Search

目的构建131I标记的肝癌核酸纳米火车（NT），并探讨其作为肝癌靶向新型核素载体的可能性。方法三条核酸短链经退火处理后自组装形成核酸长链并采用氯胺T法进行放射性碘标记得到131Ⅰ-NT，纸层析法测纳米粒子的标记率及放射化学纯度，检测标记产物在不同温度（4 ℃、室温）及不同的储存溶剂（PBS、纯血清）中的体外稳定性。通过激光共聚焦显微镜检测肝癌细胞对纳米粒子的特异性摄取情况，分别测定131Ⅰ-NT与人肝癌细胞HepG2、正常肝细胞 L02 结合后细胞的放射性摄取率。通过尾静脉注射131Ⅰ-NT至HepG2荷瘤小鼠体内，进行生物分布研究。结果131Ⅰ-NT标记率为（93.05±0.74）%，纯化后放化纯度为（98.35±0.32）%。4 ℃储存条件下，标记产物在PBS和纯血清中24 h后的放化纯度分别为（92.77±0.04）%、（89.43±0.2）%。131Ⅰ-NT分别与两种细胞孵育2 h后，HepG2细胞的放射性摄取率明显高于L02细胞。尾静脉注射131Ⅰ-NT后，荷瘤小鼠体内 30 min、1 h、2 h肿瘤部位每克组织放射性摄取值分别为（4.90±0.55）%ID/g、（10.12±0.32）%ID/g、（4.25±0.31）%ID/g，T/M比值相应为7.33±2.04、36.54±12.72、44.93±7.90。结论成功构建了131I标记的长链核酸纳米火车，具有较好体外稳定性，对HepG2细胞及HepG2细胞荷瘤小鼠模型具有较高的靶向性，显示131Ⅰ-NT可能是一种具有潜力的靶向人肝癌的核素载体，为肝癌靶向核素诊疗提供新思路。

目的研究不同类型沙眼衣原体蛋白在输卵管性不孕中的致病作用，预测具有临床检测价值的沙眼衣原体蛋白抗体。方法本研究共纳入输卵管性不孕组（TFI）58例，正常生育组（FC）41例，非输卵管性不孕组（IFC）18例。血清检测CT-IgG ELISA试剂盒检测三组人群血清中CT-IgG的表达情况；利用前期获得表达、纯化的6种沙眼衣原体蛋白，建立这6种沙眼衣原体蛋白抗体的ELISA检测方法，分别检测6种沙眼衣原体蛋白抗体在TFI组、FC组和IFC组血清中的表达情况；对三组研究对象6种沙眼衣原体蛋白抗体的OD值进行统计描述，以CT-IgG的检测结果（阳/阴）为参考标准，绘制6种沙眼衣原体蛋白抗体的受试者工作特征曲线，利用约登指数确定各抗体的截断值。以TFI作为参考类，将FC、IFC分别与参考类建立两个无序多分类logistic回归模型，探究沙眼衣原体蛋白抗体、年龄预测TFI、FC和IFC的价值，并利用后退法筛选变量。结果各组研究对象CT376和CT443抗体OD值不全相同，CT-IgG阳性率不全相同。经两两比较发现，TFI组的CT376抗体OD值高于FC组（0.86 vs. 0.60，P=0.026）。TFI组的CT376抗体OD值高于IFC组（0.86 vs. 0.64，P=0.026）。IFC组CT443抗体OD值高于TFI组（0.59 vs. 0.34，P=0.036），高于FC组（0.59 vs. 0.30，P=0.02）。经过比较，CT376抗体的阳性率在三组间不全相同（PP P=0.068， OR=0.359，95%CI（0.120，1.078）］。CT-IgG是输卵管性不孕发生的独立危险因素，CT376抗体尚不能成为输卵管性不孕的独立危险因素；TFI与IFC建立的无序多分类logistic回归分析显示，在不孕的患者中，CT-IgG ［PPP

基于密集波分复用（DWDM）的光传送网构成了整个通信网络的基础物理层。为了满足DWDM技术的应用和升级,能够进行在线监测的光通道性能模块成为当前很多光器件公司研究和开发的热点。一个典型的在线光性能监测（OPM）模块能够在线监测通道光功率、中心波长及光信噪比（OSNR）等指标。文章系统地阐述了OPM的应用背景、技术特点、性能指标以及发展前景,并对各厂家生产的OPM模块进行了比较分析。

