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104. Erratum: Corrigendum: Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution

Author

Hillier, LaDeana W, Miller, Webb, Birney, Ewan, Warren, Wesley, Hardison, Ross C, Ponting, Chris P, Bork, Peer, Burt, Peer, Groenen, Martien A M, Delany, Mary E, Dodgson, Jerry B, Chinwalla, Asif, Cliften, Paul F, Clifton, Sandra W, Delehaunty, Kimberly D, Fronick, Catrina, Fulton, Robert S, Graves, Tina A, Kremitzki, Colin, Layman, Dan, Magrini, Vincent, McPherson, John D, Miner, Tracie L, Minx, Patrick, Nash, William E, Nhan, Michael N, Nelson, Joanne O, Oddy, Lachlan G, Pohl, Craig S, Randall-Maher, Jennifer, Smith, Scott M, Wallis, John W, Yang, Shiaw-Pyng, Romanov, Michael N, Rondelli, Catherine M, Paton, Bob, Smith, Jacqueline, Morrice, David, Daniels, Laura, Tempest, Helen G, Robertson, Lindsay, Masabanda, Julio S, Griffin, Darren K., Vignal, Alain, Fillon, Valerie, Jacobbson, Lina, Kerje, Susanne, Andersson, Leif, Crooijmans, Richard P M A, Aerts, Jan, van der Poel, Jan J, Ellegren, Hans, Caldwell, Randolph B, Hubbard, Simon J, Grafham, Darren V, Kierzek, Andrzej M, McLaren, Stuart R, Overton, Ian M, Arakawa, Hiroshi, Beattie, Kevin J, Bezzubov, Yuri, Boardman, Paul E, Bonfield, James K, Croning, Michael D R, Davies, Robert M, Francis, Matthew D, Humphray, Sean J, Scott, Carol E, Taylor, Ruth G, Tickle, Cheryll, Brown, William R A, Rogers, Jane, Buerstedde, Jean-Marie, Wilson, Stuart A, Stubbs, Lisa, Ovcharenko, Ivan, Gordon, Laurie, Lucas, Susan, Miller, Marcia M, Inoko, Hidetoshi, Shiina, Takashi, Kaufman, Jim, Salomonsen, Jan, Skjoedt, Karsten, Wong, Gane Ka-Shu, Wang, Jun, Liu, Bin, Wang, Jian, Yu, Jun, Yang, Huanming, Nefedov, Mikhail, Koriabine, Maxim, de Jong, Pieter J, Goodstadt, Leo, Webber, Caleb, Dickens, Nicholas J, Letunic, Ivica, Suyama, Mikita, Torrents, David, von Mering, Christian, Zdobnov, Evgeny M, Makova, Kateryna, Nekrutenko, Anton, Elnitski, Laura, Eswara, Pallavi, King, David C, Yang, Shan, Tyekucheva, Svitlana, Radakrishnan, Anusha, Harris, Robert S, Chiaromonte, Francesca, Taylor, James, He, Jianbin, Rijnkels, Monique, Griffiths-Jones, Sam, Ureta-Vidal, Abe, Hoffman, Michael M, Severin, Jessica, Searle, Stephen M J, Law, Andy S, Speed, David, Waddington, David, Cheng, Ze, Tuzun, Eray, Eichler, Evan, Bao, Zhirong, Flicek, Paul, Shteynberg, David D, Brent, Michael R, Bye, Jacqueline M, Huckle, Elizabeth J, Chatterjee, Sourav, Dewey, Colin, Pachter, Lior, Kouranov, Andrei, Mourelatos, Zissimos, Hatzigeorgiou, Artemis G, Paterson, Andrew H, Ivarie, Robert, Brandstrom, Mikael, Axelsson, Erik, Backström, Niclas, Berlin, Sofia, Webster, Matthew T, Pourquie, Olivier, Reymond, Alexandre, Ucla, Catherine, Antonarakis, Stylianos E, Long, Manyuan, Emerson, J J, Betran, Esther, Dupanloup, Isabelle, Kaessmann, Henrik, Hinrichs, Angie S, Bejerano, Gill, Furey, Terrence S, Harte, Rachel A, Raney, Brian, Siepel, Adam, Kent, W James, Haussler, David, Eyras, Eduardo, Castelo, Robert, Abril, Josep F, Castellano, Sergi, Camara, Francisco, Parra, Genis, Guigo, Roderic, Bourque, Guillaume, Tesler, Glenn, Pevzner, Pavel A., Smit, Arian