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Some new compounds ( E)-3-aryl-1-(5-methyl-1- p-tolyl-1 H-1,2,3-triazol-4-yl)-prop-2-en-1-ones 5a-e were prepared by 1-(5-methyl-1- p-tolyl-1 H-1,2,3-triazol-4-yl)-ethanone and various aromatic aldehydes. Then one pot reaction was happened by compounds 5a-e with hydrazine hydrate in acetic acid or propionic acid, respectively, to give the title compounds 1acyl-5-aryl-3-(5-methyl-1- p-tolyl-1 H-1,2,3-triazol-4-yl)-4,5-dihydro-1 H-pyrazoles 6a-i. All structures were established by MS, IR, CHN, 1H-NMR and 13C-NMR spectral data. J. Heterocyclic Chem., (2012). [ABSTRACT FROM AUTHOR]

Some new target products 5-aryl-4,5-dihydro-3-(5-methyl-1- p-tolyl-1 H-1,2,3-triazol-4-yl)-1-(4-phenylthiazol-2-yl)pyrazoles 5a-j have been synthesized by reaction of 2-bromo-1-phenylethanone and compounds 4a-j which were prepared from the combination of thiosemicarbazide and ( E)-3-aryl-1-(5-methyl-1- p-tolyl-1 H-1,2,3-triazol-4-yl)-prop-2-en-1-ones 3a-j. All the structures were established by MS, IR, CHN, and 1H NMR spectra data. Synthesis of structure diversity is applied. J. Heterocyclic Chem., (2011). [ABSTRACT FROM AUTHOR]

(5-Methyl-3-phenyl-1 H-pyrazol-1-yl)-[5-( p-tolylamino)-2 H-1,2,3-triazol-4-yl]methanone was synthesized and characterized by 1H NMR, MS and IR spectra data. The structure of title compound was identified by X-ray diffraction. Compound, C 20H 18N 6O, Mr = 358.40, crystallizes in the triclinic space group P- 1 with unit cell parameters a = 10.303(6), b = 12.489(7), c = 15.305(9) Å, α = 108.489(12), β = 101.920(11), γ = 96.971(13)°, V = 1790.0(17) Å 3, Z = 4, Dx = 1.330 mg/cm 3. The final R was 0.0520. Graphical Abstract: (5-Methyl-3-phenyl-1H-pyrazol-1-yl)-[5-(p-tolylamino)-2H-1,2,3-triazol-4-yl]methanone was synthesized. [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]

The Ten-eleven translocation (TET) family of dioxygenases mediate cytosine demethylation by catalyzing the oxidation of 5-methylcytosine (5mC). TET-mediated DNA demethylation controls the proper differentiation of embryonic stem cells and TET members display functional redundancy during early gastrulation. However, it is unclear if TET proteins have functional significance in mammalian skeletal development. Here, we report that Tet genes deficiency in mesoderm mesenchymal stem cells results in severe defects of bone development. The existence of any single Tet gene allele can support early bone formation, suggesting a functional redundancy of TET proteins. Integrative analyses of RNA-seq, Whole Genome Bisulfite Sequencing (WGBS), 5hmC-Seal and Assay for Transposase-Accessible Chromatin (ATAC-seq) demonstrate that TET-mediated demethylation increases the chromatin accessibility of target genes by RUNX2 and facilities RUNX2-regulated transcription. In addition, TET proteins interact with RUNX2 through their catalytic domain to regulate cytosine methylation around RUNX2 binding region. The catalytic domain is indispensable for TET enzymes to regulate RUNX2 transcription activity on its target genes and to regulate bone development. These results demonstrate that TET enzymes function to regulate RUNX2 activity and maintain skeletal homeostasis. Here the authors investigate the role of the TET family of DNA demethylases in mammalian skeletal development. They find that loss of TETs leads to hypermethylation that results in decreased chromatin accessibility of RUNX2 target genes, repressing osteoblast differentiation and leading to skeletal defects in mouse such as short limbs. [ABSTRACT FROM AUTHOR]

By the shock relationships, the wavy characteristics and the forming conditions of a shock wave are analyzed. The wavy characteristics of an Euler system are studied theoretically. The present research focuses on the wavy characteristics of Tollmien-Schlichting (T-S) waves, the excitation conditions of shocklets in compressible boundary layers, and the viscous effect on shock. The possibility of existence of shocklets in the compressible boundary layer and the physical mechanism of formation are theoretically interpreted. [ABSTRACT FROM AUTHOR]

The article lists the topics featured in the journals of the Institute of Metal Finishing's (IMF's) sister societies including "The process and sequence in metal electrodopisition," by W. Plieth in the "Galvanotechnik," "Review of shot peening processes to obtain nanocrystalline surface in metal alloys," by S. Bagheri and M. Guagliano in the "Surface Engineering," and "Pretreatment process of electroplating on brass antenna mast," by Bing Xi in the "Electroplating & Finishing" in China.