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151. Global model simulations of air pollution during the 2003 European heat wave

Author: Gilles Athier, P. Moinat, Johannes Flemming, Antje Inness, Arjo Segers, M. van Weele, Jean-Pierre Cammas, O. Stein, Vincent Huijnen, Christos Zerefos, N. Elguindi, Martin G. Schultz, Valérie Thouret, Vincent-Henri Peuch, Carlos Ordóñez, Eleni Katragkou, Harald Flentje, Laboratoire d'aérologie (LAERO), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Max Planck Institute for Meteorology (MPI-M), Max-Planck-Gesellschaft, Royal Netherlands Meteorological Institute (KNMI), European Centre for Medium-Range Weather Forecasts (ECMWF), Deutscher Wetterdienst [Offenbach] (DWD), Aristotelian University of Thessaloniki, Aristotle University of Thessaloniki, Centre Européen de Recherche et de Formation Avancée en Calcul Scientifique (CERFACS), CERFACS, Groupe d'étude de l'atmosphère météorologique (CNRM-GAME), Institut national des sciences de l'Univers (INSU - CNRS)-Météo France-Centre National de la Recherche Scientifique (CNRS), The Netherlands Organisation for Applied Scientific Research (TNO), National and Kapodistrian University of Athens (NKUA), Institute for Chemistry and Dynamics of the Geosphere (ICG), FZ Jülich, Germany, Université de Toulouse (UT)-Université de Toulouse (UT)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France, Centre national de recherches météorologiques (CNRM), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)
Subjects: Pollution, Atmospheric Science, Ozone, 010504 meteorology & atmospheric sciences, media_common.quotation_subject, Air pollution, 010501 environmental sciences, Atmospheric sciences, medicine.disease_cause, 01 natural sciences, MOPITT, lcsh:Chemistry, Troposphere, chemistry.chemical_compound, ddc:550, medicine, 0105 earth and related environmental sciences, media_common, [PHYS.PHYS.PHYS-AO-PH]Physics [physics]/Physics [physics]/Atmospheric and Oceanic Physics [physics.ao-ph], Heat wave, lcsh:QC1-999, Boundary layer, lcsh:QD1-999, chemistry, 13. Climate action, Climatology, lcsh:Physics, Carbon monoxide
Abstract: Three global Chemistry Transport Models – MOZART, MOCAGE, and TM5 – as well as MOZART coupled to the IFS meteorological model including assimilation of ozone (O3) and carbon monoxide (CO) satellite column retrievals, have been compared to surface measurements and MOZAIC vertical profiles in the troposphere over Western/Central Europe for summer 2003. The models reproduce the meteorological features and enhancement of pollution during the period 2–14 August, but not fully the ozone and CO mixing ratios measured during that episode. Modified normalised mean biases are around −25% (except ~5% for MOCAGE) in the case of ozone and from −80% to −30% for CO in the boundary layer above Frankfurt. The coupling and assimilation of CO columns from MOPITT overcomes some of the deficiencies in the treatment of transport, chemistry and emissions in MOZART, reducing the negative biases to around 20%. The high reactivity and small dry deposition velocities in MOCAGE seem to be responsible for the overestimation of O3 in this model. Results from sensitivity simulations indicate that an increase of the horizontal resolution to around 1°×1° and potential uncertainties in European anthropogenic emissions or in long-range transport of pollution cannot completely account for the underestimation of CO and O3 found for most models. A process-oriented TM5 sensitivity simulation where soil wetness was reduced results in a decrease in dry deposition fluxes and a subsequent ozone increase larger than the ozone changes due to the previous sensitivity runs. However this latest simulation still underestimates ozone during the heat wave and overestimates it outside that period. Most probably, a combination of the mentioned factors together with underrepresented biogenic emissions in the models, uncertainties in the modelling of vertical/horizontal transport processes in the proximity of the boundary layer as well as limitations of the chemistry schemes are responsible for the underestimation of ozone (overestimation in the case of MOCAGE) and CO found in the models during this extreme pollution event.
Published: 2010
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152. Discovering the Discriminating Power in Patient Test Features Using Visual Analytics: A Case Study in Parkinson’s Disease

Author: Panagiotis Moschonas, Anastasios Drosou, Elias Kalamaras, Charalambos Papaxanthis, Sevasti Bostantjopoulou, Vassilia Hatzitaki, Konstantinos Votis, Dimitrios Tzovaras, Zoe Katsarou, Stavros Papadopoulos, Centre for Research and Technology Hellas [Athènes] (CERTH), Department of Neurology (Aristotle University of Thessaloniki), Aristotle University of Thessaloniki, UFR Sciences du Sport (STAPS) (Université de Bourgogne), Université de Bourgogne (UB), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Physical Education and Sports Sciences (Aristotle University of Thessaloniki), EU, NoTremor (EC FP7) 610391, Lazaros Iliadis, Ilias Maglogiannis, TC 12, WG 12.5, Centre for Research and Technology Hellas [Athène] ( CERTH ), Université de Bourgogne ( UB ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), and université de Bourgogne, CAPS
Subjects: Visual analytics, [ INFO ] Computer Science [cs], Parkinson's disease, Computer science, 02 engineering and technology, [INFO] Computer Science [cs], Machine learning, computer.software_genre, 03 medical and health sciences, 0302 clinical medicine, Multi-objective optimisation, 0202 electrical engineering, electronic engineering, information engineering, medicine, Feature (machine learning), [INFO]Computer Science [cs], In patient, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Modalities, business.industry, Feature discrimination power, medicine.disease, Test (assessment), Power (physics), Identification (information), [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Parkinson’s disease, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], 020201 artificial intelligence & image processing, Data mining, Artificial intelligence, business, computer, 030217 neurology & neurosurgery
Abstract: Part 11: New Methods and Tools for Big Data Wokshop (MT4BD); International audience; This paper presents a novel methodology for selecting the most representative features for identifying the presence of the Parkinson’s Disease (PD). The proposed methodology is based on interactive visual analytic based on multi-objective optimisation. The implemented tool processes and visualises the information extracted via performing a typical line-tracking test using a tablet device. Such output information includes several modalities, such as position, velocity, dynamics, etc. Preliminary results depict that the implemented visual analytics technique has a very high potential in discriminating the PD patients from healthy individuals and thus, it can be used for the identification of the best feature type which is representative of the disease presence.
Published: 2016
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153. SGLT2i for evidence based cardiorenal protection in diabetic and non-diabetic chronic kidney disease: a comprehensive review by EURECA-m and ERBP working groups of ERA

Author: Mark, Patrick, Sarafidis, Pantelis, Ekart, Robert, Ferro, Charles, Balafa, Olga, Fernandez-Fernandez, Beatriz, Herrington, William, Rossignol, Patrick, del Vecchio, Lucia, Valdivielso, José M., Mallamaci, Francesca, Ortiz, Alberto, Nistor, Ionut, Cozzolino, Mario, University of Glasgow, Aristotle University of Thessaloniki, Hippokration Hospital, University medical centre Maribor (UKC Maribor), University Hospitals Birmingham [Birmingham, Royaume-Uni], University of Birmingham [Birmingham], University Hospital of Ioannina, Universidad Autónoma de Madrid (UAM), Fundación Jiménez Díaz, Fundacion Jimenez Diaz [Madrid] (FJD), Nuffield Department of Population Health [Oxford], University of Oxford, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Hôpital Princesse Grace [Monaco], ASST Lecco, University of Lleida-IRBLLEIDA-PCiTA, Vascular and Renal Translational Research Group and UDETMA, IRBLleida, CNR-IFC Clinical Epidemiology and Pathophysiology of Renal Diseases and Hpertension Unit, Reggio Calabria, Reggio Calabria c/o Ospedali Riuniti, University of Medicine and Pharmacy 'Grigore T.Popa' Iasi (UMF lasi), Università degli Studi di Milano = University of Milan (UNIMI), AO/BFF research is supported by FIS/Fondos FEDER (PI18/01366, PI19/00588, PI19/00815, PI21/00251, PI20/00744, ERA-PerMed-JTC2018 (KIDNEY ATTACK AC18/00064, ISCIII-RETIC REDinREN RD016/0009), Sociedad Española de Nefrología, Sociedad Madrileña de Nefrología (SOMANE), FRIAT, Comunidad de Madrid en Biomedicina B2017/BMD-3686 CIFRA2-CM. Instituto de Salud Carlos III (ISCIII) RICORS program to RICORS2040 (RD21/0005/0001) funded by European Union – NextGenerationEU, Mecanismo para la Recuperación y la Resiliencia(MRR) and SPACKDc PMP21/00109, FEDER funds., European Project, and European Project: RD21/0005/000
Subjects: [SDV]Life Sciences [q-bio]
Abstract: International audience; Chronic kidney disease (CKD) is a major public health issue affecting an estimated 850 million people globally. The leading causes of CKD is diabetes and hypertension, which together account for more than 50% of patients with end-stage kidney disease. Progressive CKD leads to the requirement for kidney replacement therapy with transplantation or dialysis. In addition, CKD, is a risk factor for premature cardiovascular disease, particularly from structural heart disease and heart failure (HF). Until 2015, the mainstay of treatment to slow progression of both diabetic and many non-diabetic kidney diseases was blood pressure control and renin-angiotensin system inhibition; however, neither angiotensin converting enzyme inhibitors (ACEIs) nor angiotensin receptor blockers (ARBs) reduced cardiovascular events and mortality in major trials in CKD. The emergence of cardiovascular and renal benefits observed with sodium-glucose cotransporter-2 inhibitors (SGLT2i) from clinical trials of their use as antihyperglycaemic agents has led to a revolution in cardiorenal protection for patients with diabetes. Subsequent clinical trials, notably DAPA-HF, EMPEROR, CREDENCE, DAPA-CKD and EMPA-KIDNEY have demonstrated their benefits in reducing risk of HF and progression to kidney failure in patients with HF and/or CKD. The cardiorenal benefits - on a relative scale - appear similar in patients with or without diabetes. Specialty societies’ guidelines are continually adapting as trial data emerges to support increasingly wide use of SGLT2i. This consensus paper from EURECA-m and ERBP highlights the latest evidence and summarises the guidelines for use of SGLT2i for cardiorenal protection focusing on benefits observed relevant to people with CKD.
Published: 2023
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154. Insights on the Evolution of Mycoparasitism from the Genome of Clonostachys rosea

Author: Daniel Buchvaldt Amby, Mukesh Dubey, Jinhui Wang, Sabrina Sarrocco, Birgit Jensen, Yong-Hwan Lee, Bernard Henrissat, Anthony Levasseur, Dan Funck Jensen, Chatchai Kosawang, Gerald Lackner, Stefanie Pöggeler, Mikael Brandström Durling, Jaeyoung Choi, Antonio Zapparata, Giovanni Vannacci, Emmanuel Panteris, Anastasia L. Lagopodi, David B. Collinge, Kristiina Nygren, Georgios Tzelepis, Magnus Karlsson, Dirk Hoffmeister, Nathalie N. Kamou, Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences (SLU), Department of Agricultural Biotechnology, Seoul National University [Seoul] (SNU)-Center for Fungal Pathogenesis, Department of Plant and Environmental Sciences [Copenhagen], Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Department of Pharmaceutical Microbiology at the Hans-Knöll-Institute, Friedrich-Schiller-Universität Jena, Department of Medical Biochemistry and Microbiology, Uppsala University, Plant Pathology Laboratory, Aristotle University of Thessaloniki-School of Agriculture, Biodiversité et Biotechnologie Fongiques (BBF), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM), Department of Agriculture, University of Pisa - Università di Pisa -Food and Environment, Department of Agricultural Sciences, Department of Botany, Aristotle University of Thessaloniki, Department of Genetics of Eukaryotic Microorganisms, Georg-August-University [Göttingen]-Institute of Microbiology and Genetics, Architecture et fonction des macromolécules biologiques (AFMB), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Department of Forest Mycology and Plant Pathology Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning Carl Trygger Foundation Danish Agency for Science, Technology and Innovation Swedish Research Council Knut and Alice Wallenberg Foundation, École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), and Institute of Microbiology and Genetics-Georg-August-University = Georg-August-Universität Göttingen
Subjects: polyketide synthase, GENE PREDICTION, Secondary Metabolism, biological control, BIOCONTROL AGENT, phylogeny, Genome, Evolutionsbiologi, ABC TRANSPORTERS, Gene Expression Regulation, Fungal, fungicide, PHYLOGENETIC ANALYSIS, MAXIMUM-LIKELIHOOD, 2. Zero hunger, 0303 health sciences, Fungal protein, biology, Bionectria ochroleuca, food and beverages, 414 Agricultural biotechnology, Pseudomonas chlororaphis, TRICHODERMA-REESEI, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Multigene Family, Hypocreales, 1181 Ecology, evolutionary biology, ABC transporter, Genome, Fungal, Research Article, education, RHYNIE CHERT, SP RADICIS-LYCOPERSICI, GLIOCLADIUM-ROSEUM, FUNGI, Microbiology, Evolution, Molecular, Fungal Proteins, 03 medical and health sciences, Phylogenetics, Polyketide synthase, Genetics, Genetik, Pest Control, Biological, Secondary metabolism, Gene, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Evolutionary Biology, 030306 microbiology, Molecular Sequence Annotation, Genes, Mating Type, Fungal, biology.organism_classification, biology.protein
Abstract: International audience; Clonostachys rosea is a mycoparasitic fungus that can control several important plant diseases. Here, we report on the genome sequencing of C. rosea and a comparative genome analysis, in order to resolve the phylogenetic placement of C. rosea and to study the evolution of mycoparasitism as a fungal lifestyle. The genome of C. rosea is estimated to 58.3 Mb, and contains 14,268 predicted genes. A phylogenomic analysis shows that C. rosea clusters as sister taxon to plant pathogenic Fusarium species, with mycoparasitic/ saprotrophic Trichoderma species in an ancestral position. A comparative analysis of gene family evolution reveals several distinct differences between the included mycoparasites. Clonostachys rosea contains significantly more ATP-binding cassette (ABC) transporters , polyketide synthases, cytochrome P450 monooxygenases, pectin lyases, glucose-methanol-choline oxidoreductases, and lytic polysaccharide monooxygenases compared with other fungi in the Hypocreales. Interestingly, the increase of ABC transporter gene number in C. rosea is associated with phylogenetic subgroups B (multidrug resistance proteins) and G (pleiotropic drug resistance transporters), whereas an increase in subgroup C (multidrug resistance-associated proteins) is evident in Trichoderma virens. In contrast with mycoparasitic Trichoderma species, C. rosea contains very few chitinases. Expression of six group B and group G ABC transporter genes was induced in C. rosea during exposure to the Fusarium mycotoxin zearalenone, the fungicide Boscalid or metabolites from the biocontrol bacterium Pseudomonas chlororaphis. The data suggest that tolerance toward secondary metab-olites is a prominent feature in the biology of C. rosea.
Published: 2015
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155. Morphology of howler monkeys: a review and quantitative analyses

Author: Dionisios Youlatos, Sébastien Couette, Lauren B. Halenar, Department of Zoology, Aristotle University of Thessaloniki, Laboratoire Paléobiodiversité et Evolution (PALEVO), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Biogéosciences [UMR 6282] [Dijon] (BGS), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Department of Biological Sciences, City University of New York [New York] (CUNY), New York Consortium in Evolutionary Primatology (NYCEP), Funding provided by the Muséum national d’Histoire naturelle and the Centre National de la RechercheScientifique, France, the Aristotle University of Thessaloniki and the State Scholarship Foundation,Greece, and the National Science Foundation., M.M. Kowalewski, P.A. Garber, L. Cortes-Ortiz, B. Urbani & D. Youlatos, Laboratoire Paléobiodiversité et Evolution ( PALEVO ), École pratique des hautes études ( EPHE ), Biogéosciences [Dijon] ( BGS ), AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), City University of New-York [New-York] ( CUNY ), New York Consortium in Evolutionary Primatology ( NYCEP ), and M.M. Kowalewski, P.A. Garber, L. Cortes-Ortiz, B. Urbani & D. Youlatos
Subjects: Teeth, Postcrania, Morphology (biology), [SDV.BID]Life Sciences [q-bio]/Biodiversity, Biology, Hyoid, Intraspecific competition, Quadrupedalism, Postcranium, medicine, 0501 psychology and cognitive sciences, 0601 history and archaeology, 050102 behavioral science & comparative psychology, Alouatta, Morphometrics, [ SDV.BID ] Life Sciences [q-bio]/Biodiversity, 060101 anthropology, 05 social sciences, Niche differentiation, 06 humanities and the arts, Sexual dimorphism, Skull, medicine.anatomical_structure, Evolutionary biology, Cranium
Abstract: 44 pages; International audience; Recognition of a particularly derived eco-behavioral strategy for thegenus Alouatta has been crucial for studying and understanding its equally derivedcranial and postcranial morphology. The unique architecture of the skull and mandiblehas very likely evolved in relation to both masticatory correlates associatedwith an increasingly folivorous diet as well as the use of vocal communication associatedwith social behavior and an energy-minimizing strategy. Comparisons of cranialmorphology using three-dimensional geometric morphometrics havehighlighted signifi cant interspecifi c shape differences. Alouatta seniculus is themost divergent in both cranial and hyoid morphology and exhibits the most pronouncedlevels of sexual dimorphism in those areas. Cranial variability is expressedin facial prognathism and airorhynchy, basicranial fl exure, and zygomatic height.Inter- and intraspecifi c differences based on these axes of variation are very likelylinked to interspecifi c variations in diet, behavior, and life history. This is furtherevident in the dental anatomy of the genus, indicating adaptations to a shift to amore folivorous diet. In addition, recent studies provide further evidence for signifi -cant inter- and intraspecifi c variations in hyoid size and shape. Alouatta seniculuspossesses the largest and most infl ated hyoid bulla, and the species that occupy distributionalextremes ( A. palliata , A. caraya ) are differentiated by highly distinct hyoidshapes. These data indicate a complex relationship between morphology and behavior,with possible biogeographic implications. In terms of postcranial morphology, the forelimb bears a mixture of features that favor quadrupedalism with restrictedabduction and overhead extension, providing stable contact and support alongbranches. In contrast, the hind limb appears to allow for a wider range of movementin all joints, with an emphasis on thigh extension and abduction, leg rotation, andpowerful grasping with a habitually inverted foot. Interspecifi c variation revealstraits that can be ultimately related to subtle differences in the frequency of use ofdifferent positional modes, associated with variable eco-social factors. Theseresults, deriving from different anatomical regions, provide evidence for understandingmorphological variation across howler species in terms of morphofunctionaladaptations, environmental pressure, and niche partitioning.
Published: 2015
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156. GREECE DURING THE EARLY COLD WAR THE VIEW FROM THE WESTERN ARCHIVES:DOCUMENTS

Author: Chourchoulis, Dionysios, Christidis, Christos, Kalogrias, Vaios, Karavis, Periklis-Stelios, Koumas, Manolis, Papastamkou, Sofia, Queen Mary University of London (QMUL), Hellenic Open University [Patras], University of Mainz, Johannes Gutenberg - Universität Mainz (JGU), Aristotelian University of Thessaloniki, Aristotle University of Thessaloniki, National and Kapodistrian University of Athens (NKUA), Identites, relations internationales et civilisations de l'Europe (IRICE), Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), Maison européenne des sciences de l’homme et de la société - USR 3185 (MESHS), Université d'Artois (UA)-Université de Picardie Jules Verne (UPJV)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Fédération Universitaire et Polytechnique de Lille-Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), European Social Fund, Nikos Marantzidis, European Project, Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1), Maison européenne des sciences de l’homme et de la société - UAR 3185 (MESHS), and Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU)
Subjects: Greece-France, NATO, Griechenland-Großbritannien, Grèce-Allemagne, Griechenland-Frankreich, Griechenland-Italien, Griechenland-Deutschland, Grèce-France, Greece-Italy, Grèce-Royaume-Uni, Grecia-Francia, Grecia-Italia, Greece, Cold War, Guerre froide, Guerra Fredda, Greece-UK, Kalter Krieg, Grèce-Italie, OTAN, Griechenland, Grecia-Regno Unito, Greece-USA, Greece-Germany, Grèce, Grecia-Germania, [SHS.HIST]Humanities and Social Sciences/History, Grecia
Abstract: International audience; Greece‘s relation with the West during the Cold War era has constantly attracted theattention of Greek and international scholarship. In this relationship, continuities andbreaks become evident. The postwar era was marked by the continuation of theagonizing Greek effort to integrate in the West. Thus, there was an effort to bringrelations with the major Western European states (Britain, France, West Germany,Italy) back to a kind of normalcy. This, as could be expected, was a particularlydemanding endeavour, especially regarding the former Axis powers, against whichGreece had fought during the Second World War. The Cold War provided a contextor a medium which facilitated the rebuilding of bilateral contacts. There also were breaks, or at least novelties, pointing to the ascent of a newera of international relations. The US-Greek special relationship, forged during thedifficult years of the Greek civil war but also burdened by the memories of USpenetration in Greek policy-making in 1947-52, was a salient novel element. Greece‘sparticipation in NATO was an unprecedented event:this was the first time that thecountry allied formally with the major powers of the West. Last but not least,Athens‘s ambition to participate in supranational European integration resulted in the1961 Association Agreement with the European Economic Community, and openednew roads for Greece‘s internal development and international relations. This volume presents archival material from the West German, French, Italian,British and US national archives, as well as from the NATO Archives, addressingimportant aspects of this historical phenomenon. This multi-archival research wasundertaken by a large number of scholars, in the context of the Thalis project onGreece and the Cold War, coordinated by the University of Macedonia: KonstantinaE. Botsiou, Dionysios Chourchoulis, Christos Christidis, Evanthis Hatzivassiliou,Vaios Kalogrias, Periklis-Stelios Karavis, Manolis Koumas, Sofia Papastamkou, andIoannis Sakkas. All researchers also suggested documents for possible publication,thus creating a large pool of archival material. The editors then made the finalselection and prepared this volume.This volume cannot, of course, tell the whole story of Greece‘s relationshipwith the West in the postwar era. It aims to highlight important landmarks orperspectives, as seen by the other Western capitals. It is hoped, however, that it willcontribute to a widening of the debate on one of the most important aspects ofcontemporary Greek history.
Published: 2015

