404 results on '"Hiromasa Tanaka"'
Search Results
52. Synthesis and Reactivity of Cobalt-Dinitrogen Complexes Bearing Anionic PCP-Type Pincer Ligands toward Catalytic Silylamine Formation from Dinitrogen
- Author
-
Shogo Kuriyama, Shenglan Wei, Hiromasa Tanaka, Asuka Konomi, Kazunari Yoshizawa, and Yoshiaki Nishibayashi
- Subjects
Inorganic Chemistry ,Physical and Theoretical Chemistry - Abstract
A series of cobalt(I)-dinitrogen complexes bearing anionic 4-substituted benzene-based PCP-type pincer ligands are synthesized and characterized. These complexes work as highly efficient catalysts for the formation of silylamine from dinitrogen under ambient reaction conditions to produce up to 371 equiv of silylamine based on the cobalt atom of the catalyst.
- Published
- 2022
53. Gene Expression of Osteoblast-like Cells on Carbon-Nanowall as Scaffolds during Incubation with Electrical Stimulation
- Author
-
Kenji Ishikawa, Tomonori Ichikawa, Takayoshi Tsutsumi, Hiromasa Tanaka, Masaru Hori, Hiroki Kondo, and Makoto Sekine
- Subjects
musculoskeletal diseases ,biology ,Biochemistry (medical) ,Biomedical Engineering ,chemistry.chemical_element ,Osteoblast ,Stimulation ,General Chemistry ,Cell biology ,Biomaterials ,RUNX2 ,medicine.anatomical_structure ,chemistry ,Gene expression ,Osteocalcin ,biology.protein ,medicine ,Transcription factor ,Incubation ,Carbon - Abstract
Nanostructured cell-culture scaffolds of carbon nanowalls (CNWs) were prepared by changing average wall-to-wall distances either 132 or 220 nm. Osteoblast-like cells (Saos-2) proliferated during 4 day incubation on the wider (220 nm) CNW scaffolds in the presence of electrical stimulation (ES). Differentiation gene expression levels of Runt-related transcription factor 2 (Runx2) and osteocalcin (OC) were suppressed after 10 day incubation, which indicated that the average wall-to-wall distances of the CNW scaffolds affect suppression of Runx2 and OC gene expression. This technique holds promise for controlling the differentiation of osteoblast-like cells.
- Published
- 2022
54. How to Assure Good Clinical Practice in Plasma Therapy?
- Author
-
Hans-Robert Metelmann, Stefan Hammes, Kristina Hartwig, Christian Seebauer, Ajay Rana, Eun Ha Choi, Masaru Hori, Hiromasa Tanaka, Oksana Wladimirova, Vu Thi Thom, Vandana Miller, Anne Kirschner, Stefanie Kirschner, and Thomas von Woedtke
- Published
- 2022
55. Low-temperature plasma for biology, hygiene, and medicine : perspective and roadmap
- Author
-
Masaru Hori, Chunqi Jiang, Kostya Ostrikov, Dawei Liu, Sander Bekeschus, Christophe O. Laux, Dayuan Yan, Alexander Fridman, Hiromasa Tanaka, Xinpei Lu, Maksud Yusupov, Vandana Miller, Mounir Laroussi, Selma Mededovic Thagard, James L. Walsh, Annemie Bogaerts, Michael Keidar, Ali Mesbah, Katharina Stapelmann, and Stephan Reuter
- Subjects
Computer. Automation ,Chemistry ,Field (Bourdieu) ,Research community ,Perspective (graphical) ,Low temperature plasma ,Engineering ethics ,Radiology, Nuclear Medicine and imaging ,Human medicine ,Computer-mediated communication ,Instrumentation ,Engineering sciences. Technology ,Atomic and Molecular Physics, and Optics - Abstract
Plasma, the fourth and most pervasive state of matter in the visible universe, is a fascinating medium that is connected to the beginning of our universe itself. Man-made plasmas are at the core of many technological advances that include the fabrication of semiconductor devices, which enabled the modern computer and communication revolutions. The introduction of low temperature, atmospheric pressure plasmas to the biomedical field has ushered a new revolution in the healthcare arena that promises to introduce plasma-based therapies to combat some thorny and long-standing medical challenges. This article presents an overview of where research is at today and discusses innovative concepts and approaches to overcome present challenges and take the field to the next level. It is written by a team of experts who took an in-depth look at the various applications of plasma in hygiene, decontamination, and medicine, made critical analysis, and proposed ideas and concepts that should help the research community focus their efforts on clear and practical steps necessary to keep the field advancing for decades to come.
- Published
- 2022
56. Iridium-catalyzed Formation of Silylamine from Dinitrogen under Ambient Reaction Conditions
- Author
-
Hiromasa Tanaka, Ryosuke Kawakami, Yoshiaki Nishibayashi, Shogo Kuriyama, Kazunari Yoshizawa, and Asuka Konomi
- Subjects
Tris ,Reaction conditions ,chemistry.chemical_compound ,chemistry ,Trimethylsilyl ,Polymer chemistry ,Nitrogen fixation ,chemistry.chemical_element ,General Chemistry ,Iridium ,Benzene ,Pincer ligand ,Catalysis - Abstract
We have found that an iridium-dinitrogen complex bearing an anionic benzene-based PCP-type pincer ligand works as an effective catalyst for the reduction of dinitrogen into tris(trimethylsilyl)amin...
- Published
- 2020
57. Nitrogen Fixation Catalyzed by Dinitrogen‐Bridged Dimolybdenum Complexes Bearing PCP‐ and PNP‐Type Pincer Ligands: A Shortcut Pathway Deduced from Free Energy Profiles
- Author
-
Akihito Egi, Yoshiaki Nishibayashi, Hiromasa Tanaka, Asuka Konomi, and Kazunari Yoshizawa
- Subjects
Inorganic Chemistry ,Bearing (mechanical) ,law ,Chemistry ,Stereochemistry ,Nitrogen fixation ,Pincer movement ,law.invention ,Catalysis - Published
- 2020
58. Structural characterization of molybdenum–dinitrogen complex as key species toward ammonia formation by dispersive XAFS spectroscopy
- Author
-
Kazunari Yoshizawa, Akira Yamamoto, Hisao Yoshida, Kazuo Kato, Kazuya Arashiba, Shimpei Naniwa, Hiromasa Tanaka, and Yoshiaki Nishibayashi
- Subjects
Materials science ,Atmospheric pressure ,010405 organic chemistry ,General Physics and Astronomy ,chemistry.chemical_element ,Nitride ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,X-ray absorption fine structure ,chemistry.chemical_compound ,chemistry ,Molybdenum ,Physical chemistry ,Physical and Theoretical Chemistry ,Triiodide ,Spectroscopy ,Pincer ligand ,Stoichiometry - Abstract
The structural characterization of a hardly-isolatable molybdenum-dinitrogen complex bearing a PNP-type pincer ligand, which is assumed to be a key reactive complex in the stoichiometric transformation of a molybdenum triiodide complex [MoI3(PNP)] into the corresponding molybdenum nitride complex under an atmospheric pressure of dinitrogen, was carried out by using dispersive XAFS.
