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Carbuncle is a skin infection with deep subcutaneous tissue involvement and can lead to sepsis and death if not properly treated. Wound care, control of comorbid diseases that affecting the immunity are as effective as antibiotic treatment in the treatment of the carbuncle. Here, a case of carbuncle of the gluteal area is reported in a 75-year-old woman with concomitant diabetes and chronic renal failure. [ABSTRACT FROM AUTHOR]

Myiasis is an infestation of maggot flies, usually found in tropical and non-tropical regions such as Africa and South America. Although cases are reported after trips to the endemic regions, it should not be overlooked, as in our case, that they may appear especially in poor socioeconomic conditions and the individuals who have to live in the unsanitary environment. Here, we present a 7-year-old myiasis case in our region because it is rare but it can be easily treated when it is diagnosed and it causes unwanted complications if it is not treated. [ABSTRACT FROM AUTHOR]

Objective: The sharp object injuries constitute an important problem for the healthcare staff. The aim of this study is to retrospectively evaluate percutaneous injuries in Inönü University, Faculty of Medicine in the last eight years. Materials and Methods: Percutaneous injuries that occurred in our hospital between 2006 and 2013 were evaluated respectively.. Results: 144 percutaneous injuries recorded during the last eight years were included in the study. The rates of exposure were found to be 44% (63) for cleaning personnel, 17% (25) for nurses, 12% (17) for medical students, 12% (17) ancillary staff and caregivers, 6% (9) for apprentice nurses, 5% (7) for technicians, and 4% (6) for doctors. The number of percutaneous injuries were found to be 126 (87%) for needle stick injuries, 11 (8%) for lancet injuries and 7 (5%) for mucosal (eye) contacts. We have observed a significant decrease in the total injuries and injured cleaning personnel, ancillary staff, and nurses (p<0.001). Conclusions: Throughout 8 years, percutaneous injuries were significantly reduced among healthcare staff. We plan to provide continuous education for healthcare personnel and follow up feedback in our hospital. [ABSTRACT FROM AUTHOR]

The title molecules,N-(1,5-dimethyl-3-oxo-2-phenyl-1H-3-(2H)-pyrazolyl)4-nitrobenzamide (C18H16N4O4·H2O) (I) and 2,2-dimethyl-3-(4-nitrobenzoyl)-5-(phenylamino)-2,3-dihydro-1,3,4-thiyadiazole (C17H16N4O3S) (II), were prepared and characterised by1H NMR,13C NMR, infrared spectroscopy (IR) and structural X-ray diffraction (XRD) techniques. The molecular geometries, vibrational frequencies of the title compounds in the ground state have been calculated by using the density functional theory (DFT) method with 6-31G(d) basis set, and compared with the experimental data. The calculated results showed that the optimised geometries from the DFT method agree with the X-ray structures well for both compounds. Theoretical calculations of harmonic vibration frequencies are in good agreement with experimental results. To determine conformational flexibility, the molecular energy profiles of the title compounds were obtained. Besides, molecular electrostatic potential (MEP), frontier molecular orbitals (FMO) analysis and thermodynamic properties of the title compounds were investigated by theoretical calculations. [ABSTRACT FROM AUTHOR]

Livedoid vasculopathy (LV) (often mistaken for vasculitis) is a non-inflammatory occlusion of the small vessels of the skin due to thrombosis and deposition of fibrin in the vessel walls. Livedoid vasculopathy may be infrequent in children and a misdiagnosis of small or medium vessels leukocytoclastic vasculitis may cause unnecessary examinations and treatments. [Extracted from the article]