F. A., Fulton, Lucinda A., Mardis, Elaine R., Wilson, Richard K., Hillier, LaDeana W, Miller, Webb, Birney, Ewan, Warren, Wesley, Hardison, Ross C, Ponting, Chris P, Bork, Peer, Burt, Peer, Groenen, Martien A M, Delany, Mary E, Dodgson, Jerry B, Chinwalla, Asif, Cliften, Paul F, Clifton, Sandra W, Delehaunty, Kimberly D, Fronick, Catrina, Fulton, Robert S, Graves, Tina A, Kremitzki, Colin, Layman, Dan, Magrini, Vincent, McPherson, John D, Miner, Tracie L, Minx, Patrick, Nash, William E, Nhan, Michael N, Nelson, Joanne O, Oddy, Lachlan G, Pohl, Craig S, Randall-Maher, Jennifer, Smith, Scott M, Wallis, John W, Yang, Shiaw-Pyng, Romanov, Michael N, Rondelli, Catherine M, Paton, Bob, Smith, Jacqueline, Morrice, David, Daniels, Laura, Tempest, Helen G, Robertson, Lindsay, Masabanda, Julio S, Griffin, Darren K., Vignal, Alain, Fillon, Valerie, Jacobbson, Lina, Kerje, Susanne, Andersson, Leif, Crooijmans, Richard P M A, Aerts, Jan, van der Poel, Jan J, Ellegren, Hans, Caldwell, Randolph B, Hubbard, Simon J, Grafham, Darren V, Kierzek, Andrzej M, McLaren, Stuart R, Overton, Ian M, Arakawa, Hiroshi, Beattie, Kevin J, Bezzubov, Yuri, Boardman, Paul E, Bonfield, James K, Croning, Michael D R, Davies, Robert M, Francis, Matthew D, Humphray, Sean J, Scott, Carol E, Taylor, Ruth G, Tickle, Cheryll, Brown, William R A, Rogers, Jane, Buerstedde, Jean-Marie, Wilson, Stuart A, Stubbs, Lisa, Ovcharenko, Ivan, Gordon, Laurie, Lucas, Susan, Miller, Marcia M, Inoko, Hidetoshi, Shiina, Takashi, Kaufman, Jim, Salomonsen, Jan, Skjoedt, Karsten, Wong, Gane Ka-Shu, Wang, Jun, Liu, Bin, Wang, Jian, Yu, Jun, Yang, Huanming, Nefedov, Mikhail, Koriabine, Maxim, de Jong, Pieter J, Goodstadt, Leo, Webber, Caleb, Dickens, Nicholas J, Letunic, Ivica, Suyama, Mikita, Torrents, David, von Mering, Christian, Zdobnov, Evgeny M, Makova, Kateryna, Nekrutenko, Anton, Elnitski, Laura, Eswara, Pallavi, King, David C, Yang, Shan, Tyekucheva, Svitlana, Radakrishnan, Anusha, Harris, Robert S, Chiaromonte, Francesca, Taylor, James, He, Jianbin, Rijnkels, Monique, Griffiths-Jones, Sam, Ureta-Vidal, Abe, Hoffman, Michael M, Severin, Jessica, Searle, Stephen M J, Law, Andy S, Speed, David, Waddington, David, Cheng, Ze, Tuzun, Eray, Eichler, Evan, Bao, Zhirong, Flicek, Paul, Shteynberg, David D, Brent, Michael R, Bye, Jacqueline M, Huckle, Elizabeth J, Chatterjee, Sourav, Dewey, Colin, Pachter, Lior, Kouranov, Andrei, Mourelatos, Zissimos, Hatzigeorgiou, Artemis G, Paterson, Andrew H, Ivarie, Robert, Brandstrom, Mikael, Axelsson, Erik, Backström, Niclas, Berlin, Sofia, Webster, Matthew T, Pourquie, Olivier, Reymond, Alexandre, Ucla, Catherine, Antonarakis, Stylianos E, Long, Manyuan, Emerson, J J, Betran, Esther, Dupanloup, Isabelle, Kaessmann, Henrik, Hinrichs, Angie S, Bejerano, Gill, Furey, Terrence S, Harte, Rachel A, Raney, Brian, Siepel, Adam, Kent, W James, Haussler, David, Eyras, Eduardo, Castelo, Robert, Abril, Josep F, Castellano, Sergi, Camara, Francisco, Parra, Genis, Guigo, Roderic, Bourque, Guillaume, Tesler, Glenn, Pevzner, Pavel A., Smit, Arian F. A., Fulton, Lucinda A., Mardis, Elaine R., and Wilson, Richard K.