157. Global urban environmental change drives adaptation in white clover

Author: James S. Santangelo, Rob W. Ness, Beata Cohan, Connor R. Fitzpatrick, Simon G. Innes, Sophie Koch, Lindsay S. Miles, Samreen Munim, Pedro R. Peres-Neto, Cindy Prashad, Alex T. Tong, Windsor E. Aguirre, Philips O. Akinwole, Marina Alberti, Jackie Álvarez, Jill T. Anderson, Joseph J. Anderson, Yoshino Ando, Nigel R. Andrew, Fabio Angeoletto, Daniel N. Anstett, Julia Anstett, Felipe Aoki-Gonçalves, A. Z. Andis Arietta, Mary T. K. Arroyo, Emily J. Austen, Fernanda Baena-Díaz, Cory A. Barker, Howard A. Baylis, Julia M. Beliz, Alfonso Benitez-Mora, David Bickford, Gabriela Biedebach, Gwylim S. Blackburn, Mannfred M. A. Boehm, Stephen P. Bonser, Dries Bonte, Jesse R. Bragger, Cristina Branquinho, Kristien I. Brans, Jorge C. Bresciano, Peta D. Brom, Anna Bucharova, Briana Burt, James F. Cahill, Katelyn D. Campbell, Elizabeth J. Carlen, Diego Carmona, Maria Clara Castellanos, Giada Centenaro, Izan Chalen, Jaime A. Chaves, Mariana Chávez-Pesqueira, Xiao-Yong Chen, Angela M. Chilton, Kristina M. Chomiak, Diego F. Cisneros-Heredia, Ibrahim K. Cisse, Aimée T. Classen, Mattheau S. Comerford, Camila Cordoba Fradinger, Hannah Corney, Andrew J. Crawford, Kerri M. Crawford, Maxime Dahirel, Santiago David, Robert De Haan, Nicholas J. Deacon, Clare Dean, Ek del-Val, Eleftherios K. Deligiannis, Derek Denney, Margarete A. Dettlaff, Michelle F. DiLeo, Yuan-Yuan Ding, Moisés E. Domínguez-López, Davide M. Dominoni, Savannah L. Draud, Karen Dyson, Jacintha Ellers, Carlos I. Espinosa, Liliana Essi, Mohsen Falahati-Anbaran, Jéssica C. F. Falcão, Hayden T. Fargo, Mark D. E. Fellowes, Raina M. Fitzpatrick, Leah E. Flaherty, Pádraic J. Flood, María F. Flores, Juan Fornoni, Amy G. Foster, Christopher J. Frost, Tracy L. Fuentes, Justin R. Fulkerson, Edeline Gagnon, Frauke Garbsch, Colin J. Garroway, Aleeza C. Gerstein, Mischa M. Giasson, E. Binney Girdler, Spyros Gkelis, William Godsoe, Anneke M. Golemiec, Mireille Golemiec, César González-Lagos, Amanda J. Gorton, Kiyoko M. Gotanda, Gustaf Granath, Stephan Greiner, Joanna S. Griffiths, Filipa Grilo, Pedro E. Gundel, Benjamin Hamilton, Joyce M. Hardin, Tianhua He, Stephen B. Heard, André F. Henriques, Melissa Hernández-Poveda, Molly C. Hetherington-Rauth, Sarah J. Hill, Dieter F. Hochuli, Kathryn A. Hodgins, Glen R. Hood, Gareth R. Hopkins, Katherine A. Hovanes, Ava R. Howard, Sierra C. Hubbard, Carlos N. Ibarra-Cerdeña, Carlos Iñiguez-Armijos, Paola Jara-Arancio, Benjamin J. M. Jarrett, Manon Jeannot, Vania Jiménez-Lobato, Mae Johnson, Oscar Johnson, Philip P. Johnson, Reagan Johnson, Matthew P. Josephson, Meen Chel Jung, Michael G. Just, Aapo Kahilainen, Otto S. Kailing, Eunice Kariñho-Betancourt, Regina Karousou, Lauren A. Kirn, Anna Kirschbaum, Anna-Liisa Laine, Jalene M. LaMontagne, Christian Lampei, Carlos Lara, Erica L. Larson, Adrián Lázaro-Lobo, Jennifer H. Le, Deleon S. Leandro, Christopher Lee, Yunting Lei, Carolina A. León, Manuel E. Lequerica Tamara, Danica C. Levesque, Wan-Jin Liao, Megan Ljubotina, Hannah Locke, Martin T. Lockett, Tiffany C. Longo, Jeremy T. Lundholm, Thomas MacGillavry, Christopher R. Mackin, Alex R. Mahmoud, Isaac A. Manju, Janine Mariën, D. Nayeli Martínez, Marina Martínez-Bartolomé, Emily K. Meineke, Wendy Mendoza-Arroyo, Thomas J. S. Merritt, Lila Elizabeth L. Merritt, Giuditta Migiani, Emily S. Minor, Nora Mitchell, Mitra Mohammadi Bazargani, Angela T. Moles, Julia D. Monk, Christopher M. Moore, Paula A. Morales-Morales, Brook T. Moyers, Miriam Muñoz-Rojas, Jason Munshi-South, Shannon M. Murphy, Maureen M. Murúa, Melisa Neila, Ourania Nikolaidis, Iva Njunjić, Peter Nosko, Juan Núñez-Farfán, Takayuki Ohgushi, Kenneth M. Olsen, Øystein H. Opedal, Cristina Ornelas, Amy L. Parachnowitsch, Aaron S. Paratore, Angela M. Parody-Merino, Juraj Paule, Octávio S. Paulo, João Carlos Pena, Vera W. Pfeiffer, Pedro Pinho, Anthony Piot, Ilga M. Porth, Nicholas Poulos, Adriana Puentes, Jiao Qu, Estela Quintero-Vallejo, Steve M. Raciti, Joost A. M. Raeymaekers, Krista M. Raveala, Diana J. Rennison, Milton C. Ribeiro, Jonathan L. Richardson, Gonzalo Rivas-Torres, Benjamin J. Rivera, Adam B. Roddy, Erika Rodriguez-Muñoz, José Raúl Román, Laura S. Rossi, Jennifer K. Rowntree, Travis J. Ryan, Santiago Salinas, Nathan J. Sanders, Luis Y. Santiago-Rosario, Amy M. Savage, J.F. Scheepens, Menno Schilthuizen, Adam C. Schneider, Tiffany Scholier, Jared L. Scott, Summer A. Shaheed, Richard P. Shefferson, Caralee A. Shepard, Jacqui A. Shykoff, Georgianna Silveira, Alexis D. Smith, Lizet Solis-Gabriel, Antonella Soro, Katie V. Spellman, Kaitlin Stack Whitney, Indra Starke-Ottich, Jörg G. Stephan, Jessica D. Stephens, Justyna Szulc, Marta Szulkin, Ayco J. M. Tack, Ítalo Tamburrino, Tayler D. Tate, Emmanuel Tergemina, Panagiotis Theodorou, Ken A. Thompson, Caragh G. Threlfall, Robin M. Tinghitella, Lilibeth Toledo-Chelala, Xin Tong, Léa Uroy, Shunsuke Utsumi, Martijn L. Vandegehuchte, Acer VanWallendael, Paula M. Vidal, Susana M. Wadgymar, Ai-Ying Wang, Nian Wang, Montana L. Warbrick, Kenneth D. Whitney, Miriam Wiesmeier, J. Tristian Wiles, Jianqiang Wu, Zoe A. Xirocostas, Zhaogui Yan, Jiahe Yao, Jeremy B. Yoder, Owen Yoshida, Jingxiong Zhang, Zhigang Zhao, Carly D. Ziter, Matthew P. Zuellig, Rebecca A. Zufall, Juan E. Zurita, Sharon E. Zytynska, Marc T. J. Johnson, Ecological Science, Animal Ecology, Biology, Faculty of Economic and Social Sciences and Solvay Business School, Faculty of Medicine and Pharmacy, ON, University of North Carolina, LA, QC, DePaul University, IN, Universidad San Francisco de Quito USFQ, University of Georgia, Uppsala University, Hokkaido University, NSW, Programa de Pós-Graduação em Geografia da UFMT, University of British Columbia, A. C., CT, Universidad de Chile, Mount Allison University, Instituto de Ecología A. C., University of Cambridge, FL, Universidad Bernardo O'Higgins, Ghent University, West Long Branch, Lisboa, KU Leuven, Massey University, University of Cape Town, University of Münster, AB, University of Sussex, Stockholm University, Universidad San Francisco de Quito, East China Normal University, Shanghai Engineering Research Center of Sustainable Plant Innovation, MI, TX, Facultad de Agronomía, NS, Université de Rennes, IA, MN, Manchester Metropolitan University, UNAM, Aristotle University of Thessaloniki, University of Helsinki, University of Glasgow, Hendrix College, Vrije Universiteit Amsterdam, Universidad Técnica Particular de Loja, Universidade Federal de Sergipe (UFS), University of Tehran, Norwegian University of Science and Technology, AZ, Max Planck Institute for Plant Breeding Research, Universidad Nacional Autónoma de México, Potsdam-Golm, University of Alaska Anchorage, Tropical Diversity, Université de Moncton, MB, University of New Brunswick, Lincoln University, Universidad Adolfo Ibáñez, Brock University, ICB - University of Talca, Curtin University, Murdoch University, Western Oregon University, Facultad de Ciencias de la Vida, Institute of Ecology and Biodiversity (IEB), Lund University, Universidad Autónoma de Guerrero -CONACYT, University of Illinois at Chicago, Dufferin-Peel Catholic District School Board, U.S. Army ERDC-CERL, Tübingen, University of Zurich, Urban Wildlife Institute, Universidad Católica de la Santísima Concepción, CO, MS, Rutgers University-Camden, Chinese Academy of Sciences, Beijing Normal University, NM, University of Wisconsin - Eau Claire, Iranian Research Organization for Science and Technology (IROST), ME, Universidad de Antioquia, MA, Universidad de Sevilla, Universidad Mayor, Naturalis Biodiversity Center, Kyoto University, University of Alaska Fairbanks, Senckenberg Research Institute and Natural History Museum Frankfurt, Universidade Estadual Paulista (UNESP), WI, Swedish University of Agricultural Sciences, Universidad CES, Hofstra University, Nord University, VA, University of Almería, Faculty of Biological Sciences, Leiden University, Jyväskylä, KY, University of Tokyo, Ecologie Systématique et Evolution, Martin Luther University Halle-Wittenberg, University of Warsaw, Davidson College, Huazhong Agricultural University, Technical University of Munich, Lanzhou University, University of Bern, University of Liverpool, Repositório da Universidade de Lisboa, University of Toronto at Mississauga, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), University of Louisiana, Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Ecologie Systématique et Evolution (ESE), AgroParisTech-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Biodiversité agroécologie et aménagement du paysage (UMR BAGAP), Ecole supérieure d'Agricultures d'Angers (ESA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Rennes Angers, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Huazhong Agricultural University [Wuhan] (HZAU), California State University [Northridge] (CSUN), Saint Mary's University [Halifax], Kunming Institute of Botany [CAS] (KIB), Chinese Academy of Sciences [Beijing] (CAS), Concordia University [Montreal], University of Houston, Universidad San Francisco de Quito (USFQ), Technische Universität München = Technical University of Munich (TUM), and The Global Urban Evolution project was primarily funded by an NSERC DiscoveryGrant, Canada Research Chair and NSERC Steacie Fellowship to M.T.J.J.. J.S.S. receivedfunding from an NSERC CGS and C.R.F. is funded by an NSERC PDF. P.R.P.-N., R.W.N. andJ.C.C. were supported by NSERC Discovery grants. M.A. was funded by NSF RCN DEB-1840663. F.A. received funding from CAPES. MTKA was funded by CONICYT PIA APOYOCCTE AFB170008. J.R.B, T.C.L., and S.A.S were supported by Monmouth University Sch. ofSci. SRP. E.G. was funded by D. Biologie, Université de Moncton. C.G.-L. received fundingfrom the Center of Applied Ecology and Sustainability (CAPES), and ANID PIA/BASALFB0002. S.G. was funded by the Max Planck Society. P.J.-A. was funded by ANID PIA/BASALFB210006. I.N. and M.S. were supported by Leiden Municipality. K.M.O. was funded by USNSF awards IOS-1557770 and DEB-1601641. J.C.P. thanks FAPESP process 2018/00107-3, andM.C.R. thanks CNPq and FAPESP.
Subjects: sopeutuminen, Rural Population, valkoapila, Multidisciplinary, Urbanization, evoluutio, kasvillisuus, Genes, Plant, Adaptation, Physiological, Biological Evolution, SDG 11 - Sustainable Cities and Communities, evoluutioekologia, Hydrogen Cyanide, 570 Life sciences, biology, Trifolium, kaupungistuminen, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Cities, ympäristönmuutokset, Ecosystem, Genome, Plant
Abstract: Made available in DSpace on 2022-04-28T19:52:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-03-18 Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural clines was best explained by adaptive evolution, but the degree of parallel adaptation varied among cities. Our results demonstrate that urbanization leads to adaptation at a global scale. Department of Biology University of Toronto Mississauga ON Centre for Urban Environments University of Toronto Mississauga ON Department of Biology University of North Carolina, Chapel Hill Department of Biology University of Louisiana LA Department of Biology Queen's University ON Department of Biology Concordia University QC Department of Biological Sciences DePaul University Department of Biology DePauw University IN Department of Urban Design and Planning, University of Washington, Seattle, WA, USA Colegio de Ciencias Biológicas y Ambientales Universidad San Francisco de Quito USFQ Department of Genetics University of Georgia Department of Ecology and Genetics Evolutionary Biology Centre Uppsala University Field Science Center for Northern Biosphere Hokkaido University Natural History Museum Zoology University of New England NSW Programa de Pós-Graduação em Geografia da UFMT campus de Rondonópolis Department of Botany and Biodiversity Research Centre University of British Columbia Graduate Program in Genome Sciences and Technology Genome Sciences Centre University of British Columbia Department of Microbiology and Immunology University of British Columbia Red de Biología Evolutiva Instituto de Ecología A. C. School of the Environment Yale University CT Departamento de Ciencias Ecológicas Universidad de Chile, Facultad de Ciencias Instituto de Ecología y Biodiversidad Universidad de Chile Department of Biology Mount Allison University Red de Ecoetología Instituto de Ecología A. C. Department of Biology University of Ottawa ON Department of Zoology University of Cambridge Department of Biology, Washington University in St. Louis, St. Louis, MO, USA Department of Biology University of Miami FL Centro de Investigación en Recursos Naturales y Sustentabilidad (CIRENYS) Universidad Bernardo O'Higgins Department of Biology, University of La Verne, La Verne, CA, USA Département des sciences du bois et de la forêt Université Laval QC Evolution & Ecology Research Centre School of Biological Earth and Environmental Sciences UNSW Sydney NSW Department of Biology Ghent University Department of Biology Monmouth University West Long Branch Centre for Ecology Evolution and Environmental Changes Faculdade de Ciências Universidade de Lisboa Lisboa Department of Biology KU Leuven School of Agriculture and Environment Wildlife and Ecology group Massey University, Palmerston North Department of Biological Sciences University of Cape Town Institute of Landscape Ecology University of Münster Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester, NY, USA Department of Biological Sciences University of Alberta AB Louis Calder Center and Department of Biological Sciences, Fordham University, Armonk, NY, USA Departamento de Ecología Tropical, Universidad Autónoma de Yucatán, Mérida, Yucatán, México School of Life Sciences University of Sussex Department of Ecology Environment and Plant Sciences Stockholm University iBIOTROP Instituto de Biodiversidad Tropical Universidad San Francisco de Quito Department of Biology, San Francisco State University, San Francisco, CA, USA Unidad de Recursos Naturales, Centro de Investigación Científica de Yucatán AC, Mérida, Yucatán, México School of Ecological and Environmental Sciences East China Normal University Shanghai Engineering Research Center of Sustainable Plant Innovation Centre for Ecosystem Science School of Biological Earth and Environmental Sciences UNSW Sydney NSW Department of Ecology and Evolutionary Biology University of Michigan MI Department of Biosciences Rice University TX IFEVA Universidad de Buenos Aires Facultad de Agronomía, CONICET Biology Department Saint Mary's University NS Department of Biological Sciences, Universidad de los Andes Department of Biology and Biochemistry University of Houston TX Université de Rennes Department of Zoology and Biodiversity Research Centre University of British Columbia Department of Environmental Studies Dordt University Sioux Center IA Department of Biology Minneapolis Community and Technical College MN Department of Natural Sciences Ecology and Environment Research Centre Manchester Metropolitan University Instituto de Investigaciones en Ecosistemas y Sustentabilidad UNAM Department of Botany School of Biology Aristotle University of Thessaloniki Faculty of Biological and Environmental Science Organismal & Evolutionary Biology Research Programme University of Helsinki Institute of Biodiversity Animal Health and Comparative Medicine University of Glasgow Department of Biology Hendrix College Department of Ecological Science Vrije Universiteit Amsterdam Departamento de Ciencias Biológicas y Agropecuarias Universidad Técnica Particular de Loja Departamento de Biologia Universidade Federal de Santa Maria (UFSM) Department of Plant Sciences School of Biology College of Science University of Tehran NTNU University Museum Norwegian University of Science and Technology Red de Estudios Moleculares Avanzados Instituto de Ecología A. C. School of Biological Sciences, University of Reading, Whiteknights Park, Reading, Berkshire, UK Department of Biology Northern Arizona University AZ Department of Biological Sciences MacEwan University AB Max Planck Institute for Plant Breeding Research Departamento de Ecología Evolutiva Instituto de Ecología Universidad Nacional Autónoma de México Max Planck Institute of Molecular Plant Physiology Potsdam-Golm BIO5 Institute University of Arizona AZ Alaska Center for Conservation Science University of Alaska Anchorage Tropical Diversity, Royal Botanical Garden of Edinburgh Département de biologie Université de Moncton Department of Biological Sciences University of Manitoba MB Departments of Microbiology & Statistics University of Manitoba MB Department of Biology University of New Brunswick Department of Biology Kalamazoo College MI BioProtection Research Centre Lincoln University Departamento de Ciencias Facultad de Artes Liberales Universidad Adolfo Ibáñez Department of Ecology Evolution Behaviour University of Minnesota MN Department of Biological Sciences Brock University Department of Environmental Toxicology, University of California, Davis, CA, USA ICB - University of Talca School of Molecular and Life Science Curtin University College of Science Health Engineering and Education Murdoch University, Murdoch School of Life and Environmental Sciences University of Sydney NSW School of Biological Sciences, Monash University, Melbourne, VIC, Australia Department of Biological Sciences Wayne State University MI Department of Biology Western Oregon University, OR School of Natural Resources and the Environment University of Arizona AZ Departamento de Ecología Humana, Cinvestav Mérida Departamento de Ciencias Biológicas y Departamento de Ecología y Biodiversidad Facultad de Ciencias de la Vida, Universidad Andrés Bello Institute of Ecology and Biodiversity (IEB) Department of Biology Lund University Department of Biology Norwegian University of Science and Technology Escuela Superiro de Desarrollo Sustentable Universidad Autónoma de Guerrero -CONACYT Clarkson Secondary School Peel District School Board ON Homelands Sr. Public School Peel District School Board ON Department of Biological Sciences University of Illinois at Chicago Dufferin-Peel Catholic District School Board, St. James Catholic Global Learning Centre Department of Biosciences University of Calgary AB Ecological Processes Branch U.S. Army ERDC-CERL Department of Biology, Oberlin College, Oberlin, OH, USA Escuela Nacional de Estudios Superiores Unidad Morelia UNAM Institute of Evolution and Ecology University of Tübingen Tübingen Department of Evolutionary Biology and Environmental Studies University of Zurich, Winterthurerstrasse Urban Wildlife Institute Department of Conservation and Science, Lincoln Park Zoo Departamento de Ecología Universidad Católica de la Santísima Concepción Department of Biological Sciences University of Denver CO Department of Biological Sciences Mississippi State University MS Department of Biology Center for Computational & Integrative Biology Rutgers University-Camden Kunming Institute of Botany Chinese Academy of Sciences Department of Chemistry & Biochemistry Laurentian University ON Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering College of Life Sciences Beijing Normal University School of BioSciences, University of Melbourne, Melbourne, VIC, Australia Posgrado en Ciencias Biológicas Universidad Nacional Autónoma de México Department of Biological Sciences, Auburn University, Auburn, AL, USA Department of Entomology and Nematology, University of California, Davis, CA, USA Department of Biology University of New Mexico NM Department of Biology University of Wisconsin - Eau Claire Agriculture Institute Iranian Research Organization for Science and Technology (IROST) Department of Biology Colby College ME Instituto de Biología Universidad de Antioquia Department of Biology University of Massachusetts Boston MA Agricultural Biology Colorado State University CO Departamento de Biología Vegetal y Ecología Facultad de Biología Universidad de Sevilla, Av. Reina Mercedes s/n Facultad de Estudios Interdisciplinarios Centro GEMA- Genómica Universidad Mayor Evolutionary Ecology Group Naturalis Biodiversity Center Department of Biology and Chemistry Nipissing University ON, North Bay Center for Ecological Research Kyoto University Bonanza Creek Long Term Ecological Research Program University of Alaska Fairbanks Department of Botany and Molecular Evolution Senckenberg Research Institute and Natural History Museum Frankfurt Departamento de Biodiversidade Instituto de Biociências Univ Estadual Paulista - UNESP Nelson Institute for Environmental Studies University of Wisconsin-Madison WI Department of Biology, California State University, Northridge, Los Angeles, CA, USA Department of Ecology Swedish University of Agricultural Sciences Facultad de Ciencias y Biotecnologia Universidad CES Department of Biology Hofstra University Faculty of Biosciences and Aquaculture Nord University, Bodø Division of Biological Sciences, University of California San Diego, San Diego, CA, USA Department of Biology University of Richmond VA Estación de Biodiversidad Tiputini Colegio de Ciencias Biológicas y Ambientales Universidad San Francisco de Quito USFQ Department of Biological Sciences Institute of Environment Florida International University FL Agronomy Department University of Almería Department of Biological Sciences and Center for Urban Ecology and Sustainability Butler University IN Department of Biological Sciences Louisiana State University LA Faculty of Biological Sciences, Goethe University Frankfurt Institute of Biology Leiden Leiden University Department of Biological and Environmental Science University of Jyväskylä Jyväskylä Department of Biology University of Louisville KY Organization for Programs on Environmental Science University of Tokyo CNRS AgroParisTech Ecologie Systématique et Evolution, Université Paris-Saclay Department of Biology, Providence College, Providence, RI, USA General Zoology Institute for Biology Martin Luther University Halle-Wittenberg International Arctic Research Center University of Alaska Fairbanks Science, Technology and Society Department, Rochester Institute of Technology, Rochester, NY, USA SLU Swedish Species Information Centre Swedish University of Agricultural Sciences Department of Biology Westfield State University MA Centre of New Technologies University of Warsaw Department of Biology, Stanford University, Stanford, CA, USA Plant Biology Department Michigan State University MI Biology Department Davidson College College of Horticulture and Forestry Sciences/ Hubei Engineering Technology Research Center for Forestry Information Huazhong Agricultural University School of Life Sciences Technical University of Munich School of Life Sciences Lanzhou University Institute of Ecology and Evolution University of Bern Department of Evolution Ecology and Behaviour University of Liverpool Departamento de Biodiversidade Instituto de Biociências Univ Estadual Paulista - UNESP
Published: 2022
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158. Towards robust PICOSEC Micromegas precise timing detectors

Author: Lisowska, M, Angelis, Y, Aune, S, Bortfeldt, J, Brunbauer, F, Chatzianagnostou, E, Dehmelt, K, Desforge, D, Fanourakis, G, Floethner, K.J, Gallinaro, M, Garcia, F, Garg, P, Giomataris, I, Gnanvo, K, Gustavsson, T, Iguaz, F.J, Janssens, D, Kallitsopoulou, A, Kovacic, M, Legou, P, Liu, J, Lupberger, M, Malace, S, Maniatis, I, Meng, Y, Muller, H, Oliveri, E, Orlandini, G, Papaevangelou, T, Pomorski, M, Ropelewski, L, Sampsonidis, D, Scharenberg, L, Schneider, T, Scorsone, E, Sohl, L, van Stenis, M, Tsipolitis, Y, Tzamarias, S.E, Utrobicic, A, Veenhof, R, Wang, X, White, S, Zhang, Z, Zhou, Y, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Aristotle University of Thessaloniki, Ludwig-Maximilian University of Munich, CERN [Genève], Stony Brook University [SUNY] (SBU), State University of New York (SUNY), Institute of Nuclear and Particle Physics (INPAC), Shanghai Jiao Tong University [Shanghai], Laboratório de Instrumentačão e Física Experimental de Partículas (LIP), Helsinki Institute of Physics (HIP), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Thomas Jefferson National Accelerator Facility (Jefferson Lab), Laboratoire Interactions, Dynamiques et Lasers (ex SPAM) (LIDyl), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), University of Zagreb, University of Science and Technology of China [Hefei] (USTC), Universität Bonn = University of Bonn, Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire Capteurs Diamant (LCD-LIST), Département Métrologie Instrumentation & Information (DM2I), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, National Technical University of Athens [Athens] (NTUA), Ruđer Bošković Institute, the Fundação para a Ciência e a Tecnologia (FCT), Portugal (CERN/FIS-PAR/0005/2021), the US CMS program under DOE contract No. DEAC02-07CH11359, Weizmann Institute of Science, European Project: 665779,H2020,H2020-MSCA-COFUND-2014,COFUND-FP-CERN-2014(2015), and European Project: 600382,EC:FP7:PEOPLE,FP7-PEOPLE-2012-COFUND,ENHANCED EUROTALENTS(2014)
Subjects: instrumentation, Physics - Instrumentation and Detectors, detector, carbon, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), cesium iodine, electrode, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Cherenkov radiator, muon, radioactivity, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, boron, ionizing radiation, time resolution, physics.ins-det, Micromegas, performance, nuclear instrumentation
Abstract: International audience; The PICOSEC Micromegas (MM) detector is a precise timing gaseous detector consisting of a Cherenkov radiator combined with a photocathode and a MM amplifying structure. A 100-channel non-resistive PICOSEC MM prototype with 10x10 cm$^2$ active area equipped with a Cesium Iodide (CsI) photocathode demonstrated a time resolution below $\sigma$ =18 ps. The objective of this work is to improve the PICOSEC MM detector robustness aspects; i.e. integration of resistive MM and carbon-based photocathodes; while maintaining good time resolution. The PICOSEC MM prototypes have been tested in laboratory conditions and successfully characterised with 150 GeV/c muon beams at the CERN SPS H4 beam line. The excellent timing performance below $\sigma$ = 20 ps for an individual pad obtained with the 10x10 cm$^2$ area resistive PICOSEC MM of 20 M$\Omega$/sq showed no significant time resolution degradation as a result of adding a resistive layer. A single-pad prototype equipped with a 12 nm thick Boron Carbide (B$_4$C) photocathode presented a time resolution below $\sigma$ = 35 ps; opening up new possibilities for detectors with robust photocathodes. The results made the concept more suitable for the experiments in need of robust detectors with good time resolution.
Published: 2023

