490-3p significantly decreased the expression of N-cadherin (P < 0.0001) and increased E-cadherin (P < 0.0001) expression in SW1990 cell line. In contrast, downregulation of miR-490-3p significantly upregulated (P < 0.0001) the expression of N-cadherin, decreased E-cadherin (P < 0.0001) expression. 4) HMGA2 was a target gene of miR-490-3p. Conclusion These findings indicate that miR-490-3p acts as a tumor suppressor during the process of EMT through targeting HMGA2, suggesting miR-490-3p is a potential new diagnostic and therapeutic target for the treatment of pancreatic cancer. [ABSTRACT FROM AUTHOR]

bjective: To study the effect of minimally invasive drilling and drainage on the short-term curative effect of patients with hypertensive cerebral hemorrhage, intracranial infection and hematoma re-enlargement. Methods: 81 patients with hypertensive intracerebral hemorrhage from March 2017 to February 2019 were selected. According to the random number table, they were divided into observation group (n=42) and control group (n=39). The control group was treated with conventional craniotomy and hematoma removal, and the observation group was treated with minimally invasive drilling and drainage. Observe the therapeutic effects of the two groups, the amount of hematoma, myelin basic protein (MBP), central nervous system specific protein S100 levels, NIHSS, GCS scores, and adverse reactions. Results: After treatment, the total effective rate of the observation group was significantly higher than that of the control group [92.86% (39/42) vs 69.23% (27/39)] (P<0.05); hematoma volume, MBP, and S100 levels were significantly lower Control group [(9.32±2.70) m L vs (15.51±3.01) m L, (3.65±0.52) μg/L vs (4.20±0.71) μg/L, (0.98±0.26) μg/L vs (1.39±0.35) )Μg/L] (P<0.05); NIHSS score was significantly lower than the control group [(3.90±2.71) points vs (6.34±1.42) points (P<0.05); GCS score was significantly higher than the control group [(14.84±3.52) ) Points vs (10.69±3.98) points] (P<0.05); the total incidence of adverse reactions was significantly lower than that of the control group [9.52% (4/42) vs 38.46% (15/39)] (P<0.05). Conclusion: The short-term curative effect of minimally invasive drilling and drainage in the treatment of patients with hypertensive cerebral hemorrhage is significant. The hematoma is completely removed, which can effectively improve the brain nerve defect, reduce intracranial infection, and promote the recovery of the prognosis. [ABSTRACT FROM AUTHOR]

The novels of ways of the world of South Korea are closely related to the development of Korean society in the 20 th century. Park Tae-won’s Senery of A Riverside in the 1930 s and Yang Gui-ja’s A Hidden Flower in the 1980 s are both the representative works of such novels. Though different in narrative space, perspective and value expression, they demonstrate unique creative characteristics in expression, transmission mode and logical paradigm. In term of aesthetic direction, the secular definition, subjective consciousness and emotional evaluation change with the times, showing the humanistic implication and aesthetic style of such novels in different periods of time. [ABSTRACT FROM AUTHOR]

GPT2w model is commonly used to calculate the meteorological parameters at certain location, such as temperature, weighted mean temperature, pressure and vapor pressure. It is also the public empiri- cal model for tropospheric delay with the best nominal accuracy. In this paper, meteorological sounding da- ta from 2013—2015 of 86 stations in China is used, which have participated the global meteorological ex- change. Precisions of meteorological parameters from GPT2w are examined and analyzed. It turns out that the average bias (Bias) and root mean square error (RMS) of temperature are 1.31 ℃ and 3.62 ℃ , respec- tively. For weighted mean temperature, the Bias is －1.58 K and the RMS is 4.07 K. For pressure and va- por pressure, the absolute values of Bias are smaller than 1 hPa, and the RMS are 6.98 hPa and 3.04 hPa, respectively. Using the data from 2006—2015, periodic characterization of the accuracy of different latitude models are analyzed. It turns out that the RMS of temperature, weighted mean temperature, pressure and vapor pressure shows certain periodic patterns, and differs with different latitude regions. In general, GPT2w model exhibits high precision and stability within the area of China. [ABSTRACT FROM AUTHOR]