Copyright of Journal of Turkish Society for Rheumatology is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkish Journal of Dermatology / Turk Dermatoloji Dergisis is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archives of the Turkish Dermatology & Venerology / Turkderm is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Turkish Society for Rheumatology is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Turkish Society for Rheumatology is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease that can present with various forms of arthritis. This retrospective study aims to evaluate the characteristics of patients with arthritis in a large pediatric cohort of FMF patients. Methods: The demographic and clinical data were extracted from electronic medical records. Patients with arthritis were grouped as arthritis of FMF and arthritis of FMF-associated diseases. Results: A total of 541 patients were followed with a diagnosis of FMF in the last 5 years. Acute arthritis of FMF (n: 138) was the most common cause. It showed a recurrent course in the majority with a longer duration than other attack symptoms. Significantly higher frequencies of biallelic exon 10 and M694V mutations, erysipelas-like erythema, and protracted febrile myalgia were detected in these patients, particularly in those older than 2 years of age. Sacroiliitis of FMF was the second most common cause (n: 19). Patients with acute arthritis and sacroiliitis of FMF needed higher doses of colchicine. One patient with neonatal-onset FMF and M694V homozygosity was diagnosed with protracted arthritis. Arthritides of FMF-associated diseases including IgA vasculitis (n: 10), juvenile idiopathic arthritis (n: 9), chronic nonbacterial osteomyelitis (n: 5), and inflammatory bowel disease (n: 2) were detected in 26 patients. Conclusions: Arthritis is an important clinical finding of FMF mostly associated with M694V mutations. The frequency of protracted arthritis is declined, whereas sacroiliitis of FMF and arthritis of associated diseases expand the spectrum of arthritis. This study represents the changing face and current perspectives of arthritis in FMF. Key Points • Arthritis is an important clinical finding of familial Mediterranean fever (FMF) that can present in various forms • Arthritis is most likely associated with M694V mutations • The frequency of protracted arthritis is declined whereas sacroiliitis of FMF and arthritis of associated diseases expand the spectrum of arthritis in FMF [ABSTRACT FROM AUTHOR]

Background and Design: In view of the evolving knowledge about the presence of the potent proinflammatory galectin-3, a member of the galectin family, in the cells (mainly T-lymphocytes) playing a key role in the inflammation process. We aimed to determine the serum galectin-3 levels in patients with psoriasis vulgaris, a T-cell-mediated inflammatory disease, and to investigate the correlation between these levels and disease activity. Material and Method: Thirty-three patients with psoriasis vulgaris and 30 healthy subjects were included in this study. The psoriasis area and severity index (PASI) was calculated and recorded for each patient. The patients were classified in three groups as group I, II and III according to their PASI scores. Serum galectin-3 level was analyzed by ELISA method. Results: Serum galectin-3 level in psoriasis vulgaris patients was found to be minimally, although statistically significantly, lower than the control group (p=0.012). We could not detect any correlation between serum galectin-3 level and PASI scores (Spearman's rho=0.206, p=0.249). Conclusion: It seems that serum galectin-3 level is not an important factor in the ethiopathogenesis of psoriasis vulgaris and, therefore, cannot be used as a reliable indicator of exacerbation during follow-up. [ABSTRACT FROM AUTHOR]

A quiz is presented which asked about the steps that a pediatrician would take to determine the cause of hematological abnormalities resistant to therapy in a 15-year-old girl with systemic lupus erythematosus, the diagnosis for the abnormalities and what should be the management in this patient.

A new dithiocarbamate molecule, named as N-benzoyl-S-(undecyl)-dithiocarbamate (C 19 H 29 NOS 2), was synthesized and characterized by 1HNMR, 13CNMR, FT-IR spectroscopic methods. X-ray analysis of the crystal structure of title compound showed the presence of triclinic space group with a = 4.2417 (8) Å, b = 20.010 (4) Å, c = 27.959 (6) Å, Z = 4, V = 2338.9 ų. Detailed investigation of molecular packing of the molecule indicated the presence of intermolecular hydrogen bond between C1–H1⋯S4 i and C24–H24⋯S2 v that generates R 2 2 (10) motifs, and intermolecular hydrogen bonds between N1–H111⋯S4 ii and N2–H222⋯S2 iv atoms that forms R 2 2 (7) rings. Thermal properties of the title compound were investigated by thermogravimetric analysis (DTA/TG) and differential scanning calorimetry (DSC). Molecular electrostatic potential (MEP), the HOMO and LUMO energies and thermodynamic parameters of the title compound were calculated using density functional theory (DFT) with B3LYP/6-311G (d,p) level. Image 1 • Synthesis and characterization of the N-benzoyl-S-(undecyl)-dithiocarbamate is reported. • X-ray single crystal and molecular structure was determined. • MEP, HOMO-LUMO analysis were examined by using of the B3LYP/6-311G (d,p) approach. • The behavior on heating of title compound was studied by TG/DTA and DSC and was theoretically calculated. [ABSTRACT FROM AUTHOR]

