51. Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice
- Author
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Yoshimasa Takafuji, Katsumi Okumoto, Masafumi Muratani, Naoyuki Kawao, Hiroshi Kaji, Hironobu Morita, and Masayoshi Ishida
- Subjects
Male ,0301 basic medicine ,Physiology ,medicine.medical_treatment ,Adipose tissue ,White adipose tissue ,Biochemistry ,Fats ,Mice ,Endocrinology ,0302 clinical medicine ,Glucose Metabolism ,Vestibular nuclei ,Medicine and Health Sciences ,Insulin ,Vestibular system ,Multidisciplinary ,Glial fibrillary acidic protein ,biology ,Lipids ,Physiological Parameters ,Adipose Tissue ,Carbohydrate Metabolism ,Medicine ,Vestibule, Labyrinth ,Anatomy ,Research Article ,medicine.medical_specialty ,Science ,Adipokine ,Surgical and Invasive Medical Procedures ,Carbohydrate metabolism ,Diet, High-Fat ,03 medical and health sciences ,Extraction techniques ,Adipokines ,Internal medicine ,otorhinolaryngologic diseases ,medicine ,Animals ,Obesity ,Diabetic Endocrinology ,business.industry ,Body Weight ,Biology and Life Sciences ,Hormones ,RNA extraction ,Mice, Inbred C57BL ,Research and analysis methods ,Glucose ,Metabolism ,Biological Tissue ,030104 developmental biology ,Gene Expression Regulation ,biology.protein ,Energy Metabolism ,Physiological Processes ,business ,030217 neurology & neurosurgery - Abstract
The vestibular system controls balance, posture, blood pressure, and gaze. However, the roles of the vestibular system in energy and glucose metabolism remain unknown. We herein examined the roles of the vestibular system in obesity and impaired glucose metabolism using mice with vestibular lesions (VL) fed a high-sucrose/high-fat diet (HSHFD). VL was induced by surgery or arsenic. VL significantly suppressed body fat enhanced by HSHFD in mice. Glucose intolerance was improved by VL in mice fed HSHFD. VL blunted the levels of adipogenic factors and pro-inflammatory adipokines elevated by HSHFD in the epididymal white adipose tissue of mice. A β-blocker antagonized body fat and glucose intolerance enhanced by HSHFD in mice. The results of an RNA sequencing analysis showed that HSHFD induced alterations in genes, such as insulin-like growth factor-2 and glial fibrillary acidic protein, in the vestibular nuclei of mice through the vestibular system. In conclusion, we herein demonstrated that the dysregulation of the vestibular system influences an obese state and impaired glucose metabolism induced by HSHFD in mice. The vestibular system may contribute to the regulation of set points under excess energy conditions.
- Published
- 2020