151. Role of peroxide in phagocytic killing of pneumococci.
- Author
-
Pitt J and Bernheimer HP
- Subjects
- Animals, Bacterial Vaccines, Blood Bactericidal Activity, Humans, Immune Sera, Male, Peroxides metabolism, Phagocyte Bactericidal Dysfunction immunology, Rabbits immunology, Streptococcus pneumoniae metabolism, Leukocytes immunology, Phagocytosis, Streptococcus pneumoniae immunology
- Abstract
Two mutants of a pneumococcus type I with diminished peroxide production were selected from a population of nitrosoguanidine-treated cells. White cells of normal patients killed the mutant pneumococci as well as the otherwise isogenic wild-type strain. In patients studied with chronic granulomatous disease, however, the peroxide-poor strain was killed far less well than the wild type. These studies indicate that the removal of a peroxide-generating system in the phagocytic vacuole specifically brings forth the killing defect in chronic granulomatous disease.
- Published
- 1974
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