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Experience of diffusion tensor imaging and 1H spectroscopy for outcome prediction in severe traumatic brain injury: Preliminary results
- Source :
- Critical Care Medicine, Critical Care Medicine, 2009, 37 (4), pp.1448-55. ⟨10.1097/CCM.0b013e31819cf050⟩, Critical Care Medicine, Lippincott, Williams & Wilkins, 2009, 37 (4), pp.1448-55. ⟨10.1097/CCM.0b013e31819cf050⟩
- Publication Year :
- 2009
- Publisher :
- HAL CCSD, 2009.
-
Abstract
- International audience; OBJECTIVE: The objective of the study is to test whether multimodal magnetic resonance imaging can provide a reliable outcome prediction of the clinical status, focusing on consciousness at 1 year after severe traumatic brain injury (TBI). DESIGN: Single center prospective cohort with consecutive inclusions. SETTING: Critical Care Neurosurgical Unit of a university hospital. PATIENTS: Forty-three TBI patients not responding to simple orders after sedation cessation and 15 healthy controls. INTERVENTIONS: A multimodal magnetic resonance imaging combining morphologic sequences, diffusion tensor imaging (DTI), and H proton magnetic resonance spectroscopy (MRS) was performed 24 +/- 11 days after severe TBI. The ability of DTI and MRS to predict 1-year outcome was assessed by linear discriminant analysis (LDA). Robustness of the classification was tested using a bootstrap procedure. MEASUREMENTS AND MAIN RESULTS: Fractional anisotropy (FA) was computed as the mean of values at discrete brain sites in the infratentorial and supratentorial regions. The N-acetyl aspartate/creatine (NAA/Cr) ratio was measured in the thalamus, lenticular nucleus, insular cortex, occipital periventricular white matter, and pons. After 1 year, 19 (44%) patients had unfavorable outcomes (death, persistent vegetative state, or minimally conscious state) and 24 (56%) favorable outcomes (normal consciousness with or without functional impairments). Analysis of variance was performed to compare FA and NAA/Cr in the two outcome groups and controls. FA and MRS findings showed highly significant differences between the outcome groups, with significant variables by LDA being supratentorial FA, NAA/Cr (pons), NAA/Cr (thalamus), NAA/Cr (insula), and infratentorial FA. LDA of combined FA and MRS data clearly separated the unfavorable outcome, favorable outcome, and control groups, with no overlap. Unfavorable outcome was predicted with up to 86% sensitivity and 97% specificity; these values were better than those obtained with DTI or MRS alone. CONCLUSION: FA and NAA/Cr hold potential as quantitative outcome-prediction tools at the subacute phase of TBI.
- Subjects :
- Adult
Male
medicine.medical_specialty
Magnetic Resonance Spectroscopy
Time Factors
Traumatic brain injury
Critical Care and Intensive Care Medicine
030218 nuclear medicine & medical imaging
Young Adult
03 medical and health sciences
Injury Severity Score
0302 clinical medicine
Predictive Value of Tests
Intensive care
Fractional anisotropy
medicine
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging
Humans
Prospective Studies
Coma
medicine.diagnostic_test
Lenticular nucleus
business.industry
Minimally conscious state
Magnetic resonance imaging
Middle Aged
medicine.disease
3. Good health
Surgery
Diffusion Magnetic Resonance Imaging
nervous system
Brain Injuries
Female
Protons
medicine.symptom
business
Nuclear medicine
030217 neurology & neurosurgery
Diffusion MRI
Subjects
Details
- Language :
- English
- ISSN :
- 00903493 and 15300293
- Database :
- OpenAIRE
- Journal :
- Critical Care Medicine, Critical Care Medicine, 2009, 37 (4), pp.1448-55. ⟨10.1097/CCM.0b013e31819cf050⟩, Critical Care Medicine, Lippincott, Williams & Wilkins, 2009, 37 (4), pp.1448-55. ⟨10.1097/CCM.0b013e31819cf050⟩
- Accession number :
- edsair.doi.dedup.....81046c97e08b295c7e143f69b433ee1a