159. A large area 100 channel Picosec Micromegas detector with sub 20 ps time resolution

Author: Utrobicic, Antonija, Angelis, Yannis, Aune, Stephan, Bortfeldt, Jonathan, Brunbauer, Florian, Chatzianagnostou, Evridiki, Dehmelt, Klaus, Desforge, Daniel, Fanourakis, George, Floethner, Karl Jonathan, Gallinaro, Michele, Garcia, Francisco, Garg, Prakhar, Giomataris, Ioannis, Gnanvo, Kondo, Gustavsson, Thomas, Iguaz, Francisco Jose, Janssens, Djunes, Kallitsopoulou, Alexandra, Kovacic, Marinko, Legou, Philippe, Lisowska, Marta, Liu, Jianbei, Lupberger, Michael, Malace, Simona, Maniatis, Ioannis, Meng, Yue, Muller, Hans, Oliveri, Eraldo, Orlandini, Giorgio, Papaevangelou, Thomas, Pomorski, Michal, Ropelewski, Leszek, Sampsonidis, Dimos, Scharenberg, Lucian, Schneider, Thomas, Sohl, Lukas, van Stenis, Miranda, Tsipolitis, Yorgos, Tzamarias, Spyros, Veenhof, Rob, Wang, Xu, White, Sebastian, Zhang, Zhiyong, Zhou, Yi, Ruđer Bošković Institute, Aristotle University of Thessaloniki, Ludwig-Maximilian University of Munich, CERN [Genève], Stony Brook University [SUNY] (SBU), State University of New York (SUNY), Institute of Nuclear and Particle Physics (INPAC), Shanghai Jiao Tong University [Shanghai], Universität Bonn = University of Bonn, Laboratório de Instrumentačão e Física Experimental de Partículas (LIP), Helsinki Institute of Physics (HIP), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Thomas Jefferson National Accelerator Facility (Jefferson Lab), Laboratoire Interactions, Dynamiques et Lasers (ex SPAM) (LIDyl), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), University of Zagreb, University of Science and Technology of China [Hefei] (USTC), Laboratoire Capteurs Diamant (LCD-LIST), Département Métrologie Instrumentation & Information (DM2I), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, National Technical University of Athens [Athens] (NTUA), EPR & D, CERN Strategic Programme on Technologies for Future Experiments, the RD51 collaboration, in the framework of RD51 common projects, the Cross-Disciplinary Program on Instrumentation and Detection of CEA, the French Alternative Energies andAtomic Energy Commission, the PHENIICS Doctoral School Program of Université Paris-Saclay, France, the Fundamental Research Funds for the Central Universities of China, the Program of National Natural Science Foundation of China (grant number 11935014), the Fundação para a Ciência e a Tecnologia (FCT), Portugal (CERN/FIS-PAR/0005/2021), the US CMS program under DOE contract No. DE-AC02-07CH11359, Weizmann Institute of Science, RD51 at CERN, RD51 collaboration, European Project: 665779,H2020,H2020-MSCA-COFUND-2014,COFUND-FP-CERN-2014(2015), and European Project: 600382,EC:FP7:PEOPLE,FP7-PEOPLE-2012-COFUND,ENHANCED EUROTALENTS(2014)
Subjects: instrumentation, MICROPIC, GEM, Physics - Instrumentation and Detectors, detector, Cherenkov detectors, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], InGrid, Timing detectors, electronic architecture, RETHGEM, Micropattern gaseous detectors (MSGC, radioactivity, MICROMEGAS, MHSP, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, ionizing radiation, THGEM, physics.ins-det, nuclear instrumentation
Abstract: The PICOSEC Micromegas precise timing detector is based on a Cherenkov radiator coupled to a photocathode operating in a semi-transparent mode and a Micromegas amplification structure. The first proof of concept single-channel prototype was able to achieve a time resolution below 25 ps. One of the crucial aspects in the development of precise timing gaseous detectors applicable in high-energy physics experiments is a modular design that enables large area coverage. The first 19-channel multi-pad prototype with an active area of approximately 10 cm$^{2}$ suffered from degraded timing resolution due to the non-uniformity of the preamplification gap thickness. A new 100 cm$^{2}$ detector module with 100 channels based on a rigid hybrid ceramic/FR4 Micromegas board for improved drift gap uniformity was developed. Initial measurements with 80 GeV/c muons showed improvements in timing response over the measured pads and a time resolution below 25 ps. More recent measurements with a thinner drift gap detector module and newly developed RF pulse amplifiers show that the pad centre resolution can be enhanced to the level of 17 ps. This work will present the development of the detector from structural simulations, design, and beam test commissioning with a focus on the timing performance of a thinner drift gap detector module in combination with new electronics using an automated timing scan method. The PICOSEC Micromegas precise timing detector is based on a Cherenkov radiator coupled to a semi-transparent photocathode and a Micromegas amplification structure. The first proof of concept single-channel small area prototype was able to achieve time resolution below 25 ps. One of the crucial aspects in the development of the precise timing gaseous detectors applicable in high-energy physics experiments is a modular design that enables large area coverage. The first 19-channel multi-pad prototype with an active area of approximately 10 cm$^2$ suffered from degraded timing resolution due to the non-uniformity of the preamplification gap. A new 100 cm$^2$ detector module with 100 channels based on a rigid hybrid ceramic/FR4 Micromegas board for improved drift gap uniformity was developed. Initial measurements with 80 GeV/c muons showed improvements in timing response over measured pads and a time resolution below 25 ps. More recent measurements with a new thinner drift gap detector module and newly developed RF pulse amplifiers show that the resolution can be enhanced to a level of 17~ps. This work will present the development of the detector from structural simulations, design, and beam test commissioning with a focus on the timing performance of a thinner drift gap detector module in combination with new electronics using an automated timing scan method.
Published: 2023

160. A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe

Author: P. Marx-Stoelting, G. Rivière, M. Luijten, K. Aiello-Holden, N. Bandow, K. Baken, A. Cañas, A. Castano, S. Denys, C. Fillol, M. Herzler, I. Iavicoli, S. Karakitsios, J. Klanova, M. Kolossa-Gehring, A. Koutsodimou, J. Lobo Vicente, I. Lynch, S. Namorado, S. Norager, A. Pittman, S. Rotter, D. Sarigiannis, M. J. Silva, J. Theunis, T. Tralau, M. Uhl, J. van Klaveren, L. Wendt-Rasch, E. Westerholm, C. Rousselle, P. Sanders, Unión Europea. Comisión Europea. Horizonte Europa, Marx-Stoelting, P., Riviere, G., Luijten, M., Aiello-Holden, K., Bandow, N., Baken, K., Canas, A., Castano, A., Denys, S., Fillol, C., Herzler, M., Iavicoli, I., Karakitsios, S., Klanova, J., Kolossa-Gehring, M., Koutsodimou, A., Vicente, J. L., Lynch, I., Namorado, S., Norager, S., Pittman, A., Rotter, S., Sarigiannis, D., Silva, M. J., Theunis, J., Tralau, T., Uhl, M., van Klaveren, J., Wendt-Rasch, L., Westerholm, E., Rousselle, C., Sanders, P., German Federal Institute for Risk Assessment [Berlin] (BfR), Direction de l'Evaluation des Risques (DER), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), National Institute for Public Health and the Environment [Bilthoven] (RIVM), German Federal Environmental Agency / Umweltbundesamt (UBA), Flemish Institute for Technological Research (VITO), Instituto de Salud Carlos III [Madrid] (ISC), Santé publique France - French National Public Health Agency [Saint-Maurice, France], University of Naples Federico II = Università degli studi di Napoli Federico II, Aristotle University of Thessaloniki, Masaryk University [Brno] (MUNI), General Chemical State Laboratory, Β’Chemical Service of Athens, An. Tsocha 16, Athens, Greece, European Environment Agency (EEA), School of Geography, Earth and Environmental Sciences [Birmingham], University of Birmingham [Birmingham], Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal] (INSA), European Commission - DG Research and Innovation, Direction des affaires européennes et internationales (DAEI), Umweltbundesamt GmbH = Environment Agency Austria, Swedish Chemicals Agency, Direction de la Stratégie et des Programmes (DSP), and European Project: 101057014,Horizon Europe,PARC(2022)
Subjects: Hazard characterisation, Health, Toxicology and Mutagenesis, Chemical, General Medicine, Toxicology, Risk Assessment, New approach methods (NAM), Europe, Next-generation risk assessment (NGRA), Safety assessment, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Exposure assessment, Humans, Chemicals, Human biomonitoring (HBM)
Abstract: Current approaches for the assessment of environmental and human health risks due to exposure to chemical substances have served their purpose reasonably well. Nevertheless, the systems in place for different uses of chemicals are faced with various challenges, ranging from a growing number of chemicals to changes in the types of chemicals and materials produced. This has triggered global awareness of the need for a paradigm shift, which in turn has led to the publication of new concepts for chemical risk assessment and explorations of how to translate these concepts into pragmatic approaches. As a result, next-generation risk assessment (NGRA) is generally seen as the way forward. However, incorporating new scientific insights and innovative approaches into hazard and exposure assessments in such a way that regulatory needs are adequately met has appeared to be challenging. The European Partnership for the Assessment of Risks from Chemicals (PARC) has been designed to address various challenges associated with innovating chemical risk assessment. Its overall goal is to consolidate and strengthen the European research and innovation capacity for chemical risk assessment to protect human health and the environment. With around 200 participating organisations from all over Europe, including three European agencies, and a total budget of over 400 million euro, PARC is one of the largest projects of its kind. It has a duration of seven years and is coordinated by ANSES, the French Agency for Food, Environmental and Occupational Health & Safety. Open Access funding enabled and organized by Projekt DEAL. The European Partnership for the Assessment of Risks from Chemicals has received funding from the European Union’s Horizon Europe research and innovation programme under Grant Agreement No 101057014. Co-funding for the UK contribution via Innovate UK project ID 1752317 as part of the Horizon Europe Guarantee fund. Views and opinions expressed are, however, those of the author(s) only and do not necessarily refect those of the European Union or the Health and Digital Executive Agency. Neither the European Union nor the granting authority can be held responsible for them. Sí
Published: 2023
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161. Globally invariant metabolism but density-diversity mismatch in springtails

Author: Anton M. Potapov, Carlos A. Guerra, Johan van den Hoogen, Anatoly Babenko, Bruno C. Bellini, Matty P. Berg, Steven L. Chown, Louis Deharveng, Ľubomír Kováč, Natalia A. Kuznetsova, Jean-François Ponge, Mikhail B. Potapov, David J. Russell, Douglas Alexandre, Juha M. Alatalo, Javier I. Arbea, Ipsa Bandyopadhyaya, Verónica Bernava, Stef Bokhorst, Thomas Bolger, Gabriela Castaño-Meneses, Matthieu Chauvat, Ting-Wen Chen, Mathilde Chomel, Aimee T. Classen, Jerome Cortet, Peter Čuchta, Ana Manuela de la Pedrosa, Susana S. D. Ferreira, Cristina Fiera, Juliane Filser, Oscar Franken, Saori Fujii, Essivi Gagnon Koudji, Meixiang Gao, Benoit Gendreau-Berthiaume, Diego F. Gomez-Pamies, Michelle Greve, I. Tanya Handa, Charlène Heiniger, Martin Holmstrup, Pablo Homet, Mari Ivask, Charlene Janion-Scheepers, Malte Jochum, Sophie Joimel, Bruna Claudia S. Jorge, Edite Jucevica, Olga Ferlian, Luís Carlos Iuñes de Oliveira Filho, Osmar Klauberg-Filho, Dilmar Baretta, Eveline J. Krab, Annely Kuu, Estevam C. A. de Lima, Dunmei Lin, Zoe Lindo, Amy Liu, Jing-Zhong Lu, María José Luciañez, Michael T. Marx, Matthew A. McCary, Maria A. Minor, Taizo Nakamori, Ilaria Negri, Raúl Ochoa-Hueso, José G. Palacios-Vargas, Melanie M. Pollierer, Pascal Querner, Natália Raschmanová, Muhammad Imtiaz Rashid, Laura J. Raymond-Léonard, Laurent Rousseau, Ruslan A. Saifutdinov, Sandrine Salmon, Emma J. Sayer, Nicole Scheunemann, Cornelia Scholz, Julia Seeber, Yulia B. Shveenkova, Sophya K. Stebaeva, Maria Sterzynska, Xin Sun, Winda I. Susanti, Anastasia A. Taskaeva, Madhav P. Thakur, Maria A. Tsiafouli, Matthew S. Turnbull, Mthokozisi N. Twala, Alexei V. Uvarov, Lisa A. Venier, Lina A. Widenfalk, Bruna R. Winck, Daniel Winkler, Donghui Wu, Zhijing Xie, Rui Yin, Douglas Zeppelini, Thomas W. Crowther, Nico Eisenhauer, Stefan Scheu, Johann-Friedrich Blumenbach Institut für Zoologie und Anthropologie, Georg-August-University = Georg-August-Universität Göttingen, A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences [Moscow] (RAS), German Centre for Integrative Biodiversity Research (iDiv), Institute of Biology, Leipzig University, Leipzig, Germany, Department of Environmental Systems Science [ETH Zürich] (D-USYS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Department of Botany and Zoology, Biosciences Center, Federal University of Rio Grande do Norte (UFRGS), Systems Ecology, Department of Ecological Science, Vrije Universiteit, Amsterdam, The Netherlands, Community and Conservation Ecology Group [Groningen], Université de Groningen, Securing Antarctica’s Environmental Future, School of Biological Sciences, Monash University, Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Department of Zoology, Institute of Biology and Ecology, Faculty of Science, Pavol Jozef Šafárik University in Košice, Košice, Slovakia, Institute of Biology and Chemistry, Moscow Pedagogical State University, Moscow, Russia, Mécanismes Adaptatifs et Evolution (MECADEV), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Department of Soil Zoology, Senckenberg Society for Nature Research, Görlitz, Germany, Department of Soil Science, Centre for Agriculture and Veterinary Science, Santa Catarina State University (UDUESC Lages), Lages, SC, Brazil (UDUESC), Environmental Science Center, Qatar University, Doha, Qatar, Department of Sciences, CEPA Camargo, Astillero, Spain, Visva Bharati University, Bengal, India, Administración de Parques Nacionales, San Antonio, Argentina, School of Biology and Environmental Science - University College of Dublin, University College Dublin [Dublin] (UCD), UCD Earth Institute, University College Dublin, Unidad Multidisciplinaria de Docencia e Investigación, Facultad de Ciencias, Campus Juriquilla, Universidad Nacional Autónoma de México, Querétaro, México, Etude et Compréhension de la biodiversité (ECODIV), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Institute of Entomology [České Budějovice] (BIOLOGY CENTRE CAS), Biology Centre of the Czech Academy of Sciences (BIOLOGY CENTRE CAS), Czech Academy of Sciences [Prague] (CAS)-Czech Academy of Sciences [Prague] (CAS), FiBL France, Department of Ecology and Evolutionary Biology, Museum of Zoology, The University of Michigan Research Museums Center, Ann Arbor, Michigan 48108-2228, USA, Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Departmento de Biología Zoología, Universidad Autónoma de Madrid, Madrid, Spain, Institute of Biology Bucharest, Romanian Academy, Department of General and Theoretical Ecology, University of Bremen, University of Bremen, Conservation Ecology, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, The Netherlands, Department of Coastal Systems, Royal Netherlands Institute for Sea Research, ‘t Horntje, the Netherlands, Forestry and Forest Products Research Institute (FFPRI), Université du Québec à Montréal = University of Québec in Montréal (UQAM), Ningbo University (NBU), Université du Québec en Outaouais (UQO), Universidad Nacional de Misiones, University of Pretoria [South Africa], Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland (HEdS-Ge / HES-SO), Section of Terrestrial Ecology, Department of Ecoscience, Aarhus University, Aarhus, Denmark, Instituto de Recursos Naturales y Agrobiología de Sevilla (IRNAS), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Tallinn University of Technology, Tartu College, Department of Biological Sciences, University of Cape Town, Cape Town, South Africa, Department of Entomology, Iziko Museums of South Africa, Cape Town, South Africa, Ecologie fonctionnelle et écotoxicologie des agroécosystèmes (ECOSYS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS), Institute of Biology, University of Latvia, Riga, Latvia, Department of Soil Science, Centre for Agriculture and Veterinary Science, Santa Catarina State University (UDESC-Lages), Lages, SC, Brazil, Department of Animal Science, Santa Catarina State University (UDESC Oeste), Chapecó, SC, Brazil, Department of Soil and Environment, Swedish University of Agricultural Sciences, Uppsala, Sweden, Climate Impacts Research Centre (CIRC), Umeå University, Estonian University of Life Sciences (EMU), Universidade Federal do Rio de Janeiro (UFRJ), Key Laboratory of the Three Gorges Reservoir Region’s Eco-Environment, Ministry of Education, Chongqing University, Chongqing, China, Department of Biology, University of Western Ontario, University of Western Ontario (UWO), Universidad Autónoma de Madrid (UAM), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Rice University [Houston], Wildlife and Ecology Group [New Zealand], Massey University, Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama, Japan, Department of Sustainable Crop Production (DI.PRO.VE.S.), Università Cattolica del Sacro Cuore, Piacenza, Italy, University of Cadiz, Netherlands Institute of Ecology - NIOO-KNAW (NETHERLANDS), Instituto de Biología, Universidad Nacional Autónoma de México, Ciudad Universitaria México, Natural History Museum [Vienna] (NHM), University of Natural Resources and Life Sciences, Department of Integrated Biology and Biodiversity Research, Institute of Zoology (BOKU), King Abdulaziz University, Department of Biological Sciences, Université du Québec à Montréal, Lancaster Environment Centre, Lancaster University, Smithsonian Tropical Research Institute, Senckenberg Museum of Natural History Görlitz, Senckenberg – Leibniz Institution for Biodiversity and Earth System Research - Senckenberg Gesellschaft für Naturforschung, Leibniz Association-Leibniz Association, Institute for Alpine Environment, Eurac Research, Ecology, University of Innsbruck, Leopold Franzens Universität Innsbruck - University of Innsbruck, State Nature Reserve 'Privolzhskaya Lesostep', Penza, Russia, Museum and Institute of Zoology, Polish Academy of Sciences, Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China, Institute of Biology Komi Science Centre UB RAS, University of Bern, Aristotle University of Thessaloniki, Great Lakes Forestry Centre, Canadian Forest Service, Natural Resources Canada, Sault Ste. Marie, ON, Canada, Department of Ecology, Swedish University of Agricultural Sciences, Uppsala, Sweden, Greensway AB, Uppsala, Sweden, Institute of Wildlife Biology and Game Management, University of Natural Resources and Life Sciences, Institute of Wildlife Management and Wildlife Biology, University of Sopron, Sopron, Hungary, Key laboratory of Wetland Ecology and Environment, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun 130102, China, Ministry of Education Key Laboratory of Vegetation Ecology, School of Life Sciences, Northeast Normal University, Changchun 130024, Jilin Provincial Key Laboratory of Animal Resource Conservation and Utilization, School of Life Sciences, Northeast Normal University, Changchun 130024, Community Department, Helmholtz Center for Environmental Research, Halle, Germany, State University of Paraiba, Institute of Integrative Biology, Centre for Biodiversity and Sustainable Land-use [University of Göttingen] (CBL), Terrestrial Ecology (TE), Conservation Ecology Group, Govers group, Ecology & Evolution, Amsterdam Sustainability Institute, Systems Ecology, Animal Ecology, Muséum national d'Histoire naturelle (MNHN)-École Pratique des Hautes Études (EPHE), Université Paul-Valéry - Montpellier 3 (UPVM)-École Pratique des Hautes Études (EPHE), Unité Mixte de Recherche sur l'Ecosystème Prairial - UMR (UREP), and VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: [SDV]Life Sciences [q-bio], Soil Science, General Physics and Astronomy, 580 Plants (Botany), 000 Computer science, knowledge & systems, Markvetenskap, 590 Tiere (Zoologie), General Biochemistry, Genetics and Molecular Biology, Soil, terrestrial food web, SDG 13 - Climate Action, Humans, Animals, 000 Informatik, Wissen, Systeme, Macroecology, Arthropods, Tundra, Ecosystem, Ekologi, Multidisciplinary, Ecology, soil fertility, collembola, Biodiversity, General Chemistry, 580 Pflanzen (Botanik), Settore AGR/11 - ENTOMOLOGIA GENERALE E APPLICATA, [SDE]Environmental Sciences, 570 Life sciences, biology, 590 Animals (Zoology), 570 Biowissenschaften, Biologie
Abstract: Soil life supports the functioning and biodiversity of terrestrial ecosystems. Springtails (Collembola) are among the most abundant soil arthropods regulating soil fertility and flow of energy through above- and belowground food webs. However, the global distribution of springtail diversity and density, and how these relate to energy fluxes remains unknown. Here, using a global dataset representing 2470 sites, we estimate the total soil springtail biomass at 27.5 megatons carbon, which is threefold higher than wild terrestrial vertebrates, and record peak densities up to 2 million individuals per square meter in the tundra. Despite a 20-fold biomass difference between the tundra and the tropics, springtail energy use (community metabolism) remains similar across the latitudinal gradient, owing to the changes in temperature with latitude. Neither springtail density nor community metabolism is predicted by local species richness, which is high in the tropics, but comparably high in some temperate forests and even tundra. Changes in springtail activity may emerge from latitudinal gradients in temperature, predation and resource limitation in soil communities. Contrasting relationships of biomass, diversity and activity of springtail communities with temperature suggest that climate warming will alter fundamental soil biodiversity metrics in different directions, potentially restructuring terrestrial food webs and affecting soil functioning. The article is an outcome of the #GlobalCollembola community initiative that is voluntarily supported by researchers around the world. Data collection and analysis was supported by the Russian Science Foundation (19-74-00154 to A.P.) and by Deutsche Forschungsgemeinschaft (493345801 to A.P. and 192626868—SFB 990 to S.S.). We acknowledge support by the Open Access Publication Funds of the Göttingen University. The following funding bodies provided support for individual contributors: ARC SRIEAS Grant SR200100005 Securing Antarctica’s Environmental Future to S.L.C., Slovak Scientific Grant Agency VEGA 1/0438/22 to Ľ.K., RFBR 19-516-60002 to N.A.K., Carl Tryggers Stiftelse för Vetenskaplig Forskning and Qatar Petroleum to J.M.A., BIO 27 (2013-2014)-MAGyP and PICTO 2084 (2012)-ANPCyT to V.B., DAAD-19-10 and MSM200962001 to T.C., grant TE, PN-III-P1-1.1-TE-2019-0358 to C.F., NWO grant 821.01.015 to O.F., National Natural Sciences Foundation of China No 41471037 and 41871042 to M.G., BIO 27 (2013-2014), MAGyP; PICT 2084 (2012), FONCyT to D.F.G., NRF South African National Antarctic Programme grant 110734 to M.G., Natural Resources Canada (NRCan), EcoEnergy Innovation Initiative under the Office of Energy Research and Development, and the Natural Sciences and Engineering Research Council of Canada (NSERC) to I.T.H., L.A.V. and L.R., Independent Research Fund Denmark grant no. DFF-4002-00384 to M.H., Estonian Science Foundation G9145 to M.I., SA-France bilateral grant to C.J., SA (NRF)/Russia (RFBR) Joint Science and Technology Research Collaboration project no. 19-516-60002 (FRBR) and no. 118904 (NRF) to M.P. and C.J., European Research Council (ERC), European Union’s Horizon 2020 research and innovation programme (grant agreement no. 677232; to N.E.); iDiv, German Research Foundation (DFG–FZT 118, 202548816) to M.J. and N.E., French National Agency of Research (ANR) (JASSUR research project; ANR-12-VBDU-0011), «Ministère de l’Agriculture et de la Pêche» and «Ministère de l’Education Nationale de la Recherche et de la Technologie» (ACTA programme), «Ministère de l’Aménagement du Territoire et de l’Environnement» (Pnetox programme), EU-funded project, ECOGEN QLK5-CT-2002-01666 (www.ecogen.dk), “Agence de l’Environnement et de la Maîtrise de l'Énergie” (BIOINDICATEUR 2, BIOTECHNOSOL), ANDRA and GISFI (www.gisfi.fr) to S.J., GRR SER-BIODIV (Région Normandie, France) to MCha, ESF9258, B02 to A.K., Fundamental Research Funds for the Central Universities (grant no. 2018CDXYCH0014) to D.L., DFG 316045089 to J.L., Massey University Research Fund grant to M.A.M., DFG SCHE 376/38-2 to M.M.P., grant from the Austria Academy of Science: Heritage_2020-043_Modeling-Museum to P.Q., Slovak Scientific Grant Agency: VEGA Nos. 1/0441/03 and 1/3267/06 to N.R., Higher Education Commission of Pakistan to M.I.R., RSF 21-74-00126 to R.A.S., Austrian Federal Government and European Union (Rural Development 2014-2020) to J.S., АААА-А17-122040600025-2 to A.A.T., Brazilian Council for Scientific and Technological Development—CNPq (grant no. 152717/2016-1) to B.R.W., 309030/2018-8 to D.Z. and 305426/2018-4 to B.C.B., National Natural Science Foundation of China (31970434, 31772491) to N.N.G., Research and Innovation Support Foundation of Santa Catarina (FAPESC) (6.309/2011-6/FAPESC) and the CNPq (563251/2010-7/CNPq) to L.C.I.O.F., O.K.-F., the Latvian Council of Science Grants no. 90.108, 93.140, 96.0110, 01.0344 to E.J., CNPq for the Research Productivity Grant (305939/2018-1) to D.B., FPI-MICINN grant in the project INTERCAPA (CGL2014-56739-R) to P.H, the Natural Sciences and Engineering Research Council of Canada (NSERC) to Z.L., Ministry of Innovation and Technology of Hungary TKP2021-NKTA-43 to D.W. Authors are grateful to Penelope Greenslade for providing the literature on Australian Collembola communities. Authors are grateful to Frans Janssens for providing the global checklist of Collembola.
Published: 2023
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162. How to distinguish wild and domesticated grape pips: comparison of morphometric methods and insights into early viticulture in Neolithic and Bronze Age Greece

