51. Cornutins C–L, neo-clerodane-type diterpenoids from Cornutia grandifolia var. intermedia
- Author
-
Kristina Jenett-Siems, Ulrich Bienzle, Pablo N. Solis, Karsten Siems, Carola Kraft, Mahabir P. Gupta, and Inga Köhler
- Subjects
Magnetic Resonance Spectroscopy ,Molecular Structure ,Stereochemistry ,Verbenaceae ,Plasmodium falciparum ,Cornutia grandifolia ,Plant Science ,General Medicine ,Horticulture ,Biology ,Pharmacognosy ,biology.organism_classification ,Biochemistry ,Diterpenes, Clerodane ,Plant Leaves ,Antimalarials ,chemistry.chemical_compound ,chemistry ,Botany ,Animals ,Diterpenes ,Intermedia ,Diterpene ,Molecular Biology - Abstract
Ten novel neo -clerodane diterpenoids, named cornutins C–L, have been isolated from the leaves of Cornutia grandifolia var . intermedia . Their structures have been elucidated by detailed spectroscopic analysis. In addition, the in vitro antiplasmodial activity of four isolated compounds (cornutin C–F) has been evaluated, revealing only a marginal activity.
- Published
- 2003