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Role of peroxide in phagocytic killing of pneumococci.
- Source :
-
Infection and immunity [Infect Immun] 1974 Jan; Vol. 9 (1), pp. 48-52. - Publication Year :
- 1974
-
Abstract
- Two mutants of a pneumococcus type I with diminished peroxide production were selected from a population of nitrosoguanidine-treated cells. White cells of normal patients killed the mutant pneumococci as well as the otherwise isogenic wild-type strain. In patients studied with chronic granulomatous disease, however, the peroxide-poor strain was killed far less well than the wild type. These studies indicate that the removal of a peroxide-generating system in the phagocytic vacuole specifically brings forth the killing defect in chronic granulomatous disease.
Details
- Language :
- English
- ISSN :
- 0019-9567
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 4148725
- Full Text :
- https://doi.org/10.1128/iai.9.1.48-52.1974