Author: Pagnoux, Clémence, Bonhomme, Vincent, Bouby, Laurent, Ivorra, Sarah, Allen, Susan, Valamoti, Soultana-Maria, Archéozoologie, archéobotanique : sociétés, pratiques et environnements (AASPE), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), University of Cincinnati (UC), Aristotle University of Thessaloniki, ANR-16-CE27-0013,VINICULTURE,Vignes et vins en France du Néolithique au Moyen Age. Approche intégrée en archéosciences(2016), and European Project: 682529,H2020,ERC-2015-CoG,PLANTCULT(2016)
Subjects: [SDE]Environmental Sciences, [SHS]Humanities and Social Sciences
Abstract: International audience; The origins of viticulture and the domestication of the grapevine have been, for decades, the subject of much research and works, notably on the basis of archaeobotanical remains. Size and shape differences of grape pips have been used to identify wild and domesticated grapevines. Analyses have been performed on archaeological material using several measurements: length and breadth of the pip, length of the stalk, placement of the chalaza and indices involving these measurements (e.g., Mangafa & Kotsakis 1996). First investigations suggested that the performances of traditional methods based on size parameters can vary largely when applied to modern cultivars (Bouby & Marinval 2001). Recent studies using size measurements and ratios highlighted the importance of comparing archaeological material to a representative reference collection of mordern cultivars and wild populations (Bouby et al. 2013). The shape of the grape pip offers features allowing not only the distinction between wild and domesticated grapevines, but also the identification of cultivars. This approach is based on pip outline analysis using Elliptic Fourier transform (Terral et al. 2010, Pagnoux et al. 2015). However, reproducibility and measurement errors has not been extensively tested, especially for traditional methods based on size features. Yet well founded, both traditional and geometric morphometric methods need rock-solid methodological foundations.This paper aims to propose a reproducible and reliable method that combines the best discrimination between wild and domesticated grapevine. The analyses were performed on a set of modern reference consisting of 34 cultivated varieties and 13 wild individuals. Then we benchmarked predicted identification of grape pips using various combinations of measurements, provided by the above-cited works, and using state-of-the-art statistical approaches.Finally, archaeological grape pips were compared to the set of modern reference using the same measurements. We used, as a case study, grape pips from three sites located in Northern and Southern Greece and dated from the Final Neolithic (ca. 4500-4000 BC) to the Late Bronze Age (1500-1200 BC): of Dikili Tash, Tsoungiza and P.O.T.A. Romanou.
Published: 2023

163. Les sinus frontaux au cours de l’évolution humaine

Author: Balzeau, Antoine, Albessard-Ball, Lou, Kubicka, Anna Maria, Filippo, Andréa, Beaudet, Amélie, Santos, Elena, Bienvenu, Thibault, Arsuaga, Juan-Luis, Bartsiokas, Antonis, Berger, Lee, Bermúdez de Castro, José María, Brunet, Michel, Carlson, Kristian J., Daura, Joan, Gorgoulis, Vassilis G., Grine, Frederick E., Harvati, Katerina, Hawks, John, Herries, Andy, Hublin, Jean-Jacques, Martin, Jesse, Martinón-Torres, Maria, May, Hila, Mounier, Aurélien, Du Plessis, Anton, Rae, Todd, Röding, Carolin, Sanz, Montserrat, Semal, Patrick, Stratford, Dominic, Stringer, Chris, Tawane, Mirriam, Temming, Heiko, Tsoukala, Evangelia, Zilhão, João, Zipfel, Bernhard, Buck, Laura T., Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Poznan University of Life Sciences (Uniwersytet Przyrodniczy w Poznaniu) (PULS), University of Cambridge [UK] (CAM), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Departamento de Ciencias de la Vida, Universidad de Alcalá - University of Alcalá (UAH), Universität Zürich [Zürich] = University of Zurich (UZH), Democritus University of Thrace (DUTH), James Cook University (JCU), Centro Nacional de Investigación sobre la Evolución Humana (CENIEH), Department of Anthropology [University College of London], University College of London [London] (UCL), Laboratoire de paléontologie, évolution, paléoécosystèmes, paléoprimatologie (PALEVOPRIM ), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Collège de France (CdF (institution)), University of the Witwatersrand [Johannesburg] (WITS), Universitat de Barcelona (UB), University of Athens Medical School [Athens], Biomedical Research Foundation of the Academy of Athens (BRFAA), Ninewells Hospital and Medical School [Dundee], Faculty of Biology, Medicine and Health [Manchester, UK], University of Manchester [Manchester], Stony Brook University [SUNY] (SBU), State University of New York (SUNY), Senckenberg Centre for Human Evolution and Palaeoenvironment (HEP), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, University of Wisconsin-Madison, Department of Earth Ocean and Ecological Sciences [Liverpool], University of Liverpool, Collège de France - Chaire Paléoanthropologie, Max Planck Institute for Evolutionary Anthropology [Leipzig], Max-Planck-Gesellschaft, Tel Aviv University (TAU), Turkana Basin Institute, University of Roehampton, United Kingdom, UNIARQ, Universidade de Lisboa = University of Lisbon (ULISBOA), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Archaeology, School of Geography, Archaeology and Environmental Studies, University of the Witwatersrand, (GAES), The Natural History Museum [London] (NHM), Ditsong National Museum of Natural History, Department of Human Evolution [Leipzig], Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, School of Geology, Thessaloniki, Aristotle University of Thessaloniki, Institució Catalana de Recerca i Estudis Avançats (ICREA), and Centro de Arqueologia da Universidade de Lisboa (UNIARQ)
Subjects: [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, [SHS]Humanities and Social Sciences
Abstract: International audience
Published: 2023
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164. Clostridium botulinum type C, D, C/D, and D/C: An update

Author: Meurens, François, Carlin, Frédéric, Federighi, Michel, Filippitzi, Maria-Eleni, Fournier, Matthieu, Fravalo, Philippe, Vaillancourt, Jean-Pierre, Ganière, Jean-Pierre, Grisot, Lionel, Guillier, Laurent, Hilaire, Didier, Kooh, Pauline, Woudstra, Cédric, Le Bouquin-Leneveu, Sophie, Le Maréchal, Caroline, Mazuet, Christelle, Petit, Karine, Morvan, Hervé, Biologie, Epidémiologie et analyse de risque en Santé Animale (BIOEPAR), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Saskatchewan [Saskatoon] (U of S), Sécurité et Qualité des Produits d'Origine Végétale (SQPOV), Avignon Université (AU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Sécurité des Aliments (SECALIM), Aristotle University of Thessaloniki, Morphodynamique Continentale et Côtière (M2C), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Metabiot (Metabiot), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Faculté de Médecine Vétérinaire [UdeM-Saint-Hyacinthe] (FMV - UdeM), Université de Montréal (UdeM), Retired, Clinique des Tourbières, Direction de l'Evaluation des Risques (DER), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Maîtrise nucléaire, radiologique, bactériologique et chimique (MNRBC), Direction générale de l'Armement (DGA), IT University of Copenhagen (ITU), Laboratoire de Ploufragan-Plouzané-Niort [ANSES], Centre National de Référence des Bactéries Anaérobies et Botulisme - National Reference Center Anaerobic Bacteria and Botulism (CNR), and Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité)
Subjects: Microbiology (medical), Clostridium, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, botulism, cattle, poultry, [SDV]Life Sciences [q-bio], toxins, zoonosis, Microbiology
Abstract: We are grateful to the ANSES expert committee panel in charge of assessing animal health and animal welfare risk, and to the working group “Botulism,” including the authors as well as Catherine Belloc, Stéphane Bertagnoli, Alain Boissy, Henri-Jean Boulouis, Eric Collin, Jean-Claude Desfontis, David Fretin, Emmanuelle Gilot-Fromont, Etienne Giraud, Nadia Haddad, Viviane Hénaux, Elsa Jourdain, Sophie Le Poder-Alcon, Monique L’Hostis, Gilles Meyer, Elodie Monchatre-Leroy, Pierre Mormède, Carine Paraud, Ariane Payne, Carole Peroz-Sapede, Claire Ponsart, Claude Saegerman, Gaëlle Simon, Michèle Tremblay, Nathalie Arnich, Isabelle Attig, Carole Catastini, Charlotte Dunoyer, Nabila Haddache, and Elissa Khamisse.; International audience; Clostridium botulinum is the main causative agent of botulism, a neurological disease encountered in humans as well as animals. Nine types of botulinum neurotoxins (BoNTs) have been described so far. Amongst these “toxinotypes,” the A, the B and E are the most frequently encountered in humans while the C, D, C/D and D/C are mostly affecting domestic and wild birds as well as cattle. In France for instance, many cases and outbreaks are reported in these animal species every year. However, underestimation is very likely at least for avifauna species where the detection of dead animals can be challenging. Knowledge about BoNTs C, D, C/D, and D/C and the diseases they cause in animals and humans is still scarce and unclear. Specifically, the potential role of animal botulism outbreaks in cattle and poultry as a source of human illness needs to be further assessed. In this narrative review, we present the current knowledge about toxinotypes C, D, C/D, and D/C in cattle and poultry with, amongst various other aspects, their epidemiological cycles. We also discuss the zoonotic potential of these toxinotypes and some possible ways of risk mitigation. An adapted and effective management of botulism outbreaks in livestock also requires a better understanding of these less common and known toxinotypes.
Published: 2023
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165. Precipitation frequency in Med-CORDEX and EURO-CORDEX ensembles from 0.44° to convection-permitting resolution: impact of model resolution and convection representation

Author: Minh Truong Ha, S. Bastin, P. Drobinski, L. Fita, J. Polcher, O. Bock, M. Chiriaco, D. Belušić, C. Caillaud, A. Dobler, J. Fernandez, K. Goergen, Ø. Hodnebrog, S. Kartsios, E. Katragkou, A. Lavin-Gullon, T. Lorenz, J. Milovac, H.-J. Panitz, S. Sobolowski, H. Truhetz, K. Warrach-Sagi, V. Wulfmeyer, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), SPACE - LATMOS, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Météorologie Dynamique (UMR 8539) (LMD), Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-École des Ponts ParisTech (ENPC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Centro de Investigaciones del Mar y la Atmósfera (CIMA), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Facultad de Ciencias Exactas y Naturales [Buenos Aires] (FCEyN), Universidad de Buenos Aires [Buenos Aires] (UBA)-Universidad de Buenos Aires [Buenos Aires] (UBA), Institut de Physique du Globe de Paris (IPGP (UMR_7154)), Institut national des sciences de l'Univers (INSU - CNRS)-Université de La Réunion (UR)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Department of Geophysics [Zagreb], Faculty of Science [Zagreb], University of Zagreb-University of Zagreb, Swedish Meteorological and Hydrological Institute (SMHI), Centre national de recherches météorologiques (CNRM), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Norwegian Meteorological Institute [Oslo] (MET), Instituto de Física de Cantabria (IFCA), Universidad de Cantabria [Santander]-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institute of Bio- and Geosciences [Jülich] (IBG), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association-Helmholtz-Gemeinschaft = Helmholtz Association, Center for International Climate and Environmental Research [Oslo] (CICERO), University of Oslo (UiO), Department of Meteorology and Climatology [Thessaloniki], Aristotle University of Thessaloniki, Bjerknes Centre for Climate Research (BCCR), Department of Biological Sciences [Bergen] (BIO / UiB), University of Bergen (UiB)-University of Bergen (UiB), Institute of Meteorology and Climate Research, Karlsruhe Institute of Technology (KIT), Wegener Center for Climate and Global Change (WEGC), Karl-Franzens-Universität Graz, Institute of Physics and Meteorology [Stuttgart] (IPM), and University of Hohenheim
Subjects: Earth sciences, Atmospheric Science, Precipitation triggering, Convection-permitting models, Convection processes, Integrated water vapor, ddc:550, [SDU.STU.ME]Sciences of the Universe [physics]/Earth Sciences/Meteorology
Abstract: Recent studies using convection-permitting (CP) climate simulations have demonstrated a step-change in the representation of heavy rainfall and rainfall characteristics (frequency-intensity) compared to coarser resolution Global and Regional Climate models. The goal of this study is to better understand what explains the weaker frequency of precipitation in the CP ensemble by assessing the triggering process of precipitation in the different ensembles of regional climate simulations available over Europe. We focus on the statistical relationship between tropospheric temperature, humidity and precipitation to understand how the frequency of precipitation over Europe and the Mediterranean is impacted by model resolution and the representation of convection (parameterized vs. explicit). We employ a multi-model data-set with three different resolutions (0.44°, 0.11° and 0.0275°) produced in the context of the MED-CORDEX, EURO-CORDEX and the CORDEX Flagship Pilot Study "Convective Phenomena over Europe and the Mediterranean" (FPSCONV). The multi-variate approach is applied to all model ensembles, and to several surface stations where the integrated water vapor (IWV) is derived from Global Positioning System (GPS) measurements. The results show that all model ensembles capture the temperature dependence of the critical value of IWV (IWVcv), above which an increase in precipitation frequency occurs, but the differences between the models in terms of the value of IWVcv, and the probability of its being exceeded, can be large at higher temperatures. The lower frequency of precipitation in convection-permitting simulations is not only explained by higher temperatures but also by a higher IWVcv necessary to trigger precipitation at similar temperatures, and a lower probability to exceed this critical value. The spread between models in simulating IWVcv and the probability of exceeding IWVcv is reduced over land in the ensemble of models with explicit convection, especially at high temperatures, when the convective fraction of total precipitation becomes more important and the influence of the representation of entrainment in models thus becomes more important. Over lowlands, both model resolution and convection representation affect precipitation triggering while over mountainous areas, resolution has the highest impact due to orography-induced triggering processes. Over the sea, since lifting is produced by large-scale convergence, the probability to exceed IWVcv does not depend on temperature, and the model resolution does not have a clear impact on the results.
Published: 2023
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166. Compact Modeling of Nanoscale Trapezoidal FinFETs

Author: Charalabos A. Dimitriadis, T.A. Karatsori, N. Fasarakis, Matthias Bucher, Gerard Ghibaudo, D. H. Tassis, A. Tsormpatzoglou, K. A. Papathanasiou, Aristotle University of Thessaloniki, Department of Physics, Electronics Laboratory, Physics Department, Aristotle University of Thessaloniki, Technical University of Crete [Chania], Institut de Microélectronique, Electromagnétisme et Photonique - Laboratoire d'Hyperfréquences et Caractérisation (IMEP-LAHC), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National Polytechnique de Grenoble (INPG)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Université Grenoble Alpes (UGA), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)
Subjects: drain current, Materials science, business.industry, Doping, Compact modeling, Hardware_PERFORMANCEANDRELIABILITY, Electronic, Optical and Magnetic Materials, nanoscale trapezoidal FinFETs, Cross section (physics), transcapacitances, MOSFET, Electronic engineering, Hardware_INTEGRATEDCIRCUITS, Optoelectronics, Electrical and Electronic Engineering, [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, business, Drain current, Nanoscopic scale, Device parameters
Abstract: International audience; An analytical compact model for the drain current of undoped or lightly doped nanoscale FinFETs with trapezoidal cross section is proposed. The compact model of rectangular FinFETs is extended to trapezoidal FinFETs using equivalent nonplanar device parameters and corner effects. The model has been validated by comparing the results with those of 3-D numerical device simulations. The very good accuracy of the drain current and transcapacitances makes the proposed model suitable for implementation in circuit simulation tools.
Published: 2014
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167. Projet FLOCK-REPROD

Author: Pellicer-Rubio, Maria-Teresa, Rault, Sylvie, Boue, P., Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Institut Français du Cheval et de l'Equitation [Saumur]-Institut National de la Recherche Agronomique (INRA), Capgènes, REA-Research Executive Agency, FP7/2007-2013, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Instituto Nacional dos Recursos Biológicos (INRB), Università degli Studi di Sassari (UniSS), VEF, Ovidius University of Constanta, Aristotle University of Thessaloniki, Partenaires : Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Instituto Nacional dos Recursos Biológicos (INRB), Università degli Studi di Sassari (UniSS), VEF, Ovidius University of Constanta, Aristotle University of Thessaloniki, Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), ProdInra, Migration, and Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], [SDV.OT] Life Sciences [q-bio]/Other [q-bio.OT]
Abstract: Projet de recherche Européen Periodic report: Final Report Partenaires : Associations de PME. Elles représentent un total de 1549 éleveurs européens issus de 27 coopératives (CAPGENES France, ACRIMUR Espagne, KPRA Espagne, ARAL Italie, OPG Moravec Croatie, CAPRIROM Roumanie, OLYMPOS Grèce).
Published: 2013

168. Evaluating the impact of chemical boundary conditions on near surface ozone in regional climate-air quality simulations over Europe

Author: Ioannis Pytharoulis, K. Markakis, Eleni Katragkou, Th. Karacostas, Prodromos Zanis, Ioannis Tegoulias, Dimitris Akritidis, Anastasia Poupkou, Martin G. Schultz, Department of Meteorology and Climatology [Thessaloniki], Aristotle University of Thessaloniki, Institut für Energie- und Klimaforschung - Troposphäre (IEK-8), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association-Helmholtz-Gemeinschaft = Helmholtz Association, Laboratory of Atmospheric Physics [Thessaloniki], Laboratoire de Météorologie Dynamique (UMR 8539) (LMD), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS)-Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École des Ponts ParisTech (ENPC)-École polytechnique (X)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut für Energie- und Klimaforschung - Troposphäre ( IEK-8 ), Forschungszentrum Jülich GmbH, Laboratory of Atmospheric Physics, Aristotle University of Thessaloniki, Greece, Laboratoire de Météorologie Dynamique (UMR 8539) ( LMD ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -École polytechnique ( X ) -École des Ponts ParisTech ( ENPC ) -Centre National de la Recherche Scientifique ( CNRS ) -Département des Géosciences - ENS Paris, and École normale supérieure - Paris ( ENS Paris ) -École normale supérieure - Paris ( ENS Paris )
Subjects: [ SDU.OCEAN ] Sciences of the Universe [physics]/Ocean, Atmosphere, [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, Atmospheric Science, Meteorological reanalysis, Ozone, 010504 meteorology & atmospheric sciences, Scale (ratio), Forcing (mathematics), 010501 environmental sciences, Atmospheric sciences, 01 natural sciences, CAMX, chemistry.chemical_compound, chemistry, 13. Climate action, [SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/Climatology, Climatology, Climate model, Tropospheric ozone, [ SDU.STU.CL ] Sciences of the Universe [physics]/Earth Sciences/Climatology, Air quality index, 0105 earth and related environmental sciences
Abstract: International audience; A modeling system based on the air quality model CAMx driven off-line by the regional climate model RegCM3 is used for assessing the impact of chemical lateral boundary conditions (LBCs) on near surface ozone over Europe for the period 1996-2000. The RegCM3 and CAMx simulations were performed on a 50. km. ×. 50. km grid over Europe with RegCM3 driven by the NCEP meteorological reanalysis fields and CAMx with chemical LBCs from ECHAM5/MOZART global model. The recent past period (1996-2000) was simulated in three experiments. The first simulation was forced using time and space invariant LBCs, the second was based on ECHAM5/MOZART chemical LBCs fixed for the year 1996 and the third was based on ECHAM5/MOZART chemical LBCs with interannual variability. Anthropogenic and biogenic emissions were kept identical for the three sensitivity runs.In order to evaluate the ability of the RegCM3/CAMx modeling system and assess the impact of varying chemical LBCs, simulated surface ozone concentrations are compared against measurements from the EMEP network using various statistical metrics. The evaluation indicates that implementation of time and space variant chemical LBCs of a global chemistry transport model (CTM) improves the RegCM/CAMx performance with respect to seasonal variability, especially at stations close to the borders of the model domain over north and northwestern Europe. The modeling system reproduces the seasonal variability of ozone when LBCs from ECHAM5/MOZART model are applied for the vast majority of stations. On a seasonal basis, the varying chemical LBCs resulted in improvement of both model bias and variance of simulated versus observed ozone for all seasons. Finally taking into account all the statistical measures assessed for the comparison of RegCM3/CAMx and ECHAM5/MOZART with observed ozone, a slight improvement for the regional air quality model is indicated but this finding should be perceived with caution as the regional scale simulation and the global scale simulation have a different meteorological forcing. © 2013 Elsevier B.V.
Published: 2013
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169. The simulation of European heat waves from an ensemble of regional climate models within the EURO-CORDEX project