The purpose of this project is to guide students in independently designing experiments based on problemoriented approach, taking a commonplace phenomenon (white flocs formed during laundry) as the starting point. The measurement of surface tension is integrated into the process of exploring the underlying chemical principles of daily life phenomena, and an exploratory experimental model that follows a “problem identification-practical explorationtextbook consolidation” framework is established by combining a diverse array of techniques, thereby reinforcing the students’ understanding of colloid and interface chemistry. The revised experiment offers richer content, greater challenges, enhanced comprehensiveness, and increased engagement, effectively fostering students’ abilities to analyze and solve problems and nurturing their inquisitive thinking. Furthermore, this experiment ensures a high degree of safety, ease of operation, and requires no specialized equipment, making it highly suitable for undergraduate instructional labs. [ABSTRACT FROM AUTHOR]

目的 探讨 2 型糖尿病（T2DM）患者血清网膜素 1（Omentin-1）水平与骨代谢及氧化应激的关系。方法 选取 120例 T2DM患者，根据病情控制情况将其分为 A组（病情控制良好）68例和 B组（病情控制不良）52例。另选 择同期健康体检者60例作为对照组。采集受试者清晨空腹静脉血，采用ELISA法检测Omentin-1以及骨代谢指标骨 特异性碱性磷酸酶（BAP）、骨钙素（BGP）、抗酒石酸酸性磷酸酶（TrACP-5b），硫代巴比妥酸比色法测定血清丙二醛 （MDA），羟胺法测定超氧化物歧化酶（SOD）水平。比较三组血清Omentin-1水平、骨代谢指标及氧化应激指标的差异， 采用Pearson相关系数法分析T2DM患者血清Omentin-1水平与骨代谢指标及氧化应激指标的相关性。结果 A、B两 组血清Omentin-1水平均低于对照组，且B组低于A组（P均<0. 05）。与对照组比较，A、B两组血清BAP、TrACP-5b水 平升高，BGP水平降低（P均<0. 05）；与A组比较，B组血清BAP、TrACP-5b水平升高，BGP水平降低（P均<0. 05）。与对 照组比较，A、B两组血清MDA水平升高，SOD水平降低（P均<0. 05）；与A组比较，B组血清MDA水平升高，SOD水平降 低（P均<0. 05）。T2DM患者血清Omentin-1水平与BAP、TrACP-5b、MDA呈负相关（r分别为-0. 508、-0. 660、-0. 625， P<0. 05或<0. 01），与BGP、SOD呈正相关（r分别为0. 701、0. 589，P<0. 05或<0. 01）。结论 T2DM患者血清Omentin-1 水平降低，血糖控制不佳者下降更显著；Omentin-1水平与骨代谢异常及氧化应激反应有关，可能在糖尿病进展及骨 代谢异常中发挥作用。 [ABSTRACT FROM AUTHOR]

目的观察对精神分裂症合并糖尿病患者进行膳食干预的效果,并分析其影响因素。方法收集接受糖尿病膳食干预满1个月的精神分裂症合并糖尿病患者的相关资料,包括一般情况、疾病情况及膳食干预前后血糖、血压、血脂等指标。分析精神分裂症合并糖尿病患者膳食干预效果的影响因素。结果干预后患者空腹血糖(FPG)、糖化血清蛋白(GSP)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)水平及BMI较干预前有所降低(P均<0.05)。FPG、血压达标率(分别为63.5%、51.3%)均较干预前提高(分别为22.8%、21.8%),P均<0.05;干预前后血脂达标率和体质量达标率差异无统计学意义。多因素Logistic回归分析显示,不服用降糖药、精神分裂症病程大于5年而糖尿病病程小于5年的患者血糖控制效果较好。结论糖尿病膳食干预可有效改善精神分裂症合并糖尿病患者的血糖、血压控制效果,血糖的控制效果与患者是否服用降糖药、精神分裂症和糖尿病病程有关。 [ABSTRACT FROM AUTHOR]

