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Screening of plant extracts for antiprotozoal and cytotoxic activities
- Source :
- Journal of ethnopharmacology. 89(2-3)
- Publication Year :
- 2003
-
Abstract
- Methanolic and aqueous extracts derived from 43 plant species, selected either from ethnobotanical or chemotaxonomical data, were screened for their antiprotozoal activity against Leishmania donovani and Trypanosoma brucei brucei. The cytotoxic activity against KB cells was also determined. Eight extracts had IC50 values of less than 10 microg/ml against Leishmania donovani. The most active was Triclisia patens with an IC50 value of 1.5 microg/ml against Leishmania donovani. Annona purpurea and Alstonia macrophylla had IC50 values below 10 microg/ml against Trypanosoma brucei brucei. Annona purpurea was the most cytotoxic against KB cells.
- Subjects :
- medicine.drug_class
Trypanosoma brucei brucei
Leishmania donovani
Antiprotozoal Agents
Antineoplastic Agents
Trypanosoma brucei
Pharmacognosy
KB Cells
Microbiology
Antiprotozoal Agent
parasitic diseases
Drug Discovery
medicine
Animals
Humans
Pharmacology
Plants, Medicinal
biology
Plant Extracts
Methanol
Kinetoplastida
Water
biology.organism_classification
Annona purpurea
Alstonia macrophylla
Antiprotozoal
Subjects
Details
- ISSN :
- 03788741
- Volume :
- 89
- Issue :
- 2-3
- Database :
- OpenAIRE
- Journal :
- Journal of ethnopharmacology
- Accession number :
- edsair.doi.dedup.....bc88206bdf8020dc7ef768ed8ae0701e