Abstract

International Chicken Genome Sequencing Consortium. The Original Article was published on 09 December 2004. Nature432, 695–716 (2004). In Table 5 of this Article, the last four values listed in the ‘Copy number’ column were incorrect. These should be: LTR elements, 30,000; DNA transposons, 20,000; simple repeats, 140,000; and satellites, 4,000. These errors do not affect any of the conclusions in our paper. Additional information. The online version of the original article can be found at 10.1038/nature03154

Published
2005

106. Transcriptome profiling of the Caenorhabditis elegansintestine reveals that ELT-2 negatively and positively regulates intestinal gene expression within the context of a gene regulatory network

Author

Williams, Robert T P, King, David C, Mastroianni, Izabella R, Hill, Jessica L, Apenes, Nicolai W, Ramirez, Gabriela, Miner, E Catherine, Moore, Andrew, Coleman, Karissa, and Nishimura, Erin Osborne

Abstract

ELT-2 is the major transcription factor (TF) required for Caenorhabditis elegansintestinal development. ELT-2 expression initiates in embryos to promote development and then persists after hatching through the larval and adult stages. Though the sites of ELT-2 binding are characterized and the transcriptional changes that result from ELT-2 depletion are known, an intestine-specific transcriptome profile spanning developmental time has been missing. We generated this dataset by performing Fluorescence Activated Cell Sorting on intestine cells at distinct developmental stages. We analyzed this dataset in conjunction with previously conducted ELT-2 studies to evaluate the role of ELT-2 in directing the intestinal gene regulatory network through development. We found that only 33% of intestine-enriched genes in the embryo were direct targets of ELT-2 but that number increased to 75% by the L3 stage. This suggests additional TFs promote intestinal transcription especially in the embryo. Furthermore, only half of ELT-2's direct target genes were dependent on ELT-2 for their proper expression levels, and an equal proportion of those responded to elt-2depletion with over-expression as with under-expression. That is, ELT-2 can either activate or repress direct target genes. Additionally, we observed that ELT-2 repressed its own promoter, implicating new models for its autoregulation. Together, our results illustrate that ELT-2 impacts roughly 20–50% of intestine-specific genes, that ELT-2 both positively and negatively controls its direct targets, and that the current model of the intestinal regulatory network is incomplete as the factors responsible for directing the expression of many intestinal genes remain unknown.

Published
2023
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109. Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression

Author

Cheng, Yong, primary, Wu, Weisheng, additional, Ashok Kumar, Swathi, additional, Yu, Duonan, additional, Deng, Wulan, additional, Tripic, Tamara, additional, King, David C., additional, Chen, Kuan-Bei, additional, Zhang, Ying, additional, Drautz, Daniela, additional, Giardine, Belinda, additional, Schuster, Stephan C., additional, Miller, Webb, additional, Chiaromonte, Francesca, additional, Zhang, Yu, additional, Blobel, Gerd A., additional, Weiss, Mitchell J., additional, and Hardison, Ross C., additional

Published
2009
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110. Transcriptional enhancement by GATA1-occupied DNA segments is strongly associated with evolutionary constraint on the binding site motif

Author

Cheng, Yong, primary, King, David C., additional, Dore, Louis C., additional, Zhang, Xinmin, additional, Zhou, Yuepin, additional, Zhang, Ying, additional, Dorman, Christine, additional, Abebe, Demesew, additional, Kumar, Swathi A., additional, Chiaromonte, Francesca, additional, Miller, Webb, additional, Green, Roland D., additional, Weiss, Mitchell J., additional, and Hardison, Ross C., additional

Published
2008
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112. Comparative genomics to find function in noncoding DNA

Author

Hardison, Ross C., primary, King, David C., additional, Taylor, James, additional, Wang, Hao, additional, Zhang, Ying, additional, Zhou, Yuepin, additional, Cheng, Yong, additional, Dorman, Christine, additional, Dore, Louis C., additional, Weiss, Mitchell J., additional, Chiaromonte, Francesca, additional, and Miller, Webb, additional