Agricultural engineering in China is the pillar and pillar of agricultural and rural modernization. Agricultural engineering management innovation, promoting the prosperity of rural industry, promoting the well-off life of farmers, and improving the level of ecological livability are the important ways to implement the strategy of rural revitalization. But at present, China’s agricultural engineering management system has not yet been effectively established, engineering management lags behind technology management, the main role and enthusiasm of the main operators are not fully played, and the management methods of agricultural engineering need to be improved urgently, and the management efficiency needs to be improved urgently. The key to the management of Agricultural Engineering in the new era is to innovate in concept and method in an all-round way. This paper puts forward the “four-all” management method system based on the whole system integration, all-factor integration, all-link optimization and all-round coordination of agricultural engineering. That is to say, through the whole system integration, to form the overall solution of agricultural engineering planning and design, to provide scientific decision support for agricultural engineering construction; through the integration of all factors, to form an integrated technology and construction standard system of agricultural engineering, to provide a scientific and efficient implementation path for agricultural engineering construction; through the optimization of all links, to form a fully in line with local reality, complete industrial chain, high quality. Effective ecological agricultural engineering optimization construction mode provides precise and dynamic management and control methods for agricultural engineering construction; through all-round coordination, a new type of agricultural engineering management and operation mechanism is formed, which includes strategic and tactical co-ordination, central and local co-ordination, interaction of all parties concerned, mutual benefit and win-win of business entities, economic, social and ecological co-promotion, and provides a systematic target promoter for agricultural engineering construction. A little. This method is used to analyze three key links of agricultural engineering management, namely, target management, process management and dynamic control. Target management must regard the five basic objectives of economy, technology, society, ecology and security as a system to ensure the realization of all the basic objectives and the realization of the overall objectives of the project. Process management focuses on the establishment of technical system, standard system and mode system of agricultural and rural modernization project construction, and carries out systematic research on integrated technology, mode and standard of agricultural engineering. The dynamic control management of agricultural engineering includes feedforward control, field control and feedback control. The dynamic control of management system can be realized by combining feedforward control, field control and feedback control. Finally, specific suggestions on strengthening top-level design of agricultural engineering, division of labor among departments, legislative construction, supervision and evaluation are put forward. This method system can provide reference for agricultural engineering management. [ABSTRACT FROM AUTHOR]

The structure of medical compression nebulizer plays a decisive role in the atomized inhalation treatment of respiratory diseases. The effects of the nozzle structure, gas flow rate and liquid channel width of the medical compression nebulizer on the atomization effect were studied by the volume of fluid-discrete particle model (VOF-DPM). The results show that the kinetic energy of the droplets after compression atomization and the proportion of droplet size below 5 μm are proportional to the gas flow rate. With the increase of the width of the liquid channel, the kinetic energy of the droplets will increase after atomization, but the proportion of droplet size below 5 μm will be relatively reduced. The use of conical crushing baffle structure can not only improve the kinetic energy of the droplets after atomization, but also increase the proportion of droplet size below 5 μm by about 5% ~ 7% compared with the original. By changing the shape of the chemical solution crushing baffle, the proportion of droplet diameter below 5 μm, and the kinetic energy of the droplet after atomization of the chemical solution are increased, which improves the atomization effect of the atomizer. These analysis results have guiding significance for the performance characterization and structural optimization design of subsequent medical compression nebulizers. [ABSTRACT FROM AUTHOR]

Objective：To investigate probiotic supplementation on blood sugar and lipids in patients with polycystic ovary syndrome. Methods：A total of 60 PCOS patients visited our hospital from March 2015 to January 2016 were divided into observed group (probiotic supplementation) and control group (metformin), each group of 30 cases. Serum levels of Fasting blood sugar (FBS), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), fasting serum insulin (FSI), luteotropic hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), progesterone (P), estradiol (E2), testosterone (T) was detected in this study; HOMA-IR were calculated in all patients. Results：Serum FBS, FSI, HOMA-IR, TG and VLDL leves in observed group were significantly decreased compared with control group after treatment (P＜0.05). After treatment, serum LH and T levels in observed group were lower than those before treatment (P＜0.05). In addition, probiotic supplementation in PCOS patients resulted in a significant reduction in weight and BMI compared with those patients without treatment. Conclusions：PCOS patients with probiotic supplementation have favourable effects on blood sugar, blood lipids and weight loss, which could alleviate PCOS and its associated complications development. [ABSTRACT FROM AUTHOR]

Current problems and demands of intraoperative diagnosis were presented. Basic theories and classification of fluorescent diagnostic techniques were introduced, and the advantages compared with traditional pathology were also analyzed. Current research and application status of fluorescent diagnostic techniques were summarized and analyzed in two aspects: spectroscopy analysis and image analysis, and it was indicated that fluorescent diagnosis was important for research and clinical application. Furthermore, future development directions of fluorescent diagnostic techniques were analyzed, and improving accuracy and combining diagnosis with clinical treatment were growing trends in fluorescent diagnostic techniques. [ABSTRACT FROM AUTHOR]

The difficulties of clinical diagnosis and treatment in neurosurgery were introduced in brief. The application and important meaning of the deep learning technology, multimodal fusion technology and image guidance techniques in the diagnosis and treatment of neurosurgery were elaborated. In addition, the development and challenges of precise diagnosis and treatment in neurosurgery were discussed. It's pointed out continuous progress of intelligent analysis of medical images would help achieve accurate diagnosis and treatment for neurosurgery, thus reduce the occurrence of misdiagnosis and improve the success rate of operation. Furthermore, it would promote the intelligent development of clinical diagnosis and treatment in neurosurgery. [ABSTRACT FROM AUTHOR]