- Published
- 2020
59. Social Cognition of Temporality and Environment: Lingua Franca English Construction
- Author
-
Florin Nechita and Hiromasa Tanaka
- Subjects
Social cognition ,Temporality ,General Medicine ,Sociology ,Project-based learning ,Lingua franca ,computer ,Linguistics ,computer.programming_language - Published
- 2020
60. A Mass Balance Study of14C‐Labeled JTZ‐951 (Enarodustat), a Novel Orally Available Erythropoiesis‐Stimulating Agent, in Patients With End‐Stage Renal Disease on Hemodialysis
- Author
-
Maekawa Michihide, Ryosuke Koretomo, Sudhakar M. Pai, Seiji Enya, Barbara Gerhardt, Tomohiro Ishikawa, Hiromasa Tanaka, Hiroyuki Yamada, and Jeffrey Connaire
- Subjects
business.industry ,Metabolite ,medicine.medical_treatment ,Area under the curve ,Pharmaceutical Science ,Urine ,Pharmacology ,030226 pharmacology & pharmacy ,End stage renal disease ,Excretion ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,chemistry ,Pharmacokinetics ,030220 oncology & carcinogenesis ,Medicine ,Pharmacology (medical) ,Hemodialysis ,business ,Whole blood - Abstract
The mass balance, pharmacokinetics, and biotransformation of JTZ-951 (enarodustat), a novel hypoxia-inducible factor prolyl hydroxylase inhibitor, were characterized in patients (N = 6) with end-stage renal disease on hemodialysis. Following a 10-mg (100 µCi) oral dose of 14 C-JTZ-951, whole blood, feces, dialysate, and, if feasible, urine were obtained for pharmacokinetic assessments and for metabolite profiling and identification in appropriate matrices. Fecal excretion was the major route of elimination of radioactivity, and urinary excretion a minor route, with mean (coefficient of variation [%CV]) recovery of 77.1 (16.2)% and 10.9 (92.0)% of the dose, respectively. Radioactivity was not detected in the dialysate, and mean (%CV) total recovery in excreta was 88.0 (14.9)%. For parent JTZ-951 in plasma, the mean (%CV) effective half-life was 8.96 (7.7)% hours, and area under the curve over 24 hours comprised the majority (>80%) of total exposure, with relatively low variability in these pharmacokinetic variables. Based on profiling of plasma radioactivity, parent JTZ-951 was the predominant circulating component, accounting for 93.7% or more of radioactivity, and metabolite M2 (hydroxylated product) was the only detectable metabolite, but its exposure was minor (
- Published
- 2019
61. Mechanistic Study on Catalytic Disproportionation of Hydrazine by a Protic Pincer‐Type Iron Complex through Proton‐Coupled Electron Transfer
- Author
-
Shigeki Kuwata, Seiji Hitaoka, Hiromasa Tanaka, Kazunari Yoshizawa, and Kazuki Umehara
- Subjects
Inorganic Chemistry ,Reaction mechanism ,chemistry.chemical_compound ,Chemistry ,Hydrogen bond ,Hydrazine ,Iron complex ,Disproportionation ,Proton-coupled electron transfer ,Photochemistry ,Catalysis ,Pincer movement - Published
- 2019
62. Biocompatibility of conformal silicon carbide on carbon nanowall scaffolds
- Author
-
Koki Ono, Takashi Koide, Kenji Ishikawa, Hiromasa Tanaka, Hiroki Kondo, Ayae Sugawara-Narutaki, Yong Jin, Shigeo Yasuhara, Masaru Hori, and Wakana Takeuchi
- Subjects
Physics and Astronomy (miscellaneous) ,General Engineering ,General Physics and Astronomy - Abstract
Silicon carbide (SiC) was coated onto carbon nanowall (CNW) scaffolds using chemical vapor deposition with a vinylsilane precursor at 700 °C to investigate the influence of the wall edge width, wall-to-wall distance, and surface morphology. The wall edge width ranged from 10 nm to those filling the wall-to-wall space without disrupting the CNW morphology. When SiC-coated CNWs (SiC/CNWs) were used as scaffolds for cell culture, cell viability increased until the edge area ratio reached 40%. In over 40% of edge area ratio, cell viability was saturate and comparable to flat surfaces such as SiC films on the Si substrate (SiC/Si) and control samples prepared using polystyrene. Calcification was suppressed in the CNWs, SiC/CNWs, and SiC/Si scaffolds compared to polystyrene. Our results suggest that SiC-coated CNW scaffolds could suppress calcification and promote cell proliferation.
- Published
- 2022
63. Tetrachloroaurate (III)–induced Oxidation Increases Non-thermal Plasma-induced Oxidative Stress
- Author
-
Ken-ichiro Matsumoto, Kanako Sasaki, Hiromasa Tanaka, Nanami Ito, Masaru Hori, Yasumasa Okazaki, and Shinya Toyokuni
- Subjects
Glutathione Disulfide ,Plasma Gases ,Chemistry ,Electron Spin Resonance Spectroscopy ,General Medicine ,Hydrogen Peroxide ,Nonthermal plasma ,medicine.disease_cause ,Biochemistry ,Glutathione ,Thiobarbituric Acid Reactive Substances ,Oxidative Stress ,medicine ,Biophysics ,Humans ,Oxidation-Reduction ,Oxidative stress - Abstract
Non-thermal plasma (NTP) devices have been explored for medical applications. NTP devices discharge electrons, positive ions, ultraviolet, and reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as the hydroxyl radical (●OH), singlet oxygen (1O2), superoxide (O2●−), hydrogen peroxide (H2O2), ozone, and nitric oxide, at near-physiological temperature. At preclinical stages or in human clinical trials, NTP promotes blood coagulation, eradication of bacterial, viral, and biofilm-related infections, wound healing, and cancer cell death. Here, we observed that ferric, vanadium, and gold(III) ions, measured by 2-thiobarbituric acid-reactive substances (TBARS) in combination with NTP exposure, significantly elevated lipid peroxidation. Using 3,3,5,5-tetramethyl-1-pyrroline-N-oxide (M4PO) as a spin probe in electron paramagnetic resonance (EPR), we observed that tetrachloroaurate (III) yielded an M4PO-X spin adduct. Tetrachloroaurate-induced oxidation was attenuated efficiently by reduced (GSH) and oxidized glutathione (GSSG), while glycine (Gly) and L-glutamate (Glu), components of GSH, were ineffective. Furthermore, GSH and GSSG efficiently suppressed tetrachloroaurate-induced lipid peroxidation, while Gly and Glu were ineffective in suppressing TBARS elevation. These results indicate that tetrachloroaurate-induced oxidation is attenuated by GSH as well as GSSG. Further studies are warranted to elucidate the redox reactions between metal ions and biomolecules to advance the clinical application of NTP.
- Published
- 2021
64. Search for neutrinos in coincidence with gravitational wave events from the LIGO–Virgo O3a observing run with the Super-Kamiokande detector
- Author
-
Y. Kanemura, A. Giampaolo, W. R. Kropp, Y. Hayato, A. A. Sztuc, P. Mehta, Pablo Fernandez, T. Hasegawa, F. Iacob, D. Bravo-Berguño, Y. Kuno, T. Towstego, O. Drapier, H. Ito, Sei-ichiro Watanabe, G.D. Barr, J. Bian, N. Piplani, S. Miki, S. V. Cao, M. R. Vagins, K. Martens, Y. Takemoto, L. F. Thompson, S. Imaizumi, A. Coffani, O. Stone, J. S. Jang, M. Taani, Seiko Hirota, T. Kikawa, M. Gonin, J. Xia, Masahiro Kuze, A. Goldsack, S. Han, M. J. Wilking, R. A. Wendell, M. B. Smy, Junjie Jiang, F. Nova, E. Radicioni, Kimihiro Okumura, B. Zaldivar, J. Y. Kim, S. Izumiyama, A. Orii, S. Mine, L. Cook, J. Migenda, John Hill, A. T. Suzuki, K. Okamoto, T. Horai, R. Sasaki, J. F. Martin, J. Kameda, B. Bodur, Yuichi Oyama, T. Nakadaira, J. McElwee, J. L. Stone, I. T. Lim, F. Di Lodovico, D. L. Wark, Vincenzo Berardi, Y. Maekawa, S. El Hedri, T. Sekiguchi, L. Ludovici, Th. A. Mueller, N. Ospina, K. Ohta, G. De Rosa, Hiromasa Tanaka, V. Takhistov, Hiroaki Menjo, C. Simpson, J. G. Learned, K. M. Tsui, P. Mijakowski, J. Y. Yang, K. Abe, J. L. Raaf, M. Tsukada, M. Thiesse, K. Iwamoto, H. K. Tanaka, Yasunari Suzuki, S. Samani, G. D. Megias, A. Konaka, M. G. Catanesi, N. J. Griskevich, Y. Nishimura, David Hadley, F. d. M. Blaszczyk, M. Inomoto, S. Locke, Masaki Ishitsuka, M. Jakkapu, Yusuke Koshio, S. Sakai, D. Barrow, M. Lamoureux, P. Weatherly, P. de Perio, T. Boschi, T. Niwa, K. Nakamura, T. Yoshida, A. Pritchard, C. K. Jung, R. Matsumoto, M. Hartz, T. Shiozawa, C. Vilela, Ahmed Ali, M. Koshiba, Masato Shiozawa, H. Ozaki, T. Tashiro, S. Moriyama, S. Nakayama, R. Akutsu, L. H. V. Anthony, Hussain Kitagawa, S. J. Jenkins, B. Jamieson, R. G. Park, Song Chen, P. Paganini, M. Miura, Masayuki Nakahata, H. W. Sobel, Yuuki Nakano, Y. Uchida, B. D. Xu, Ll. Marti, Kate Scholberg, K. Hagiwara, Yutaka Nakajima, B. W. Pointon, D. Martin, Manabu Tanaka, K. Sato, G. Pintaudi, H. Okazawa, M. Ikeda, L. Wan, S. Molina Sedgwick, Hirokazu