Author: Tomas Halenka, Ivan Güttler, Michel Déqué, Erik van Meijgaard, Grigory Nikulin, Martin Suklitsch, Robert Vautard, Volker Wulfmeyer, Andreas Gobiet, Theodore Karacostas, Augustin Colette, Markel García-Díez, Michal Belda, Mirta Patarčić, Klaus Goergen, Jesús Fernández, Pascal Yiou, Eleni Katragkou, Stephanie Mayer, Kirsten Warrach-Sagi, Klaus Keuler, John Scinocca, Sven Kotlarski, Daniela Jacob, Stefan Sobolowski, Claas Teichmann, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Extrèmes : Statistiques, Impacts et Régionalisation (ESTIMR), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Wegener Center for Climate and Global Change (WEGC), Karl-Franzens-Universität Graz, Institute for Geophysics, Astrophysics and Meteorology [Graz] (IGAM), Climate Service Center, Department of Meteorology and Environment Protection, Charles University [Prague] (CU), Institut National de l'Environnement Industriel et des Risques (INERIS), Centre national de recherches météorologiques (CNRM), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Department Applied Mathematics and Computer Science, Universidad de Cantabria [Santander], Instituto de Fisica de Cantabria, Instituto de Física de Cantabria, Centre de Recherche Public - Gabriel Lippmann (LUXEMBOURG), Croatian Meteorological and Hydrological Service (DHMZ), Aristotelian University of Thessaloniki, Aristotle University of Thessaloniki, Brandenburg University of Technology [Cottbus – Senftenberg] (BTU), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Bjerknes Centre for Climate Research (BCCR), Department of Biological Sciences [Bergen] (BIO / UiB), University of Bergen (UiB)-University of Bergen (UiB), Royal Netherlands Meteorological Institute (KNMI), Swedish Meteorological and Hydrological Institute (SMHI), Canadian Centre for Climate Modelling and Analysis (CCCma), Environment and Climate Change Canada, Max Planck Institute for Meteorology (MPI-M), Max-Planck-Gesellschaft, Institute of Physics and Meteorology [Stuttgart] (IPM), University of Hohenheim, European Commission, Fonds National de la Recherche Luxembourg, Ministerio de Ciencia e Innovación (España), Charles University (Czech Republic), Deutsche Forschungsgemeinschaft, Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Karl-Franzens-Universität [Graz, Autriche], Groupe d'étude de l'atmosphère météorologique (CNRM-GAME), Institut national des sciences de l'Univers (INSU - CNRS)-Météo France-Centre National de la Recherche Scientifique (CNRS), and German Research Foundation
Subjects: Convection, Atmospheric Science, Percentile, 010504 meteorology & atmospheric sciences, 0207 environmental engineering, Scale (descriptive set theory), 02 engineering and technology, 01 natural sciences, Heat waves, Hot Temperature, Climate projections, Precipitation, Bowen ratio, 020701 environmental engineering, Model evaluation, 0105 earth and related environmental sciences, Microphysics, Regional climate modeling, regional climate modeling, heat waves, model evaluation, climate projection, EURO-CORDEX, Climate projection, 13. Climate action, Climatology, [SDE]Environmental Sciences, Environmental science, Climate model
Abstract: The ability of a large ensemble of regional climate models to accurately simulate heat waves at the regional scale of Europe was evaluated. Within the EURO-CORDEX project, several state-of-the art models, including non-hydrostatic meso-scale models, were run for an extended time period (20 years) at high resolution (12 km), over a large domain allowing for the first time the simultaneous representation of atmospheric phenomena over a large range of spatial scales. Eight models were run in this configuration, and thirteen models were run at a classical resolution of 50 km. The models were driven with the same boundary conditions, the ERA-Interim re-analysis, and except for one simulation, no observations were assimilated in the inner domain. Results, which are compared with daily temperature and precipitation observations (ECA&D and E-OBS data sets) show that, even forced by the same re-analysis, the ensemble exhibits a large spread. A preliminary analysis of the sources of spread, using in particular simulations of the same model with different parameterizations, shows that the simulation of hot temperature is primarily sensitive to the convection and the microphysics schemes, which affect incoming energy and the Bowen ratio. Further, most models exhibit an overestimation of summertime temperature extremes in Mediterranean regions and an underestimation over Scandinavia. Even after bias removal, the simulated heat wave events were found to be too persistent, but a higher resolution reduced this deficiency. The amplitude of events as well as the variability beyond the 90th percentile threshold were found to be too strong in almost all simulations and increasing resolution did not generally improve this deficiency. Resolution increase was also shown to induce large-scale 90th percentile warming or cooling for some models, with beneficial or detrimental effects on the overall biases. Even though full causality cannot be established on the basis of this evaluation work, the drivers of such regional differences were shown to be linked to changes in precipitation due to resolution changes, affecting the energy partitioning. Finally, the inter-annual sequence of hot summers over central/southern Europe was found to be fairly well simulated in most experiments despite an overestimation of the number of hot days and of the variability. The accurate simulation of inter-annual variability for a few models is independent of the model bias. This indicates that internal variability of high summer temperatures should not play a major role in controlling inter-annual variability. Despite some improvements, especially along coastlines, the analyses conducted here did not allow us to generally conclude that a higher resolution is clearly beneficial for a correct representation of heat waves by regional climate models. Even though local-scale feedbacks should be better represented at high resolution, combinations of parameterizations have to be improved or adapted accordingly. © 2013 Springer-Verlag Berlin Heidelberg., The EURO-CORDEX simulations and analysis were carried out in several groups within the framework of the IMPACT2C FP7 project (Grant FP7-ENV.2011.1.1.6-1). The BTU Cottbus offered an exchange ftp site for sharing all model simulation files. The contribution from CRP-GL was funded by the Luxembourg National Research Fund (FNR) through Grant FNR C09/SR/16 (CLIMPACT). We acknowledge financial support from the Spanish R&D program through Grants CGL2010-21869 (EXTREMBLES) and CGL2010-22158-C02-01 (CORWES). Charles University runs were supported partially in framework of the Research Plan of MSMT (No. MSM 0021620860) and GACR project No. P209/11/2405. The contribution from UHOH was funded by the German Science Foundation (DFG) through project FOR 1695. The REMO simulations were supported by CSC, MPI, as well as BMBF and performed under the ‘‘Konsortial’’ share at the German Climate Computing Centre (DKRZ), as well as the CCLM simulations carried out by BTU, which we are further thankful for their various support. We are thankful to the French CCRT/TGCC supercomputing center support and the CEA and GENCI computing resource allocation agency for the WRF-IPSL-INERIS runs. The development of the modeling chain at INERIS and IPSL was carried out in part within the French national project SALUT’AIR (PRIMEQUAL research program). Part of SMHI contribution was done in the ECLISE projects that receive funding from the European Union Seventh Framework Programme (FP7/2007–2013) under Grant agreement 265240 and in the Swedish Mistra-SWECIA programme founded by Mistra (the Foundation for Strategic Environmental Research). DHMZ contribution was partially supported by the Croatian Ministry of Science, Education and Sports (Grant No. 004-1193086-3035).
Published: 2013
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170. Perspectives for integrating human and environmental risk assessment and synergies with socio-economic analysis

Author: Jean-Marc Brignon, Sylvie Tissot, Jean-Christophe Vergnaud, Michael Faust, Enrico Mombelli, Gerrit Schüürmann, Sandrine Andres, Thomas Backhaus, Martin F. Wilks, Philippe Ciffroy, Alexandre R.R. Pery, Cleo Tebby, S. Georgiou, Konstadinos Mattas, Lynn J. Frewer, Mark T. D. Cronin, Lothar Aicher, Ettore Capri, Alexandru Vasile Marchis, Willie J.G.M. Peijnenburg, Institut National de l'Environnement Industriel et des Risques (INERIS), Centre for Environmental Research, Institute for Organic Chemistry, Technishe Universität Bergakademie Freiberg (TU Bergakademie Freiberg), EDF R&D (EDF R&D), EDF (EDF), Faust & Backhaus Environmental Consulting GbR, University of Basel (Unibas), Liverpool University, University of Liverpool, SYNGENTA Crop protection AG, Food and Society Centre for Rural Economy, Newcastle University [Newcastle], Chemicals Regulation Directorate, Health and Safety Executive, Aristotelian University of Thessaloniki, Aristotle University of Thessaloniki, Centre d'économie de la Sorbonne (CES), Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), National Institute for Public Health and the Environment, National Institute for Public Health and the Environment [Bilthoven] (RIVM), OPERA Research Centre, and Università cattolica del Sacro Cuore [Milano] (Unicatt)
Subjects: Engineering, Environmental Engineering, Standardization, media_common.quotation_subject, HAZARD ASSESSMENT, CHEMICAL EXPOSURE, 010501 environmental sciences, Hazard analysis, Animal Testing Alternatives, Risk Assessment, 01 natural sciences, Hazardous Substances, 03 medical and health sciences, Toxicity Tests, Adverse Outcome Pathway, Animals, Humans, Environmental Chemistry, media_common.cataloged_instance, Quality (business), European Union, European union, Waste Management and Disposal, Risk management, 030304 developmental biology, 0105 earth and related environmental sciences, Exposure assessment, media_common, 0303 health sciences, business.industry, Environmental resource management, SOCIO-ECONOMIC ANALYSIS, ENVIRONMENTAL RISK ASSESSMENT, Environmental Exposure, Pollution, Hazard, Socioeconomic Factors, Risk analysis (engineering), 13. Climate action, [SDV.TOX]Life Sciences [q-bio]/Toxicology, [SDE]Environmental Sciences, Government Regulation, HUMAN RISK ASSESSMENT, business, INTEGRATION
Abstract: International audience; For more than a decade, the integration of human and environmental risk assessment (RA) has become an attractive vision. At the same time, existing European regulations of chemical substances such as REACH (EC Regulation No. 1907/2006), the Plant Protection Products Regulation (EC regulation 1107/2009) and Biocide Regulation (EC Regulation 528/2012) continue to ask for sector-specific RAs, each of which have their individual information requirements regarding exposure and hazard data, and also use different methodologies for the ultimate risk quantification. In response to this difference between the vision for integration and the current scientific and regulatory practice, the present paper outlines five medium-term opportunities for integrating human and environmental RA, followed by detailed discussions of the associated major components and their state of the art. Current hazard assessment approaches are analyzed in terms of data availability and quality, and covering non-test tools, the integrated testing strategy (ITS) approach, the adverse outcome pathway (AOP) concept, methods for assessing uncertainty, and the issue of explicitly treating mixture toxicity. With respect to exposure, opportunities for integrating exposure assessment are discussed, taking into account the uncertainty, standardization and validation of exposure modeling as well as the availability of exposure data. A further focus is on ways to complement RA by a socio-economic assessment (SEA) in order to better inform about risk management options. In this way, the present analysis, developed as part of the EU FP7 project HEROIC, may contribute to paving the way for integrating, where useful and possible, human and environmental RA in a manner suitable for its coupling with SEA.
Published: 2013
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171. VP35.11: Fetal growth prescriptive charts evaluation: a systematic review

Author: Julien Stirnemann, Laurent Salomon, Christos Chatzakis, Alexandros Sotiriadis, C.J. Arthuis, Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Imagine Institute, Aristotle University of Thessaloniki, Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), and MOYON, Thomas
Subjects: [SDV] Life Sciences [q-bio], medicine.medical_specialty, Reproductive Medicine, Radiological and Ultrasound Technology, business.industry, [SDV]Life Sciences [q-bio], Fetal growth, Obstetrics and Gynecology, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, business, Intensive care medicine
Abstract: International audience
Published: 2021
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172. Extraction of Environmental Data from On-Line Environmental Information Sources

Author: Victor Epitropou, Jürgen Moßgraber, Stefanos Vrochidis, Ioannis Kompatsiaris, Anastasios Bassoukos, Sascha Voth, Kostas Karatzas, Jaakko Kukkonen, Anastasia Moumtzidou, Ari Karppinen, Informatics and Telematics Institute/Centre for Research Hellas, Informatics Systems and Applications Group [Aristotle University of Thessaloniki], Aristotle University of Thessaloniki, Fraunhofer Institute of Optronics, System Technologies and Image Exploitation (Fraunhofer IOSB), Fraunhofer (Fraunhofer-Gesellschaft), Finnish Meteorological Institute (FMI), Lazaros Iliadis, Ilias Maglogiannis, Harris Papadopoulos, Kostas Karatzas, Spyros Sioutas, TC 12, and WG 12.5
Subjects: 010504 meteorology & atmospheric sciences, heatmap, Computer science, Image map, Image processing, 02 engineering and technology, computer.software_genre, data reconstruction, 01 natural sciences, Environmental data, Task (project management), Environmental, 0202 electrical engineering, electronic engineering, information engineering, [INFO]Computer Science [cs], Air quality index, 0105 earth and related environmental sciences, template configuration, Optical character recognition, air quality, Variety (cybernetics), image processing, OCR, 020201 artificial intelligence & image processing, Data mining, Line (text file), computer
Abstract: Part 6: Third Intelligent Systems for Quality of Life Information Services Workshop (ISQL 2012); International audience; Analysis of environmental information is considered of utmost importance for humans, since environmental conditions are strongly related to health issues and to a variety of everyday activities. Despite the fact that there are already many free on-line services providing environmental information, there are several cases, in which the presentation format complicates the extraction and processing of such data. A very characteristic example is the air quality forecasts, which are usually encoded in image maps of heterogeneous formats, while the initial (numerical) pollutant concentrations, calculated and predicted by a relevant model, remain unavailable. This work addresses the task of semi-automatic extraction of such information based on a template configuration tool, on methodologies for data reconstruction from images, as well as on Optical Character Recognition (OCR) techniques. The framework is tested with a number of air quality forecast heatmaps demonstrating satisfactory results.
Published: 2012
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173. A Mahalanobis Distance Based Approach towards the Reliable Detection of Geriatric Depression Symptoms Co-existing with Cognitive Decline

Author: Anastasia Semertzidou, Ana B. Vivas, Panagiotis D. Bamidis, Manousos A. Klados, Evdokimos I. Konstantinidis, Christos A. Frantzidis, Magda Tsolaki, Charalampos Bratsas, Maria D. Diamantoudi, Eirini Grigoriadou, C. Pappas, Antonis Billis, Laboratory of Medical Informatics [Aristotle University of Thessaloniki] (LOMI), Aristotle University of Thessaloniki, Department of Psychology [Sheffield], University of Sheffield [Sheffield], South East European Research Centre (SEERC), Mathematics Department (Quezon City), Ateneo de Manila University, Department of Neurology (Aristotle University of Thessaloniki), Lazaros Iliadis, Ilias Maglogiannis, Harris Papadopoulos, Kostas Karatzas, Spyros Sioutas, TC 12, and WG 12.5
Subjects: Mahalanobis distance, Mild Cognitive Impairment, Resting state fMRI, medicine.diagnostic_test, Computer science, Neuropsychological Estimation, Neuropsychology, Context (language use), Electroencephalography, Geriatric Depression, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Mahalanobis Distance Classifier, Wavelet Entropy, Pattern recognition (psychology), medicine, [INFO]Computer Science [cs], 030212 general & internal medicine, Cognitive decline, 030217 neurology & neurosurgery, Depression (differential diagnoses), Clinical psychology
Abstract: Part 1: Second Artificial Intelligence Applications in Biomedicine Workshop (AIAB 2012); International audience; Geriatric depression is a highly frequent medical condition that influences independent living and social life of senior citizens. It also affects their medical condition due to reduced commitment to the appropriate treatment. Coexistence of depressive symptoms in Mild Cognitive Impairment (MCI) and lack of objective tools towards their reliable distinction from neurodegeneration, motivated this study to propose a computerized approach of depression recognition. Resting state electroencephalographic data of both rhythmic activity and synchronization features were extracted and the Mahalanobis Distance (MD) classifier was adopted in order to differentiate 33 depressive patients from an equal number of age-matched controls. Both groups demonstrated cognitive decline within the context of MCI. The promising results (89.39% overall classification accuracy, 93.94% sensitivity and 84.85% specificity) imply that combination of neurophysiological (EEG) and neuropsychological tools with pattern recognition techniques may provide an integrative diagnosis of geriatric depression with high accuracy.
Published: 2012
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174. Projet FLOCK-REPROD

Author: Pellicer-Rubio, Maria-Teresa, Boue, P., Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Capgènes, REA-Research Executive Agency, FP7/2007-2013, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Instituto Nacional dos Recursos Biológicos (INRB), Università degli Studi di Sassari (UniSS), VEF, Ovidius University of Constanta, Aristotle University of Thessaloniki, Partenaires : Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Instituto Nacional dos Recursos Biológicos (INRB), Università degli Studi di Sassari (UniSS), VEF, Ovidius University of Constanta, Aristotle University of Thessaloniki, Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), and ProdInra, Migration
Subjects: [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], [SDV.OT] Life Sciences [q-bio]/Other [q-bio.OT]
Published: 2012

175. Instantanés des diverses activités d’une maisonnée néolithique: la maison 1 de Dikili Tash

Author: Pascal Darcque, Koukouli-Chrysanthaki Chaido, Dimitra Malamidou, Zoï Tsirtsoni, Soultana Maria Valamoti, Archéologies et Sciences de l'Antiquité (ArScAn), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Institut national de recherches archéologiques préventives (Inrap)-Centre National de la Recherche Scientifique (CNRS), École française d'Athènes (EfA), Ministère grec de la Culture, Ephorie de Kavala, Archéologie et Archéométrie (ArAr), Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Aristotelian University of Thessaloniki, Aristotle University of Thessaloniki, Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Lumière - Lyon 2 (UL2)
Subjects: Habitat, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Néolithique, Dikili Tash, Grèce, Fouille, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract: National audience
Published: 2012

176. Personalized Environmental Service Orchestration for Quality of Life Improvement

Author: Wanner, L., Vrochidis, S., Rospocher, M., Mossgraber, J., Bosch, H., Karppinen, A., Myllynen, M., Tonelli, S., Bouayad-Agha, N., Bugel, U., Casamayor, G., Ert, T., Hilbring, D., Karatzas, K., Kompatsiaris, I., Koskentalo, T., Mille, S., Moumtzidou, A., Pianta, E., Saggion, H., Serafini, L., Tarvainen, V., Universitat Pompeu Fabra [Barcelona] (UPF), Informatics and Telematics Institute/Centre for Research Hellas, Fondazione Bruno Kessler [Trento, Italy] (FBK), Fraunhofer Institute of Optronics, System Technologies and Image Exploitation (Fraunhofer IOSB), Fraunhofer (Fraunhofer-Gesellschaft), Institute for Visualization and Interactive Systems (VIS), Universität Stuttgart [Stuttgart], Finnish Meteorological Institute (FMI), Helsinki Regional Environmental Services Authority (HSY), Informatics Systems and Applications Group [Aristotle University of Thessaloniki], Aristotle University of Thessaloniki, Lazaros Iliadis, Ilias Maglogiannis, Harris Papadopoulos, Kostas Karatzas, Spyros Sioutas, TC 12, and WG 12.5
Subjects: knowledge, services, decision support, Knowledge management, Computer science, media_common.quotation_subject, Population, decision support, semantic web, environment, 02 engineering and technology, infrastructure, computer.software_genre, Personalization, semantic web, environmental node discovery, 020204 information systems, 0202 electrical engineering, electronic engineering, information engineering, [INFO]Computer Science [cs], Quality (business), Use case, Orchestration (computing), Everyday life, education, personalization, media_common, environmental information service, Service (business), education.field_of_study, Multimedia, business.industry, Knowledge base, 020201 artificial intelligence & image processing, business, environment, computer
Abstract: Part 6: Third Intelligent Systems for Quality of Life Information Services Workshop (ISQL 2012); International audience; Environmental and meteorological conditions are of utmost importance for the population, as they are strongly related to the quality of life. Citizens are increasingly aware of this importance. This awareness results in an increasing demand for environmental information tailored to their specific needs and background. We present an environmental information platform that supports submission of user queries related to environmental conditions and orchestrates results from complementary services to generate personalized suggestions. From the technical viewpoint, the system discovers and processes reliable data in the web in order to convert them into knowledge. At run time, this information is transferred into an ontology-structured knowledge base, from which then information relevant to the specific user is deduced and communicated in the language of their preference. The platform is demonstrated with real world use cases in the south area of Finland showing the impact it can have on the quality of everyday life.
Published: 2012
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177. Construction du lexique LGLex à partir des tables du Lexique-Grammaire des verbes du grec moderne

Author: Ioannidou, Kyriaki, Tolone, Elsa, Equipe de Linguistique Informatique, Laboratoire de Traduction et de Traitement Automatique du Langage (LTTL), Aristotle University of Thessaloniki-Aristotle University of Thessaloniki, Equipe d'Informatique Linguistique - Grupo de Procesamiento de Lenguaje Natural (PLN), Laboratoire d'Informatique Gaspard-Monge (LIGM), Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Bézout-ESIEE Paris-École des Ponts ParisTech (ENPC)-Université Paris-Est Marne-la-Vallée (UPEM)-Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Bézout-ESIEE Paris-École des Ponts ParisTech (ENPC)-Université Paris-Est Marne-la-Vallée (UPEM)-Facultad de Matemática, Astronomía y Física [Cordoba] (FaMAF), Universidad Nacional de Córdoba [Argentina]-Universidad Nacional de Córdoba [Argentina], and Université Paris-Est Marne-la-Vallée (UPEM)-École des Ponts ParisTech (ENPC)-ESIEE Paris-Fédération de Recherche Bézout-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Est Marne-la-Vallée (UPEM)-École des Ponts ParisTech (ENPC)-ESIEE Paris-Fédération de Recherche Bézout-Centre National de la Recherche Scientifique (CNRS)-Facultad de Matemática, Astronomía y Física [Cordoba] (FaMAF)
Subjects: Computer Science - Computation and Language, Lexique-Grammaire, LGLex, Classification ACM - I.: Computing Methodologies/I.2: ARTIFICIAL INTELLIGENCE/I.2.7: Natural Language Processing, InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, verbes du grec moderne, lexique syntaxique, [SCCO.COMP]Cognitive science/Computer science, table des classes, [SCCO.LING]Cognitive science/Linguistics, ComputingMethodologies_ARTIFICIALINTELLIGENCE, [INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL]
Abstract: In this paper, we summerize the work done on the resources of Modern Greek on the Lexicon-Grammar of verbs. We detail the definitional features of each table, and all changes made to the names of features to make them consistent. Through the development of the table of classes, including all the features, we have considered the conversion of tables in a syntactic lexicon: LGLex. The lexicon, in plain text format or XML, is generated by the LGExtract tool (Constant & Tolone, 2010). This format is directly usable in applications of Natural Language Processing (NLP)., Comment: 30\`eme Colloque international sur le Lexique et la Grammaire (LGC'11), Nicosie : Chypre (2011)
Published: 2011

178. Prognostic utility of β-tubulin isotype III and correlations with other molecular and clinicopathological variables in patients with early breast cancer: A translational Hellenic Cooperative Oncology Group (HeCOG) study

