51. Polymorphisms in TICAM2 and IL1B are associated with TB
- Author
-
Keith A. Chervenak, L Tao, Robert P. Igo, Moses Joloba, Audrey H. Schnell, Brenda Okware, LaShaunda L. Malone, Noemi B. Hall, Harriet Mayanja-Kizza, Catherine M. Stein, T R Hawn, Barbara Truitt, Mary Nsereko, Christina Lancioni, and W. H. Boom
- Subjects
Adult ,Male ,Candidate gene ,NOD1 ,Tuberculosis ,genetic epidemiology ,Adolescent ,Immunology ,Interleukin-1beta ,Tuberculin ,Single-nucleotide polymorphism ,TRAM ,Polymorphism, Single Nucleotide ,Article ,Mycobacterium tuberculosis ,Young Adult ,Genetics ,medicine ,Genetic predisposition ,Humans ,Genetic Predisposition to Disease ,Uganda ,nod-like receptor ,Child ,Genetics (clinical) ,Adaptor Proteins, Signal Transducing ,biology ,interleukin ,Haplotype ,biology.organism_classification ,medicine.disease ,Virology ,3. Good health ,Haplotypes ,TLR6 ,Child, Preschool ,toll-like receptor ,Female - Abstract
Background Human genetic susceptibility for tuberculosis (TB) has been demonstrated by several studies, but few have examined multiple innate and adaptive immunity genes comprehensively, age-specific effects, and/or resistance to Mycobacterium tuberculosis (Mtb) infection (RSTR). We hypothesized that RSTR, defined by a persistently negative tuberculin skin test, may have different genetic influences than Mtb disease. Methods We examined 29 candidate genes in pathways that mediate immune responses to Mtb in subjects in a household contact study in Kampala, Uganda. We genotyped 546 haplotype-tagging single nucleotide polymorphisms (SNPs) in 835 individuals from 481 families; 28.7% had TB, 10.5% were RSTR, and the remaining 60.8% had latent Mtb infection. Results Among our most significant findings were SNPs in TICAM2 (p=3.6×10−6) and IL1B (p=4.3×10−5) associated with TB. Multiple SNPs in IL4 and TOLLIP were associated with TB (p
- Published
- 2014