Search

Your search keyword '"Marcus, J. Tim"' showing total 454 results
Start Over Author "Marcus, J. Tim"
454 results on '"Marcus, J. Tim"'

103. Corrigendum to ‘Systolic pulmonary artery pressure and heart rate are main determinants of oxygen consumption in the right ventricular myocardium of patients with idiopathic pulmonary arterial hypertension’ [Eur J Heart Fail 2012;13:1290-1295]

Author

Wong, Yeun Ying, primary, Westerhof, Nico, additional, Ruiter, Gerrina, additional, Lubberink, Mark, additional, Raijmakers, Pieter, additional, Knaapen, Paul, additional, Marcus, J. Tim, additional, Boonstra, Anco, additional, Lammertsma, Adriaan A., additional, van der Laarse, Willem J., additional, and Vonk-Noordegraaf, Anton, additional

Published
2012
Full Text
View/download PDF

105. Right Ventricular Failure in Idiopathic Pulmonary Arterial Hypertension Is Associated With Inefficient Myocardial Oxygen Utilization

Author

Wong, Yeun Ying, primary, Ruiter, Gerrina, additional, Lubberink, Mark, additional, Raijmakers, Pieter G., additional, Knaapen, Paul, additional, Marcus, J. Tim, additional, Boonstra, Anco, additional, Lammertsma, Adriaan A., additional, Westerhof, Nico, additional, van der Laarse, Willem J., additional, and Vonk-Noordegraaf, Anton, additional

Published
2011
Full Text
View/download PDF

114. Relation between three-dimensional echocardiography derived left ventricular volume and MRI derived circumferential strain in patients eligible for cardiac resynchronization therapy

Author

Rüssel, Iris K., primary, van Dijk, Jeroen, additional, Kleijn, Sebastiaan A., additional, Germans, Tjeerd, additional, de Roest, Gerjan, additional, Marcus, J. Tim, additional, Kamp, Otto, additional, Götte, Marco J. W., additional, and van Rossum, Albert C., additional

Published
2008
Full Text
View/download PDF

121. The effect of left bundle branch block on left ventricular remodeling, dyssynchrony and deformation of the mitral valve apparatus: an observational cardiovascular magnetic resonance imaging study

Author

van der Land, Vroni, primary, Germans, Tjeerd, additional, van Dijk, Jeroen, additional, Zwanenburg, Jaco J. M., additional, Spreeuwenberg, Marieke, additional, Marcus, J. Tim, additional, Kamp, Otto, additional, Götte, Marco J. W., additional, and van Rossum, Albert C., additional

Published
2006
Full Text
View/download PDF

123. Does Myocardial Fibrosis Hinder Contractile Function and Perfusion in Idiopathic Dilated Cardiomyopathy? PET and MR Imaging Study

Author

Knaapen, Paul, primary, Götte, Marco J. W., additional, Paulus, Walter J., additional, Zwanenburg, Jaco J. M., additional, Dijkmans, Pieter A., additional, Boellaard, Ronald, additional, Marcus, J. Tim, additional, Twisk, Jos W. R., additional, Visser, Cees A., additional, van Rossum, Albert C., additional, Lammertsma, Adriaan A., additional, and Visser, Frans C., additional

Published
2006
Full Text
View/download PDF

142. Signs of Right Ventricular Deterioration in Clinically Stable Patients With Pulmonary Arterial Hypertension

Author

van de Veerdonk, Mariëlle C., Marcus, J. Tim, Westerhof, Nico, de Man, Frances S., Boonstra, Anco, Heymans, Martijn W., Bogaard, Harm-Jan, and Vonk Noordegraaf, Anton

Abstract

BACKGROUND: Even after years of stable response to therapy, patients with idiopathic pulmonary arterial hypertension (IPAH) may show an unexpected clinical deterioration due to progressive right ventricular (RV) failure. Therefore, the aim of this study was to assess in 5-year clinically stable patients with IPAH whether initial differences or subsequent changes in RV volumes precede late clinical progression.

Published
2015
Full Text
View/download PDF

143. Right Ventricular Diastolic Impairment in Patients With Pulmonary Arterial Hypertension.

Author

Rain, Silvia, Handoko, M. Louis, Trip, Pia, Tji-Joong Gan, C., Westerhof, Nico, Stienen, Ger J., Paulus, Walter J., Ottenheijm, Coen A. C., Marcus, J. Tim, Dorfmüller, Peter, Guignabert, Christophe, Humbert, Marc, MacDonald, Peter, dos Remedios, Cris, Postmus, Piet E., Saripalli, Chandra, Hidalgo, Carlos G., Granzier, Henk L., Vonk-Noordegraaf, Anton, and van der Velden, Jolanda

Published
2013
Full Text
View/download PDF

144. Progressive Changes in Right Ventricular Geometric Shortening and Long-term Survival in Pulmonary Arterial Hypertension.