The scale of Monopterus albus farming in Hubei Province is large, but there are few pre-treatment processing devices. The current Monopterus albus pretreatment device is mainly dissected and killed. Aiming at the problems of poor stability, low efficiency, and low meat yield of existing Monopterus albus deboning devices, an adaptive Monopterus albus deboning device was designed, which was mainly composed of laparotomy components, transitional components, and deboning components. The theoretical analysis of the process of fish laparotomy, transition transportation, and deboning was carried out, and the key factors affecting the performance of the deboning device were obtained. Taking the meat yield rate and sensory quality scores as evaluation indexes, the single-factor test of the distance between the pressure wheel and the V-block, the initial clearance of the transition wheel, the rotational speed of the transition wheel, the shape of the deboning blade disc and the rotational speed of deboning blade disc were carried out to determine the reasonable range of each parameter. The test results showed that when the distance between the pressure wheel and the V-block was 15.50-16.75 mm, the meat yield rate was higher; when the initial clearance of the transition wheel was 9 mm, the sensory quality scores of the fish body was the highest; the increase of the rotational speed of the transition wheel and the rotational speed of the deboning blade disc is beneficial to improve the meat yield rate and sensory quality scores; and the shape of the boning blade disc had little influence on the meat yield rate and the sensory quality scores. The orthogonal test of four factors and three levels was carried out with the distance between the pressure wheel and the V-block, the initial clearance of the transition wheel, the rotational speed of the transition wheel, and the rotational speed of the deboning blade disc as the test factors. The results showed that the order of significance of each test factor on the meat yield rate was the distance between the pressure wheel and the V-block, the initial clearance of the transition wheel, the rotational speed of the transition wheel, and the rotational speed of the deboning blade disc; and the order of significance on the sensory quality scores was the initial clearance of the transition wheel, the distance between the pressure wheel and the V-block, the rotational speed of the transition wheel and the rotational speed of the deboning blade disc. When the distance between the pressure wheel and the V-block was 16.75 mm, the initial clearance of the transition wheel was 9 mm, the rotational speed of the transition wheel was 648 r/min, and the rotational speed of the deboning blade disc was3200 r/min, the deboning effect was the best. The meat yield rate of the deboning device was 84%, and the total sensory quality scores of the fish after processing reached 17.3. The device can process Monopterus albus with a body mass of 75-150 g, and the production efficiency reaches 16.8 strips/min. Compared with the current commercially available deboning device, the feeding is more convenient and the production efficiency is higher. It can provide a reference for the research of Monopterus albus pretreatment device. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Anhui Agricultural Sciences is the property of Journal of Anhui Agricultural Sciences Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Electric Power Automation Equipment / Dianli Zidonghua Shebei is the property of Electric Power Automation Equipment Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Lubrication Engineering (0254-0150) is the property of Editorial Office of LUBRICATION ENGINEERING and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To investigate the stability of jointed slopes under seismic action, a random joint fracture network model was established using the Monte Carlo method. The discrete element program 3DEC was utilized to conduct a numeri- cal simulation study on the stability of an open-pit mine slope under seismic action. The results indicate that under seismic action, the vibration intensity and displacement at the bottom of the slope are significantly stronger than those at the top. The joint fractures within the slope have a notable attenuating effect on the energy of seismic waves. The bottom of the slope primarily exhibits a shear failure mode, indicating the need to reinforce the seismic resistance of the slope's bottom structure during routine production. [ABSTRACT FROM AUTHOR]