Ishino, Y. Kotsar, N. F. Calabria, Yuto Ashida, C. Yanagisawa, E. Kearns, C. Bronner, Masashi Yokoyama, Intae Yu, K. Yasutome, T. Nakamura, G. Collazuol, J. Walker, L. N. Machado, N. Ogawa, K. Nishijima, T. Wester, L. Bernard, T. Ishizuka, M. Harada, Tsuyoshi Nakaya, Y. Nagao, Atsushi Takeda, A. Minamino, Rongkun Wang, S. B. Kim, M. Shinoki, A. K. Ichikawa, N. McCauley, L. Labarga, T. Kobayashi, M. Malek, N. W. Prouse, B. Richards, T. Matsubara, S. Yamamoto, C. W. Walter, K. Sakashita, J. Feng, M. Posiadala-Zezula, W. Ma, B. Quilain, Hiroyuki Sekiya, Y. Kataoka, Y. Fukuda, Y. Takeuchi, T. Kajita, Takatomi Yano, M. Friend, M. Mori, Y. Sonoda, S. Sano, Yoshitaka Itow, G. Pronost, Shintaro Ito, S. Zsoldos, T. Tsukamoto, T. Okada, T. Ishida, A. Takenaka, UAM. Departamento de Física Teórica, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Super-Kamiokande, Abe, K., Bronner, C., Hayato, Y., Ikeda, M., Imaizumi, S., Kameda, J., Kanemura, Y., Kataoka, Y., Miki, S., Miura, M., Moriyama, S., Nagao, Y., Nakahata, M., Nakayama, S., Okada, T., Okamoto, K., Orii, A., Pronost, G., Sekiya, H., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Wang, R., Xia, J., Megias, G. D., Bravo-Berguno, D., Labarga, L., Marti, Ll., Zaldivar, B., Pointon, B. W., Blaszczyk, F. D. M., Kearns, E., Raaf, J. L., Stone, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Kropp, W. R., Locke, S., Mine, S., Smy, M. B., Sobel, H. W., Takhistov, V., Weatherly, P., Hill, J., Kim, J. Y., Lim, I. T., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Bernard, L., Coffani, A., Drapier, O., El Hedri, S., Giampaolo, A., Gonin, M., Mueller, Th. A., Paganini, P., Quilain, B., Ishizuka, T., Nakamura, T., Jang, J. S., Learned, J. G., Anthony, L. H. V., Martin, D. G. R., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Nascimento Machado, L., de Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Ospina, N., Ludovici, L., Maekawa, Y., Nishimura, Y., Cao, S., Friend, M., Hasegawa, T., Ishida, T., Jakkapu, M., Kobayashi, T., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Kotsar, Y., Nakano, Y., Ozaki, H., Shiozawa, T., Suzuki, A. T., Takeuchi, Y., Yamamoto, S., Ali, A., Ashida, Y., Feng, J., Hirota, S., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Fernandez, P., Mccauley, N., Mehta, P., Pritchard, A., Tsui, K. M., Fukuda, Y., Itow, Y., Menjo, H., Niwa, T., Sato, K., Tsukada, M., Mijakowski, P., Jiang, J., Jung, C. K., Vilela, C., Wilking, M. J., Yanagisawa, C., Hagiwara, K., Harada, M., Horai, T., Ishino, H., Ito, S., Koshio, Y., Kitagawa, H., Ma, W., Piplani, N., Sakai, S., Kuno, Y., Barr, G., Barrow, D., Cook, L., Goldsack, A., Samani, S., Simpson, C., Wark, D., Nova, F., Boschi, T., Di Lodovico, F., Migenda, J., Molina Sedgwick, S., Taani, M., Zsoldos, S., Yang, J. Y., Jenkins, S. J., Malek, M., Mcelwee, J. M., Stone, O., Thiesse, M. D., Thompson, L. F., Okazawa, H., Kim, S. B., Yu, I., Nishijima, K., Koshiba, M., Iwamoto, K., Nakajima, Y., Ogawa, N., Yokoyama, M., Martens, K., Vagins, M. R., Izumiyama, S., Kuze, M., Tanaka, M., Yoshida, T., Inomoto, M., Ishitsuka, M., Ito, H., Matsumoto, R., Ohta, K., Shinoki, M., Martin, J. F., Tanaka, H. A., Towstego, T., Akutsu, R., Hartz, M., Konaka, A., de Perio, P., Prouse, N. W., Chen, S., Xu, B. D., Posiadala-Zezula, M., Hadley, D., Richards, B., Jamieson, B., Walker, J., Minamino, A., Pintaudi, G., Sano, S., Sasaki, R., and Ichikawa, A. K.
- Subjects
Astrophysics ,KAMIOKANDE ,Neutrino Astronomy ,GeV ,01 natural sciences ,7. Clean energy ,High Energy Physics - Experiment ,High Energy Physics - Experiment (hep-ex) ,Neutrino astronomy Gravitational wave astronomy High energy astrophysics Black holes Compact objects Neutron stars Transient sources ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,LIGO ,010303 astronomy & astrophysics ,QC ,QB ,Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,energy: emission ,Black holes ,Neutrino ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics ,High energy astrophysics ,High-energy astronomy ,Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,Gravitational-wave astronomy ,Neutron stars ,neutrino: spectrum ,0103 physical sciences ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,Compact objects ,flavor ,010308 nuclear & particles physics ,Gravitational wave ,background ,gravitational radiation ,Física ,Astronomy and Astrophysics ,trigger ,Transient sources ,flux ,Neutron star ,VIRGO ,Space and Planetary Science ,High Energy Physics::Experiment ,Gravitational wave astronomy ,Neutrino astronomy ,Super-Kamiokande ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,statistical - Abstract
The Super-Kamiokande detector can be used to search for neutrinos in time coincidence with gravitational waves detected by the LIGO-Virgo Collaboration (LVC). Both low-energy ($7-100$ MeV) and high-energy ($0.1-10^5$ GeV) samples were analyzed in order to cover a very wide neutrino spectrum. Follow-ups of 36 (out of 39) gravitational waves reported in the GWTC-2 catalog were examined; no significant excess above the background was observed, with 10 (24) observed neutrinos compared with 4.8 (25.0) expected events in the high-energy (low-energy) samples. A statistical approach was used to compute the significance of potential coincidences. For each observation, p-values were estimated using neutrino direction and LVC sky map ; the most significant event (GW190602_175927) is associated with a post-trial p-value of $7.8\%$ ($1.4\sigma$). Additionally, flux limits were computed independently for each sample and by combining the samples. The energy emitted as neutrinos by the identified gravitational wave sources was constrained, both for given flavors and for all-flavors assuming equipartition between the different flavors, independently for each trigger and by combining sources of the same nature., Comment: 16 pages, 5 figures. v2: adding corrections from The Astrophysical Journal review
- Published
- 2021
65. Catalytic Reduction of Dinitrogen to Ammonia and Hydrazine Using Iron–Dinitrogen Complexes Bearing Anionic Benzene-Based PCP-type Pincer Ligands
- Author
-
Takeru Kato, Hiromasa Tanaka, Asuka Konomi, Shogo Kuriyama, Kazunari Yoshizawa, and Yoshiaki Nishibayashi
- Subjects
chemistry.chemical_compound ,Ammonia ,chemistry ,Hydrazine ,Nitrogenase ,Selective catalytic reduction ,Reactivity (chemistry) ,General Chemistry ,Benzene ,Medicinal chemistry ,Catalysis ,Pincer movement - Abstract
Among synthetic models of nitrogenases, iron–dinitrogen complexes with a Fe–C bond have attracted increasing attention in recent years. Here we report the synthesis of square-planar iron(I)–dinitrogen complexes supported by anionic benzene-based PCP- and POCOP-type pincer ligands as carbon donors. These complexes catalyze the formation of ammonia and hydrazine from the reaction of dinitrogen (1 atm) with a reductant and a proton source at -78 °C, producing up to 252 equiv of ammonia and 68 equiv of hydrazine (388 equiv of fixed N atom) based on the iron atom of the catalyst. Anionic iron(0)–dinitrogen complexes, considered an essential reactive species in the catalytic reaction, are newly isolated from the reduction of the corresponding iron(I)–dinitrogen complexes. This study examines their reactivity using experiments and DFT calculations.
- Published
- 2021
66. Catalytic Reduction of Dinitrogen into Ammonia and Hydrazine Using Chromium Complexes Bearing PCP-Type Pincer Ligand
- Author
-
Shogo Kuriyama, Kazunari Yoshizawa, Yoshiaki Nishibayashi, Yuya Ashida, Akihito Egi, Hiromasa Tanaka, and Kazuya Arashiba
- Subjects
Ammonia ,chemistry.chemical_compound ,Chromium ,chemistry ,Ligand ,Hydrazine ,chemistry.chemical_element ,Selective catalytic reduction ,Pincer ligand ,Medicinal chemistry ,Carbene ,Catalysis - Abstract
A series of chromium–halide, –nitride, and –dinitrogen com-plexes bearing a carbene- and phosphine-based PCP-type pin-cer ligand is newly prepared and some of them are found to work as effective catalysts to reduce dinitrogen under atmos-pheric pressure, whereby up to 8.40 equiv of ammonia and 2.46 equiv of hydrazine (13.32 equiv of fixed N atom) are produced based on the chromium atom. To the best of our knowledge, this is the first successful example of chromium-catalyzed conversion of dinitrogen to ammonia and hydrazine under mild reaction conditions.