This paper designed a simple method to fabricate Fe3O4 microsphere-graphene oxide (Fe3O4-G0) composite which is applied for the determination of phenolic compound. The Fe3O4 microspheres were well-distributed on the graphene oxide ( GO) surface after ultrasonic treatment. GO was synthesized from natural graphite flakes by the hummers method. Fe3O4 microspheres about 200 nm in diameter were synthesized by the solvothermal method, and scanning electron microscopy ( SEM ) was used to explore the morphology of Fe3O4-G0. This work showed that the approach is simple and effective for the preparation of Fe3O4-G0, which can be effectively applied to detect the phenolic compounds. [ABSTRACT FROM AUTHOR]

OBJECTIVE: The progress of liquid treatment is developing with the accompany of the deep understanding of the body fluid metabolism pathological physiological mechanism ， research of infusion products and improvement of the clinical monitoring means. Fluid capacity， osmotic pressure and electrolyte content are the basic guarantee for maintaining matter metabolism, stable internal environment and physiological function in human body. The surgical patients were suppose to get rational fluid therapy for the disorder of body fluid balance caused by disease， fasting and surgical trauma，etc. Therefore， it is important to improve the prognosis of patients by the rational selection of types and dosage， the effective maintaining of systemic circulation and microcirculation， the normal operation of organ function and the reduction of incidence of perioperative complications. At present， the commonly used liquid are liquid crystal and colloid. Carbohydrate and electrolyte injection as one of the basic drugs for liquid treatment in clinic， on behalf of crystal infusion of new glucose electrolyte solution， developed rapidly in recent years. This thesis aims to review the purpose， the related theories， concrete proposal of surgical liquid treatment and the clinical application of new glucose and electrolyte infusion. [ABSTRACT FROM AUTHOR]

According to the analysis of tag co-occurance with set-valued attribute, users can mine frequent patterns and detect anomalies. In order to improve the performance of computing tag co-occurance, this paper proposed a k-set-over based distributed tag co-occurrence algorithm in streaming data. It applied the inclusion-exclusion principle to analyze the problem of tag co-occurance, partitioned the total invert index into multiple distributed nodes based on k-set-cover, updated the local index for each distributed node dynamically according to the streaming data, and got the final result by aggregating all results from distributed nodes. The experiments show that, compared with the related works, the proposed algorithm has less average update time while keeping less index replication, and thus is more suitable for computing tag co-occurance in large-scale streaming data. [ABSTRACT FROM AUTHOR]

Objective: To explore the clinical effect and safety of posterior interbody fusion under percutaneous hollow pedicle screws on lumbar disc herniation. Methods: 174 patients diagnosed as lumbar disc herniation treated in our hospital from December 2009 to December 2009 were selected and divided into the observation group and control group according to the random number table method,137 cases in each group. The observation group was treated by the channel of Quadrant minimally invasive percutaneous pedicle screw hollow intervertebral fusion, and the control group was imposed by the open intervertebral fusion after into the road. The visual analogue scoring system(VAS) pain scores, Oswestry disability index(ODI) preoperation and at the end of follow-up visit and incidence of postoperative complications were compared between two groups. Results: No significant difference was found in the difference preoperation, on discharge and at the end of 1st follow-up visit between two groups(P>0.05). The operative incision length,postoperative hospital stay and intraoperative blood loss of observation group were significantly better than those of control group, and the operation time was significantly longer(P<0.01). 20(22.99%) cases of nerverootinjury, 3 cases of intervertebral space infection were observed in the control group after operation, the total incidence rate of complications was 26.44%, while only 3(3.45%) cases of nerverootinjury were observed in the observation group, the incidence rate was significantly lower than that of the control group(P<0.01).Conclusion: Posterior interbody fusion under percutaneous hollow pedicle screws had positive effect on lumbar disc herniation, which could reduce the wound, control the occurrence of postoperative complications, and had high clinical application value. [ABSTRACT FROM AUTHOR]