The Transformer-based image captioning models have shown remarkable performance based on the powerful sequence modeling capability. However, most of them focus only on learning deterministic mappings from image space to caption space, i. e., learning how to improve the accuracy of predicting "average" captions, which generally tends to common words, repeated phrases and single sentence, leading to the severe mode collapse problem. To this end, this paper combined the conditional variational encoder with the Transformer-based image captioning model, and proposed the sentence-level and word-level diverse image captioning models, respectively. The proposed models introduced the global and sequential latent embedding learning based on the evidence lower bound (ELBO), which promoted the diversity of Transformer-based image captioning. Quantitative and qualitative experiments on MSCOCO dataset show that both models have the ability of learning one-to-many projections between the image space and the caption space. Compared with the state-of-the-art COS-CVAE, the proposed method with 20 samples improves the CIDEr and Div-2 scores by 1.3 and 33% respectively in the case of 20 samples, improves the CIDEr and Div-2 scores by 11.4 and 14%, respectively in the case of 100 samples. The proposed method can fit the distribution of ground-truth captions well, and achieve a better balance between diversity and accuracy. [ABSTRACT FROM AUTHOR]

Copyright of Pearl River is the property of Pearl River Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Science & Technology of Cereals, Oils & Foods is the property of Science & Technology of Cereals, Oils & Foods Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Mining Magazine is the property of China Mining Magazine Co., Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Hydrogeology & Engineering Geology / Shuiwendizhi Gongchengdizhi is the property of Hydrogeology & Engineering Geology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Materials Engineering / Cailiao Gongcheng is the property of Journal of Materials Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Preventive Medicine is the property of Modern Preventive Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Ground Improvement is the property of Journal of Ground Improvement Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Xinyang Normal University Natural Science Edition is the property of Journal of Xinyang Normal University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the influence of butorphanol pretreatment combined with ultrasound-guided thoracic paraverte- bral nerve block anesthesia (TPVB) on analgesic effect and stress response in patients undergoing thoracoscopic radical resection of lung cancer. Methods: Sixty patients with lung cancer in our hospital were selected from May 2021 to June 2022 and were classified into ob- servation group (n=30) and control group (n=30) by random number table method. Both groups received intravenous anesthesia and were treated with patient-controlled intravenous analgesia (PCIA) after surgery, and the observation group performed ultrasound-guided TPVB before surgery and was given butorphanol pretreatment. The hemodynamics, anesthetic effect, postoperative pain status, stress response and occurrence of adverse reactions were compared between the two groups. Results: Compared with To, the heart rate (HR) and mean arterial pressure (MAP) in the two groups were decreased at T1 (P<0.05). The HR and MAP were increased at T2 in the two groups compared with those at T 1(P<0.05). The HR and MAP at T2 and T3 in observation group were lower compared to control group (P<0.05). The propofol dosage, remifentanil dosage, extubation time and PCIA use frequency in observation group were lower, shorter or less than those in control group (P<0.05). At 8 h, 12 h and 24 h after surgery, the pain degrees at rest and cough in observation group were milder than those in control group(P<0.05). After surgery, the levels of epinephrine (E), cortisol (Cor) and adrenocorticotropic hormone (ACTH) were risen in the two groups (P<0.05), but the observation group had lower levels (P<0.05). There was no significant difference in the total incidence rate of adverse reactions between the two groups (P>0.05). Conclusion: Butorphanol pretreatment combined with ultrasound-guided TPVB can control the hemodynamics and total dosage of opioids of patients undergoing thoracoscopic radical resection of lung cancer, shorten the extubation time, and relieve the postoperative pain and stress response. [ABSTRACT FROM AUTHOR]

