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In vivo functional and MRS metabolic evaluation of the heart graft; application to improvements of cardiac preservation
- Source :
- ResearcherID
- Publication Year :
- 2000
- Publisher :
- Springer Science and Business Media LLC, 2000.
-
Abstract
- Previous MRS studies o11 heart preservation have been mostly conducted oil ex vivo preparations which allow easily concomitant 3~p MRS and functional evaluation. Despite its limitations due to improper evahtation of the contractility, the standard heterotopic transplantation in rat offers close similarity to clinical situations and provides in-vivo blood reperfusion. Therefore this experimental model allows to study the recovery of the heart late after the initial period of reperfusion as opposed to ex vivo perfusion models which are not suitable for delayed study due to the limited stability of the preparation. We aimed to develop a new experimental model in order (i) to study the evolution of function and phosphorous metabolism of the heart graft during prolonged blood reperfusion; and (ii) to evaluate in-vivo the role of L-arginine as an adjuvant to the Centre de R6sonance Magnetique Biologique et M6dicale (CRMBM) heart preservation solution after prolonged cardioplegic arrest.
- Subjects :
- Male
medicine.medical_specialty
Magnetic Resonance Spectroscopy
Biophysics
Heart preservation
Contractility
In vivo
Internal medicine
medicine
Animals
Radiology, Nuclear Medicine and imaging
Heart graft
Heterotopic transplantation
Radiological and Ultrasound Technology
business.industry
Myocardium
Heart
Organ Preservation
Rats
Surgery
Transplantation
Rats, Inbred Lew
Concomitant
Cardiology
Heart Transplantation
business
Ex vivo
Subjects
Details
- ISSN :
- 13528661
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine
- Accession number :
- edsair.doi.dedup.....a4b90da71109ccc62c464e84571d583f