Letter to the editor regarding article "El-Hamd MA, El Taieb MA, Ibrahim HM, Aly SS. Vitamin D levels in acne vulgaris patients treated with oral isotretinoin. We read that serum levels of 25-hydroxy (OH) vitamin D were significantly lower in patients with acne vulgaris than healthy controls, and there was a significant increase in serum 25-OH vitamin D levels after 3 months of isotretinoin treatment. They also express nuclear vitamin D receptor which mediates the genomic actions of 1,25 (OH) SB 2 sb vitamin D.[[1]] So while evaluating the acne and vitamin D, two forms should be evaluated separately. [Extracted from the article]

Amaç: Ürik asit pürin metabolizmasının son ürünüdür. Atılımının yaklaşık %80'i böbrekler yoluyla olmaktadır. Ürik asit yüksekliği; distal tubül ve toplayıcı kanallarda çökme sonucu akut ürik asit nefropatisine, medullanın interstisyumunda birikimiyle kronik ürat nefropatisine ve son olarak ürik asit taşları oluşturarak böbrek hasarına neden olabilir. Yoğun bakım ünitesine yatırılan hastalarda Akut Böbrek Hasarı (ABH) gelişiminin mortaliteyi arttırdığı bilinmektedir. Bizde bu bilgiler ışığında yoğun bakım ünitesine yatırılan hastalarda ürik asit yüksekliğinin akut böbrek hasarı gelişimi ve mortalite üzerine etkisini araştırmayı amaçladık. Gereç-Yöntem: Çalışmamızda 01 Ocak-01 Eylül 2019 tarihleri arasında Dicle Üniversitesi Tıp Fakültesi Genel Dahiliye Yoğun Bakım Ünitesine yatırılan cinsiyet ayrımı yapılmayan 110 hastanın verileri retrospektif olarak incelendi. Hastaların yaş, cinsiyet, başvuru anındaki serum ürik asit değerleri, serum kreatinin düzeylerine ve yoğun bakımda kalış sürelerine bakıldı. Akut Böbrek Hasarı KDIGO kriterleri kullanılarak değerlendirildi. Hastalar ürik asit değeri <7.2 mg/dl (Grup 1) ve >=7.2 mg /dl (Grup 2) olacak şekilde iki gruba ayrıldı (Hastanemiz serum ürik asit referans değerleri 2.6-7.2 mg/dl). Gruplar ABH gelişimi ve mortalite açısından karşılaştırıldı. Bulgular: Hastaların 54'ü erkek, 56'sı kadın hastaydı. 74 hastada (%67.3) ABH gelişti ve 70 hasta (%63.6) ex oldu. Grup 1'de 51 hasta, Grup 2 'de 59 hasta mevcuttu. Gruplar arasında cinsiyet açısından istatiksel olarak anlamlı fark saptanmadı (p:0.257). Grup 1 ve Grup 2'de ABH gelişme oranı sırasıyla %35.3- %94.9 saptanırken ex olanların oranı %45- %79.6 olup bu bulgular istatiksel olarak anlamlıydı (p<0.01). Gruplar arası dağılım Tablo 1'de gösterilmiştir. Yoğun bakım ünitesinde kalış süreleri median değer olarak gruplar arasında sırasıyla 13 (%95 CI: 8.9-17.2) ve 6 (%95 CI: 4.2-7.8) olup Log rank testiyle grup 2 de istatiksel olarak anlamlı düşük saptandı (p:0.003). Grupların Kaplan-meier sağ kalım analizi şekil 1'de gösterilmiştir. Cox regresyon analiziyle serum ürik asit değerinin >=7.2 mg /dl olması ABH'ını 2.9 kat (p<0.001) ve mortaliteyi 2.1 kat (p:0.005) arttırdığını tespit ettik. Sonuç: Çalışmamızda serum ürik asit yüksekliğinin ABH'ı ve mortaliteyi arttırdığı görülmektedir. Bu nedenle yoğun bakım hastalarında serum ürik asit düzeyinin yakın takip edilmesi gerekmektedir. Hiperürisemi saptanan hastalarda uygun medikal tedavi ile serum ürik asit düzeyinin düşürülmesi hem ABH'nı hem de mortaliteyi azaltabileceği kanaatindeyiz. [ABSTRACT FROM AUTHOR]