Published
2007
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113. Validation of predicted erythroid cis-regulatory modules

Author

Zhou, Yuepin, primary, Cheng, Yong, additional, Wang, Hao, additional, Zhang, Ying, additional, King, David C., additional, Taylor, James, additional, Chiaromonte, Francesca, additional, Dorman, Christine, additional, Miller, Webb, additional, Dore, Louis C., additional, Weiss, Mitchell J., additional, and Hardison, Ross C., additional

Published
2007
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114. Multifunctional cytomegalovirus (CMV)-specific CD8+ T cells are not restricted by telomere-related senescence in young or old adults.

Author

Riddell, Natalie E., Griffiths, Stephen J., Rivino, Laura, King, David C. B., Teo, Guo H., Henson, Sian M., Cantisan, Sara, Solana, Rafael, Kemeny, David M., MacAry, Paul A., Larbi, Anis, and Akbar, Arne N.

Subjects
CYTOMEGALOVIRUS diseases, CD8 antigen, T cells, TELOMERES, CELLULAR aging, INTERFERONS, CELL differentiation, PHYSIOLOGY
Abstract

Antigen-specific multifunctional T cells that secrete interferon- γ, interleukin-2 and tumour necrosis factor- α simultaneously after activation are important for the control of many infections. It is unclear if these CD8+ T cells are at an early or late stage of differentiation and whether telomere erosion restricts their replicative capacity. We developed a multi-parameter flow cytometric method for investigating the relationship between differentiation (CD45RA and CD27 surface phenotype), function (cytokine production) and replicative capacity (telomere length) in individual cytomegalovirus (CMV) antigen-specific CD8+ T cells. This involves surface and intracellular cell staining coupled to fluorescence in situ hybridization to detect telomeres (flow-FISH). The end-stage/senescent CD8+ CD45RA+ CD27− T-cell subset increases significantly during ageing and this is exaggerated in CMV immune-responsive subjects. However, these end-stage cells do not have the shortest telomeres, implicating additional non-telomere-related mechanisms in inducing their senescence. The telomere lengths in total and CMV (NLV)-specific CD8+ T cells in all four subsets defined by CD45RA and CD27 expression were significantly shorter in old compared with young individuals in both a Caucasian and an Asian cohort. Following stimulation by anti-CD3 or NLV peptide, similar proportions of triple-cytokine-producing cells are found in CD8+ T cells at all stages of differentiation in both age groups. Furthermore, these multi-functional cells had intermediate telomere lengths compared with cells producing only one or two cytokines after activation. Therefore, global and CMV (NLV)-specific CD8+ T cells that secrete interferon- γ, interleukin-2 and tumour necrosis factor- α are at an intermediate stage of differentiation and are not restricted by excessive telomere erosion. [ABSTRACT FROM AUTHOR]

Published
2015
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116. Experimental validation of predicted mammalian erythroid cis-regulatory modules

Author

Wang, Hao, primary, Zhang, Ying, additional, Cheng, Yong, additional, Zhou, Yuepin, additional, King, David C., additional, Taylor, James, additional, Chiaromonte, Francesca, additional, Kasturi, Jyotsna, additional, Petrykowska, Hanna, additional, Gibb, Brian, additional, Dorman, Christine, additional, Miller, Webb, additional, Dore, Louis C., additional, Welch, John, additional, Weiss, Mitchell J., additional, and Hardison, Ross C., additional

Published
2006
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123. Chapter 12: Moving Voters in the 2000 Presidential Campaign.

Author

King, David C. and Morehouse, David

Subjects
TELEVISION advertising, VOTERS, PRESIDENTIAL elections
Abstract

Chapter 12 of the book "Lights, Camera, Campaign!" is presented. It focuses on the importance of television commercials and local campaign appearances to move voters during presidential campaign in the U.S. It explores the effects of Vice President Al Gore's trip to the Mississippi River on moving voter preferences in August 2000. It enumerates the advantage of state-level polling data to campaigns.

Published
2004

127. Improving Heat Exchanger Designs.

Author

Bennett, Christopher A., Kistler, R. Stanley, Lestina, Thomas G., and King, David C.