Copyright of Steel Pipe is the property of Steel Pipe Magazine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Art Panorama is the property of Art Panorama Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of University Chemistry is the property of Peking University, College of Chemistry & Molecular Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Natural Gas Geoscience is the property of Natural Gas Geoscience and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Mycosystema is the property of Mycosystema Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of e-Education Research is the property of Northwest Normal University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food & Fermentation Industries is the property of Food & Fermentation Industries and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Low-Carbon Chemistry & Chemical Engineering is the property of Low-Carbon Chemistry & Chemical Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to evaluate heavy metal contamination in Sidi River Basin mining area of Yangshuo County, Guangxi, the watershed hydrological model by ArcSWAT and the solute transport model by MT3DMS in groundwater modeling system (GMS) were combined to quantitatively analyze the migration of zinc and cadmium. The results suggest that utilizing ArcSWAT and GMS can more accurately determine the vertical infiltration amount and accurately groundwater numerical simulation. Without prevention and control measures, mine wastewater poses a significant pollution threat to groundwater environment. It is found that the content of zinc and cadmium in water sample of tailing cave outlet is 18. 62 mg / L and 0. 096 mg / L respectively, which is the source of heavy metal contamination in entire basin. Within simulated period of 20 years, the contaminated halo of zinc and cadmium reaches the river after about 16 d and 44 d respectively, and the farthest front end of halo is 2 303. 75 m and 1 887. 04 m away from the center. The longest part at both ends is 3 159. 57 m and 2 478. 57 m, and the widest part is 1 533. 54 m and 1 128. 36 m. The mass of zinc and cadmium entered basin is 3 512. 44 g and 18. 15 g, and flowed out is 1 640. 49 g and 8. 47 g, remaining proportion are 53. 28% and 53. 33% separately in basin. There are existing research results show that Solanum nigrum L. is hyperaccumulator for cadmium that the highest accumulation in plant is 1 084. 4 mg / kg and strong tolerance to zinc with enrichment exceeding 1 000 mg / kg. Therefore, a simulated circumstance is set up to evaluate the ecological restoration of tailings reservoir. The content of zinc is 0. 284 mg / L and cadmium is 0. 002 mg / L in tailings pond which is taken as alternative contaminated source. The migration speed of zinc along river valley reduces from 94. 38 m/ a to 80. 78 m/ a, and cadmium reduced from 86. 09 m/ a to 69. 13 m/ a during simulated period. The maximum halo of zinc reduced from 3. 80 × 10 6 m ² to 2. 50 × 10 6 m 2 and of cadmium from 1. 67 × 10 6 m 2 to 1. 29 × 10 6 m ² . It indicated that the ecological restoration has achieved better effects and proposed continue investing in construction. According to simulation results, it is recommended to construct anti-seepage curtains and other prevention measures at the mine tunnel outlet. And prevention areas are classified to strengthen groundwater quality monitoring. Simultaneously, emergency plans for groundwater accidents can be formulated to avoid further deterioration of contamination. [ABSTRACT FROM AUTHOR]

Objective To investigate the correlation between plasma β -like amyloid (Aβ), phosphorylated tau181 protein (P-tau181) levels and cognitive impairment (CI) in patients on maintenance hemodialysis (MHD). Methods One hundred and twenty-two MHD patients were divided into the CI group (MoCA score<26, n=47) and the non-CI group (MoCA score≥26, n=75) according to Montreal Cognitive Assessment Scale (MoCA) score. Plasma Aβ and P-tau181 levels were measured using enzyme-linked immunosoradsorption assay. The clinical data were compared between the two groups of patients. Spearman's analysis was used to analyze the correlation between MoCA score and plasma Aβ and P-tau181 levels in MHD patients. Binary Logistic regression was used to analyze influencing factors of concurrent CI in MHD patients. The value of plasma Aβ, P-tau181 levels in diagnosing concurrent CI in MHD patients was analyzed by applying the receiver operating characteristic curve (ROC). Results Compared with the non-CI group, patients in the CI group had lower proportions of hypertension, years of education and diastolic blood pressure, and higher proportions of diabetes, P-tau181 and Aβ levels (P < 0.05). Plasma Aβ and P-tau181 levels were negatively correlated with MOCA scores in MHD patients (rs = -0.343, -0.402, respectively, P＜0.05). Logistic regression analysis showed that elevated P-tau181 and Aβ were risk factors for concurrent CI in MHD patients. ROC curves showed that the areas under the curves for plasma Aβ, P-tau181 and the combination of the two for diagnosis of concurrent CI in MHD patients were 0.725, 0.752 and 0.801, respectively. The difference in diagnostic value between the three was not statistically significant. Conclusion Elevated plasma levels of Aβ and P-tau181 are correlated with the occurrence of CI in MHD patients, and both have good diagnostic value for CI in patients with MHD. [ABSTRACT FROM AUTHOR]

Copyright of Taiwan Jurist is the property of Angle Publishing Co., Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Electric Power Automation Equipment / Dianli Zidonghua Shebei is the property of Electric Power Automation Equipment Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Hydrogeology & Engineering Geology / Shuiwendizhi Gongchengdizhi is the property of Hydrogeology & Engineering Geology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Lubrication Engineering (0254-0150) is the property of Editorial Office of LUBRICATION ENGINEERING and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Computer Engineering & Applications is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)