Stratiform chromite deposits in China have long been considered to form by fractional crystallization of mafic magma. However, some researchers recently proposed that some chromite deposits are also hosted in ophiolite. In this study, Cr-spinels of the dunites, wehrlites and clinopyroxenites from the Fangmayu chromite deposit in Beijing are analyzed by EPMA. Results show that Cr-spinels of dunites and wehrlites at the early stage of magma differentiation are rich in Cr with an average Cr2O3 content of 43.32%. At the late stage of magma differentiation, the crystallization of clinopyroxenites consumed large amounts of Cr3+ and elevated the oxygen fugacity, leading to the Cr-rich magnetite and Al-rich spinel with average Cr2O3 contents of 10.32% and 15.77%, respectively. By comparing with the chemical composition of different types of Cr-spinels from the world, the suggestion is that Fangmayu chromite deposit was a magmatic deposit hosted in Alaskan-type intrusion, and was not related to ophiolite. The constraints on the genesis and metallogenic specialization provide evidence for mineral prospecting of Cr, Cu-Ni and PGE deposits hosted in mafic-ultramafic intrusions. [ABSTRACT FROM AUTHOR]

For the time delay difference tracking estimation methods based on particle filter in wireless sensor network (WSN) , the key issue is to generate an accurate proposal distribution for particle filter. An time delay difference estimation algorthm based on improved unscented particle filter (IUPF) is proposed to overcome the degeneracy phenomenon of particles. The least square method is used to achive the initial target position, and then the unscented particle filter (UPF) and Gauss-Newton rule are used to incorporate the most current observations and provide more accurate importance density function for the particle filter by introducing a scaled correction factor. Finally, IUPF is applied to the time delay difference localization estimation methods in WSN. The simulation results show that, when the particle number is limited, the proposed algorithm can improves the target tracking accuracy and achieve faster convergence speed under non-Gauss noise environment in WSN. [ABSTRACT FROM AUTHOR]

Objective: To retrospectively compare the clinical efficacy of transoral oral vestibular approach and transthoracic breast approach in the treatment of papillary thyroid microcarcinoma (PTMC). Methods: The clinical data of 141 patients with unilateral PTMC who were admitted to Department of Thyroid and Vascular Surgery, Nanhai Hospital Affiliated to Southern Medical University from January 2019 to June 2021 were retrospectively analyzed. The patients were divided into group A ( n = 83 transthoracic breast approach) and group B (n=58, transoral oral vestibular approach) according to the different approaches. The operation-related indicators, traumatic stress indicators, cosmetic satisfaction, complications and follow-up prognosis were compared in the two groups. Results: The operation time in the group B was longer than that in the group A, the number of central lymph nodes dissected was more than that in the group A, the drainage volume on 1 d after operation and intraoperative blood loss were less than those in the group A, the neck VAS score on 1 d after operation and the total length of incision were less than those in the group A, and the postoperative hospital stay was shorter than that in the group A (P < 0.05) . There were no significant differences in white blood cell count (WBC), C-reactive protein (CRP), prostaglandin E2(PGE) and cortisol (Cor) between the two groups before operation and 2 d after operation (P > 0.05) . 0.2d after operation, the levels of WBC, PGE2, CRP and Cor in the two groups were significantly higher than those before operation, and the differences were statistically significant (P < 0.05) . The cosmetic satisfaction rate in the group B was higher than that in the group A ( p < 0 . 05). There was no difference in the incidence of complications in the two groups (P>0.05). At 1-year postoperative follow-up, the rates of death, recurrence, and cervical lymph node metastasis were 0 in both groups, with no differences between the two groups (P > 0.05) Conclusion: Transoral oral vestibular approach can achieve the same surgical effect as transthoracic breast approach in the treatment of PTMC. However, transoral oral vestibular approach removes more central lymph nodes, has less trauma, less postoperative pain, and has a higher cosmetic satisfaction. [ABSTRACT FROM AUTHOR]

The ice problem is a major problem in winter water deliver^^ in cold area. Predicting icedischarge capacity of narrow sections where ice jam usually occurs has a significant mean to safety deliver ice-water two-phase flow. Through analyzing the ice discharge capacity of channel 5 s pier column section by conducting physical experiment, according to the experiment data, combining dimensional analysis and BP neural network to predict ice discharge capacity of channel5 s pier column section. It is found that this method is much more accuracy than that of single BP neural network and nonlinear fitting method. [ABSTRACT FROM AUTHOR]