Subjects
HEAT exchangers, CHEMICAL engineering equipment, HEAT transfer, REFRIGERATION & refrigerating machinery
Abstract

The article focuses on the factors that affect heat exchanger design margins. Capital costs can be lowered and plant operation is improved through the proper application of design margins. Heat exchanger design margin was discussed at the Heat Transfer Research Inc.'s Exchanger Design Margins Task Force.

Published
2007

128. The Microcomputer: A Symbol for Our Times.

Author

King, David C.

Abstract

Suggests that educators must share the responsibility for training people for living in the twenty-first century. Notes implication to education of the development of the microcomputer. (KC)

Published
1980

130. The Government and the Individual: Future Relations

Author

King, David C.

Abstract

Case studies which illustrate issues of immediate or potential importance to Americans are presented. It is suggested that the material is pertinent for use in many classroom activities designed to clarify the future relationship of the individual and his government (role-playing, discussion, research topics, panel reports, and debates). (SM)

Published
1973

132. Re-Tooling the Social Studies Textbook.

Author

King, David C.

Subjects
STUDENTS, EDUCATION, TEXTBOOKS, TEACHING aids
Abstract

Focuses on the means to help students understand issues and concerns that make up the U.S. societal agenda. Reasons for the failure to deal educationally with controversial issues; Limitations of textbooks as teaching tools; Outcome of the textbook's space constraints.

Published
1984

134. Basic Insurance Optimization For BC/DR.

Author

King, David C.

Subjects
INSURANCE policies, EMERGENCY management, ELECTRIC power failures, BUSINESS insurance, INSURANCE
Abstract

The article presents a 12-step checklist for optimizing insurance policies for business continuity and disaster recovery. It is shown that in an "All Risk" or "Special" Cause of Loss policy, the covered causes of loss must be determined, and that in an Off-Premises Utility Services-Direct Damage policy, coverage should respond to damage caused by off-premises utility interruption. In a Spoilage policy, coverage should reportedly respond to damage caused by power breakdown and outage.

Published
2011

135. WEB SITES.

Author

King, David C.

Abstract

This is a list of websites on topics related to the American Revolution that appear in the book 'Saratoga.'

Published
2002

136. INDEX.

Author

King, David C.

Abstract

This is an index to topics discussed in the book 'Saratoga.' The index also indicates which topics have accompanying illustrations.

Published
2002

137. OTHER SOURCES.

Author

King, David C.

Abstract

This is a list of some books used as sources of information for the book 'Saratoga.' 'The American Revolutionaries: A History in Their Own Words,' edited by Milton Melzer, and 'The Almanac of American History,' by Arthur M. Schlesinger Jr., are among these.

Published
2002

138. SOURCE NOTES.

Author

King, David C.

Abstract

These notes provide information on the sources used in the book 'Saratoga.' 'United States History,' by David C. King et al., and 'Military Journal of the American Revolution ,' by James Thacher, are among these.

Published
2002

139. FURTHER READING.

Author

King, David C.

Abstract

This list suggests books for further reading on topics related to the Battle of Saratoga, a major turning point in the American Revolution, that appear in the book 'Saratoga.' 'Traitor: The Case of Benedict Arnold,' by Jean Fritz, and 'The Battles of Saratoga: The Turning of the Tide,' by John R. Cuneo, are among these.

Published
2002

140. CHRONOLOGY OF THE REVOLUTIONARY WAR.

Author

King, David C.

Abstract

This is a chronological list of events in the American Revolution that appear in the book 'Saratoga.' In September 1774, the First Continental Congress met in Philadelphia, Pennsylvania. In April, 1775, the British army and the Massachusetts militia fought at Lexington and Concord near Boston, Massachusetts. In May 1775, Massachusetts and Vermont militias captured Fort Ticonderoga on Lake Champlain in New York.

Published
2002

141. HISTORY REMEMBERED.

Author

King, David C.

Abstract

In the independent U.S., battlefield sites related to the Battle of Saratoga, 1777, were converted to the Saratoga National Historical Park. The park gives visitors an opportunity to walk in the footsteps of those who fought in the historic battle. Some other historical monuments related to the American Revolution have also been preserved. Among these are the Schuyler House, Fort Stanwix and the Bennington Battle Monument.

Published
2002

142. SARATOGA: THE TURNING POINT OF THE AMERICAN REVOLUTION.

Author

King, David C.

