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Reduced risk for hospitalization due to hyponatraemia in lithium treated patients: A Swedish population-based case-control study
- Source :
- Journal of Psychopharmacology (Oxford, England)
- Publication Year :
- 2020
-
Abstract
- Background:Many drugs used in psychiatry have been reported to cause hyponatraemia. However, lithium may be an exception due to its potential for causing nephrogenic diabetes insipidus, but clinical data are largely absent. The objective of this investigation was to study the association between lithium therapy and hospitalization due to hyponatraemia.Methods:This study was a register-based case–control investigation of the general Swedish population. Patients hospitalized with a principal diagnosis of hyponatraemia ( n=11,213) were compared with matched controls ( n=44,801). Analyses using multivariable logistic regression adjusting for co-medication, diseases, previous hospitalizations and socioeconomic factors were deployed to calculate the association between severe hyponatraemia and the use of lithium. Additionally, newly initiated (⩽90 days) and ongoing lithium therapy was studied separately.Results:Compared with controls, the unadjusted odds ratio (OR) (95% confidence interval (CI)) for hospitalization due to hyponatraemia was 1.07 (0.70–1.59) for lithium. However, after adjustment for confounding factors the risk was reduced (adjusted OR: 0.53 (0.31–0.87)). Newly initiated lithium therapy was not significantly associated with hyponatraemia (adjusted OR 0.73 (0.35–5.38)). In contrast, for ongoing therapy the corresponding adjusted OR was significantly reduced (adjusted OR: 0.52 (0.30–0.87)).Conclusions:A marked inverse association was found between ongoing lithium therapy and hospitalization due to hyponatraemia.
- Subjects :
- Adult
Male
Pediatrics
medicine.medical_specialty
Reduced risk
Lithium (medication)
Adolescent
adverse reaction
030204 cardiovascular system & hematology
Lithium
03 medical and health sciences
Young Adult
0302 clinical medicine
Swedish population
Risk Factors
medicine
Odds Ratio
Humans
Pharmacology (medical)
Adverse effect
Aged
Retrospective Studies
Pharmacology
Aged, 80 and over
Sweden
business.industry
hyponatraemia
Case-control study
SIADH
Middle Aged
Nephrogenic diabetes insipidus
medicine.disease
Original Papers
Hospitalization
Psychiatry and Mental health
Logistic Models
Case-Control Studies
Lithium Compounds
Female
business
030217 neurology & neurosurgery
medicine.drug
Hyponatremia
Subjects
Details
- ISSN :
- 14617285
- Volume :
- 35
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of psychopharmacology (Oxford, England)
- Accession number :
- edsair.doi.dedup.....8d2fec010aa78619984bcc31a2ce006c