Hemodiyaliz Hastalarında Okült Hepatit B ile Hepatit C Prevalansı ve Fibrometer ile Karaciğer Fibrozis Düzeyinin Değerlendirilmesi.

Objective: In this study, it was aimed to determine the HCV prevalence and the occult HBV prevalence by HBV DNA analysis in serum samples of HBsAg patients undergoing routine hemodialysis. It was also aimed to determine the liver fibrosis level with fibrometer, which is a non-invasive method. Methods: The study included 100 patients who applied for routine hemodialysis and were negative for HBsAg in screening tests. In samples from the patient, ALT, HBsAg, Anti-HBc IgG, HBV DNA, Anti HCV, HCV RNA and fibrometer were studied from serum samples from the same system. HBsAg negative and HBV DNA positive occult hepatitis B were accepted. Results: HBV DNA was found positive in 100 positive 4 (4%). Viral load was <10 IU/ml in two of the HBV DNA positive cases, and 17 and 16 IU/ml in the other two cases. While Anti HCV positive was detected in one patient; HCV RNA could not be detected in any patient. While there was a significant difference in scores compared to those who did not have occult B; The score of histological activity and necrosis were not significantly different. Conclusion: Since antigen asntibody-based serology tests may be insufficient in the diagnosis of occult HBV, determination of HBV DNA level in special groups such as hemodialysis patients is important in terms of early recognition of occult HBV and preventing important complications such as cirrhosis and hepatocellular cancer. The absence of a previous study on occult hepatitis B and fibrometer in the literature has increased the importance of this study. [ABSTRACT FROM AUTHOR]