目的：探讨脑出血、脑梗死急性发作期患者血压、血脂、凝血纤溶功能差异及其临床意义。方法选取脑出血急性发作期患者52例（脑出血组）、脑梗死急性发作期患者48例（脑梗死组），另选体检健康者40例（对照组），均测量SBP、DBP，检测血浆TC、TG、LDL-C、HDL-C、脂蛋白a[Lp（a）]及抗凝血酶Ⅲ（AT-Ⅲ）、纤维蛋白原（FIB）、蛋白C（PC）、D-二聚体（D-D）。结果脑出血组、脑梗死组SBP和DBP均高于对照组（P均＜0．05）。脑出血组血浆TG、LDL-C及Lp（ a）水平均高于对照组，血浆TC、HDL-C水平均低于对照组；脑梗死组血浆TC、TG、LDL-C及Lp（ a）水平均高于对照组，血浆HDL-C水平低于对照组；脑出血组血浆TC、TG、LDL-C水平均低于脑梗死组；组间比较P均＜0．05。脑出血组、脑梗死组血浆FIB和D-D水平均高于对照组，血浆AT-Ⅲ水平均低于对照组；脑出血组PC活性高于脑梗死组及对照组；组间比较P均＜0．05。结论脑出血及脑梗死急性发作期患者均存在血压、血脂、凝血纤溶功能异常；脑梗死患者TC、TG、LDL-C水平及凝血纤溶亢进程度更高。 [ABSTRACT FROM AUTHOR]

辅助生殖技术（assisted reproductive technology，ART）能否成功的关键在于获卵数、卵子质量和优质胚胎数。由于生殖老化导致卵泡数量急剧下降，且易出现卵子细胞核异常（包括纺锤体异常和非整倍体异常），颗粒细胞增殖率下降，凋亡率升高，黄素化颗粒细胞经培养后产生的激素水平也急剧下降，在临床中通过加大促性腺激素的用量，仍然获卵较少，卵子质量下降，可供移植的胚胎较少，胚胎着床率及临床妊娠率降低，流产率升高，分娩率下降。通过提高卵巢局部雄激素水平，从而改善生殖老化状态，对提高ART成功率具有重要意义。 [ABSTRACT FROM AUTHOR]

【Objective】Land use is comprehensively affected by natural conditions and socio-economic factors, and the study of time series changes in land use is conducive to providing a scientific basis for the rational use of urban land resources.【Method】Landsat satellite remote sensing images of six periods were selected at five-year intervals for land use classification from 1995 to 2020, and the land use structure, dynamics and land use transfer in Guangzhou were analyzed. The influence intensity and interaction mechanism of various factors on land use change in different periods were discussed by using geographic detectors. 【Result】（i） Under the scenario of long time series（1995-2020） urban land use change, geodetector model could analyze the factors of urban land use change in different periods and reveal its change rules.（ii） From 1995 to 2020, the construction land in Guangzhou showed a trend of ‘stable-slow increase-sharp increase’, while the cultivated land showed a trend of ‘slow decrease-stable-substantial decrease’, and the transferred area mainly came from cultivated land and forest land. The forest land and grassland showed a monotonous decreasing trend, mainly transferred out as construction land and forest land. The water area fluctuated up and down, mainly from cultivated land. Unused land was gradually reduced, mainly converted into construction land.（iii）In different periods from 1995 to 2020, the influence of driving factors of land use change in Guangzhou was different. Among them, the influence of socioeconomic factors on land use change was higher than that of physical geography.（iv） In different periods from 1995 to 2020, the q value of the interaction factor was higher than that of the single factor q value, which showed that the interaction between the factors was two-factor enhancement. 【Conclusion】The impacts of human activities on land use change are obviously different in spatial distribution. The overlapping of multiple factors will aggravate the conflict of land use. Reducing the impact of human activities on the environment is an important way to achieve sustainable development. [ABSTRACT FROM AUTHOR]

脑卒中是心房颤动致死、致残的主要原因。房间隔缺损的持续存在会导致诸多并发症，心房颤动是房间隔缺损最常见的并发症之一。本例老年患者，因体力活动出现明显的胸闷入住我院，心脏彩超提示房间隔缺损，心电图示心房颤动，住院期间采取房缺封堵术解决左向右血液分流，并进行左心耳封堵术预防房颤有关的脑卒中。 [ABSTRACT FROM AUTHOR]

