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目的 探讨腹腔镜右半结肠癌术后胃瘫发生的影响因素。方法 选取470例右半结肠癌患者，均行右半 结肠完整结肠系膜切除术（CME），其中腹腔镜根治性右半结肠切除术 368例，腹腔镜根治性扩大右半结肠切除术 102例，观察术后胃瘫的发生情况，采用单因素和多因素回归分析影响胃瘫发生的影响因素。结果 470例患者中9 例发生术后胃瘫，发生率为1. 9%。单因素分析结果显示，年龄、围手术期血糖水平、焦虑自评量表评分及手术切除 范围与术后胃瘫发生有关（P 均<0. 05），而性别、手术时间、糖尿病、围手术期白蛋白水平与术后胃瘫发生无关（P 均>0. 05）。多因素 Logistic回归分析结果显示，年龄>70岁、围手术期血糖≥11. 1 mmol/L、焦虑自评量表评分≥50分 及根治性扩大右半结肠切除术是胃瘫发生的危险因素。结论 右半结肠癌术后胃瘫的发生与年龄、围手术期血糖 水平、焦虑自评量表评分及手术切除范围有关。 [ABSTRACT FROM AUTHOR]

Objective: To study the effects of Guizhi Fuling bolus combine with mifepristone on hemorheology, hemoglobin (Hb) and human epididymis protein 4 (HE4) in patients with hysteromyoma. Methods: 172 patients with hysteromyoma treated in 3201 Hospital Affiliated to Medical College of Xi'an Jiaotong University from March 2016 to May 2017 were selected, the patients were randomly divided into the observation group (n=86) and the control group (n=86). The control group was treated with mifepristone, the observation group was treated with Guizhi Fuling bolus on the basis of the control group, the efficacy was compared between the two groups after 3 months treatment, the Hb, HE4, myoma volume, blood rheology indexes were compared between the two groups before treatment and after 3 months treatment, the adverse reaction was compared between the two groups. Results: The total effective rate of the observation group was 97.67%, which was higher than 89.53%of the control group (P<0.05). After treatment, the levels of Hb in both groups were significantly higher than before treatment, which in the observation group was higher than the control group (P<0.05). The level of HE4 in both groups was lower than that before treatment, the observation group was lower than that in the control group (P<0. 05), and the fibroid volume was smaller than that before treatment, and the observation group was smaller than that in the control group (P<0.05). After treatment, the total blood viscosity (HBV), total blood viscosity (LBV), plasma viscosity (PV) and platelet aggregation rate (PAR) of the two groups were lower than before treatment, and the observation group was lower than the control group (P<0.05). The total incidence of adverse reactions in the observation group and control group were 13.95% and 10.47%, which was no significant difference (P>0.05). Conclusion: Guizhi poring bolus combined with mifepristone is effective in treating uterine fibroids, which can improve the level of hemorheology, Hb, HE4 and other indicators, with good safety and worth popularizing. [ABSTRACT FROM AUTHOR]

Objective To evaluate early bone loss by radionuclide 99m Tc-MDP bone imaging and to intervene in early stage． Methods Early bone loss and osteoporosis models were produce in rabbits by intramuscular injection of dexamethasone sodium phosphate ( DX) and then a treatment was used on the model rabbits． The treatment drug 99Tc-MDP was injected once a week，up to 14 weeks． The ratio between region of interest ( ＲOI) site of radionuclide bone imaging and the fixed radioactive standard source ( ＲSF) ，bone histopathology，bone histomorphometry，bone mineral density，bone biomechanics，serum bone alkaline phosphatase ( BALP) ，osteocalcin ( BGP) ，and X ray and CT radiography of the lumbar vertebrae were determined，and the differences between the groups of were compared． Ｒesults After injection of different doses of DX on experimental rabbits，bone tissue pathological section，indexes of Bone morphological metrology，bone density，bone biomechanics，and BALP and BGP were used to confirm that the animal model was established successfully． After treatment for 14 weeks，early bone loss group showed that trabecular bone of the femoral head was arranged regularly and the trabecular bone was thickening comparing with those in the model group． However，the osteoporosis treatment group showed that trabecular bone was slightly sparse，and trabecular thickness was not uniform，but no fracture was found． The uptake of 99m Tc MDP bone scintigraphy agent in early bone loss model and osteoporosis bone tissue was significantly higher than that in control group ( P ＜ 0. 05) ，but the uptake of imaging agent in the treatment group was significantly decreased than the corresponding model group ( P ＜ 0. 05) ． Bone mineral density and bone histomorphometry were not significantly different between early bone loss treatment group and the control group ( P ＞ 0. 05) ． But the uptake of imaging agent in the early bone loss treatment group was significantly higher than that in the normal control group ( P ＜ 0. 05) ． Bone mineral density，bone biomechanics，and BALP and BGP were significantly different between bone osteoporosis therapy group and normal control group，and the greatest improvement was found in osteoporosis treatment group ( P ＜ 0. 05) ． Conclusion Ｒadionuclide “99m Tc-MDP”bone imaging can detect early bone loss in different individuals，and the effect of intervention on early bone loss stage is significantly better than that of severe osteoporosis． [ABSTRACT FROM AUTHOR]

