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Antifungal principles of Baccharis pedunculata
- Source :
- Planta medica. 61(4)
- Publication Year :
- 1995
-
Abstract
- Four compounds including a flavone, an acetylenic lactone, a prenylated coumarin, and a 3-methyl ether flavone were isolated from the dichloromethane leaf extract of Baccharis pedunculata (Mill.) Cabr. (Asteraceae). The latter three compounds were identified to be responsible for the antifungal activity against some human pathogenic and phytopathogenic fungi. The most active compound, lachnophyllum lactone, an acetylenic lactone, showed a very high toxicity (LD50 2 micrograms/ml) against human keratinocytes.
- Subjects :
- Antifungal
Keratinocytes
Antifungal Agents
Stereochemistry
medicine.drug_class
Cell Survival
Baccharis pedunculata
Pharmaceutical Science
Ether
Microbial Sensitivity Tests
Analytical Chemistry
chemistry.chemical_compound
Lactones
Structure-Activity Relationship
Coumarins
Drug Discovery
medicine
Humans
Cells, Cultured
Dichloromethane
Pharmacology
chemistry.chemical_classification
Flavonoids
biology
Plant Extracts
Organic Chemistry
Fungi
Asteraceae
biology.organism_classification
Coumarin
Plant Leaves
Complementary and alternative medicine
chemistry
Active compound
Molecular Medicine
Lactone
Subjects
Details
- ISSN :
- 00320943
- Volume :
- 61
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Planta medica
- Accession number :
- edsair.doi.dedup.....1faf6e51744269fd285a30c9bc7c97df