- Published
- 2021
67. Plasma Medicine Technologies
- Author
-
Abraham Lin, Sander Bekeschus, Eun Ha Choi, Nagendra Kumar Kaushik, and Hiromasa Tanaka
- Subjects
Engineering ,Technology ,QH301-705.5 ,QC1-999 ,02 engineering and technology ,Basic research ,stem cells ,0202 electrical engineering, electronic engineering, information engineering ,cancer ,General Materials Science ,dental material ,Biology (General) ,nonthermal plasma ,Instrumentation ,QD1-999 ,Interdisciplinarity ,Fluid Flow and Transfer Processes ,neuronal regeneration ,business.industry ,Process Chemistry and Technology ,Physics ,General Engineering ,plasma medicine ,021001 nanoscience & nanotechnology ,Engineering (General). Civil engineering (General) ,Computer Science Applications ,Chemistry ,Neuronal regeneration ,020201 artificial intelligence & image processing ,Engineering ethics ,Human medicine ,Plasma medicine ,TA1-2040 ,0210 nano-technology ,business - Abstract
This Special Issue, entitled “Plasma Medicine Technologies”, covers the latest remarkable developments in the field of plasma bioscience and medicine. Plasma medicine is an interdisciplinary field that combines the principles of plasma physics, material science, bioscience, and medicine, towards the development of therapeutic strategies. A study on plasma medicine has yielded the development of new treatment opportunities in medical and dental sciences. An important aspect of this issue is the presentation of research underlying new therapeutic methods that are useful in medicine, dentistry, sterilization, and, in the current scenario, that challenge perspectives in biomedical sciences. This issue is focused on basic research on the characterization of the bioplasma sources applicable to living cells, especially to the human body, and fundamental research on the mutual interactions between bioplasma and organic–inorganic liquids, and bio or nanomaterials.
- Published
- 2021
68. Oxidative stress-dependent and -independent death of glioblastoma cells induced by non-thermal plasma-exposed solutions
- Author
-
Hiroaki Kajiyama, Hiroki Kondo, Kae Nakamura, Fumitaka Kikkawa, Nobuhisa Yoshikawa, Hiromasa Tanaka, Hiroshi Hashizume, Masaaki Mizuno, Kenji Ishikawa, Shinya Toyokuni, Masaru Hori, Yasumasa Okazaki, and Yuko Katsumata
- Subjects
Cell signaling ,Ringer's Lactate ,Plasma Gases ,Cell Survival ,SOD2 ,lcsh:Medicine ,medicine.disease_cause ,Article ,Glutathione Peroxidase GPX1 ,Cell Line, Tumor ,medicine ,Humans ,lcsh:Science ,Cell Proliferation ,Oligonucleotide Array Sequence Analysis ,Cancer ,Glutathione Peroxidase ,Multidisciplinary ,Brain Neoplasms ,Superoxide Dismutase ,Chemistry ,Gene Expression Profiling ,lcsh:R ,Catalase ,Electrical and electronic engineering ,In vitro ,humanities ,Gene Expression Regulation, Neoplastic ,Oxidative Stress ,Apoptosis ,Cell culture ,Cancer cell ,Cancer research ,lcsh:Q ,Glioblastoma ,Oxidative stress ,Intracellular - Abstract
Non-thermal atmospheric pressure plasma has been widely used for preclinical studies in areas such as wound healing, blood coagulation, and cancer therapy. We previously developed plasma-activated medium (PAM) and plasma-activated Ringer’s lactate solutions (PAL) for cancer treatments. Many in vitro and in vivo experiments demonstrated that both PAM and PAL exhibit anti-tumor effects in several types of cancer cells such as ovarian, gastric, and pancreatic cancer cells as well as glioblastoma cells. However, interestingly, PAM induces more intracellular reactive oxygen species in glioblastoma cells than PAL. To investigate the differences in intracellular molecular mechanisms of the effects of PAM and PAL in glioblastoma cells, we measured gene expression levels of antioxidant genes such as CAT, SOD2, and GPX1. Microarray and quantitative real-time PCR analyses revealed that PAM elevated stress-inducible genes that induce apoptosis such as GADD45α signaling molecules. PAL suppressed genes downstream of the survival and proliferation signaling network such as YAP/TEAD signaling molecules. These data reveal that PAM and PAL induce apoptosis in glioblastoma cells by different intracellular molecular mechanisms.
- Published
- 2019
69. Endoscopic treatment of pancreatic diseases via Duodenal Minor Papilla: 135 cases treated by Sphyncterotomy, Endoscopic Pancreatic Duct Balloon Dilation (EPDBD), and Pancreatic Stenting (EPS)
- Author
-
Toshiharu Kakimoto, Hisada S, Amano Y, M Katoh, G Sun, Kogiso T, Hiroyuki Kaneda, Y Moriya, K Yatsuji, N. Tsurumi, Kuniharu Miura, S Mano, Y. Hoshino, Hiroshi Shinozaki, Norio Okamoto, Kazuo Yamafuji, Ono M, Ohishi K, Kubochi M, A Sugiyama, Hiromasa Tanaka, Takao Masuda, Iimura M, Nyuhzuki S, Tetsuya Mizutani, J. Won, Kaoru Takeshima, Hideyuki Katsura, T Shinobi, and Tadao Tsuji
- Subjects
Major duodenal papilla ,Pancreatic duct ,medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,medicine ,Balloon dilation ,General Medicine ,General Chemistry ,business ,Endoscopic treatment ,Surgery - Published
- 2019
70. Dehydroascorbic acid recycled by thiols efficiently scavenges non-thermal plasma-induced hydroxyl radicals
- Author
-
Masaru Hori, Shinya Toyokuni, Hiromasa Tanaka, and Yasumasa Okazaki
- Subjects
0301 basic medicine ,Plasma Gases ,Reducing agent ,viruses ,Radical ,Biophysics ,Ascorbic Acid ,medicine.disease_cause ,Biochemistry ,Dithiothreitol ,Cyclic N-Oxides ,03 medical and health sciences ,chemistry.chemical_compound ,medicine ,Molecular Biology ,chemistry.chemical_classification ,Reactive oxygen species ,030102 biochemistry & molecular biology ,Hydroxyl Radical ,Electron Spin Resonance Spectroscopy ,Free Radical Scavengers ,Glutathione ,Ascorbic acid ,Dehydroascorbic Acid ,Combinatorial chemistry ,Acetylcysteine ,030104 developmental biology ,chemistry ,Spin Labels ,Dehydroascorbic acid ,Oxidative stress - Abstract
Recent development in electronics has enabled the use of non-thermal plasma (NTP) to strictly direct oxidative stress in a defined location at near-physiological temperature. In preclinical studies or human clinical trials, NTP promotes blood coagulation, wound healing with disinfection, and selective killing of cancer cells. Although these biological effects of NTP have been widely explored, the stoichiometric quantitation of free radicals in liquid phase has not been performed in the presence of biocompatible reducing agents, which may modify the final biological effects of NTP. Here we quantitated hydroxyl radicals, a major reactive oxygen species generated after NTP exposure, by electron paramagnetic resonance (EPR) spectroscopy using two distinct spin-trapping probes, 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and 3,3,5,5-tetramethyl-1-pyrroline-N-oxide (M4PO), in the presence of thiols or antioxidants. l -Ascorbic acid (AsA) at 25–50 μM concentrations (physiological concentration in the serum) significantly scavenged these hydroxyl radicals, whereas dithiothreitol (DTT), reduced glutathione (GSH), and N-acetyl-cysteine (NAC) as thiols were required in millimolar concentrations to perform scavenging activities. l -Dehydroascorbic acid (DHA), an oxidized form of AsA, necessitated the presence of 25–50 μM DTT or sub-millimolar concentrations of GSH and NAC for the scavenging of hydroxyl radicals and failed to scavenge hydroxyl radicals by itself. These results suggest that the redox cycling of AsA/DHA via thiols and cellular AsA metabolism are important processes to be considered while applying NTP to cells and tissues. Further studies are warranted to elucidate the interaction between other reactive species generated by NTP and biomolecules to promote biological and medical applications of NTP.
- Published
- 2019
71. Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)-dependent manner
- Author
-
Kotaro Sato, Shinya Toyokuni, Masaru Hori, Masaaki Mizuno, Yuuki Ohara, Fumiya Ito, Hiromasa Tanaka, Hideharu Hibi, Yashiro Motooka, Tasuku Hirayama, and Lei Shi
- Subjects
0301 basic medicine ,non-thermal plasma ,Clinical Biochemistry ,Medicine (miscellaneous) ,Nonthermal plasma ,Catalysis ,Lipid peroxidation ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Annexin ,medicine ,catalytic ferrous iron ,Basal cell ,030109 nutrition & dietetics ,Nutrition and Dietetics ,apoptosis ,Cancer ,medicine.disease ,ferroptosis ,oral squamous cell carcinoma ,stomatognathic diseases ,chemistry ,Apoptosis ,Cancer cell ,Cancer research ,030211 gastroenterology & hepatology ,Original Article - Abstract
Oral cancer accounts for ~2% of all cancers worldwide, and therapeutic intervention is closely associated with quality of life. Here, we evaluated the effects of non-thermal plasma on oral squamous cell carcinoma cells with special reference to catalytic Fe(II). Non-thermal plasma exerted a specific killing effect on oral squamous cell carcinoma cells in comparison to fibroblasts. Furthermore, the effect was dependent on the amounts of catalytic Fe(II), present especially in lysosomes. After non-thermal plasma application, lipid peroxidation occurred and peroxides and mitochondrial superoxide were generated. Cancer cell death by non-thermal plasma was promoted dose-dependently by prior application of ferric ammonium citrate and prevented by desferrioxamine, suggesting the association of ferroptosis. Potential involvement of apoptosis was also observed with positive terminal deoxynucleaotidyl transferase-mediated dUTP nick end labeling and annexin V results. Non-thermal plasma exposure significantly suppressed the migratory, invasive and colony-forming abilities of squamous cell carcinoma cells. The oral cavity is easily observable; therefore, non-thermal plasma can be directly applied to the oral cavity to kill oral squamous cell carcinoma without damaging fibroblasts. In conclusion, non-thermal plasma treatment is a potential therapeutic option for oral cancer.