Author: Pentheroudakis, George, Batistatou, Anna, Kalogeras, K. T., Kronenwett, R., Wirtz, R. M., Bournakis, E., Eleftheraki, A. G., Pectasides, Dimitrios, Bobos, M., Papaspirou, I., Kamina, S., Gogas, H., Koutras, A. K., Pavlidis, Nicholas, Fountzilas, George, Pavlidis, Nicholas [0000-0002-2195-9961], Pentheroudakis, George [0000-0002-6632-2462], Department of Medical Oncology, Ioannina University Hospital, Department of Pathology, School of medicine [Thessaloniki], Aristotle University of Thessaloniki-Aristotle University of Thessaloniki, Translational Research Section, Hellenic Cooperative Oncology Group, Data Office, Siemens Healthcare Diagnostics, Sividon Diagnostics GmbH, Stratifyer Molecular Pathology GmbH, Department of Clinical Therapeutics, Alexandra Hospital, University of Athens School of Medicine, Section of Biostatistics, Section of Oncology, 2nd Department of Internal Medicine, Hippokration Hospital, University of Athens School of Medicine, Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research, Aristotle University of Thessaloniki School of Medicine, Department of Histopathology, Alexandra Hospital, 1st Department of Medicine, Laiko General Hospital, University of Athens School of Medicine, Division of Oncology, Department of Medicine, and University Hospital, University of Patras Medical School
Subjects: Oncology, Β-tubulin isotype iii, Messenger rna, Progesterone receptor, Multiple cycle treatment, Breast cancer, Medicine, Protein analysis, skin and connective tissue diseases, Disease free survival, β-tubulin isotype III, Mastectomy, Gene expression regulation, Genetic transcription, Prognosis, Immunohistochemistry, Gene expression profiling, Gene Expression Regulation, Neoplastic, Retrospective study, Paclitaxel, Granulocyte colony stimulating factor, Reverse transcription polymerase chain reaction, Beta tubulin, Human, medicine.medical_specialty, Tumor gene, Major clinical study, Article, Cancer grading, Epidermal growth factor receptor 2, Prognostic/predictive factors, Humans, Predictive value of tests, RNA, Messenger, Cyclophosphamide, Survival analysis, Retrospective Studies, Aged, TUBB3, Follow up, medicine.disease, Survival Analysis, Retrospective studies, Tamoxifen, Methotrexate, chemistry, Protein expression, Gene expression, Breast neoplasms, Cancer Research, Unclassified drug, Messenger, Partial mastectomy, Beta tubulin iii, Cancer staging, chemistry.chemical_compound, Tubulin, Estrogen receptor, Overall survival, Middle aged, Priority journal, Middle Aged, Excision repair cross complementing protein 1, Female, Breast disease, Fluorouracil, Cancer tissue, Adult, Predictive value, Histopathology, Breast Neoplasms, Young Adult, Predictive Value of Tests, Internal medicine, Tau protein, Early cancer, Human tissue, Neoplasm Staging, Epirubicin, Neoplastic, Taxane, Beta tubulin iii gene, business.industry, Gene Expression Profiling, Cancer, Translational research, Genetic translation, Adjuvant chemotherapy, Drug efficacy, Outcome assessment, Young adult, Multivariate analysis, Multivariate Analysis, Neoplasm staging, Cancer patient, Rna, business, Axillary lymph node, Controlled study
Abstract: We evaluated the prognostic and predictive utility of β-tubulin isotype III (TUBB3) tumour gene transcription in early breast cancer patients enrolled in a randomised study. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was applied for assessment of TUBB3, ER, PgR, HER2 and MAPT messenger RNA and immunohistochemistry (IHC) for protein expression in 314 patients enrolled in trial HE10/97, evaluating epirubicin-alkylator adjuvant chemotherapy with or without paclitaxel. High TUBB3 mRNA status was associated with advanced T stage, high histological grade, low mRNA and protein levels of ER, PgR and MAPT, and high levels of HER2 (p < 0.001). At a median follow-up of 98 months, multivariate analysis showed high TUBB3 mRNA status to have prognostic significance for DFS (HR = 1.83, 95% CI 1.25-2.68, p = 0.002) and OS (HR = 1.71, 95% CI 1.03-2.83, p = 0.038), along with the number of involved axillary nodes, PgR mRNA status and tumour grade. TUBB3 mRNA levels did not predict benefit from inclusion of paclitaxel in adjuvant chemotherapy (test for interaction p = 0.96 for OS, p = 0.46 for DFS). Transcriptional activity of β-tubulin isotype III in early breast cancer is an adverse prognostic factor, though not a predictive one for taxane efficacy. © 2011 Springer Science+Business Media, LLC. 127 1 179 193
Published: 2011
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179. Osteoarticular Mycoses

Author: Maria N. Gamaletsou, Blandine Rammaert, Barry Brause, Marimelle A. Bueno, Sanjeet S. Dadwal, Michael W. Henry, Aspasia Katragkou, Dimitrios P. Kontoyiannis, Matthew W. McCarthy, Andy O. Miller, Brad Moriyama, Zoi Dorothea Pana, Ruta Petraitiene, Vidmantas Petraitis, Emmanuel Roilides, Jean-Pierre Sarkis, Maria Simitsopoulou, Nikolaos V. Sipsas, Saad J. Taj-Aldeen, Valérie Zeller, Olivier Lortholary, Thomas J. Walsh, Laiko General Hospital, University of Athens School of Medicine, Pharmacologie des anti-infectieux et antibiorésistance (PHAR2), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Université de Poitiers - Faculté de Médecine et de Pharmacie, Université de Poitiers, Hospital for Special Surgery, Far Eastern Federal University (FEFU), City of Hope National Medical Center, Nationwide Children's Hospital, The Ohio State University School of Medicine, The University of Texas M.D. Anderson Cancer Center [Houston], Weill Medical College of Cornell University [New York], New York Presbyterian Hospital, NIH Clinical Center, Bethesda, Maryland, Hippokration General Hospital, Aristotle University of Thessaloniki, Hamad Medical Corporation [Doha, Qatar], Groupe Hospitalier Diaconesses Croix Saint-Simon, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Génomique évolutive, modélisation et santé (GEMS), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), and Center for Innovative Therapeutics and Diagnostics, Richmond, Virginia
Subjects: Microbiology (medical), cryptococcosis, phaeohyphomycosis, General Immunology and Microbiology, histoplasmosis, Epidemiology, coccidioidomycosis, Public Health, Environmental and Occupational Health, osteomyelitis, candidiasis, mucormycosis, antifungal therapy, Infectious Diseases, aspergillosis, mycoses, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
Abstract: Osteoarticular mycoses are chronic debilitating infections that require extended courses of antifungal therapy and may warrant expert surgical intervention. As there has been no comprehensive review of these diseases, the International Consortium for Osteoarticular Mycoses prepared a definitive treatise for this important class of infections. Among the etiologies of osteoarticular mycoses are Candida spp., Aspergillus spp., Mucorales, dematiaceous fungi, non-Aspergillus hyaline molds, and endemic mycoses, including those caused by Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides species. This review analyzes the history, epidemiology, pathogenesis, clinical manifestations, diagnostic approaches, inflammatory biomarkers, diagnostic imaging modalities, treatments, and outcomes of osteomyelitis and septic arthritis caused by these organisms. Candida osteomyelitis and Candida arthritis are associated with greater events of hematogenous dissemination than those of most other osteoarticular mycoses. Traumatic inoculation is more commonly associated with osteoarticular mycoses caused by Aspergillus and non-Aspergillus molds. Synovial fluid cultures are highly sensitive in the detection of Candida and Aspergillus arthritis. Relapsed infection, particularly in Candida arthritis, may develop in relation to an inadequate duration of therapy. Overall mortality reflects survival from disseminated infection and underlying host factors.
Published: 2022
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180. EXpert consensus On Diaphragm UltraSonography in the critically ill (EXODUS): a Delphi consensus statement on the measurement of diaphragm ultrasound-derived parameters in a critical care setting

Author: Mark E. Haaksma, Jasper M. Smit, Alain Boussuges, Alexandre Demoule, Martin Dres, Giovanni Ferrari, Paolo Formenti, Ewan C. Goligher, Leo Heunks, Endry H. T. Lim, Lidwine B. Mokkink, Eleni Soilemezi, Zhonghua Shi, Michele Umbrello, Luigi Vetrugno, Emmanuel Vivier, Lei Xu, Massimo Zambon, Pieter R. Tuinman, Intensive care medicine, Radiology and nuclear medicine, Epidemiology and Data Science, APH - Methodology, ACS - Diabetes & metabolism, ACS - Pulmonary hypertension & thrombosis, Amsterdam UMC - Amsterdam University Medical Center, Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Nord [CHU - APHM], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Mauriziano Umberto Hospital [Turin, Italy] (MUH), Ospedale San Paolo, Partenaires INRAE, University of Toronto, University Health Network, Toronto General Hospital Research Institute [Canada] (TGHRI), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Vrije Universiteit Amsterdam [Amsterdam] (VU), Papageorgiou General Hospital, AO 'Ospedale San Carlo Borromeo', University 'G. d'Annunzio' of Chieti-Pescara [Chieti], SS Annunziata Hospital, Centre hospitalier Saint Joseph - Saint Luc [Lyon], Graduate School, Intensive Care Medicine, Service de Médecine Intensive et Réanimation - R3S [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Department of Medical Sciences [Turin, Italy] (DMS), Università degli studi di Torino = University of Turin (UNITO), VU University Medical Center [Amsterdam], Aristotle University of Thessaloniki, Capital University of Medical Sciences [Beijing] (CUMS), Ospedale San Paolo-Polo Universitario, ASST Santi Paolo e Carlo, Milan, Università degli studi 'G. d'Annunzio' Chieti-Pescara [Chieti-Pescara] (Ud'A), Chongqing University [Chongqing], Università degli Studi di Milano = University of Milan (UNIMI), Lucas, Nelly, and Internal Medicine
Subjects: [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Consensus, Critical Care, Delphi Technique, Critical Illness, [SDV]Life Sciences [q-bio], Diaphragm, Ultrasound, Humans, Critical Care and Intensive Care Medicine, Delphi, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Ultrasonography
Abstract: Background Diaphragm ultrasonography is rapidly evolving in both critical care and research. Nevertheless, methodologically robust guidelines on its methodology and acquiring expertise do not, or only partially, exist. Therefore, we set out to provide consensus-based statements towards a universal measurement protocol for diaphragm ultrasonography and establish key areas for research. Methods To formulate a robust expert consensus statement, between November 2020 and May 2021, a two-round, anonymous and online survey-based Delphi study among experts in the field was performed. Based on the literature review, the following domains were chosen: “Anatomy and physiology”, “Transducer Settings”, “Ventilator Impact”, “Learning and expertise”, “Daily practice” and “Future directions”. Agreement of ≥ 68% (≥ 10 panelists) was needed to reach consensus on a question. Results Of 18 panelists invited, 14 agreed to participate in the survey. After two rounds, the survey included 117 questions of which 42 questions were designed to collect arguments and opinions and 75 questions aimed at reaching consensus. Of these, 46 (61%) consensus was reached. In both rounds, the response rate was 100%. Among others, there was agreement on measuring thickness between the pleura and peritoneum, using > 10% decrease in thickness as cut-off for atrophy and using 40 examinations as minimum training to use diaphragm ultrasonography in clinical practice. In addition, key areas for research were established. Conclusion This expert consensus statement presents the first set of consensus-based statements on diaphragm ultrasonography methodology. They serve to ensure high-quality and homogenous measurements in daily clinical practice and in research. In addition, important gaps in current knowledge and thereby key areas for research are established. Trial registration The study was pre-registered on the Open Science Framework with registration digital object identifier https://doi.org/10.17605/OSF.IO/HM8UG.
Published: 2022
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181. Precise timing and recent advancements with segmented anode PICOSEC Micromegas prototypes

Author: Manthos, I., Aune, S., Bortfeldt, J., Brunbauer, F., David, C., Desforge, D., Fanourakis, G., Gallinaro, M., García, F., Giomataris, I., Gustavsson, T., Iguaz, F. J., Kallitsopoulou, A., Kebbiri, M., Kordas, K., Lampoudis, C., Legou, P., Lisowska, M., Liu, J., Lupberger, M., Maillard, O., Maniatis, I., Müller, H., Oliveri, E., Papaevangelou, T., Paraschou, K., Pomorski, M., Qi, B., Resnati, F., Ropelewski, L., Sampsonidis, D., Scharenberg, L., Schneider, T., Sohl, L., van Stenis, M., Tsiamis, A., Tsipolitis, Y., Tzamarias, S. E., Utrobicic, A., Veenhof, R., Wang, X., White, S., Zhang, Z., Zhou, Y., Aristotle University of Thessaloniki, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, CERN [Genève], Institute of Nuclear and Particle Physics (NCSR DEMOKRITOS), Universidade de Lisboa, Helsinki Institute of Physics (HIP), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Laboratoire Interactions, Dynamiques et Lasers (ex SPAM) (LIDyl), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Center for Interdisciplinary Research and Innovation (CIRI), University of Science and Technology of China [Hefei] (USTC), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire Capteurs et Instrumentation pour la Mesure (LCIM-LIST), Département d'instrumentation Numérique (DIN (CEA-LIST)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, and National Technical University of Athens [Athens] (NTUA)
Subjects: Physics - Instrumentation and Detectors, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, Instrumentation, physics.ins-det, Mathematical Physics
Abstract: Timing information in current and future accelerator facilities is important for resolving objects (particle tracks, showers, etc.) in extreme large particles multiplicities on the detection systems. The PICOSEC Micromegas detector has demonstrated the ability to time 150\,GeV muons with a sub-25\,ps precision. Driven by detailed simulation studies and a phenomenological model which describes stochastically the dynamics of the signal formation, new PICOSEC designs were developed that significantly improve the timing performance of the detector. PICOSEC prototypes with reduced drift gap size ($\sim$\SI{119}{\micro\metre}) achieved a resolution of 45\,ps in timing single photons in laser beam tests (in comparison to 76\,ps of the standard PICOSEC detector). Towards large area detectors, multi-pad PICOSEC prototypes with segmented anodes has been developed and studied. Extensive tests in particle beams revealed that the multi-pad PICOSEC technology provides also very precise timing, even when the induced signal is shared among several neighbouring pads. Furthermore, new signal processing algorithms have been developed, which can be applied during data acquisition and provide real time, precise timing., 5 pages, 3 figures, 12th International Conference on Position Sensitive Detectors
Published: 2022
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182. NodeSig: Binary Node Embeddings via Random Walk Diffusion

Author: Çelikkanat, Abdulkadir, Malliaros, Fragkiskos D., Papadopoulos, Apostolos N., Department of Applied Mathematics and Computer Science [Lyngby] (DTU Compute), Danmarks Tekniske Universitet = Technical University of Denmark (DTU), OPtimisation Imagerie et Santé (OPIS), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de vision numérique (CVN), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-CentraleSupélec-Université Paris-Saclay, Centre de vision numérique (CVN), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay, Université Paris-Saclay, and Aristotle University of Thessaloniki
Subjects: Social and Information Networks (cs.SI), FOS: Computer and information sciences, Computer Science - Machine Learning, [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], Statistics - Machine Learning, Computer Science - Social and Information Networks, Machine Learning (stat.ML), [INFO.INFO-SI]Computer Science [cs]/Social and Information Networks [cs.SI], Machine Learning (cs.LG)
Abstract: Graph Representation Learning (GRL) has become a key paradigm in network analysis, with a plethora of interdisciplinary applications. As the scale of networks increases, most of the widely used learning-based graph representation models also face computational challenges. While there is a recent effort toward designing algorithms that solely deal with scalability issues, most of them behave poorly in terms of accuracy on downstream tasks. In this paper, we aim to study models that balance the trade-off between efficiency and accuracy. In particular, we propose NodeSig, a scalable model that computes binary node representations. NodeSig exploits random walk diffusion probabilities via stable random projections towards efficiently computing embeddings in the Hamming space. Our extensive experimental evaluation on various networks has demonstrated that the proposed model achieves a good balance between accuracy and efficiency compared to well-known baseline models on the node classification and link prediction tasks., Comment: The manuscript was accepted to the 2022 IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining (ASONAM)
Published: 2022
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183. Geomagnetic field intensity variations during the second millennium BCE: new data from the Greek Middle and Late Bronze Age

Author: E. Aidona, D. Kondopoulou, E.-G. Kyriakidou, P. Camps, C. Sarafidis, G.S Polymeris, R. Orgeolet, School of Geology [Thessaloniki], Aristotle University of Thessaloniki, Géosciences Montpellier, Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)-Université de Montpellier (UM), Department of Physics [Thessaloniki], Institute of Nanoscience and Nanotechnology 'Demokritos' [Greece] (INN), National Center for Scientific Research 'Demokritos' (NCSR), Centre Camille Jullian - Histoire et archéologie de la Méditerranée et de l'Afrique du Nord de la protohistoire à la fin de l'Antiquité (CCJ), Aix Marseille Université (AMU)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), and The INSTAP center and the French School at Athens (EFA) provided financial support for Kirrha and the Phryktoriae sampling and dating.
Subjects: geomagnetism, Geophysics, Physics and Astronomy (miscellaneous), Greece, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Space and Planetary Science, [SDU.STU.GP]Sciences of the Universe [physics]/Earth Sciences/Geophysics [physics.geo-ph], Astronomy and Astrophysics, archaeology, [SHS.ANTHRO-SE]Humanities and Social Sciences/Social Anthropology and ethnology, [SHS.ART]Humanities and Social Sciences/Art and art history, [SHS.CLASS]Humanities and Social Sciences/Classical studies
Abstract: International audience; The archaeointensity records from Greece present several gaps in the prehistoric period among which the ones in the third and second millennia BCE (Early and Middle Bronze Age) are not justified by the abundance of relevant settlements in the broader Greek area. Their excavations yielded numerous collections of pottery and ceramics, well-studied to a big extent from archaeological and archaeometric point of view. We collected six groups of fragments dated from 2200 BCE to 1500 BCE which were subjected to a classical archaeomagnetic study. The material response to the experiments was mostly satisfactory, and the archaeointensity was calculated both with Thellier-Thellier and multispecimen protocols. These results, complemented by the ones recently published for the period 1500-900 BCE, and plotted versus the existing secular variation curves for Greece and relevant geomagnetic field models allow the recovery of a smooth V-shape already suggested for 2 the Middle East. Nevertheless, we only observed a slight intensity maximum around 1900-1800 BCE while the minimum suggested for the Near East around 1800 BCE is probably shifted to an earlier period.
Published: 2022
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184. Sub-25 ps timing measurements with 10 × 10 cm 2 PICOSEC Micromegas detectors

Author: Lisowska, M., Bortfeldt, J., Brunbauer, F., Fanourakis, G., Floethner, K.J., Gallinaro, M., Garcia, F., Giomataris, I., Gustavsson, T., Iguaz, F.J., Janssens, D., Kallitsopoulou, A., Kovacic, M., Legou, P., Liu, J., Lupberger, M., Maniatis, I., Meng, Y., Muller, H., Oliveri, E., Orlandini, G., Papaevangelou, T., Pomorski, Michal, Ropelewski, L., Sampsonidis, D., Scharenberg, L., Schneider, T., Sohl, L., van Stenis, M., Tsipolitis, Y., Tzamarias, S.E., Utrobicic, A., Veenhof, R., Wang, X., White, S., Zhang, Z., Zhou, Y., CERN [Genève], Université Paris-Saclay, Ludwig-Maximilians University [Munich] (LMU), National Center for Scientific Research 'Demokritos' (NCSR), Universität Bonn = University of Bonn, University of Lisboa, Helsinki Metropolia University of Applied Sciences, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Interactions, Dynamiques et Lasers (ex SPAM) (LIDyl), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Dynamique et Interactions en phase Condensée (DICO), Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire Interactions, Dynamiques et Lasers (ex SPAM) (LIDyl), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), University of Zagreb, University of Science and Technology of China [Hefei] (USTC), Aristotle University of Thessaloniki, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Laboratoire Capteurs Diamant (LCD-LIST), Département Métrologie Instrumentation & Information (DM2I), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, National Technical University of Athens [Athens] (NTUA), University of Virginia, We acknowledge the financial support of the EP R&D, CERN Strategic Programme on Technologies for Future Experiments, the RD51 collaboration, in the framework of RD51 common projects, the Cross-Disciplinary Program on Instrumentation and Detection of CEA, the French Alternative Energies and Atomic Energy Commission, the PHENIICS Doctoral School Program of Universit ́e Paris-Saclay, the Fundamental Research Funds for the Central266Universities of China, the Program of National Natural Science Foundation of China (grant number 11935014), the COFUND-FP-CERN-2014 program (grant number 665779), the Funda ̧c ̃ao para a Ciˆencia e a Tecnologia (FCT), Portugal (grants IF/00410/2012 and CERN/FIS-PAR/0006/2017), the Enhanced Eurotalents program (PCOFUND-GA-2013-600382), and the US CMS program under DOE contract No. DE-AC02-07CH11359.
Subjects: instrumentation, detector, Electronic architecture, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], PICOSEC Micromegas detector
Abstract: International audience; The PICOSEC Micromegas detector is a precise timing gaseous detector based on a Cherenkov radiator coupled to a semi-transparent photocathode and a Micromegas amplifying structure. First single-pad prototypes demonstrated a time resolution below = 25 ps, however, to make the concept appropriate to physics applications, several developments are required. The objective of this work was to achieve an equivalent time resolution for a 10 × 10 cm area PICOSEC Micromegas detector. The prototype was designed, produced and tested in the laboratory and successfully operated with a 80 GeV/c muon beam. Preliminary results for this device equipped with a CsI photocathode demonstrated a time resolution below = 25 ps for all measured pads. The time resolution was reduced to be below = 18 ps by decreasing the drift gap to 180 m and using dedicated RF amplifier cards as new electronics. The excellent timing performance of the single-channel proof of concept was not only transferred to the 100-channel prototype, but even improved, making the PICOSEC Micromegas detector more suitable for large-area experiments in need of detectors with high time resolutions.
Published: 2022
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185. Toward a common approach for assessing the conservation status of marine turtle species within the European marine strategy framework directive

Author: Fanny Girard, Alexandre Girard, Jonathan Monsinjon, Antonella Arcangeli, Eduardo Belda, Luis Cardona, Paolo Casale, Sidonie Catteau, Léa David, Florence Dell’Amico, Delphine Gambaiani, Marc Girondot, Imed Jribi, Giancarlo Lauriano, Paolo Luschi, David March, Antonios D. Mazaris, Claude Miaud, Andreas Palialexis, Jacques Sacchi, Ricardo Sagarminaga, Paola Tepsich, Jesús Tomás, Frederic Vandeperre, Françoise Claro, Patrimoine naturel (PatriNat), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Office français de la biodiversité (OFB), Ecologie Systématique et Evolution (ESE), AgroParisTech-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Istituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA), Universitat Politècnica de València (UPV), Universitat de Barcelona (UB), University of Pisa - Università di Pisa, Institut EcoOcean, Partenaires INRAE, Aquarium La Rochelle, Université de Sfax - University of Sfax, Centre for Ecology and Conservation, University of Exeter, Aristotle University of Thessaloniki, Société Herpétologique de France (SHF), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), and European Commission - Joint Research Centre [Ispra] (JRC)
Subjects: Global and Planetary Change, ZOOLOGIA, Northeast Atlantic Ocean, Ocean Engineering, Aquatic Science, Oceanography, [SDE.ES]Environmental Sciences/Environmental and Society, 14.- Conservar y utilizar de forma sostenible los océanos, mares y recursos marinos para lograr el desarrollo sostenible, Good environmental status, Mediterranean Sea, Indicators, MSFD, Sea turtles, [SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/Oceanography, Water Science and Technology
Abstract: [EN] Environmental policies, including the European Marine Strategy Framework Directive (MSFD), generally rely on the measurement of indicators to assess the good environmental status (GES) and ensure the protection of marine ecosystems. However, depending on available scientific knowledge and monitoring programs in place, quantitative GES assessments are not always feasible. This is specifically the case for marine turtle species, which are listed under the Biodiversity Descriptor of the MSFD. Relying on an expert consultation, the goal of this study was to develop indicators and a common assessment approach to be employed by European Union Member States to evaluate the status of marine turtle populations in the frame of the MSFD. A dedicated international expert group was created to explore and test potential assessment approaches, in coherence with other environmental policies (i.e. Habitats Directive, OSPAR and Barcelona Conventions). Following a series of workshops, the group provided recommendations for the GES assessment of marine turtles. In particular, indicators and assessment methods were defined, setting a solid basis for future MSFD assessments. Although knowledge gaps remain, data requirements identified in this study will guide future data collection initiatives and inform monitoring programs implemented by EU Member States. Overall this study highlights the value of international collaboration for the conservation of vulnerable species, such as marine turtles., This study was funded by the French Ministry of Environment (MTES-MNHN Conventions n degrees 2102636187 (2019) and n degrees 2102994526 (2020)). DM acknowledges support from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement n degrees 794938. The work of ADM was supported by the Hellenic Foundation for Research and Innovation (H.F.R.I.) under the "First Call for H.F.R.I. Research Projects to support Faculty members and Researchers and the procurement of high-cost research equipment grant" (Project Number: 2340). FV was supported by the Investigator Programme of the Fundacao para a Ciencia e Tecnologia (FCT, CEECIND/03469/2017, CEECIND/03426/2020).
Published: 2022
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186. Wide genome transcription and metabolome profiles reprogrammed by sucrose under xenobiotic constraints

