Back to Search
Start Over
Quality of Life in Men With Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
- Source :
- Frontiers in Endocrinology, 12, Frontiers in Endocrinology, Vol 12 (2021), Frontiers in Endocrinology
- Publication Year :
- 2021
-
Abstract
- Contains fulltext : 232500.pdf (Publisher’s version ) (Open Access) Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is a disorder of adrenal steroid biosynthesis, leading to hypocortisolism, hypoaldosteronism, and hyperandrogenism. Impaired quality of life (QoL) has been demonstrated in women with CAH, but data on men with CAH are scarce. We hypothesized that disease severity and poor treatment control are inversely associated with QoL. In this study, 109 men (16-68 years) with 21OHD were included. The WHOQOL-BREF questionnaire was used to measure self-reported QoL domain scores on a 0-100 scale, where higher scores reflect better QoL. QoL domain scores were compared to published data on healthy and chronically ill reference populations from France, Germany, the Netherlands, and the United Kingdom. Differences in QoL scores among groups of disease severity and treatment control were tested within the study population. Overall, the men with CAH in this study appeared to rate their QoL as good. Median domain scores were 78.6 (IQR: 67.9-85.7) for physical health, 79.2 (IQR: 66.7-87.5) for psychological health, 75.0 (IQR: 58.3-83.3) for social relationships, and 81.3 (IQR: 71.9-90.6) for environment. In general, these scores were similar to WHOQOL-BREF domain scores in healthy references and higher compared to chronically ill reference populations. The domain scores did not differ among genotype groups, but patients with undertreatment or increased 17-hydroxyprogestrone concentrations scored higher on several QoL domains (p
- Subjects :
- Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
WHOQOL BREF
Severity of Illness Index
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Young Adult
03 medical and health sciences
Endocrinology
0302 clinical medicine
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency
21 hydroxylase deficiency
Quality of life
Prednisone
Surveys and Questionnaires
Internal medicine
medicine
Humans
Congenital adrenal hyperplasia
Dexamethasone
Original Research
lcsh:RC648-665
Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17]
Adrenal Hyperplasia, Congenital
business.industry
Hyperandrogenism
Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16]
medicine.disease
humanities
Women's cancers Radboud Institute for Health Sciences [Radboudumc 17]
3. Good health
CYP21A2
Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]
Mental Health
quality of life
030220 oncology & carcinogenesis
Population study
Self Report
business
congenital adrenal hyperplasia (CAH)
Hypoaldosteronism
medicine.drug
Subjects
Details
- ISSN :
- 16642392
- Database :
- OpenAIRE
- Journal :
- Frontiers in Endocrinology, 12, Frontiers in Endocrinology, Vol 12 (2021), Frontiers in Endocrinology
- Accession number :
- edsair.doi.dedup.....8dc4b3d4104c4c0395755f3451b75392