- Published
- 2019
72. Rapid bacterial identification by direct PCR amplification of 16S rRNA genes using the MinION™ nanopore sequencer
- Author
-
Yoshiyuki Matsuo, Kiichi Hirota, Tadashi Imanishi, Teppei Iwai, Shinichi Kai, Kirill Kryukov, Shino Matsukawa, So Nakagawa, and Hiromasa Tanaka
- Subjects
0301 basic medicine ,Staphylococcus aureus ,Method ,MinION ,Computational biology ,Biology ,Polymerase Chain Reaction ,General Biochemistry, Genetics and Molecular Biology ,Bacterial cell structure ,law.invention ,Nanopores ,03 medical and health sciences ,0302 clinical medicine ,law ,RNA, Ribosomal, 16S ,Escherichia coli ,Humans ,16S rRNA ,Gene ,Polymerase chain reaction ,Sequence Analysis, RNA ,direct PCR ,Ribosomal RNA ,16S ribosomal RNA ,DNA extraction ,bacterial identification ,nanopore sequencer ,030104 developmental biology ,030220 oncology & carcinogenesis ,Minion ,Nanopore sequencing - Abstract
Rapid identification of bacterial pathogens is crucial for appropriate and adequate antibiotic treatment, which significantly improves patient outcomes. 16S ribosomal RNA (rRNA) gene amplicon sequencing has proven to be a powerful strategy for diagnosing bacterial infections. We have recently established a sequencing method and bioinformatics pipeline for 16S rRNA gene analysis utilizing the Oxford Nanopore Technologies MinION™ sequencer. In combination with our taxonomy annotation analysis pipeline, the system enabled the molecular detection of bacterial DNA in a reasonable time frame for diagnostic purposes. However, purification of bacterial DNA from specimens remains a rate‐limiting step in the workflow. To further accelerate the process of sample preparation, we adopted a direct PCR strategy that amplifies 16S rRNA genes from bacterial cell suspensions without DNA purification. Our results indicate that differences in cell wall morphology significantly affect direct PCR efficiency and sequencing data. Notably, mechanical cell disruption preceding direct PCR was indispensable for obtaining an accurate representation of the specimen bacterial composition. Furthermore, 16S rRNA gene analysis of mock polymicrobial samples indicated that primer sequence optimization is required to avoid preferential detection of particular taxa and to cover a broad range of bacterial species. This study establishes a relatively simple workflow for rapid bacterial identification via MinION™ sequencing, which reduces the turnaround time from sample to result, and provides a reliable method that may be applicable to clinical settings.
- Published
- 2019
73. Synergistic Effects on Hyperthermic Cancer Therapy Using Plasma-activated Acetated Ringer’s Solution
- Author
-
HIROMASA TANAKA and MASARU HORI
- Published
- 2021
74. Cytotoxicity of plasma-irradiated lactate solution produced under atmospheric airtight conditions and generation of the methyl amino group
- Author
-
Daiki Ito, Naoyuki Iwata, Kenji Ishikawa, Kae Nakamura, Hiroshi Hashizume, Camelia Miron, Hiromasa Tanaka, Hiroaki Kajiyama, Shinya Toyokuni, Masaaki Mizuno, and Masaru Hori
- Subjects
General Engineering ,General Physics and Astronomy ,humanities - Abstract
Ringer’s lactate solution was irradiated with non-equilibrium plasma under airtight conditions. The plasma-activated lactate (PAL) was produced with argon, oxygen, and nitrogen gases following purging of Ar. Cytotoxicity could be controlled by diluting PAL, and a killing effect was selectively obtained on cancer cells compared to normal cells for Ar+O2+N2 PALs. Nonetheless, cytotoxicity was partly reproduced by similar concentrations of H2O2 and NO2 − in the PALs. The organics produced by plasma irradiation to lactate were investigated using nuclear magnetic resonance, and the generation of methyl amino species was confirmed.
- Published
- 2022
75. Density-Functional Tight-Binding Study on the Effects of Interfacial Water in the Adhesion Force between Epoxy Resin and Alumina Surface
- Author
-
Kazunari Yoshizawa, Hiromasa Tanaka, and Hiroyuki Murata
- Subjects
Surface (mathematics) ,Materials science ,02 engineering and technology ,Surfaces and Interfaces ,Adhesion ,Epoxy ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,Tight binding ,visual_art ,Electrochemistry ,visual_art.visual_art_medium ,Adhesion force ,General Materials Science ,Composite material ,0210 nano-technology ,Spectroscopy - Abstract
Adhesion is one of the most interesting subjects in interface phenomena from the viewpoint of wide-range applications as well as basic science. Interfacial water has significant effects on coatings, adhesives, and fiber-reinforced polymer composites, often causing adhesion loss. The way of thinking based on quantum mechanics is essential for a better understanding of physical and chemical properties of adhesive interfaces. In this work, the molecular mechanism of the adhesion interaction between epoxy resin and hydroxylated alumina surface in the presence of interfacial water molecules is investigated by using density-functional tight-binding calculations. Periodic slab model calculations demonstrate that hydrogen bond is an important factor at the adhesion interface. Effects of interfacial water molecules located between epoxy resin and hydroxylated alumina surface are assessed by using a dry model without interfacial water and wet models with water layers of 3, 6, and 9 Å thicknesses. Interesting first- and second-layer structures are observed in the distribution of interfacial water molecules in the tight space between the adhesive and adherend. Energy plots with respect to the displacement of epoxy resin from the alumina surface are nicely approximated by the Morse potential. The adhesion force and stress are theoretically obtained by differentiating the potential curve with respect to the displacement of epoxy resin. Computational results show that the adhesion force and stress are significantly weakened with an increase in the thickness of interfacial water layer. Thus, interfacial water molecules have a clue as to the role of water in the loss of adhesion.
- Published
- 2018
76. Molecular understanding of the adhesive interactions between silica surface and epoxy resin: Effects of interfacial water
- Author
-
Kazunari Yoshizawa, Chisa Higuchi, and Hiromasa Tanaka
- Subjects
Surface (mathematics) ,Materials science ,010304 chemical physics ,Hydrogen bond ,General Chemistry ,Adhesion ,Epoxy ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,Computational Mathematics ,Adsorption ,Chemical engineering ,visual_art ,0103 physical sciences ,Slab ,visual_art.visual_art_medium ,Molecule ,Adhesive - Abstract
The molecular mechanism of the adhesion between silica surface and epoxy resin under atmospheric conditions is investigated by periodic density-functional-theory (DFT) calculations. Slab models of the adhesion interface were built by integrating a fragment of epoxy resin and hydroxylated (0 0 1) surface of α-cristobalite in the presence of adsorbed water molecules. Effects of adsorbed water on the adhesion interaction are evaluated on the basis of geometry-optimized structures, adhesion energies, and forces. Calculated results demonstrate that adsorbed water molecules significantly reduce both the adhesion energies and forces of the silica surface-epoxy resin interface. The reduction of adhesion properties can be associated with structural deformation of water molecules confined in the tight space between the adhesive and adherend as well as structural flexibility of the hydrogen-bonding network in the interfacial region during detachment of the epoxy resin from the hydrophilic silica surface. © 2018 Wiley Periodicals, Inc.