Effective ingredients extracted from natural plant Polygonum cuspidatum, and a biodegradable material poly(butyl diacid butyl glycol ester (PBS) composite, explores the influence on PBS,Polygonum cuspidatum extract will composite material crushing and mixed in the soil at the same time, by detecting the earthworm body protein content, catalase and cellulose enzyme activity of soil pollution on the environment evaluation, The results showed that the hydrophilicity of Polygonum cuspidatum extract/PBS composite material increased greatly, and the extract also promoted the crystallization of PBS to a certain extent. The degradation of Polygonum cuspidatum extracts/PBS composites was accompanied by the synergistic degradation of PBS and the degradation of extracts. The extracts, as small molecules, were first eroded by microorganisms, which increased the contact area between the composites and microorganisms and water molecules. The extracts of Polygonum cuspidatum and its composite material can promote the synthesis of protein, catalase (CAT) and cellulase activity in earthworm, which is friendly to the environment. [ABSTRACT FROM AUTHOR]

以聚己内酯二元醇(PCL)为软段,二羟甲基丙酸(DMPA)为扩链剂,异佛尔酮二异氰 酸酯(IPDI)为硬段,合成了水性聚氨酯预聚体.通过进一步添加双酚芴(BPFL)反应合成一系 列含 Cardo环水性聚氨酯(WPUS).利用傅里叶变换红外光谱、粒径、热重、力学、X灢射线衍射、 水接触角测定和纸张表面施胶等方法对制备的 WPUS的结构和性能进行表征.结果表明,当 WPUS的 BPFL含量为3%时,WPUS乳液的粒径增大至95.21nm;膜的耐热性最大提高 31.36%;水接触角提升32.13%.不同乳液对纸张表面施胶后与未施胶纸张相比,WPUS3纸 张水接触角提升887.6%;抗张强度最大可达57.1N/mm2,提升46.41%;纸张耐折度最大可 达74次,比未施胶原纸高出60次. [ABSTRACT FROM AUTHOR]

According to the engineering geological analysis, there was the possibility of sliding failure on the recommended slope of Beipanjiang Bridge after applying the engineering load. To judge the stability of the Anlong bank slope,FLAC3D software and slope stability analysis software slide. v6007, Phase2 V9. 0 were used to analyze the two-dimensional and three-dimensional stability of the Anlong bank slope, respectively. The calculation and analysis show that the safety factor of Anlong bank slope stability calculation is greater than the design standard of safety factor. From the theoretical analysis, the slope is in a stable state with a certain safety margin. Compared with the calculated safety factor of two-dimensional analysis, the calculated safety factor of three-dimensional analysis was larger. The stability analysis conclusion of the Anlong bank slope provided a reasonable basis for the preliminary design of the recommended position of Beipanjiang bridge. [ABSTRACT FROM AUTHOR]

Objective　To study the therapeutic value of 99Tc－MDP for bone repairing in aseptic necrosis of the femoral head （ANFH）．Methods　The animal experiment included ２ stages： the establishment of animal model and the treatment observation． ANFH animal model was made by dexamethasone intramuscular injection．Intramuscular injection of dexamethasone was used to establish the ANFH model．In the first stage of ８ weeks， normal group （Group A） and ANFH model group （Group B） were set up．The successful animal model was proved by cell pathology， bone morphology， BMD， tetracycline double labeling， bone scintigraphy ROI value， X－ray， and CT．In the second stage of １６ weeks， normal control group （Group C）， ANFH model control Group （Group D），99Tc－MDP therapy Group (Group E), and alendronate sodium therapy group （Group F） were set up．The same tests were applied like in stage １ and the efficacy in Group E and Group F was valued．SPSS１３ was used for statistical analysis． Results　At the end of stage １， the pathology showed that no bone tissue was destroyed in Group A， but in Group B the surface soft tissue of the femoral head was destroyed， and bone trabecular breaking and bone lacuna increased．BMD， bone histomorphology， tetracycline double labeling decreased and bone scintigraphy ROI， serum BALP and BGP increased in Group B． ANFH could be seen by X ray and CT in Group B．After １６－week therapy in Group E and Group F， all the test results showed a nearly same results between Group A， C and Group B， D．Improved result showed in Group E and Group F， especially in Group E for bone repairing， bone trabecular increasing， and bone lacuna disappearing．All the results were comparable between Group E and Group C．Conclusion　Animal study shows an apparent result of 99Tc－MDP treatment for ANFH. 99Tc－MDP not only has the same function like alendronate sodium showing increased bone trabeculae in tetracycline double labeling test， but also reveals the potential function in promoting osteoblast function and bone tissue repairing indicated by bone lacuna disappearing． [ABSTRACT FROM AUTHOR]