Objective: In this study, it was aimed to determine the HCV prevalence and the occult HBV prevalence by HBV DNA analysis in serum samples of HBsAg patients undergoing routine hemodialysis. It was also aimed to determine the liver fibrosis level with fibrometer, which is a non-invasive method. Methods: The study included 100 patients who applied for routine hemodialysis and were negative for HBsAg in screening tests. In samples from the patient, ALT, HBsAg, Anti-HBc IgG, HBV DNA, Anti HCV, HCV RNA and fibrometer were studied from serum samples from the same system. HBsAg negative and HBV DNA positive occult hepatitis B were accepted. Results: HBV DNA was found positive in 100 positive 4 (4%). Viral load was <10 IU/ml in two of the HBV DNA positive cases, and 17 and 16 IU/ml in the other two cases. While Anti HCV positive was detected in one patient; HCV RNA could not be detected in any patient. While there was a significant difference in scores compared to those who did not have occult B; The score of histological activity and necrosis were not significantly different. Conclusion: Since antigen asntibody-based serology tests may be insufficient in the diagnosis of occult HBV, determination of HBV DNA level in special groups such as hemodialysis patients is important in terms of early recognition of occult HBV and preventing important complications such as cirrhosis and hepatocellular cancer. The absence of a previous study on occult hepatitis B and fibrometer in the literature has increased the importance of this study. [ABSTRACT FROM AUTHOR]

The SAPHO syndrome was given its acronymic name based on the presence of Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis in patients. The presence of joint and bone pain in patients with treatment resistance severe acne should suggest SAPHO syndrome. In addition, isotretinoin is an appropriate treatment for severe, scarring acne and may also improve osteoarticular manifestations.2,3,8 The current study described a rare case of SAPHO syndrome with diffuse nodulocystic acne, and musculoskeletal involvement of the sacroiliac joint, vertebrae and anterior chest wall arthritis or osteitis. [Extracted from the article]