Author: Richard Berthomé, Anne-Sophie Dumas, Emilie Jarde, Nataliia Ryzhenko, Evangelos Barbas, Abdelhak El Amrani, Laboratoire des Interactions Plantes Microbes Environnement (LIPME), Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Géosciences Rennes (GR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre Armoricain de Recherches en Environnement-Centre National de la Recherche Scientifique (CNRS), Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), State Ecological Academy of Postgraduate Education and Management, and Aristotle University of Thessaloniki
Subjects: Sucrose, [SDV]Life Sciences [q-bio], Phenanthrene, [SDE]Environmental Sciences, Metabolome, Arabidopsis, Transcriptome, Stress
Abstract: Plants have developed strategies to adapt quickly to environmental changes. However, the regulation of these adaptive responses and coordination of signals network remains poorly understood for many environmental constraints. Indeed, signalling molecules play a central role in environmental stimuli and may coordinate plants development under environmental cues. Sucrose is the major transport carbohydrate in higher plants, in addition to its metabolic role; recent investigations suggested that sucrose impact the plasticity of plant development by controlling gene expression. Sucrose was also suggested as a ROS scavenger and as a signalling molecule. In this paper we showed that sucrose mitigated phenanthrene induced stress. Since, exogenous sucrose allowed growth and chlorophyll accumulation in the presence of high phenanthrene concentrations, whereas Arabidopsis development was blocked and seedlings were unable to accumulate chlorophyll in the presence of phenanthrene solely. To decipher the earlier molecular changes involved in sucrose tolerance to phenanthrene, wide transcriptional genes analysis and targeted metabolic profiling were carried out. We showed that sucrose driving plant response was associated with a deep reconfiguration of both genes expression and metabolites accumulation during the first hours of treatment, suggesting that sucrose, allowed plants to sustain the primary metabolism and to overcome the phenanthrene induced injuries.
Published: 2022

187. Metallic Trace Elements Shipping Profile by PM1 Source Apportionment in a Mediterranean PortCity

Author: Le Berre, L, Chazeau, B, Temime-Roussel, B, Lanzafame, G, Armengaud, A, Sauvage, S, Ntziachristos, L, Marchand, N, d'Anna, B, Wortham, H, Paul Scherrer Institute (PSI), Laboratoire Chimie de l'environnement (LCE), Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), AtmoSud, Regional Agency for Air Quality Monitoring, and Aristotle University of Thessaloniki
Subjects: [CHIM.ANAL]Chemical Sciences/Analytical chemistry, [SDE.MCG]Environmental Sciences/Global Changes, [SDE]Environmental Sciences
Abstract: International audience; Shipping emissions in ports can have substantial impacts on air quality and population health in the nearby urbanenvironment. Legislative efforts made in recent years have reduced emissions of some gaseous pollutants but theaerosol chemical composition, in particular metals composition in submicronic fraction, is little documented.More than 30 trace metals have been monitored with two online metals analysers (Xact 625i) in addition to regulatedpollutants (PM2.5, PM10, NOX, O3 and SO2) and ultrafine particle number during two intensive campaigns in Marseille(France) in the summer 2021. Samples were taken simultaneously along the port berths and on the urban backgroundaerosol site MRS-LCP located 2 km from the port. As the second largest city of France, Marseille represents achallenging environment for source apportionment (SA), as it combines multiple anthropogenic sources includingintensive traffic and various industrial activities in addition to shipping.This work presents the SA analysis performed on trace elements using Positive Matrix Factorization (PMF) resolvedwith the multilinear engine approach (SoFi Pro) on both sampling sites.Inside the port area, the half hourly metals measurements allowed to define a “shipping” profile by SA analysis. Thisprofile is dominated by Vanadium (V) and Nickel (Ni) and is associated with ultrafine particles (Dmob
Published: 2022

188. Impact of Drug Pressure versus Limited Access to Drug in Malaria Control: The Dilemma

Author: Chinedu Ogbonnia Egwu, Nwogo Ajuka Obasi, Chinyere Aloke, Joseph Nwafor, Ioannis Tsamesidis, Jennifer Chukwu, Sunday Elom, Pharmacochimie et Biologie pour le Développement (PHARMA-DEV), Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Alex Ekwueme Federal University Ndufu-Alike, Ikwo (AE-FUNAI), University of the Witwatersrand [Johannesburg] (WITS), and Aristotle University of Thessaloniki
Subjects: treatment, [SDV]Life Sciences [q-bio], malaria drug-pressure limited-access antimalarials treatment, General Engineering, malaria, Review, limited-access, antimalarials, parasitic diseases, General Earth and Planetary Sciences, Medicine, drug-pressure, General Environmental Science
Abstract: Malaria burden has severe impact on the world. Several arsenals, including the use of antimalarials, are in place to curb the malaria burden. However, the application of these antimalarials has two extremes, limited access to drug and drug pressure, which may have similar impact on malaria control, leading to treatment failure through divergent mechanisms. Limited access to drugs ensures that patients do not get the right doses of the antimalarials in order to have an effective plasma concentration to kill the malaria parasites, which leads to treatment failure and overall reduction in malaria control via increased transmission rate. On the other hand, drug pressure can lead to the selection of drug resistance phenotypes in a subpopulation of the malaria parasites as they mutate in order to adapt. This also leads to a reduction in malaria control. Addressing these extremes in antimalarial application can be essential in maintaining the relevance of the conventional antimalarials in winning the war against malaria.
Published: 2022
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189. Prenatal diagnosis of thoracic kidney in the 2nd trimester with delayed manifestation of associated diaphragmatic hernia

Author: Aikaterini Karavida, Christos Arnaoutoglou, Basil C. Tarlatzis, Apostolos Athanasiadis, Menelaos Zafrakas, Panayiota Papasozomenou, 1st Department of Obstetrics & Gynecology, School of medicine [Thessaloniki], Aristotle University of Thessaloniki-Aristotle University of Thessaloniki, Prenatal Diagnostic Center of Thessaloniki, Fetal Medicine Unit, 1st Department of Obstetrics & Gynecology, Papageorgiou Hospital, and Aristotle University of Thessaloniki
Subjects: Adult, Male, medicine.medical_specialty, Diaphragmatic breathing, Prenatal diagnosis, Choristoma, Kidney, Ultrasonography, Prenatal, Thoracic Diseases, Pregnancy, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Diaphragmatic hernia, Hernia, Hernia, Diaphragmatic, business.industry, Infant, Newborn, Pregnancy Outcome, Congenital diaphragmatic hernia, medicine.disease, Ectopic kidney, Magnetic Resonance Imaging, Surgery, medicine.anatomical_structure, Pregnancy Trimester, Second, Female, Radiology, Hernias, Diaphragmatic, Congenital, business
Abstract: International audience; Ectopic kidney is a rare congenital malformation, caused by renal malpositioning during embryogenesis. We report a rare case of ectopic kidney located in the left hemithorax of a male fetus. The unique features in this case were early sonographic prenatal diagnosis of thoracic kidney at 22 weeks gestation, which was confirmed by fetal MRI, and delayed ultrasound manifestation of associated congenital diaphragmatic hernia at 27 weeks.
Published: 2010
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190. Hepatitis B virus kinetics under antiviral therapy sheds light on differences in hepatitis B e antigen positive and negative infections

Author: Kimberly A. Powers, Paul Nikolaidis, Bertrand Pellegrin, Ruy M. Ribeiro, Georgios Germanidis, Jean-Michel Pawlotsky, Alan S. Perelson, Los Alamos National Laboratory (LANL), Pathology Clinic, Aristotle University of Thessaloniki-Papageorgiou General Hospital, Centre National de Référence Virus des hépatites B, C et Delta, Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), First Department of Internal Medicine, Gastrointestinal and Hepatology Division, Aristotle University of Thessaloniki-AHEPA University General Hospital [Thessaloniki], Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), and Guellaen, Georges
Subjects: MESH: Antiviral Agents, HBsAg, medicine.drug_class, MESH: Hepatitis B, Chronic, viruses, Biology, medicine.disease_cause, HBeAg, 03 medical and health sciences, 0302 clinical medicine, Orthohepadnavirus, e antigen, medicine, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, HBV, Immunology and Allergy, MESH: Animals, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, MESH: Hepatitis B e Antigens, 030304 developmental biology, Hepatitis B virus, 0303 health sciences, MESH: Humans, MESH: Middle Aged, virus diseases, MESH: Adult, dynamics, Hepatitis B, medicine.disease, biology.organism_classification, Virology, digestive system diseases, MESH: Male, 3. Good health, MESH: DNA, Viral, MESH: Hepatitis B virus, Infectious Diseases, Hepadnaviridae, Immunology, 030211 gastroenterology & hepatology, Antiviral drug, MESH: Viral Load, Viral load, mathematical model
Abstract: Approximately 2 billion people have been infected with hepatitis B virus (HBV) in their lifetime [1, 2]. Since only a small percentage of infected adults develops chronic hepatitis B, global prevalence of this disease is estimated at 350 million people [1]. End-stage HBV infection can lead to cirrhosis and to hepatocellular carcinoma (HCC), and up to 1.2 million people die every year from the consequences of this infection [1]. Chronic HBV infection (CHB) is usually characterized by detectable HBV DNA in serum, as well as the presence of hepatitis B surface antigen (HBsAg). Hepatitis B e antigen (HBeAg) can also be present. However, a large proportion of infected individuals are HBeAg-negative [3], because they are infected with HBV variants that are unable to produce high amounts of the excreted protein that bears the HBe epitope. These HBV mutants are rather uncommon in North America and Northern Europe, but the vast majority of patients with CHB in Southern Europe and Africa is infected with variants that express little or no HBeAg, and prevalence of HBeAg-negative CHB seems to be increasing worldwide [3–5]. Infection with HBeAg-negative hepatitis B variants is associated with lower serum viral levels [6–8], higher intra-hepatic necroinflammatory lesions and more severe progression of disease, with frequent development of cirrhosis and/or HCC [9, 10], than infection with HBeAg-positive strains [6, 11]. Taken together these observations may indicate a stronger immune response against HBeAg-negative infection. Consistent with this, even though the function of the HBe protein is not clear, it has been suggested that it serves to down modulate the immune response [12, 13]. In addition, HBeAg-negative HBV patients represent a more difficult to treat patient pool, due to lower off-treatment sustained responses [7, 14, 15]. Modeling of different viral infections and their treatment has given insight into aspects of viral evolution, pathogenesis and the mechanisms of antiviral drug action [16–20]. Such analyses of HBeAg-positive HBV infection showed that this virus has a short half-life in plasma and rapid viral production. We and others have calculated that the daily production of HBV in HBeAg-positive infection is in excess of 1011 virions and that infected cell lifespan is very variable but can be as short as 2 days [21, 22]. A few studies have also analyzed the effect of drug therapy on the kinetics of HBeAg-negative viral infection [23, 24]. The results from these studies suggest that viral clearance may be even faster in the setting of HBeAg-negative infection. Here we analyze the dynamics of HBeAg-negative infection under a variety of drug treatments and conduct an exhaustive meta-analysis of published results concerning HBV viral dynamics. Our goal was to understand the respective roles of viral production and the immune response in HBeAg-negative infection and compare them with HBeAg-positive infection.
Published: 2010
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191. Memantine for patients with Parkinson's disease dementia or dementia with Lewy bodies: a randomised, double-blind, placebo-controlled trial

Author: Emre, M, Tsolaki, M, Bonuccelli, U, Destee, A, Tolosa, E, Kutzelnigg, A, CEBALLOS BAUMANN, A, Zdravkovic, S, Bladstrom, A, Jones, R, 11018 Study Investigators, Zappia, Mario, Department of Neurology, Behavioural Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, 3rd Department of Neurology, Aristotle University of Thessaloniki-General Hospital of Thessaloniki George Papanikolaou, Département de neurologie[Lille], Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Parkinson Disease Unit, ICN. CIBERNED. IDIBAPS. Universitat de Barcelona, Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III [Madrid] (ISC)-Instituto de Salud Carlos III [Madrid] (ISC), Département de neurologie [Lille], Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Aristotle University of Thessaloniki-G. Papanikolaou Hospital, and CIBER de Enfermedades Neurodegenerativas (CIBERNED)
Subjects: Lewy Body Disease, Male, medicine.medical_specialty, Internationality, Turkey, [SDV]Life Sciences [q-bio], Placebo-controlled study, Placebo, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Double-Blind Method, law, Memantine, Internal medicine, medicine, Clinical endpoint, Dementia, Humans, 030212 general & internal medicine, Adverse effect, Aged, Aged, 80 and over, Dementia with Lewy bodies, Parkinson Disease, medicine.disease, 3. Good health, Europe, Physical therapy, Accidental Falls, Female, Neurology (clinical), Sleep Stages, Psychology, 030217 neurology & neurosurgery, medicine.drug
Abstract: Summary Background Previous studies have suggested that patients with Lewy-body-related dementias might benefit from treatment with the N-methyl D-aspartate receptor antagonist memantine, but further data are needed. Therefore, the efficacy and safety of memantine were investigated in patients with mild to moderate Parkinson's disease dementia (PDD) or dementia with Lewy bodies (DLB). Methods Patients (≥50 years of age) with mild to moderate PDD or DLB were recruited from 30 specialist centres in Austria, France, Germany, the UK, Greece, Italy, Spain, and Turkey. They were randomly assigned to placebo or memantine (20 mg per day) according to a computer-generated list. Patients and all physicians who had contact with them were masked to treatment assignment. No primary endpoint was defined. Safety analyses were done for all patients who took at least one dose of memantine or placebo, and efficacy analyses were done for all patients who had at least one valid postbaseline assessment. This trial is registered with ClinicalTrials.gov, number NCT00855686. Findings Of the 199 patients randomly assigned to treatment, 34 with DLB and 62 with PDD were given memantine, and 41 with DLB and 58 with PDD were given placebo. 159 (80%) patients completed the study: 80 in the memantine group and 79 in the placebo group. 93 patients treated with memantine and 97 patients treated with placebo were included in the efficacy analysis. At week 24, patients with DLB who received memantine showed greater improvement according to Alzheimer's disease cooperative study (ADCS)-clinical global impression of change scores than did those who received placebo (mean change from baseline 3·3 vs 3·9, respectively, difference −0·6 [95% CI −1·2 to −0·1]; p=0·023). No significant differences were noted between the two treatments in patients with PDD (3·6 with memantine vs 3·8 with placebo, −0·1 [−0·6 to 0·3]; p=0·576) or in the total population (3·5 with memantine vs 3·8 with placebo, −0·3 [−0·7 to 0·1]; p=0·120). Neuropsychiatric-inventory scores showed significantly greater improvement in the memantine group than in the placebo group (−4·3 vs 1·7, respectively, −5·9 [−11·6 to −0·2]; p=0·041) in patients with DLB, but not in those with PDD (−1·6 vs −0·1, respectively, −1·4 [−5·9 to 3·0]; p=0·522) or in the total patient population (−2·6 vs 0·4, respectively, −2·9 [−6·3 to 0·5]; p=0·092). In most of the cognitive test scores, ADCS-activities of daily living, and Zarit caregiver burden scores, there were no significant differences between the two treatment groups in any of the study populations. The incidence of adverse events and number of discontinuations due to adverse events were similar in the two groups. The most common serious adverse events were stroke (n=3 in memantine group), falls (n=2 in memantine group; n=1 in placebo group), and worsening of dementia (n=2 in memantine group). Interpretation Memantine seems to improve global clinical status and behavioural symptoms of patients with mild to moderate DLB, and might be an option for treatment of these patients. Funding Lundbeck.
Published: 2010
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192. Hypertension in kidney transplantation: a consensus statement of the 'hypertension and the kidney' working group of the European Society of Hypertension

Author: Alexandre Persu, Davide Bolignano, Michel Burnier, Charles J. Ferro, Gérard M. London, Jean-Michel Halimi, Pantelis Sarafidis, Anna Pisano, Alberto Ortiz, Francesca Mallamaci, Nada Kanaan, John Boletis, Patrick Rossignol, Liffert Vogt, Bénédicte Sautenet, Carmine Zoccali, Grégoire Wuerzner, Service de néphrologie et immunologie clinique [CHRU Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours (UT), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Universidad Autónoma de Madrid (UAM), Aristotle University of Thessaloniki, Department of Nephrology, Hippokration Hospital, Azienda Ospedaliera Ospedali Civili Riuniti, Lausanne University Hospital, Institute of Clinical Physiology, CNR, Centre Hospitalier Manhès [Fleury-Mérogis], Université Catholique de Louvain = Catholic University of Louvain (UCL), Cliniques Universitaires Saint-Luc [Bruxelles], Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR des Sciences Pharmaceutiques et Biologiques (Nantes Université - UFR Pharmacie), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), University Hospitals Birmingham [Birmingham, Royaume-Uni], Laiko General Hospital, University of Athens School of Medicine, National and Kapodistrian University of Athens (NKUA), Amsterdam UMC - Amsterdam University Medical Center, Università degli Studi 'Magna Graecia' di Catanzaro = University of Catanzaro (UMG), Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), AO research is supported by FIS/Fondos FEDER (PI17/00257, PI18/01386, PI19/00588, PI19/00815, DTS18/00032, ERA-PerMed-JTC2018 (KIDNEY ATTACK AC18/00064 and PERSTIGAN AC18/00071, ISCIII-RETIC REDinREN RD016/0009), Sociedad Española de Nefrología, FRIAT, Comunidad de Madrid en Biomedicina B2017/BMD-3686 CIFRA2-CM. LV is supported by Senior Kolff grant (18OKG12) of the Dutch Kidney Foundation.This work was planned as part of the activities of the « Kidney and Hypertension » working group of the European Society of Hypertension (ESH)., European Project: PI17/00257, European Project, BOZEC, Erwan, FEDER PI17/00257 - PI17/00257 - INCOMING, ISCIII-RETIC REDinREN RD016/0009 - INCOMING, FEDER PI18/01386 - INCOMING, FEDER PI19/00588 - INCOMING, FEDER PI19/00815 - INCOMING, FEDER DTS18/00032 - INCOMING, KIDNEY ATTACK AC18/00064 - INCOMING, PERSTIGAN AC18/00071 - INCOMING, Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR des Sciences Pharmaceutiques et Biologiques (Nantes Univ - UFR Pharmacie), UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - (SLuc) Service de néphrologie, Nephrology, ACS - Microcirculation, and APH - Health Behaviors & Chronic Diseases
Subjects: medicine.medical_specialty, Consensus, Ambulatory blood pressure, Physiology, Population, Kidney, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, Internal Medicine, medicine, Humans, education, Antihypertensive Agents, Kidney transplantation, education.field_of_study, business.industry, medicine.disease, Kidney Transplantation, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Transplantation, Masked Hypertension, medicine.anatomical_structure, Blood pressure, surgical procedures, operative, Hypertension, Cardiology and Cardiovascular Medicine, business, Kidney disease
Abstract: International audience; Hypertension is common in kidney transplantation recipients and may be difficult to treat. Factors present before kidney transplantation, related to the transplantation procedure itself and factors developing after transplantation may contribute to blood pressure (BP) elevation in kidney transplant recipients. The present consensus is based on the results of three recent systematic reviews, the latest guidelines and the current literature. The current transplant guidelines, which recommend only office BP assessments for risk stratification in kidney transplant patients should be reconsidered, given the presence of white-coat hypertension and masked hypertension in this population and the better prediction of adverse outcomes by 24-h ambulatory BP monitoring as indicated in recent systematic reviews. Hypertension is associated with adverse kidney and cardiovascular outcomes and decreased survival in kidney transplant recipients. Current evidence suggests calcium channel blockers could be the preferred first-step antihypertensive agents in kidney transplant patients, as they improve graft function and reduce graft loss, whereas no clear benefit is documented for renin-angiotensin system inhibitor use over conventional treatment in the current literature. Randomized control trials demonstrating the clinical benefits of BP lowering on kidney and major cardiovascular events and recording patient-related outcomes are still needed. These trials should define optimal BP targets for kidney transplant recipients. In the absence of kidney transplant-specific evidence, BP targets in kidney transplant recipients should be similar to those in the wider chronic kidney disease population.
Published: 2021
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193. Clinical assessment of stereoscopic optic disc photographs for glaucoma: the European Optic Disc Assessment Trial

Author: Gábor Holló, Christoph Faschinger, Hans G Lemij, P. Juhani Airaksinen, Andrea Mistlberger, Jost B. Jonas, Michele Iester, Alfonso Antón, Thierry Zeyen, Alain M. Bron, David F. Garway-Heath, Nicolaas J. Reus, Fotis Topouzis, The Rotterdam Eye Hospital, Moorfields Eye Hospital, Service d'Ophtalmologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), University of Genoa (UNIGE), Department of Ophthalmology, School of Medicine [Thessaloniki, Grèce], Aristotle University of Thessaloniki, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Centre des Sciences du Goût et de l'Alimentation [Dijon] ( CSGA ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), University of Genoa ( UNIGE ), and A' Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki
Subjects: Male, Intraocular pressure, MESH: Ophthalmology, genetic structures, Optic disk, MESH : Aged, Ocular hypertension, Glaucoma, Scanning laser polarimetry, MESH: Observer Variation, MESH: Aged, 80 and over, Photography, MESH : Female, Tomography, MESH : Glaucoma, MESH : Intraocular Pressure, MESH: Aged, Aged, 80 and over, Observer Variation, MESH: Middle Aged, medicine.diagnostic_test, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, MESH: Tomography, MESH : Adult, Middle Aged, MESH: Reproducibility of Results, Europe, medicine.anatomical_structure, Scanning Laser Polarimetry, [ SDV.MHEP.OS ] Life Sciences [q-bio]/Human health and pathology/Sensory Organs, MESH : Ophthalmoscopy, MESH: Optic Disk, Female, MESH : Sensitivity and Specificity, MESH : Tomography, MESH: Glaucoma, Optic disc, Adult, medicine.medical_specialty, MESH : Male, Health Personnel, MESH : Europe, Optic Disk, [ SDV.MHEP.GEG ] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, Sensitivity and Specificity, Ophthalmoscopy, MESH: Intraocular Pressure, Ophthalmology, MESH : Optic Disk, medicine, MESH : Ocular Hypertension, Humans, MESH : Middle Aged, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, MESH : Aged, 80 and over, Intraocular Pressure, MESH : Scanning Laser Polarimetry, Aged, MESH: Humans, business.industry, MESH: Scanning Laser Polarimetry, MESH : Reproducibility of Results, MESH : Humans, Reproducibility of Results, MESH: Adult, MESH : Observer Variation, medicine.disease, MESH: Photography, eye diseases, MESH: Sensitivity and Specificity, MESH: Male, MESH: Ocular Hypertension, MESH: Ophthalmoscopy, MESH : Ophthalmology, Optometry, MESH: Health Personnel, Ocular Hypertension, MESH : Health Personnel, sense organs, MESH: Europe, business, MESH : Photography, MESH: Female, Kappa
Abstract: International audience; PURPOSE: To determine the diagnostic accuracy of judging optic disc photographs for glaucoma by ophthalmologists. DESIGN: Evaluation of diagnostic test and technology. PARTICIPANTS: A total of 243 of 875 invited ophthalmologists in 11 European countries. METHODS: We determined how well each participant classified 40 healthy eyes and 48 glaucomatous eyes with varying severity of the disease on stereoscopic slides. Duplicate slides were provided for determining intraobserver agreement. All eyes were also imaged with the GDx with variable corneal compensation (GDx-VCC) (Carl Zeiss Meditec AG, Jena, Germany) and the Heidelberg Retina Tomograph (HRT) I (Heidelberg Engineering GmbH, Heidelberg, Germany). Diagnostic accuracies of clinicians were compared with those of the best machine classifiers. MAIN OUTCOME MEASURES: Accuracy of classification, expressed as sensitivity, specificity, and overall accuracy. Intraobserver agreement (kappa). RESULTS: The overall diagnostic accuracy of ophthalmologists was 80.5% (standard deviation [SD], 6.8; range, 61.4%-94.3%). The machine classifiers outperformed most observers in diagnostic accuracy; the GDx-VCC nerve fiber indicator and the HRT's best classifier correctly classified 93.2% and 89.8% of eyes, respectively. The intraobserver agreement (kappa) varied between -0.13 and 1.0 and was on average good (0.7). CONCLUSIONS: In general, ophthalmologists classify optic disc photographs moderately well for detecting glaucoma. There is, however, large variability in diagnostic accuracy among and agreement within clinicians. Common imaging devices outperform most clinicians in classifying optic discs. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.
Published: 2009
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194. On methods and tools for rigorous system design