Objective To investigate the value of 99Tc-MDP therapy in aseptic necrosis femur head (ANFH). Methods The animal experiment was divided into 2 stages: animal model establishment and clinical observation. In the first stage, Group A (normal group) and Group B(ANFH group) were set up. The animal ANFH model was established by intravenous injection of dexamethasone sodium phosphate for 8 weeks. Bone pathology, histomorphology, bone mineral density, tetracycline double labeling experiment, radionuclide bone scintigraphy ROI ratio value, X-ray, and CT were examined. The second stage of the experiment started until the ANFH model had been proved. During the second stage, these groups were set up for the further 16 week-therapy based on the ANFH animal model: Group C (normal control), Group D(ANFH control), Group E(99Tc-MDP therapy), and Group F(alendronate therapy). After the treatment, the efficacy in Group E and Group F was valued. A SPPSS13. 0 softw are was used for statistical analysis. Results After 2 stages of ANFH model establishment and clinical observation, the results, including bone pathology, histomorphology, bone mineral density, tetracycline double labeling experiment, and ROI ratio of radionuclide bone scintigraphy, show ed apparent difference between Group A and B(p < 0. 01), indicating the success of animal modeling. After the treatment, the bone pathology in Group E show ed that trabecular bone in the femoral head lined regularly with a little scatter. But the repair was apparent comparing with that in Group D. In Group F trabecular bone in the femoral head show ed scattered and irregular lining and little broken. Comparing with that in Group D, the situation improved in Group F. The results of bone mineral density, tetracycline double labeling experiment, and ROI ratio of radionuclide bone scintigraphy also supported the improvement(p < 0. 05). Conclusion On the bases of ANFH animal model, 99Tc-MDP and Alendronate have got different therapy value and99Tc-MDP show ed an apparent remoulding result. 99Tc-MDP can reach the ANFH target tissue. Besides controlling bone absorption, it also can maintain the activity of superoxide dismutase(SOD), protect the bone tissue absorption from free radius and prevent from its further damaging. From the tetracycline double labeling experiment we can conclude that the increased deposition rate maybe relate to the bone cell proliferation. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of 2 types of bisphosphonates combined with Gukangling decoction on the treatment of aseptic necrosis of the femoral head( ANFH) in a rabbit model. Methods Animal experiment included 2 stages,model establishment and grouping therapy. In the first stage,rabbit ANFH model was established by intramuscular injection of dexamethasone( DX) for 8 weeks. After 8 weeks,bone histopathology,bone mineral density( BMD),bone biomechanics,Xray,CT,region of interest ratio( ROI ratio) on 99mTc-MDP bone scans,and serum bone alkaline phosphatase( BALP) and osteocalcin( BGP) were detected and analyzed to evaluate the successful establishment of the rabbit ANFH model. In the second stage,rats were divided into group A( normal control),group B( ANFH control),group C( ANFH treated with 99Tc-MDP),group D( ANFH treated with alendronate sodium),group E( ANFH treated with Gukangling decoction),group F( ANFH treated with99Tc-MDP and Gukangling decoction),group G( ANFH treated with alendronate sodium and Gukangling decoction). After 16-week treatment,the above indexes were detected and analyzed to evaluate the therapeutic effect. Statistic analysis was performed using SPSS 17. 0. Results Histopathology results in the first stage demonstrated that the trabeculae displayed regularly without bone destruction in rats of group A. However,in group B the bone trabeculae were sparse and ruptured. BMD and biomechanical parameters were declined. 99mTc-MDP was significant uptaken at the femoral head in and BALP and BGP increased,indicating the rabbit model of ANFH was established successfully. In the second stage,histopathology results were similar to the first stage in group A and B. Bone trabeculae were significantly restored in group F,almost similar to group A. Bone trabeculae were also restored in group C,D,and G comparing to those in group B. In group E,density of bone trabeculae slightly increased,while the trabecular bone repair was not obvious. Results of BMD,bone morphology,bone biomechanics,biomechanical parameters,femoral head ROI ratio on 99mTc-MDP bone scan,BALP,BGP,and bone mineral deposition in different groups changed in various degrees. Relative efficacy evaluation results showed that group F was markedly effective,group C,D,and G were effective,but group E was not obviously effective. Conclusion 99Tc-MDP combined with Gukangling decoction shows markedly therapeutic effect, and the maximal effect is achieved in group F,indicating that 99Tc-MDP combined with right recipe of Chinese herbal medicine may have great value in the treatment of ANFH. [ABSTRACT FROM AUTHOR]