Author

Mauritz, Gert-Jan, Kind, Taco, Marcus, J. Tim, Bogaard, Harm-Jan, de Veerdonk, Mariëlle van, Postmus, Pieter E., Boonstra, Anco, Westerhof, Nico, and Vonk-Noordegraaf, Anton

Subjects
RIGHT heart ventricle, PULMONARY hypertension, PULMONARY artery diseases, CARDIAC catheterization, CARDIAC magnetic resonance imaging
Abstract

The article focuses on a study which described the time courses of right ventricular (RV) geometric changes during the progression of RV failure. The study included 42 patients with pulmonary arterial hypertension (PAH), who underwent right-sided heart catheterization and cardiac magnetic resonance imaging (MRI). Study authors concluded that progressive RV failure in patients with PAH is link with a parallel decline in longitudinal and transverse shortening of RV.

Published
2012
Full Text
View/download PDF

145. Supine-exercise-induced oxygen supply to the right myocardium is attenuated in patients with severe idiopathic pulmonary arterial hypertension.

Author

Yeun Ying Wong, Raijmakers, Pieter G., Knaapen, Paul, Lubberink, Mark, Ruiter, Gerrina, Marcus, J. Tim, Boonstra, Anco, Lammertsma, Adriaan A., Westerhof, Nico, van der Laarse, Willem J., and Vonk-Noordegraaf, Anton

Subjects
VENTRICULAR outflow obstruction, BRUGADA syndrome, IDIOPATHIC pulmonary fibrosis, PULMONARY hypertension, SUPINE position, EXERCISE therapy, CARDIOPULMONARY system physiology
Abstract

Background Impaired right ventricular (RV) myocardial blood flow (MBF) has been associated with RV dysfunction and fatal RV failure in idiopathic pulmonary hypertension during stress. MBF and O2 extraction from myocardial capillaries (O2 extraction fraction (OEF)) influence myocardial O2 supply. Objective To determine how the baseline RV OEF affects the amount of MBF increase induced by supine exercise, the authors hypothesise that higher baseline OEF (H-OEF) results in limited O2 extraction during exercise and that MBF must therefore be increased to obtain sufficient O2. Methods In 18 patients with idiopathic pulmonary hypertension, baseline OEF, resting MBF and exercise-induced MBF at 40% of maximal cardiopulmonary exercise testing load were measured using positron emission tomography and [15O]O2, [15O]H2O and [15O]CO. Results For the whole population, exercise increased RV MBF from 0.68±0.16 to 1.13±0.38 ml/min/g (p<0.0001). The MBF exercise-to-rest ratio (reserve) was 1.7±0.7. The median baseline OEF was 0.73 at which the patient population was split into H-OEF and lower baseline OEF (L-OEF). Baseline MBF values (0.61±0.11 and 0.74±0.17 ml/min/g, respectively) were similar, and exercise induced a significant MBF increase in both groups (p=0.0001). However, exercise-induced increase in MBF was significantly less in the H-OEF group than in the L-OEF group (0.97±0.30 and 1.30±0.39 ml/min/g, respectively, p<0.05). Moreover, H-OEF patients had lower baseline stroke volume and cardiac output than the L-OEF group (52±19 ml and 4.0±1.1 l/min vs 78±18 ml and 5.5±0.9 l/min, respectively, both p<0.05). Conclusions H-OEF patients were hemodynamically poorer and showed a lower exercise-induced MBF increase compared to L-OEF patients, suggesting exercise-induced O2 supply limitation. [ABSTRACT FROM AUTHOR]

Published
2011
Full Text
View/download PDF

146. Right Ventricular Failure in Idiopathic Pulmonary Arterial Hypertension Is Associated With Inefficient Myocardial Oxygen Utilization.

Author

Yeun Ying Wong, Ruiter, Gerrina, Lubberink, Mark, Raijmakers, Pieter G., Knaapen, Paul, Marcus, J. Tim, Boonstra, Anco, Lammertsma, Adriaan A., Westerhof, Nico, van der Laarse, Willem J., and Vonk-Noordegraaf, Anton

Subjects
VENTRICULAR outflow obstruction, PULMONARY hypertension diagnosis, CARDIAC catheterization complications, POSITRON emission tomography, EDUCATION
Abstract

The article discusses a study on the association between right ventricular (RV) failure in idiopathic pulmonary arterial hypertension (IPAH) and reduced efficiency of myocardial oxygen utilization. The study involved patients in the New York Heart Association (NYHA) class II and class III. The patients underwent right heart catheterization and positron emission tomography (PET). Both groups had similar RV power and oxygen supply. Class II had lower RV oxygen extraction compared with class III.