Author: Saddek Bensalem, Martin Wirsing, Simon Bliudze, Panagiotis Katsaros, Self-adaptation for distributed services and large software systems (SPIRALS), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Aristotle University of Thessaloniki, VERIMAG (VERIMAG - IMAG), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), and Ludwig-Maximilians-Universität München (LMU)
Subjects: 0209 industrial biotechnology, Sequence, [INFO.INFO-PL]Computer Science [cs]/Programming Languages [cs.PL], Correctness, Theoretical computer science, Computer science, 05 social sciences, 050301 education, [INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE], 02 engineering and technology, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, 020901 industrial engineering & automation, [INFO.INFO-MA]Computer Science [cs]/Multiagent Systems [cs.MA], Theory of computation, Key (cryptography), A priori and a posteriori, Systems design, [INFO.INFO-ES]Computer Science [cs]/Embedded Systems, Software system, 0503 education, Software, Information Systems
Abstract: Full a posteriori verification of the correctness of modern software systems is practically infeasible due to the sheer complexity resulting from their intrinsic concurrent nature. An alternative approach consists of ensuring correctness by construction. We discuss the Rigorous System Design (RSD) approach, which relies on a sequence of semantics-preserving transformations to obtain an implementation of the system from a high-level model while preserving all the properties established along the way. In particular, we highlight some of the key requirements for the feasibility of such an approach, namely availability of (1) methods and tools for the design of correct-by-construction high-level models and (2) definition and proof of the validity of suitable domain-specific abstractions. We summarise the results of the extended versions of seven papers selected among those presented at the $$1\mathrm {st}$$ 1 st and the $$2\mathrm {nd}$$ 2 nd International Workshops on Methods and Tools for Rigorous System Design (MeTRiD 2018–2019), indicating how they contribute to the advancement of the RSD approach.
Published: 2021
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195. First-line thrombectomy strategy for anterior large vessel occlusions: results of the prospective ETIS egistry

Author: Benjamin, Maïer, Stephanos, Finitsis, Romain, Bourcier, Panagiotis, Papanagiotou, Sébastien, Richard, Gaultier, Marnat, Igor, Sibon, Cyril, Dargazanli, Caroline, Arquizan, Raphael, Blanc, Michel, Piotin, Bertrand, Lapergue, Arturo, Consoli, Francois, Eugene, Stephane, Vannier, Suzana, Saleme, Francisco, Macian, Frédéric, Clarençon, Charlotte, Rosso, Olivier, Naggara, Guillaume, Turc, Alain, Viguier, Christophe, Cognard, Valerie, Wolff, Raoul, Pop, Mikael, Mazighi, Benjamin, Gory, Thomas, Ronziere, Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), UFR Médecine [Santé] - Université Paris Cité (UFR Médecine UPCité), Université Paris Cité (UPCité), Aristotle University of Thessaloniki, Centre hospitalier universitaire de Nantes (CHU Nantes), Klinikum Bremen-Mitte, National and Kapodistrian University of Athens (NKUA), Service de neurologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Département de Neuro-Radiologie [Bordeaux] (DNR - Bordeaux), CHU Bordeaux [Bordeaux], Service de neurologie [Bordeaux], CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Département de Neuroradiologie[Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Département de neurologie [Montpellier], Service Neuroradiologie diagnostique et interventionnelle [Hôpital Foch], Hôpital Foch [Suresnes], Département de Radiologie [Rennes], Université de Rennes (UR), Service de Neurologie [Rennes] = Neurology [Rennes], CHU Pontchaillou [Rennes], Service de Neuroradiologie interventionnelle [CHU Limoges], CHU Limoges, Service de Neurologie [CHU Limoges], Service de Neuroradiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Sorbonne Paris Nord, Service d'Urgences Cérébro-Vasculaires [CHU Pitié-Salpêtrière], Service de Neurologie [CH Saint-Anne], Centre Hospitalier Sainte Anne [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Neurologie Vasculaire [Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Pôle Neurosciences [CHU Toulouse], Service de Neurologie [Strasbourg], CHU Strasbourg-Hopital Civil, Département de Neuroradiologie [Strasbourg], Les Hôpitaux Universitaires de Strasbourg (HUS), Institut de Chirurgie guidée par l'Image, and Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy]
Subjects: medicine.medical_specialty, MESH: Endovascular Procedures, medicine.medical_treatment, Arterial Occlusive Diseases, MESH: Stroke, Brain Ischemia, law.invention, Randomized controlled trial, Modified Rankin Scale, law, medicine.artery, Internal medicine, Stent, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, medicine, Humans, Device, MESH: Thrombectomy, Prospective Studies, Stroke, Ischemic Stroke, Retrospective Studies, Thrombectomy, MESH: Treatment Outcome, Catheter, MESH: Arterial Occlusive Diseases, MESH: Humans, Cerebral infarction, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, Endovascular Procedures, MESH: Brain Ischemia, MESH: Retrospective Studies, General Medicine, Thrombolysis, medicine.disease, MESH: Prospective Studies, MESH: Stents, Treatment Outcome, Cardiology, Stents, Surgery, Neurology (clinical), Internal carotid artery, business, MESH: Ischemic Stroke
Abstract: BackgroundThe best recanalization strategy for mechanical thrombectomy (MT) remains unknown as no randomized controlled trial has simultaneously evaluated first-line stent retriever (SR) versus contact aspiration (CA) versus the combined approach (SR+CA).ObjectiveTo compare the efficacy and safety profiles of SR, CA, and SR+CA in patients with acute ischemic stroke (AIS) treated by MT.MethodsWe analyzed data of the Endovascular Treatment in Ischemic Stroke (ETIS) Registry, a prospective, multicenter, observational study of patients with AIS treated by MT. Patients with M1 and intracranial internal carotid artery (ICA) occlusions between January 2015 and March 2020 in 15 comprehensive stroke centers were included. We assessed the association of first-line strategy with favorable outcomes at 3 months (modified Rankin Scale score 0–2), successful recanalization rates (modified Thrombolysis In Cerebral Infarction (mTICI) 2b/3), and safety outcomes.ResultsWe included 2643 patients, 406 treated with SR, 1126 with CA, and 1111 with SR+CA. CA or SR+CA achieved more successful recanalization than SR for M1 occlusions (aOR=2.09, (95% CI 1.39 to 3.13) and aOR=1.69 (95% CI 1.12 to 2.53), respectively). For intracranial ICA, SR+CA achieved more recanalization than SR (aOR=2.52 (95% CI 1.32 to 4.81)), no differences were observed between CA and SR+CA. SR+CA was associated with lower odds of favorable outcomes compared with SR (aOR=0.63 (95% CI 0.44 to 0.90)) and CA (aOR=0.71 (95% CI 0.55 to 0.92)), higher odds of mortality at 3 months (aOR=1.56 (95% CI 1.22 to 2.0)) compared with CA, and higher odds of symptomatic intracranial hemorrhage (aOR=1.59 (95% CI 1.1 to 2.3)) compared with CA.ConclusionsDespite high recanalization rates, our results question the safety of the combined approach, which was associated with disability and mortality. Randomized controlled trials are needed to evaluate the efficacy and safety of these techniques.
Published: 2021
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196. Selective-area growth of GaN nanowires on SiO{sub 2}-masked Si (111) substrates by molecular beam epitaxy

Author: Komninou, Ph. [Department of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki (Greece)]
Published: 2016
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197. A twenty year record of greenhouse gases in the Eastern Mediterranean atmosphere

Author: Nikos Gialesakis, Nikos Kalivitis, Giorgos Kouvarakis, Michel Ramonet, Morgan Lopez, Camille Yver Kwok, Clement Narbaud, Nikos Daskalakis, Marios Mermigkas, Nikolaos Mihalopoulos, Maria Kanakidou, Environmental Chemical Processes Laboratory [Heraklion] (ECPL), Department of Chemistry [Heraklion], University of Crete [Heraklion] (UOC)-University of Crete [Heraklion] (UOC), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), ICOS-RAMCES (ICOS-RAMCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), ICOS-ATC (ICOS-ATC), Laboratory for Modeling and Observation of the Earth System (LAMOS), Institut für Umweltphysik [Bremen] (IUP), Universität Bremen-Universität Bremen, and Aristotle University of Thessaloniki
Subjects: [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, Environmental Engineering, Environmental Chemistry, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, Pollution, Waste Management and Disposal
Abstract: International audience
Published: 2022
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198. Increasing resilience of small ruminants farming systems: 3 management strategies across countries

Author: Quenon, Julien, Thenard, Vincent, Arsenos, Georgios, Bailo, Giovanni, Baptista, Rebeca, de Barbieri, Ignacio, Bruni, Guido, Freire, Fernando, Theodoridis, Alexandros, Vouraki, Sotiria, AGroécologie, Innovations, teRritoires (AGIR), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Aristotle University of Thessaloniki, Associazione Regionale Allevatori della Lombardia (ARA Lombardia), Instituto Nacional de Investigación Agropecuaria (INIA), OVIGEN, UE 2020, European Project: 772787,H2020-EU.3.2.1.1., and H2020-EU.3.2.,SMARTER(2018)
Subjects: [SDV.SA.SPA]Life Sciences [q-bio]/Agricultural sciences/Animal production studies, farming systems, [SDV.SA.ZOO]Life Sciences [q-bio]/Agricultural sciences/Zootechny, small ruminants, breeding practices, resilience
Abstract: International audience; The sustainability of small ruminant livestock is one of the pillars of socio-economic sustainability and ecosystem services in many rural communities around the world. It is to help redefine these selection criteria that the European H2020 project SMARTER was established. The objective of this study was to analyse the genetic management practices of small ruminant breeders and the socio-technical elements that condition them. It is based on on-farm surveys conducted in five countries (France, Spain, Italy, Greece, Uruguay) among 272 breeders of 13 sheep and goat breeds (15 breed × systems). The information was collected in three sections. The first section dealt with general elements of structure and management of the system and the flock. The second section focused on genetic management practices: criteria for culling and replacement of females, selection criteria for males, use of EBV’s and synthetic indexes, preferences for indexing new traits to increase the resilience of their system. The third section aimed to collect socio-technical information. We used a data abstraction method to standardize the representation of these data. A mixed data factor analysis (MDFA) followed by a hierarchical ascending classification allowed the characterization of three profiles of genetic management: (1) A profile of farmers (n=93) of small herds, with little knowledge or use of genetic selection tools (index, AI, performance testing). They do not feel that they need new traits to improve the sustainability of their system. (2) A profile of farmers (n=34) of multi-breed herds in very grazing systems. They are familiar with genetic tools: they currently use AI little and would like the indexes to include more traits related to health or robustness to make their system more resilient. (3) A profile of farmer-breeders (n=145) of large herds, with demanding culling practices. These breeders are satisfied with the indexes as they are to ensure the resilience of their system. These results are elements that can be used by selection organizations and companies to support their reflection on the evolution of selection objectives to increase the resilience of small ruminant breeding systems.
Published: 2022

199. Bringing the margin to the focus:10 challenges for riparian vegetation science and management

Author: Patricia M. Rodríguez‐González, Eleni Abraham, Francisca Aguiar, Andrea Andreoli, Ligita Baležentienė, Naim Berisha, Ivan Bernez, Michael Bruen, Daniel Bruno, Carlo Camporeale, Andraž Čarni, Mila Chilikova‐Lubomirova, Dov Corenblit, Renata Ćušterevska, Tanya Doody, Judy England, André Evette, Robert Francis, Virginia Garófano‐Gómez, Marta González del Tánago, Yasar Selman Gultekin, Florian Guyard, Seppo Hellsten, Georgi Hinkov, Jiří Jakubínský, Philippe Janssen, Roland Jansson, Jochem Kail, Emine Keles, Mary Kelly‐Quinn, Anna Kidová, Tímea Kiss, Mart Kulvik, Nicola La Porta, Marianne Laslier, Melissa Latella, Stefan Lorenz, Dejan Mandžukovski, Paraskevi Manolaki, Vanesa Martinez‐Fernández, David Merritt, Adrien Michez, Jelena Milovanović, Tomasz Okruszko, Eva Papastergiadou, Ellis Penning, Remigiusz Pielech, Emilio Politti, Ana Portela, Tenna Riis, Željko Škvorc, Michal Slezák, Barbara Stammel, John Stella, Danijela Stesevic, Vladimir Stupar, Olga Tammeorg, Priit Tammeorg, Therese Moe Fosholt, Gorazd Urbanič, Marc Villar, Ioannis Vogiatzakis, Paul Vrchovsky, Rasoul Yousefpour, Peggy Zinke, Tzvetan Zlatanov, Simon Dufour, Ecosystems and Environment Research Programme, Department of Agricultural Sciences, Viikki Plant Science Centre (ViPS), Crop Science Research Group, Helsinki Institute of Sustainability Science (HELSUS), AgriChar research group, Plant Production Sciences, University of Helsinki, Centro de Estudos Florestais, Instituto Superior de Agronomia [Lisboa] (ISA), Universidade de Lisboa = University of Lisbon (ULISBOA)-Universidade de Lisboa = University of Lisbon (ULISBOA), Laboratório Associado Terra, School of Agriculture, Forestry and Natural Environment, Aristotle University of Thessaloniki, Faculty of Science and Technology, Free University of Bozen-Bolzano, Institute of Environment and Ecology, Vytautas Magnus University - Vytauto Didziojo Universitetas (VDU), Department of Biology, Faculty of Mathematics and Natural Sciences, University of Prishtina, Dynamique et durabilité des écosystèmes : de la source à l’océan (DECOD), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), UCD Earth Institute & UCD Dooge Centre for Water Resources Research, University College Dublin [Dublin] (UCD), Laboratoire des EcoSystèmes et des Sociétés en Montagne (UR LESSEM), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Instituto Pirenaico de Ecologìa = Pyrenean Institute of Ecology [Zaragoza] (IPE - CSIC), Department of environmental, land and infrastructure engineering, Politecnico di Torino = Polytechnic of Turin (Polito), Scientific Research Centre of the Slovenian Academy of Sciences and Arts, Bulgarian Academy of Sciences (BAS), Laboratoire de Géographie Physique et Environnementale (GEOLAB), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Faculty of Natural Sciences and Mathematics, Institute of Biology, Ss Cyril and Methodius University in Skopje, CSIRO Land and Water, Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), Environment Agency, King‘s College London, Instituto de Investigación para la Gestión Integrada de Zonas Costeras [Universitat Politècnica de València] (IGIC), Universitat Politècnica de València (UPV), Laboratorio de Hidrobiología, Universidad Politécnica de Madrid (UPM), Forest Economics Department, Düzce University, Geography and Spatial Planning, Université de Rennes 2 (UR2), Finnish Environment Institute (SYKE), Forest Research Institute - Department of Forest Entomology - Bulgarian Academy of Sciences (BAS), Global Change Research, Institute CAS, Department of Ecology and Environmental Science [Umeå], Umeå University, Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Faculty of Architecture, Department of Landscape Architecture, Trakya University, School of Biology & Environmental Science and UCD Earth Institute, Geophysical Institute of the Slovak Academy of Sciences, Department of Geoinformatics, Physical and Environmental Geography, University of Szeged [Szeged], Estonian University of Life Sciences (EMU), Centro Ricerca e Innovazione, Fondazione Edmund Mach, Instituto Agrario S. Michele all' Adige, Ecologie et Dynamique des Systèmes Anthropisés - UMR CNRS 7058 (EDYSAN), Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), Institute for Ecological Chemistry, Plant Analysis and Stored Product Protection, Julius Kuehn-Institut, Federal Research Centre for Cultivated Plants, Institute for Plant Protection in Field Crops and Grassland, Braunschweig, Germany, Department for Forest Management Planning, PE Nacionalni sumi, Faculty of Pure and Applied Sciences, Open University of Cyprus, Museo Nacional de Ciencias Naturales [Madrid] (MNCN), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), National Stream and Aquatic Ecology Center, Biological and Physical Resources Staff, USDA, TERRA Teaching and Research Centre, Gembloux Agro-Bio Tech, Université de Liège - Gembloux-Université de Liège - Gembloux, Environment and Sustainable Development, Singidunum University, Institute of Environmental Engineering, Warsaw University of Life Sciences (SGGW), University of Patras, Department of Inland Water Systems, Deltares [The Netherlands], University of Agriculture in Krakow, Department of civil, environmental and mechanical engineering [Trento], University of Trento [Trento], Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Universidade do Porto = University of Porto, CIBIO-InBIO - Universidade do Porto, Program in Genomics, Biodiversity and Land Planning (BIOPOLIS), Department of Biology, Aarhus Universitet, Faculty of Forestry and Wood Technology [Zagreb], University of Zagreb, Institute of Forest Ecology, Slovak Academy of Sciences (SAS), Floodplain Institute, Catholic University of Eichstätt-Ingolstadt, Department of Sustainable Resources Management, SUNY College of Environmental Science and Forestry (SUNY-ESF), State University of New York (SUNY)-State University of New York (SUNY), University of Montenegro (UCG), Department of Forest Ecology, University of Banja Luka, Department of Agricultural Science, Norwegian Institute for Water Research (NIVA), Institute for Holistic Environmental Management, Ltd. (URBANZERO), Biologie intégrée pour la valorisation de la diversité des Arbres et de la Forêt (BioForA), Office national des forêts (ONF)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institute of Forestry and Conservation, John H. Daniels Faculty of Architecture, Landscape, and Design, University of Toronto, Chair of Forestry Economics and Forest Planning, University of Freiburg, Sciencemonastery AS, Institute of Biodiversity and Ecosystem Research, Littoral, Environnement, Télédétection, Géomatique (LETG - Rennes ), Université de Brest (UBO)-Université de Rennes 2 (UR2)-Nantes Université (Nantes Univ)-Littoral, Environnement, Télédétection, Géomatique UMR 6554 (LETG), Université de Brest (UBO)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (Nantes Univ - IGARUN), Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (Nantes Univ - IGARUN), Nantes Université (Nantes Univ), Suomen ympäristökeskus, and The Finnish Environment Institute
Subjects: rantakasvillisuus, luonnonhoito, Settore AGR/05 - ASSESTAMENTO FORESTALE E SELVICOLTURA, riparian zone, river management, socioecosystem, nature management, water, vesi, nature conservation, Ocean Engineering, Oceanografi, hydrologi och vattenresurser, Management, Monitoring, Policy and Law, Aquatic Science, SALICACEAE, Oceanography, riparian zone, Oceanography, Hydrology and Water Resources, vegetation, RIVER, river management, socioecosystem, PLANTS, 1172 Environmental sciences, aquatic ecosystems, Water Science and Technology, Ekologi, [SDV.EE]Life Sciences [q-bio]/Ecology, environment, Ecology, vesiekosysteemit, kasvillisuus, Miljövetenskap, ecosystems (ecology), FRAMEWORK, waterside vegetation, [SDE.ES]Environmental Sciences/Environmental and Society, ekologia, ekosysteemit (ekologia), ekosysteemipalvelut, [SDE]Environmental Sciences, FEEDBACKS, luonnonsuojelu, ecosystem services, Biologie, Environmental Sciences
Abstract: Riparian zones are the paragon of transitional ecosystems, providing critical habitat and ecosystem services that are especially threatened by global change. Following consultation with experts, 10 key challenges were identified to be addressed for riparian vegetation science and management improvement: (1) Create a distinct scientific community by establishing stronger bridges between disciplines; (2) Make riparian vegetation more visible and appreciated in society and policies; (3) Improve knowledge regarding biodiversity—ecosystem functioning links; (4) Manage spatial scale and context-based issues; (5) Improve knowledge on social dimensions of riparian vegetation; (6) Anticipate responses to emergent issues and future trajectories; (7) Enhance tools to quantify and prioritize ecosystem services; (8) Improve numerical modeling and simulation tools; (9) Calibrate methods and increase data availability for better indicators and monitoring practices and transferability; and (10) Undertake scientific validation of best management practices. These challenges are discussed and critiqued here, to guide future research into riparian vegetation. This article is categorized under: Water and Life > Nature of Freshwater Ecosystems Water and Life > Stresses and Pressures on Ecosystems Water and Life > Conservation, Management, and Awareness
Published: 2022
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200. Sampling molecular state transitions in a line-by-line Monte Carlo approach to estimate radiative forcing for climate change studies

Author: NYFFENEGGER-PERE, Yaniss, Blanco, Stéphane, Dufresne, Jean-Louis, El-Hafi, Mouna, Eymet, Vincent, Forest, Vincent, Fournier, Richard, Mellado, Nicolas, Mourtaday, Nada Chems, Paulin, Mathias, Groupe de Recherche Energétique, Plasmas et Hors Equilibre (LAPLACE-GREPHE), LAboratoire PLasma et Conversion d'Energie (LAPLACE), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Laboratoire de Météorologie Dynamique (UMR 8539) (LMD), Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-École des Ponts ParisTech (ENPC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Institut Pierre-Simon-Laplace (IPSL (FR_636)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre de recherche d'Albi en génie des procédés des solides divisés, de l'énergie et de l'environnement (RAPSODEE), Centre National de la Recherche Scientifique (CNRS)-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Méso-Star, Structural Models and Tools in Computer Graphics (IRIT-STORM), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Laboratory of Atmospheric Physics (LAP) of the Aristotle University of Thessaloniki (AUTH), International Radiation Commission (IRC) of the International Association of Meteorology and Atmospheric Sciences (IAMAS), and ANR-18-CE46-0012,MCG-Rad,Calcul par Monte-Carlo des forçages radiatifs à l'échelle globale(2018)
Subjects: [SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/Climatology, [PHYS.MECA.THER]Physics [physics]/Mechanics [physics]/Thermics [physics.class-ph], [INFO.INFO-GR]Computer Science [cs]/Graphics [cs.GR]
Abstract: International audience; A major challenge of the beginning of the century is the nation’s actions over the terrestrial climate to counter the global warming. This warming is caused by the human activity and in particular by the emission of important amounts of greenhouse gases. Its close understanding and precise estimate are necessary to take appropriate actions and one of the driving concepts along this line is radiative forcing. This forcing is defined as the difference between two Top Of Atmosphere (TOA) radiative fluxes, both integrated spatially over all the Earth and temporally over a climatic period, the difference being due to a change of one single parameter. Here we focus on the forcing to carbon dioxide. So, our question is the estimation of the difference between two integrated TOA fluxes, before and after we change the CO2 concentration field.
Published: 2022

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