- Published
- 2018
77. Molecular mechanisms of non-thermal plasma-induced effects in cancer cells
- Author
-
Hiromasa Tanaka, Kenji Ishikawa, Fumitaka Kikkawa, Hiroaki Kajiyama, Masaaki Mizuno, Masaru Hori, and Shinya Toyokuni
- Subjects
0301 basic medicine ,Plasma Gases ,biochemical networks ,viruses ,Clinical Biochemistry ,Gene regulatory network ,Apoptosis ,Nonthermal plasma ,reactive oxygen species (ROS) ,01 natural sciences ,Biochemistry ,03 medical and health sciences ,Immune system ,Neoplasms ,0103 physical sciences ,Tumor Cells, Cultured ,Humans ,Molecular Biology ,010302 applied physics ,Chemistry ,plasma medicine ,Cell biology ,030104 developmental biology ,plasma cancer therapy ,Cancer cell ,Plasma medicine ,Wound healing ,Signal Transduction - Abstract
Plasma is the fourth state of matter with higher energy than gas; non-thermal plasma (NTP) is currently available. As NTP is useful in sterilization, promoting wound healing and cancer treatments, the molecular mechanisms of plasma-induced effects in living cells and microorganisms are of significant interest in plasma medicine with medical-engineering collaboration. Molecular mechanisms of plasma-induced effects in cancer cells will be described in this minireview. Both direct and indirect methods to treat cancer cells with NTP have been developed. NTP interacts directly with not only cancer cells but also the liquids surrounding cancer cells and the immune cells that target them. Reactive oxygen and nitrogen species play key roles in NTP-induced effects; however, other mechanisms have been suggested. The complex interactions between NTP, cells and liquids have been extensively studied. In the future, details regarding NTP-induced effects on gene regulatory networks, signaling networks, and metabolic networks will be elucidated., ファイル公開日:2020/01/01
- Published
- 2018
78. Measurements of ν̅ μ and ν̅ μ + ν μ charged-current cross-sections without detected pions or protons on water and hydrocarbon at a mean anti-neutrino energy of 0.86 GeV
- Author
-
M. Barbi, T. Vladisavljevic, A. Longhin, A. Shaykina, M. Lawe, Michelangelo Pari, A. Blanchet, Thorsten Lux, Y. Sonoda, L. Molina Bueno, T. Kikawa, S. Parsa, V. Q. Nguyen, H. W. Sobel, M. Gonin, J. Xia, A. T. Suzuki, A. Dergacheva, C. E. R. Naseby, J. F. Martin, N. Kukita, M. Licciardi, T. Feusels, Y. Tanihara, C. Alt, T. Nakadaira, Shuji Tanaka, R. Shah, J. Lagoda, R. J. Wilson, M. Pavin, S. J. Jenkins, J. R. Wilson, D. Fukuda, L. O'Sullivan, Jochen Steinmann, Xianguo Lu, M. R. Vagins, H. Kikutani, J. G. Walsh, A. Bubak, P. Jonsson, R. A. Owen, P. Novella, K. Iwamoto, K. Niewczas, André Rubbia, Jaroslaw Pasternak, Y. Yoshimoto, M. Batkiewicz-Kwasniak, M. Miura, Marco Laveder, A. Zykova, J. P. Coleman, T. Hayashino, Yuto Ashida, A. J. Finch, R. Fukuda, C. Wret, A. Knox, T. Arihara, T. Sekiguchi, R. Akutsu, J. Morrison, N. McCauley, M. Guigue, A. Pritchard, P. B. Jurj, A. A. Sztuc, J. L. Palomino, G. Zarnecki, Patrick Dunne, P. Paudyal, A. Blondel, T. Koga, B. A. Popov, T. Honjo, A. Rychter, P. Hamacher-Baumann, Oleg Mineev, C. Pistillo, M. Jakkapu, M. Buizza Avanzini, B. Jamieson, G. Christodoulou, K. Nakamura, T. A. Doyle, E. Reinherz-Aronis, Keigo Nakamura, Takaaki Kajita, E. Rondio, B. Quilain, C. J. Densham, K. Yasutome, K. Fusshoeller, Hiroyuki Sekiya, S. L. Cartwright, F. Shaker, W. Uno, C. M. Nantais, F. Nova, K. Porwit, P. F. Denner, R. Fujita, Y. Fukuda, Kendall Mahn, A. K. Ichikawa, V. Paolone, Akitaka Ariga, Ko Okumura, G. Pintaudi, S. Moriyama, Kate Scholberg, D. Cherdack, M. Ziembicki, S. Roth, J. Kameda, J. Zalipska, C. Vilela, S. Kuribayashi, E. S. Pinzon Guerra, Th. A. Mueller, B. Radics, M. Ikeda, A. Zalewska, Federico Sanchez, B. Bourguille, Yousuke Kataoka, Z. Vallari, Y. Takeuchi, K. Wood, R.P. Kurjata, L. F. Thompson, S. Valder, T. Ogawa, T. Golan, M. Hartz, E. D. Zimmerman, C. McGrew, Masayuki Nakahata, C. Pidcott, L. Koch, Y. Asada, A. Gorin, G. A. Fiorentini, A. Knight, A. Shvartsman, N. Teshima, C. Checchia, A. Bravar, Vladimir Volkov, Y. Uchida, Shigeki Aoki, Yuichi Oyama, A. Nakamura, S. Suvorov, R. P. Litchfield, Takatomi Yano, Y. Hayato, C. Andreopoulos, R. A. Wendell, S. Bolognesi, H. M. O'Keeffe, J. Holeczek, S. Hassani, G. Fiorillo, T. Radermacher, Thomas B. Campbell, Yuki Fujii, K. Nakayoshi, D. Bravo Berguño, E. Radicioni, T. Kobata, W. H. Toki, Hiromasa Tanaka, V. A. Matveev, M. B. Smy, T. Towstego, L. Maret, P. N. Ratoff, T. Kutter, Koji Yamamoto, M. McCarthy, M. Zito, Hidekazu Kakuno, Pablo Fernandez, M. O. Wascko, S. Mine, G. Yang, E. Mazzucato, K. Kowalik, Laura Gutermuth Anthony, M. Yu, D. L. Wark, F. Di Lodovico, Yutaka Nakajima, Jan Kisiel, T. Bonus, M. Friend, Teppei Katori, Yanbin Wang, M. Tada, D. J. Payne, K. Abe, T. Okusawa, Jungsang Kim, S. Y. Suzuki, N. Izumi, D. Vargas, J. Dumarchez, N. Chikuma, Vincenzo Berardi, D. Barrow, Etam Noah, C. Bronner, Steven C. Johnson, S. Nakayama, F. J. P. Soler, L. L. Kormos, W. Shorrock, Masaki Ishitsuka, Yoshihiro Suzuki, M. Kuze, T. Tsukamoto, K. Skwarczynski, L. Labarga, A. Eguchi, K. Sakashita, S. M. Oser, L. Berns, S. Yen, M. Hogan, T. Kobayashi, N. C. Hastings, M. Antonova, R. Okada, T. Odagawa, Yoshikazu Yamada, A. N. Khotjantsev, Alan Cosimo Ruggeri, J. Schwehr, D. Karlen, T. Yoshida, Y. Seiya, A. Minamino, Hidetoshi Kubo, A. D. Marino, Hyun-Chul Kim, A. Izmaylov, L. Pickering, Y. Nishimura, S. Manly, S. Ban, S. Bienstock, K. M. Tsui, K. S. McFarland, F. Bench, A. C. Weber, Y. Katayama, G. Vasseur, C. Jesús-Valls, C. Ruggles, G. Santucci, O. Drapier, D. A. Harris, S. Emery-Schrenk, H. K. Tanaka, T. Wachala, T. Ishida, S. P. Kasetti, N. Akhlaq, M. M. Khabibullin, S. L. Liu, M. Posiadala-Zezula, M. G. Catanesi, M. Malek, L. Magaletti, C. Giganti, N. Dokania, S. Berkman, Roberto Spina, A. C. Kaboth, A. Cervera, G. Collazuol, Mark Scott, M. Kabirnezhad, K. Mavrokoridis, J. A. Nowak, A. Chappell, Lars Eklund, T. S. Nonnenmacher, C. Barry, S. Murphy, C. Riccio, C. Mauger, T. Dealtry, E. T. Atkin, M. Cicerchia, Alexei Yu. Smirnov, Yuta Kato, K. Nishikawa, M. Lamoureux, L. N. Machado, J. T. Haigh, S. Zsoldos, V. Palladino, S. B. Boyd, L. Marti-Magro, K. Zaremba, Jan T. Sobczyk, Stephanie Bron, Atsushi Takeda, J. McElwee, D. Sgalaberna, Ahmed Ali, C. Francois, Y. Awataguchi, Xiao-yan Li, W. G. S. Vinning, C. Wilkinson, T. V. Ngoc, C. Yanagisawa, Gareth J. Barker, Yuuki Nakano, D. Coplowe, T. Ishii, A. Hiramoto, T. Hasegawa, Takahiko Matsubara, S. V. Cao, C. Touramanis, M. J. Wilking, M. Jiang, Antonio Ereditato, N. Yershov, T. Maruyama, K. Gameil, J. C. Nugent, G.D. Barr, S. King, F. Iacob, M. Mezzetto, D. R. Hadley, Y. Nagai, W. C. Parker, M. Tani, E. Kearns, G. C. Penn, Masashi Yokoyama, M. Tzanov, C. J. Metelko, Yu.A. Kudenko, A. Dabrowska, K. Matsushita, D. Brailsford, N. T. Hong Van, J. Walker, A. Mefodiev, S. Dolan, T. Lindner, A. Cudd, S. R. Dennis, Tsuyoshi Nakaya, C. M. Schloesser, C. K. Jung, Masato Shiozawa, L. Ludovici, A. Kostin, S. Bhadra, L. Cook, A. Beloshapkin, G. De Rosa, J. Calcutt, A. Shaikhiev, A. Konaka, L. Munteanu, M. Tajima, and Yusuke Koshio
- Subjects
chemistry.chemical_classification ,Physics ,Particle physics ,Muon ,Proton ,010308 nuclear & particles physics ,General Physics and Astronomy ,01 natural sciences ,Hydrocarbon ,Pion ,chemistry ,0103 physical sciences ,010306 general physics ,Nucleon ,Energy (signal processing) ,Charged current ,Bar (unit) - Abstract