Published
2011
Full Text
View/download PDF

147. Clinically Significant Change in Stroke Volume in Pulmonary Hypertension.

Author

van Wolferen, Serge A., van de Veerdonk, Marielle C., Mauritz, Gert-Jan, Jacobs, Wouter, Marcus, J. Tim, Marques, Koen M. J., Bronzwaer, Jean G. F., Heymans, Martijn W., Boonstra, Anco, Postmus, Pieter E., Westerhof, Nico, and Noordegraaf, Anton Vonk

Subjects
PULMONARY hypertension, RIGHT heart ventricle, PULMONARY circulation, HEMODYNAMICS, BLOOD circulation
Abstract

The article attempts to determine the minimal important difference (MID) in stroke volume among patients with pulmonary hypertension (PH). According to the authors, stroke volume is arguably the best hemodynamic parameter because it reflects right ventricular function in response to its load. They report that in the experiment conducted, change in stroke volume was found to be correlated with the change in six-min walk test (6MWT). They conclude that a 10-mL change in stroke volume during follow-up can be considered as clinically relevant.

Published
2011
Full Text
View/download PDF

148. Progressive Dilatation of the Main Pulmonary Artery Is a Characteristic of Pulmonary Arterial Hypertension and Is Not Related to Changes in Pressure.

Author

Boerrigter, Bart, Mauritz, Gert-Jan, Marcus, J. Tim, Helderman, Frank, Postmus, Pieter E., Westerhof, Nico, and Vonk-Noordegraaf, Anton

Subjects
PULMONARY hypertension, PULMONARY artery diseases, HEART failure, LUNG diseases, RESPIRATORY diseases
Abstract

The article discusses the conducted study to analyze the pulmonary artery (PA) size in treated patients with pulmonary arterial hypertension (PAH) and determine if PA size reflects pulmonary vascular hemodynamics. PAH is a clinical syndrome due to increased pulmonary vascular resistance (PVR) resulting to right-side heart failure and, eventually, death. The study utilized cardiac magnetic resonance imaging (CMR) images to obtain PA diameter (PAD) and the ratio of PAD and ascending aorta diameter.

Published
2010
Full Text
View/download PDF

149. Use of H215O-PET and DCE-MRI to Measure Tumor Blood Flow.

Author

De Langen, Adrianus J., Van Den Boogaart, Vivian E. M., Marcus, J. Tim, and Lubberink, Mark

Subjects
POSITRON emission tomography, MAGNETIC resonance imaging, BLOOD flow, PERFUSION, NEOVASCULARIZATION, ONCOLOGY
Abstract

Positron emission tomography (PET) with H2 15 and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provide noninvasive measurements of tumor blood flow. Both tools offer the ability to monitor the direct target of antiangiogenic treatment, and their use is increasingly being studied in trials evaluating such drugs. Antiangiogenic therapy offers great potential and, to an increasing extent, benefit for oncological patients in a variety of palliative and curative settings. Because this type of targeted therapy frequently results in consolidation of the tumor mass instead of regression, monitoring treatment response with the standard volumetric approach (Response Evaluation Criteria in Solid Tumors) leads to underestimation of the response rate. Monitoring direct targets of anticancer therapy might be superior to indirect size changes. In addition, measures of tumor blood flow contribute to a better understanding of tumor biology. This review shows that DCE-MRI and H2 15O-PET provide reliable measures of tumor perfusion, provided that a certain level of standardization is applied. Heterogeneity in scan acquisition and data analysis complicates the interpretation of study results. Also, limitations inherent to both techniques must be considered when interpreting DCE-MRI and H2 15O-PET results. This review focuses on the technical and physiological aspects of both techniques and aims to provide the essential information necessary to critically evaluate the use of DCE-MRI and H2 15O-PET in an oncological setting. [ABSTRACT FROM AUTHOR]

Published
2008
Full Text
View/download PDF

150. Right Ventricular Diastolic Dysfunction and the Acute Effects of Sildenafil in Pulmonary Hypertension Patients.

Author

Tji-Joong Gan, C., Holverda, Sehastloan, Marcus, J. Tim, Panlus, Walter J., Marques, Koen M., Bronzwaer, Jean G.F., Twisk, Jos W., Boonstra, Anco, Postmus, Pieter K., and Vonk-Noordegraaj, Anton

Subjects
SILDENAFIL, CYCLIC nucleotide phosphodiesterase inhibitors, PULMONARY hypertension, HEART ventricle diseases, THERAPEUTICS
Abstract

The article presents a study on the acute effects of Sildenafil in pulmonary hypertension and right ventricular diastolic dysfunction. It aims to investigate the relationship of the right ventricular (RV) diastolic function impairment in pulmonary hypertension patients to RV mass and afterload of the oral intake of Sildenafil.

Published
2007
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results