201. Motor cortical reorganization is present after a single attack of multiple sclerosis devoid of cortico-spinal dysfunction
- Author
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Jean-Philippe Ranjeva, Bertrand Audoin, Jean Pouget, Wafaa Zaaraoui, Shahram Attarian, Jean Pelletier, Sylviane Confort-Gouny, Elisabeth Soulier, Françoise Reuter, Irina Malikova, Patrick J. Cozzone, Jérôme Franques, Audrey Rico, Centre de résonance magnétique biologique et médicale (CRMBM), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), and Ben Dahan, David
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Multiple Sclerosis ,medicine.medical_treatment ,Biophysics ,Pyramidal Tracts ,Motor Activity ,Activation pattern ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,medicine ,Biological neural network ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,10. No inequality ,030304 developmental biology ,0303 health sciences ,Brain Mapping ,Clinically isolated syndrome ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Multiple sclerosis ,Motor Cortex ,Middle Aged ,medicine.disease ,Evoked Potentials, Motor ,Magnetic Resonance Imaging ,Transcranial magnetic stimulation ,Motor task ,nervous system ,Female ,Functional magnetic resonance imaging ,business ,030217 neurology & neurosurgery ,Demyelinating Diseases - Abstract
International audience; OBJECT: While occurrence of motor cortical reorganization has been clearly demonstrated in patients with multiple sclerosis (MS), it is not yet clear whether this cortical reorganization constitutes a response to cortico-spinal lesions or to more diffuse damage affecting the neuronal network involved in motor act preparation, or both. We proposed to investigate the changes in the activation pattern during a simple motor task devoid of cortico-spinal dysfunction occurring in patients with clinically isolated syndrome (CIS) suggestive of MS. MATERIALS AND METHODS: Among 15 right-handed CIS patients, we selected eight patients with a preserved central motor pathway established by motor evoked potentials. Ten healthy right-handed gender- and age-matched volunteers were also included. After morphological MRI, subjects performed calibrated conjugated finger flexion and extension movements during fMRI acquisition. RESULTS: In CIS patients, simple movements of the non-dominant hand induced recruitment of the anterior cingulate cortex (BA32) usually involved in complex motor movements. This reorganization was correlated with the diffuse brain tissue damage (brain T lesion load). CONCLUSION: These results suggest that at least part of the cortical reorganization observed during very simple tasks in the earliest stage of MS occurs whether or not the efferent pathways are intact.
- Published
- 2010