We report measurements of the flux-integrated ν̅μ and ν̅μ + νμ charged-current cross-sections on water and hydrocarbon targets using the T2K anti-neutrino beam with a mean beam energy of 0.86 GeV. The signal is defined as the (anti-)neutrino charged-current interaction with one induced $\mu^\pm$ and no detected charged pion or proton. These measurements are performed using a new WAGASCI module recently added to the T2K setup in combination with the INGRID Proton Module. The phase space of muons is restricted to the high-detection efficiency region, $p_{\mu}>400~{\rm MeV}/c$ and $\theta_{\mu}200~{\rm MeV}/c$, $\theta_{\pi}600~{\rm MeV}/c$, $\theta_{\rm p}
- Published
- 2021
79. Differential data on the responsiveness of multiple cell types to cell death induced by non-thermal atmospheric pressure plasma-activated solutions
- Author
-
Keiichiro Hyakutake, Ko Eto, Hiromasa Tanaka, Chiaki Ishinada, Masaru Hori, and Takuya Suemoto
- Subjects
Cell death ,Cell type ,Programmed cell death ,Science (General) ,Cancer cells ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Cell morphology ,03 medical and health sciences ,chemistry.chemical_compound ,Q1-390 ,0302 clinical medicine ,Murine embryonic fibroblasts ,Programmed cell death 4 ,Myocyte ,Non-thermal atmospheric pressure plasma-activated solutions ,030304 developmental biology ,Data Article ,0303 health sciences ,Multidisciplinary ,Cellular shrinkage ,Embryonic stem cell ,Murine myoblast C2C12 cells ,Human neuroblastoma SH-SY5Y cells ,Cell biology ,chemistry ,Cancer cell ,Trypan blue ,C2C12 ,030217 neurology & neurosurgery - Abstract
A discovery that cells die of a novel and distinctive process, along with some characteristic events, such as cellular shrinkage and Programmed cell death 4 disappearance, has been done by using non-thermal atmospheric pressure plasma-activated solutions [1]. Data on the responsiveness of multiple cell types to the induction of cellular shrinkage and cell death and the loss of Programmed cell death 4 by exposure to the non-thermal atmospheric pressure plasma-activated solutions were collected. Human neuroblastoma SH-SY5Y cells, murine myoblast C2C12 cells, and murine embryonic fibroblasts were cultured for various periods in each of the non-thermal atmospheric pressure plasma-activated solutions and then examined by light field microscopic observation for their effects on cell morphology, by Trypan blue dye exclusion assay for those on cell death, and by Western blotting for those on Programmed cell death 4 disappearance. The data clarified some differences in the responsiveness to the induction of cellular shrinkage, cell death, and Pdcd4 disappearance by all the non-thermal atmospheric pressure plasma-activated solutions among the cells.
- Published
- 2021
80. Plasma-Treated Solutions (PTS) in Cancer Therapy
- Author
-
Sander Bekeschus, Dayun Yan, Mounir Laroussi, Masaru Hori, Hiromasa Tanaka, Michael Keidar, Nagoya University, Leibniz Institute for Plasma Science and Technology (INP), Leibniz Association, The George Washington University (GW), and Old Dominion University [Norfolk] (ODU)
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,Cancer therapy ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Review ,lcsh:RC254-282 ,01 natural sciences ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,0103 physical sciences ,cold physical plasma ,medicine ,nonthermal plasma ,Reactive nitrogen species ,010302 applied physics ,chemistry.chemical_classification ,reactive oxygen species ,Reactive oxygen species ,Chemotherapy ,business.industry ,plasma-activated medium ,[SPI.PLASMA]Engineering Sciences [physics]/Plasmas ,Therapeutic effect ,plasma medicine ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,3. Good health ,reactive nitrogen species ,chemistry ,Mechanism of action ,030220 oncology & carcinogenesis ,oncology ,PAM ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,low-temperature plasma ,medicine.symptom ,Plasma medicine ,business ,Adjuvant - Abstract
Simple Summary Cold physical plasma is a partially ionized gas generating various reactive oxygen and nitrogen species (ROS/RNS) simultaneously. ROS/RNS have therapeutic effects when applied to cells and tissues either directly from the plasma or via exposure to solutions that have been treated beforehand using plasma processes. This review addresses the challenges and opportunities of plasma-treated solutions (PTSs) for cancer treatment. Abstract Cold physical plasma is a partially ionized gas generating various reactive oxygen and nitrogen species (ROS/RNS) simultaneously. ROS/RNS have therapeutic effects when applied to cells and tissues either directly from the plasma or via exposure to solutions that have been treated beforehand using plasma processes. This review addresses the challenges and opportunities of plasma-treated solutions (PTSs) for cancer treatment. These PTSs include plasma-treated cell culture media in experimental research as well as clinically approved solutions such as saline and Ringer’s lactate, which, in principle, already qualify for testing in therapeutic settings. Several types of cancers were found to succumb to the toxic action of PTSs, suggesting a broad mechanism of action based on the tumor-toxic activity of ROS/RNS stored in these solutions. Moreover, it is indicated that the PTS has immuno-stimulatory properties. Two different routes of application are currently envisaged in the clinical setting. One is direct injection into the bulk tumor, and the other is lavage in patients suffering from peritoneal carcinomatosis adjuvant to standard chemotherapy. While many promising results have been achieved so far, several obstacles, such as the standardized generation of large volumes of sterile PTS, remain to be addressed.
- Published
- 2021
81. Measuring Competence for Global Business: In Search of Authentic Data in Japanese Business Corporations
- Author
-
Hiromasa Tanaka
- Subjects
Communicative competence ,Global business ,Intercultural competence ,business.industry ,Public relations ,computer.software_genre ,Focus group ,Vignette ,Scripting language ,Confidentiality ,business ,Psychology ,Competence (human resources) ,computer - Abstract
Research on global communication competence, intercultural competence, and communicative competence relies heavily on second-hand data collected through surveys and interviews due to the limited first-hand access researchers have to naturally occurring data. This chapter reports on a case where Japanese researchers needed access to authentic critical incident scenarios for the development of a situational judgment test to be used to assess the Global Business Discourse Competence (GBDC) of Japanese business practitioners. The development of these scenarios was dependent on the collection of naturally occurring data from business interactions on job sites. However, access to such data was problematic because of the unpredictability of incidents and the strong concerns by the participant business corporations concerning the privacy and confidentiality of their people and processes. The solution was to devise a series of simulated vignettes using data from multiple sources including interviews, focus group meetings and surveys. Researchers used feedback from subject matter specialists and pre-test participants to revise the vignette scripts to ensure that they accurately represented real incidents typically taking place on job sites. This chapter raises the questions of authenticity in business discourse data and the extent to which simulations can evidence real-time communicative events in critical-incident cases.