Abstract

The Saratoga campaign in 1777 changed the course of the American Revolution. Despite suffering twice as many casualties as the Americans, the British claimed victory in the first battle of Saratoga on September 19, 1777. The second battle of Saratoga on October 7 ended in a stunning American victory and a British surrender. The dramatic American victory at Saratoga persuaded France to join the war against Great Britain.

Published
2002

143. THE AMERICAN REVOLUTION: THE PATRIOTS FIGHT FOR FREEDOM.

Author

King, David C.

Abstract

Enraged by the heavy taxation imposed by the British Parliament, the 13 British colonies in America went to war against Great Britain in the spring of 1775. Contrary to British expectations, the war went on for a long time. In July 1776, the Americans issued the Declaration of Independence. In early 1777, the British planned a three-pronged attack to gain control of New York and isolate the New England colonies from the rest.

Published
2002

144. CHRONOLOGY OF THE WAR OF 1812.

Author

King, David C.

Abstract

This is a chronological list of events related to the War of 1812 between the U.S. and Great Britain, that appear in the book 'New Orleans.' It begins with the Napoleonic Wars in Europe in 1803 and ends with the arrival of the news of a peace treaty in Washington D.C. on February 9, 1815.

Published
2002

145. NEW ORLEANS: 'ONE OF THE MOST BRILLIANT VICTORIES'.

Author

King, David C.

Abstract

In 1814, the British planned to capture New Orleans, Louisiana, to drive Americans out of Louisiana and the Floridas. In spite of facing many problems, the American commander in chief Andrew Jackson was able to motivate his soldiers. During the first clashes, the British troops under General Edward Pakenham faced stiff resistance from the Americans. On January 8, 1815, in the final battle, the Americans won overwhelmingly.

Published
2002

146. THE WAR OF 1812: THE SECOND WAR FOR INDEPENDENCE.

Author

King, David C.

Abstract

In the early 1800s, Great Britain was seizing American trade ships on their way to its adversary France. When the British refused to stop harassing Americans, the U.S. imposed a trade embargo on them. On June 16, 1812, U.S. President James Madison officially declared war against Great Britain. The U.S. suffered heavy losses in the war. After defeating France in 1814, the British concentrated on the American campaign.

Published
2002

147. Jarabadash.

Author

King, David C.

Subjects
PLAY
Abstract

The article provides instructions on how to play jarabadash, a game being played in the dirt in western African villages using stones as game pieces.

Published
2007

150. Hyper-active RAS/MAPK introduces cancer-specific mitotic vulnerabilities.

Author

Herman, Jacob A., Romain, Romario R., Hoellerbauer, Pia, Shirnekhi, Hazheen K., King, David C., DeLuca, Keith F., Nishimura, Erin Osborne, Paddison, Patrick J., and DeLuca, Jennifer G.

Subjects
*MITOGEN-activated protein kinases, *CHROMOSOME segregation, *KINETOCHORE, *ANEUPLOIDY, *INTEGERS
Abstract

Aneuploidy, the incorrect number of whole chromosomes, is a common feature of tumors that contributes to their initiation and evolution. Preventing aneuploidy requires properly functioning kinetochores, which are large protein complexes assembled on centromeric DNA that link mitotic chromosomes to dynamic spindle microtubules and facilitate chromosome segregation. The kinetochore leverages at least two mechanisms to prevent aneuploidy: error correction and the spindle assembly checkpoint (SAC). BubR1, a factor involved in both processes, was identified as a cancer dependency and therapeutic target in multiple tumor types; however, it remains unclear what specific oncogenic pressures drive this enhanced dependency on BubR1 and whether it arises from BubR1’s regulation of the SAC or error-correction pathways. Here, we use a genetically controlled transformation model and glioblastoma tumor isolates to show that constitutive signaling by RAS or MAPK is necessary for cancer-specific BubR1 vulnerability. TheMAPK pathway enzymatically hyperstimulates a network of kinetochore kinases that compromises chromosome segregation, rendering cells more dependent on two BubR1 activities: counteracting excessive kinetochore–microtubule turnover for error correction and maintaining the SAC. This work expands our understanding of how chromosome segregation adapts to different cellular states and reveals an oncogenic trigger of a cancer-specific defect. [ABSTRACT FROM AUTHOR]

Published
2022
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