Populational number of fish is of great significance in the intelligent aquaculture. An accurate and rapid target detection has been always obtained from the underwater images. Much attention is still paid on the single target during underwater fish detection so far. However, the overlapping target is largely limited to the applicative scenes. In this work, an overlapping fish detection model was proposed using image enhancement and an improved Faster-RCNN network, named after CP-Faster-RCNN. First, 15 healthy grass carps were fed in a test tank for 15 days, where the images of fish movement were collected by the equipped underwater camera. The total 2 077 available images were filtered to serve as the dataset for the modelling. The training, test, and validation set were divided, according to the rate of 6:2:2, respectively. In the training set, all recognized fishes in each image were labelled by the rectangle bounding boxes via a labelImg tool. Next, three most commonly-used detection models (YOLOv3-spp, SSD300, and YOLOv5x6), as well as the new proposed model (CP-Faster-RCNN) were trained using the training and test set, and then were verified by the validation set. Among them, the CP-Faster-RCNN model was optimized for such the overlapping fishes in the images. Hence, some improvements were made using the original Faster-RCNN model. The details were as follows. 1) The MSRCR combined with the adaptive median filtering was adapted to improve the definition of underwater images; 2) The ResNeXt101 network was served as the backbone network to enhance the feature extraction capability of the model; 3) A specific bilinear path aggregation network (Bi-PANet) with the Convolution Block Attention Module (CBAM) attention mechanism was designed to fully use the multi-scale feature maps, which was effectively reduced the interference of background information. 4) The PAM clustering was chosen to optimize the scale and number of initial anchors of the network, which was used to speed up the convergence of the model; 5) The Non-Maximum Suppression was replaced by the Soft Non-Maximum Suppression, in order to reduce the missed detection for the overlapping objects. The results showed that the mean Average Precision (mAP) values of CP-Faster-RCNN were 32.9, 12.3, and 6.7 percentage higher than those of YOLOv3-spp, SSD300, and YOLOv5x6, respectively, indicating the best performance of detection. Besides, 300 extra images were randomly selected from the validation set to test the actual performance of the four models. Statistical analysis demonstrated that there was the different detection accuracy at the different number of overlapping fishes in clusters. Once the number was from 2 to 5, the mAPs of CP-Faster-RCNN decreased orderly, which were 80.4%, 75.6%, 65.1%, and 55.6%, respectively. More importantly, the mAPs of CP-Faster-RCNN was rather higher than that of other three models in the same way, indicating the better suitable performance in the scenes of overlapping fishes. Last, five ablation tests were carried out to investigate the specific effects of five improvements, where the mAP was the index of assessment. It was found that the mAP of the CP-Faster-RCNN was 76.8%, which was the totally 8.4 percentage increase than that of the original Faster-RCNN network. The backbone network was replaced for the 5.7 percentage mAP increase, due to the more substantially complex model. Meantime, the pre-processing of dataset was also offered a 0.9 percentage increase of mAP. The other three improvements for the Faster-RCNN posed the positive impacts on the model complexity. All improvements were promoted the more accurate detection for the model. Therefore, the improved model can be expected to achieve the much more accurate fish detection, especially for the overlapping fish images in the complex underwater backgrounds. [ABSTRACT FROM AUTHOR]

Hepatocellular carcinoma (HCC) is a disease with high incidence and mortality and has become a serious threat to human health. So far, none of the available markers can be used alone for early diagnosis of HCC. Recently identified serum markers with potential clinical value for early diagnosis of HCC are summarized, and their diagnostic sensitivity and specificity, as well as their applications in assessment of progression of the disease, are reviewed. It is suggested that alpha-fetoprotein should be used in combination with other serum markers to achieve accurate diagnosis of HCC at early stages. [ABSTRACT FROM AUTHOR]