Objective: We hypothesised that women with fear of childbirth (FOC) may have increased vascular resistance in maternal and foetal vascular beds due to maternal psychological stress. For this purpose, we investigated pulsatility (PI) and resistance (RI) index values for uterine, umbilical and mid cerebral arter ies in term pregnant women who were diagnosed with FOC and we compared these values than those of women without FOC. Methods: Women between 20-40 years with full-term singleton pregnancies (⩾37 gestational weeks) were included. All patients were questioned with Turkish form of Wijma Delivery Expectancy/Experience Questionnaire (W-DEQ) version A. Maternal age, gestational week, parity, body mass index and total W-DEQ scores of patients were recorded. Women with W-DEQ scores ⩾85 was defined as FOC. Forty women diagnosed with FOC (FOC group) and 45 women with W-DEQ scores <85 (control group) underwent Doppler waveform analysis and the pulsatility (PI) and resistance (RI) index values for uterine, umbilical and mid cerebral arteries were recorded. Data were analysed using SPSS software 12.0 (SPSS Inc., Chicago, IL, USA) and expressed as mean ⩾ standard deviation, P < 0.05 was considered significant. The normality of variables was tested using the Kolmogorov-Smirnov test. If the data was not normally distributed, Mann-Whitney U-test was used. Comparisons were done using the independent samples t-test when the data was normally distributed and the Fisher's exact test was used to compare the percentage values. Results: There were no differences between groups in terms of maternal age, parity, body mass index and gestational week values. Control group had lower W-DEQ scores compared with FOC group (p<0.001). Both groups had similar PI and RI values for umbilical and mid cerebral arteries (p>0.05). However, PI and RI values for both right and left uterine arteries were higher in FOC group than control group (p<0.05, for right uterine artery PI; p< 0.001, for left uterine artery RI and p<0.01, for others). Conclusions: It may be suggested that the presence of FOC in term pregnant women seems to have a negative effect on uterine blood flow parameters. When diagnosed with FOC, the women should be referred to a specialist for psycho-education and psychosomatic support in order to decrease her fear and to minimize the negative impact of fear on the foetus. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Medical & Surgical Intensive Care Medicine / Dahili ve Cerrahi Yoğun Bakım Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Autoinflammatory diseases (AIDs) are a recently described group of conditions caused by mutations in multiple genes that code for proteins of the innate immune system. Cryopyrin-associated periodic syndromes (CAPS) are autoinflammatory diseases comprising three clinically overlapping disorders: familial cold urticarial syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease (NOMID). CAPS have been associated with gain-of-function variations in NLRP3 (NOD-like receptor family, pyrin containing domain-3). However, a new class of autoinflammatory disease resembling FCAS or MWS has been described in patients with NLRP12 mutations. Here, we report a 6-year-old boy diagnosed with AID who developed an unexpected C3 glomerulopathy during attacks and carried a novel variation in NLRP12. Following treatment with IL (interleukin) 1 targeting agents, all symptoms and inflammation resolved. This is the first case in the literature affected by both autoinflammatory disease and C3 glomerulopathy. [ABSTRACT FROM AUTHOR]

Two new dithiocarbamate molecules were synthesized and characterized by 1 H NMR, 13 C NMR, IR, and structural X-ray diffraction techniques. The molecular geometry, vibrational frequencies of the title compounds in the ground state have been calculated by using the Hartree-Fock (HF) and density functional theory (DFT) methods with 6–31G(d) basis set, also gauge-independent atomic orbital (GIAO) 1 H and 13 C NMR chemical shift values of the title compound (I) have been calculated by the same methods and compared with the experimental data. The calculated results show that the optimized geometries can well reproduce the crystal structural parameters. A detailed vibrational spectral analysis has been carried out and assignments of observed fundamental bands have been proposed on basis of peak positions. The scaled theoretical frequencies showed very good agreement with experimental values. In addition, the computed 1 H and 13 C NMR chemical shift values are in line with experimental data. To determine conformational flexibility, the molecular energy profile of the title compounds were obtained in respect of the selected torsion angle, which were varied from −180° to +180° in steps of 10°. Besides, frontier molecular orbitals (FMO), molecular electrostatic potential (MEP)analysis and thermodynamic properties were investigated by theoretical calculations. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Medical & Surgical Intensive Care Medicine / Dahili ve Cerrahi Yoğun Bakım Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: The purpose of this study was to compare the demographic, clinical and laboratory characteristics of patients with enthesitis‐related arthritis (ERA), familial Mediterranean fever (FMF) and inflammatory bowel disease (IBD), which are inflammatory diseases that may develop sacroiliitis. Thus, it was aimed to reveal various findings that may indicate primary disease in patients with sacroiliitis. Methods: Pediatric patients aged 6–18 years, who were being followed with a diagnosis of ERA (n = 62), FMF (n = 590), and IBD (n = 56) over the period 2013–2021 were included in the study. Sacroiliitis (n = 55) was diagnosed by magnetic resonance imaging of the sacroiliac joint, obtained from clinically suspected patients. Results: Sacroiliitis was detected in 54.8% of ERA patients, 2.3% of FMF patients, and 12.5% of IBD patients. The mean follow‐up period was 4.1 ± 2.8 years (10 months‐8 years) for the entire study group. The most common MRI finding for sacroiliitis was bone marrow edema. Peripheral joint involvement (73.5%) and HLA B27 positivity (64.7%) was significantly higher in ERA patients, and ERA was diagnosed more frequently in patients presenting with sacroiliitis. Non‐steroidal anti‐inflammatory drugs (NSAIDs) were the first choice of treatment agent when sacroiliitis developed in all three patient groups. Conclusions: The clinical and laboratory findings of ERA, FMF and IBD can sometimes be intertwined or can even coexist. Treatment may differ depending on the disease associated with sacroiliitis, although NSAIDs may be used in the first‐line treatment of all three diseases. Sacroiliitis patients with HLA B27 positivity and peripheral arthritis may need to be addressed as ERA. [ABSTRACT FROM AUTHOR]

