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Activation of trigeminal nociceptive neurons by parotid PAR-2 activation in rats
- Source :
- NeuroReport. 15:1617-1621
- Publication Year :
- 2004
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2004.
-
Abstract
- To clarify involvement of protease-activated receptor-2 (PAR-2) in parotid pain, we examined whether PAR-2 activation in the parotid gland could activate trigeminal nociceptive neurons in anesthetized rats, by analyzing immunoreactive Fos as a nociceptive marker. Either the PAR-2 agonist SLIGRL-NH2 or capsaicin, injected into the parotid duct, caused expression of Fos in the trigeminal subnucleus caudalis, although the PAR-2-inactive reversed peptide had no such effect. The Fos expression caused by PAR-2 activation was inhibited by ablation of capsaicin-sensitive sensory neurons. Intraductal SLIGRL-NH2 did not increase vascular permeability in the parotid gland. Our data thus reveal that activation of PAR-2 in the parotid gland can cause activation of trigeminal nociceptive neurons via capsaicin-sensitive sensory nerves most probably by a non-inflammatory mechanism.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Cell Count
In Vitro Techniques
Parotid duct
Functional Laterality
Trigeminal ganglion
stomatognathic system
Internal medicine
medicine
Animals
Parotid Gland
Receptor, PAR-2
Drug Interactions
Receptor, PAR-1
RNA, Messenger
Rats, Wistar
Neurons
Medulla Oblongata
Reverse Transcriptase Polymerase Chain Reaction
Chemistry
General Neuroscience
Spinal trigeminal nucleus
Nociceptors
Immunohistochemistry
Sensory neuron
Rats
Parotid gland
Oncogene Proteins v-fos
medicine.anatomical_structure
Endocrinology
Trigeminal Ganglion
Medulla oblongata
Nociceptor
Capsaicin
Oligopeptides
Sensory nerve
Subjects
Details
- ISSN :
- 09594965
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- NeuroReport
- Accession number :
- edsair.doi.dedup.....44fce96d7d1bb3fb04dcce35b370be82