Objective·To screen the potential hub genes associated with myocardial ischemia-reperfusion injury (MIRI) in mice by bioinformatics analysis based on gene expression omnibus (GEO) database. Methods·The mouse MIRI data sets GSE61592, GSE83472 and GSE160516 were obtained from GEO database. The differentially expressed genes (DEGs) in each data set were screened by limma package, and then robust DEGs were screened by robust sorting integration (RRA) method. The protein-protein interaction (PPI) network of robust DEGs was constructed, and the submodules and hub genes in the PPI network were screened. The clusterProfiler package was used to analyze the robust DEGs, the most important submodule genes and hub genes by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Eighteen male C57BL/6 J mice aged 6 ‒ 8 weeks were randomly divided into sham group and MIRI group, 9 mice each group. The MIRI model was constructed by left anterior descending coronary artery ligation for 30 min ischemia and 24 h reperfusion, and the mRNA expression of hub genes was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Results·RRA method identified 294 robust DEGs in three data sets. In PPI network, a total of 14 sub-modules were screened, of which module 1 was the most important and 17 hub genes were found. GO and KEGG analysis showed that the robust DEGs, module 1 genes, and the hub genes were mainly involved in regulating the migration of inflammatory cells, the activity of chemokines and cytokines and their receptors, Toll-like receptors and other biological function and signaling pathways. RT-qPCR results showed that compared with the sham group, the expressions of chemokine (C-C motif) ligand 4 (Ccl4), Ccl6, Ccl7, chemokine (C-X-C motif) receptor 4 (Cxcr4), chemokine (C-C motif) receptor 2 (Ccr2), signal-regulatory protein β1 (Sirpb1), low affinity immunoglobulin gamma Fc region receptor Ⅱb (Fcgr2b), leukocyte surface antigen CD53 (Cd53), arachidonate 5-lipoxygenase activating protein (Alox5ap), myeloid differentiation primary response gene 88 (Myd88), macrophage scavenger receptor 1 (Msr1), matrix metallopeptidase 14 (Mmp14), triggering receptor expressed on myeloid cells 2 (Trem2) and leupaxin (Lpxn) were up-regulated in the myocardium of the MIRI group, but there was no difference in low affinity immunoglobulin gamma Fc region receptor Ⅲ (Fcgr3), complement C1q subcomponent subunit B (C1qb) and a disintegrin and metalloproteinase domain-containing protein 8 (Adam8). By reviewing the literatures, Trem2, Lpxn, Cd53, Alox5ap, Sirpb1 and Fcgr2b were not reported to participate in MIRI. Conclusion·This study has unearthed 6 potential hub genes for MIRI in mice, and the results can provide new ideas and entry points for further exploring the molecular mechanism and therapeutic targets of MIRI. [ABSTRACT FROM AUTHOR]

目的探讨急性脑出血（ACH)患者血清血小板反应蛋白l(TSP-l)、血小板反应蛋白2(TSP-2)、基质金 属蛋白酶2(MMP-2)、基质金属蛋白酶9(MMP-9)水平变化及其与脑血肿量、脑水肿量的关系。方法选择ACH 患者95例为观察组，同期体检健康者100例为对照组。采用ELISA法检测两组血清TSP-1、TSP-2、MMP-2、MMP-9d 计算观察组脑血肿量及脑水肿量，分析血清TSP-1、TSP-2、MMP-2、MMP-9与脑血肿量、脑水肿量的关系结果观 察组血清TSP-l、TSP-2、MMP-2、MMP-9水平均高于对照组（P均<0.05)。观察组脑血肿量、脑水肿量分别为 (27. 23 ± 8.44)、(20. 99 ± 3. 65) mL0 Spearman相关性分析结果显示，观察组血清TSP-1与脑血肿量、脑水肿量均无 相关性(P均>0. 05) ;TSP-2与脑血肿量呈负相关(P = -0.639，P <0.05)，与脑水肿量无相关性（P >0.05); MMP-2 与脑血肿量无相关性（P >0. 05)，与脑水肿量呈正相关(r =0. 582，P <0. 05); MMP-9与脑血肿量、脑水肿量均呈正 相关(r分别为0.589、0.630，P均<0. 05)结论ACH患者血清TSP-1、TSP-2、MMP-2、MMP-9水平均升高，并与 患者脑血肿量及脑水肿量密切相关。 [ABSTRACT FROM AUTHOR]

In offshore fracturing operation, formulating a fracturing fluid with fresh water results in high transportation cost and long time of formulation. If seawater is used to formulate the fracturing fluid, a large amount of chelating agents which crosslink in alkaline environment shall be used, and this results in high material cost, while the ability of the fracturing fluid formulated to resist high temperature may not be satisfactory. To solve this problem, an organic titanium zirconium crosslinking agent is stepwise synthesized with reactants tetra-isopropyl titanate and zirconium sulphate etc. Characterization of the reaction product with NMR and SEM (after precipitation of the crosslinking agent) shows that the crosslinking agent is an organic chelating agent. The particle sizes of the crosslinking agent are distributed in a range of 1 nm to 100 nm, as measured with dynamic and static synchronous laser scattering instrument, and this indicates that the crosslinking agent has excellent reactivity. This crosslinking agent can crosslink in neutral conditions, a good property for formulating fracturing fluids with high salinity waters such as seawater. The microstructure of the crosslinking product is a stable honeycomb-like hexagonal grid structure. With this organic titanium-zirconium crosslinking agent, the fracturing fluids formulated have better viscoelasticity than the fracturing fluids formulated with crosslinking agents containing only titanium. The high temperature resistance of the fracturing fluids formulated using the organic titanium-zirconium crosslinking agent is 180 ℃. Field application of this new crosslinking agent in formulating a fracturing fluid with seawater for fracturing a high temperature well of CNOOC in south China Sea has obtained good results [ABSTRACT FROM AUTHOR]