Objective: In this study, it was aimed to evaluate the demographic, clinical and laboratory characteristics of MIS-C patients in our hospital, to share our treatment approach, and to assess the outcomes of short- and long-term follow-up. Methods: MIS-C patients who were admitted and treated in our hospital between July 2020 and July 2021 were evaluated. Demographic, clinical, laboratory, and follow-up data were collected from patient records retrospectively. Results: A total of 123 patients with MIS-C (median age, 9.6 years) were included the study. Nineteen (15.4%) were mild, 56 (45.6%) were moderate, and 48 (39%) were severe MIS-C. High CRP, ferritin, pro-BNP, troponin, IL-6, and D-dimer values were found in proportion to the severity of the disease (p < 0.001, p < 0.001, p < 0.001, p < 0.001, p = 0.005, p < 0.001), respectively. Two (1.6%) patients died. The mean follow-up period was 7.8 months. Valve failure, left ventricular dysfunction/hypertrophy, coronary involvement, and pericardial effusion were the most common cardiac pathologies in the short- and long-term follow-up of the patients. In the long-term follow-up, the most common reasons for admission to the hospital were recurrent abdominal pain (14.2%), cardiac findings (14.2%), pulmonary symptoms (8%), fever (7.1%), neuropsychiatric findings (6.2%) and hypertension (3.5%). Neuropsychiatric abnormalities were observed significantly more common in severe MIS-C patients at follow-up (p = 0.016). In the follow-up, 6.2% of the patients required recurrent hospitalization. Conclusion: MIS-C is a serious and life-threatening disease, according to short-term outcomes. In addition to the cardiac findings of patients with MIS-C, long-term outcomes such as neuropsychiatric findings, persistent gastrointestinal symptoms, fever and pulmonary symptoms should be monitored. Key Points • In MIS-C patients, attention should be paid not only to cardiac findings, but also to symptoms related to other systems. • Patients should be followed up in terms of neuropsychiatric findings, persistent gastrointestinal symptoms, fever and pulmonary symptoms that may occur during follow-up. [ABSTRACT FROM AUTHOR]

Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening hyperinflammation syndrome emerging after COVID-19. The serum delta neutrophil index (DNI) reflects the fraction of circulating immature granulocytes and is evaluated in infection and inflammation. The aim of this study is to evaluate the usefulness of DNI as a diagnostic marker in patients with MIS-C and to assess its role in determining the severity of MIS-C. This retrospective, observational study included 83 patients with MIS-C and 113 patients with COVID-19, and 102 healthy controls. C-reactive protein (CRP), the absolute neutrophil count (ANC), absolute lymphocyte count (ALC), DNI, and the platelet count were recorded. The DNI levels were 4.60 ± 5.70% in the MIS C group, 0.30 ± 0.99% in the COVID group, and 0.20 ± 0.56% in the control group (p < 0.001). According to the severity of MIS-C, the DNI level was found to be 1.22% in mild MIS-C, 4.3% in moderate MIS-C, and 5.7% in severe MIS-C. There was a statistically significant correlation between DNI levels and the severity of MIS-C. The cutoff value of DNI for predicting MIS-C was 0.45%. In the analysis of the diagnostic performance of DNI compared with CRP, ANC, ALC and platelet counts, sensitivity, specificity, positive predictive value, and negative predictive value were found to be 79.5%, 97.1%, 95.7%, and 85.3%, respectively. Conclusions: The delta neutrophil index was identified as a diagnostic marker for MIS-C such as ANC, ALC, platelet count, and CRP. DNI levels in hemogram analysis may guide clinicians in determining the diagnosis and severity of MIS-C. What is Known: • Although CRP, sedimentation, ALC, ANC, platelet count, sodium, and albumin are used as first step tests, there is no specific laboratory marker used in the diagnosis of MIS C. • The serum delta neutrophil index (DNI) reflects the fraction of circulating immature granulocytes and is elevated in infection and inflammation. What is New: • DNI is a promising and easily accessible marker that can be used with other markers in the diagnosis and determines the severity of MIS C. • DNI is an easily accessible, inexpensive, and dynamic marker and its levels in simple hemogram analysis will guide pediatricians in determining the diagnosis and severity in MIS C. [ABSTRACT FROM AUTHOR]

Abstract: The title molecule (C19H17N5O4S·H2O) was synthesized and characterized by IR-NMR spectroscopy, MS and single-crystal X-ray diffraction. The molecular geometry, vibrational frequencies and gauge-independent atomic orbital (GIAO) 1H and 13C NMR chemical shift values of the compound in the ground state have been calculated by using the density functional theory (DFT) method with 6-31G(d) basis set, and compared with the experimental data. All the assignments of the theoretical frequencies were performed by potential energy distributions using VEDA 4 program. The calculated results show that the optimized geometries can well reproduce the crystal structural parameters, and the theoretical vibrational frequencies and 1H and 13C NMR chemical shift values show good agreement with experimental data. To determine conformational flexibility, the molecular energy profile of the title compound was obtained with respect to the selected torsion angle, which was varied from −180° to +180° in steps of 10°. Besides, molecular electrostatic potential (MEP), frontier molecular orbitals (FMO) analysis and thermodynamic properties of the compound were investigated by theoretical calculations. [Copyright &y& Elsevier]

Background: A good glycemic regulation should be provided to reduce mortality and morbidity in patients with end-stage renal failure due to diabetes mellitus. However, the use of insulin therapies in patients with renal failure is troublesome due to the increased rate of side effects. In our study, we investigated the frequency of hypoglycemia and its symptoms in patient groups receiving intensive and mixed insulin therapies. Materials and methods: This prospective study included 89 hemodialysis patients with DM-related stage 5 chronic kidney disease who were followed up in a nephrology clinic of a university hospital between January 2013 and August 2015. Our study group was divided into two groups as those receiving intensive insulin therapy and mixed insulin therapy. Group 1 and group 2 consisted of 46 patients and 43 patients, respectively. Hypoglycemia (glucose < 70 mg/dl) was investigated in patients with HbA1c levels that decreased below 7% after treatment, and the symptoms were evaluated according to the hypoglycemic scale. The results between the groups were evaluated using chi-square and Student's t test Results: A total of 89 patients were included in the study. HbA1c was 6.83% in the group receiving intensive insulin therapy and 6.95% in the group receiving mixed insulin therapy (p > 0.05). Hypoglycemia was detected in 27 patients (58.7%) in the intensive insulin therapy group and 14 patients (32.6%) in the mixed insulin therapy group. There was a significant level of hypoglycemia in the group receiving intensive insulin therapy (p < 0.05). In our study, the group receiving intensive insulin therapy had higher frequency and severity of common hypoglycemia symptoms such as confusion, sweating, weakness, dysphasia, palpitations, blurred vision, and feeling hungry. Conclusion: There was a higher frequency of hypoglycemia under intensive insulin therapy in patients undergoing dialysis due to chronic kidney failure, which suggests that mixed insulin therapy is the ideal treatment to avoid hypoglycemia in this group of patients. [ABSTRACT FROM AUTHOR]