101. Bone mineral density and fractures in congenital adrenal hyperplasia: Findings from the dsd‐LIFE study
- Author
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Robert Roehle, Marcus Quinkler, Henrik Falhammar, Gabriel Riehl, Nicole Reisch, and Hedi Claahsen van der Grinten
- Subjects
Adult ,Male ,musculoskeletal diseases ,medicine.medical_specialty ,Adolescent ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Fractures, Bone ,03 medical and health sciences ,Absorptiometry, Photon ,0302 clinical medicine ,Endocrinology ,Sex hormone-binding globulin ,Bone Density ,Internal medicine ,medicine ,Humans ,Congenital adrenal hyperplasia ,Glucocorticoids ,Testosterone ,Dual-energy X-ray absorptiometry ,Hydrocortisone ,Bone mineral ,Lumbar Vertebrae ,Adrenal Hyperplasia, Congenital ,biology ,medicine.diagnostic_test ,Trochanter ,business.industry ,Infant, Newborn ,medicine.disease ,030220 oncology & carcinogenesis ,biology.protein ,Prednisolone ,Female ,business ,medicine.drug - Abstract
BACKGROUND In patients with congenital adrenal hyperplasia (CAH) type and doses of glucocorticoids used as well as sex hormone secretion during puberty have important actions on bone mineral density (BMD) in adulthood. AIM To evaluate BMD in adult CAH patients depending on current glucocorticoid therapy and on androgen levels in adulthood and at age 16 years. METHODS We included 244 CAH patients from the dsd-LIFE cohort (women n = 147, men n = 97; salt-wasting n = 148, simple-virilizing n = 71, nonclassical n = 25) in which BMD and bloods were available. Clinical and hormonal data at age 16years were retrieved from patients' files. RESULTS Simple-virilizing women showed lower BMD compared to salt-wasting women at trochanter (0.65 ± 0.12 vs 0.75 ± 0.15 g/cm2 ; P
- Published
- 2020