- Published
- 2021
82. Search for tens of MeV neutrinos associated with gamma-ray bursts in Super-Kamiokande
- Author
-
P. Fernandez, Y. Nishimura, M. Inomoto, J. Bian, P. de Perio, G. Pronost, L. Wan, M. Lamoureux, Shintaro Ito, S. Zsoldos, Y. Takeuchi, K. Martens, J. Xia, Y. Sonoda, O. Drapier, Takatomi Yano, S. El Hedri, T. Shiozawa, Ahmed Ali, Ll. Marti, K. Nakamura, C. Xu, Hiroaki Menjo, C. Bronner, A. Konaka, T. Sekiguchi, K. S. Ganezer, M. Hartz, A. Giampaolo, B. Jamieson, N. F. Calabria, J. G. Learned, Takaaki Kajita, K. Yasutome, S. Nakayama, A. Takenaka, M. Harada, Vincenzo Berardi, William R. Kropp, S. Chen, R. G. Park, L. Ludovici, Kimihiro Okumura, Yasuhiro Takemoto, K. M. Tsui, A. Takeda, Hiromasa Tanaka, C. W. Walter, H. Okazawa, K. Okamoto, Y. Ashida, J. McElwee, S. Izumiyama, D. Barrow, Y. Fukuda, M. Ikeda, R. P. Litchfield, T. Okada, Intae Yu, N. Ogawa, Kate Scholberg, H. Miyabe, G. D. Megias, C. Simpson, Makoto Sakuda, L. Bernard, S. Samani, M. G. Catanesi, J. Y. Yang, Masaki Ishitsuka, M. Thiesse, F. d. M. Blaszczyk, Jl Stone, Yoshitaka Kuno, G. Pintaudi, K. Ohta, Hiroyuki Sekiya, F. Nova, Y. Kato, P. Weatherly, K. Abe, S. Han, T. Sugimoto, Hirokazu Ishino, Masayuki Nakahata, N. McCauley, C. M. Nantais, B. Zaldivar, T. Nakadaira, S. Sakai, E. Kearns, A. Goldsack, Michael B. Smy, M. Jakkapu, R. A. Wendell, Y. Uchida, M. Posiadala-Zezula, Y. Oyama, B. Bodur, C. Vilela, G. De Rosa, K. Sato, G. Collazuol, Luis Labarga, J. Kameda, J. Feng, D. Fukuda, T. Niwa, P. Mijakowski, P. Paganini, B. D. Xu, N. J. Griskevich, P. Mehta, T. Horai, C. K. Jung, Lester D.R. Thompson, Yusuke Koshio, D. Bravo-Berguño, S. Matsuno, T. Tsukamoto, K. Hagiwara, S. Hirota, M. Koshiba, Y. Nakajima, G.D. Barr, Yuuki Nakano, T. Mochizuki, Stephen J. Jenkins, I. T. Lim, T. Ishida, Y. Isobe, L. N. Machado, T. Boschi, John Walker, Th. A. Mueller, Hiroshi Ito, B. W. Pointon, M. Taani, R. Akutsu, A. A. Sztuc, Makoto Hasegawa, L. H. V. Anthony, Tatsuya Kikawa, Volodymyr Takhistov, Yousuke Kataoka, N. W. Prouse, S. V. Cao, A. Pritchard, M. Tsukada, M. Gonin, Yoshihiro Suzuki, Y. Nagao, A. Minamino, M. Shinoki, M. Malek, J. Y. Kim, J. L. Raaf, S. Yamamoto, T. Nakamura, S. Locke, M. Jiang, A. Coffani, Yasuhiro Kishimoto, O. Stone, Takashi Kobayashi, T. Towstego, T. Hasegawa, S. Mine, Takahiko Matsubara, K. Frankiewicz, N. Piplani, A. Orii, Mark R. Vagins, S. B. Kim, A. K. Ichikawa, K. E. Nakamura, S. Molina Sedgwick, B. Richards, Ken Sakashita, W. Ma, R. Matsumoto, B. Quilain, J. F. Martin, M. Friend, Masato Shiozawa, Y. Choi, L. Cook, A. Suzuki, Masashi Yokoyama, T. Ishizuka, Tsuyoshi Nakaya, J. S. Jang, Masahiro Kuze, R. Sasaki, Henry W. Sobel, Kyoshi Nishijima, Natalv Ospina, Shigetaka Moriyama, H. A. Tanaka, S. Imaizumi, K. Iwamoto, T. Tashiro, Manabu Tanaka, Yoshinari Hayato, C. Yanagisawa, T. Wester, Yoshitaka Itow, M. Miura, M. J. Wilking, Takashi Yoshida, F. Iacob, E. Radicioni, John Hill, D. L. Wark, Y. Takahira, R. Wang, M. Mori, F. Di Lodovico, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Super-Kamiokande, and Super-Kamiokande Collaboration
- Subjects
Astrophysics::High Energy Astrophysical Phenomena ,General Physics and Astronomy ,FOS: Physical sciences ,Astrophysics ,KAMIOKANDE ,gamma ray: burst ,01 natural sciences ,Fluence ,Coincidence ,High Energy Physics - Experiment ,High Energy Physics - Experiment (hep-ex) ,Positron ,F03 Ultra-high energy phenomena of cosmic rays ,neutrino: energy ,0103 physical sciences ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,010303 astronomy & astrophysics ,Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,010308 nuclear & particles physics ,background ,High Energy Physics::Phenomenology ,F22 Neutrinos from supernova remnant and other astronomical objects ,network ,positron ,High Energy Physics::Experiment ,C43 Underground experiments ,Underground experiments Ultra-high energy phenomena of cosmic rays Neutrinos from supernova remnant and other astronomical objects ,Neutrino ,Astrophysics - High Energy Astrophysical Phenomena ,Super-Kamiokande ,Gamma-ray burst ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,Energy (signal processing) ,Bar (unit) - Abstract
A search for neutrinos produced in coincidence with Gamma-Ray Bursts(GRB) was conducted with the Super-Kamiokande (SK) detector. Between December 2008 and March 2017, the Gamma-ray Coordinates Network recorded 2208 GRBs that occurred during normal SK operation. Several time windows around each GRB were used to search for coincident neutrino events. No statistically significant signal in excess of the estimated backgrounds was detected. The $\bar\nu_e$ fluence in the range from 8 MeV to 100 MeV in positron total energy for $\bar\nu_e+p\rightarrow e^{+}+n$ was found to be less than $\rm 5.07\times10^5$ cm$^{-2}$ per GRB in 90\% C.L. Upper bounds on the fluence as a function of neutrino energy were also obtained., Comment: 29 pages, 16 figures, 5 tables, accepted by PTEP
- Published
- 2021
- Full Text
- View/download PDF
83. Dynamic analysis of reactive oxygen nitrogen species in plasma-activated culture medium by UV absorption spectroscopy.
- Author
-
Brubaker, Timothy R., Kenji Ishikawa, Keigo Takeda, Jun-Seok Oh, Hiroki Kondo, Hiroshi Hashizume, Hiromasa Tanaka, Knecht, Sean D., Bilén, Sven G., and Masaru Hori
- Subjects
REACTIVE oxygen species ,REACTIVE nitrogen species ,ULTRAVIOLET spectroscopy ,PLASMA sources ,COLORIMETRIC analysis - Abstract
The liquid-phase chemical kinetics of a cell culture basal medium during treatment by an argonfed, non-equilibrium atmospheric-pressure plasma source were investigated using real-time ultraviolet absorption spectroscopy and colorimetric assays. Depth- and time-resolved NO
2 - and NO3 - concentrations were strongly inhomogeneous and primarily driven by convection during and after plasma-liquid interactions. H2 O2 concentrations determined from deconvolved optical depth spectra were found to compensate for the optical depth spectra of excluded reactive species and changes in dissolved gas content. Plasma-activated media remained weakly basic due to NaHCO3 buffering, preventing the Hþ-catalyzed decomposition of NO2 - seen in acidic plasma-activated water. An initial increase in pH may indicate CO2 sparging. Furthermore, the pH-dependency of UV optical depth spectra illustrated the need for pH compensation in the fitting of optical depth data. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
84. Crystallization of calcium oxalate dihydrate in a buffered calcium-containing glucose solution by irradiation with non-equilibrium atmospheric pressure plasma.
- Author
-
Naoyuki Kurake, Hiromasa Tanaka, Kenji Ishikawa, Kae Nakamura, Hiroaki Kajiyama, Fumitaka Kikkawa, Masaaki Mizuno, Yuzuru Ikehara, and Masaru Hori
- Subjects
- *
CALCIUM oxalate , *CRYSTALLIZATION , *GLUCOSE , *IRRADIATION , *GLUCONIC acid , *CALCIUM ions , *PLASMA gases - Abstract
Oxalate was synthesized in the glucose solution by irradiation with non-equilibrium atmospheric pressure plasma (NEAPP), in which the NEAPP plume contacted the solution surface, via the generation of several intermediate organic products such as gluconic acid. A thermodynamically unstable phase of calcium oxalate dihydrate crystallized rapidly during incubation of a NEAPP-irradiated glucose solution that contained calcium ions and was buffered at neutral pH. Longer irradiation times increased the growth rate and the number of seed crystals. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
85. Synthesis and Reactivity of Cobalt-Dinitrogen Complexes Bearing Anionic PCP-Type Pincer Ligands toward Catalytic Silylamine Formation from Dinitrogen.
- Author
-
Kuriyama, Shogo, Shenglan Wei, Hiromasa Tanaka, Asuka Konomi, Kazunari Yoshizawa, and Yoshiaki Nishibayashi
- Published
- 2022
- Full Text
- View/download PDF
86. Preparation and reactivity of molybdenum complexes bearing pyrrole-based PNP-type pincer ligand
- Author
-
Kazunari Yoshizawa, Yoshiaki Tanabe, Yoshiaki Nishibayashi, Shogo Kuriyama, Hiromasa Tanaka, Yoshiya Sekiguchi, and Asuka Konomi
- Subjects
Bearing (mechanical) ,Metals and Alloys ,chemistry.chemical_element ,General Chemistry ,Catalysis ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,law.invention ,chemistry.chemical_compound ,chemistry ,law ,Molybdenum ,Polymer chemistry ,Materials Chemistry ,Ceramics and Composites ,Reactivity (chemistry) ,Pincer ligand ,Pyrrole - Abstract
Molybdenum complexes bearing an anionic pyrrole-based PNP-type pincer ligand have been prepared and have been found to work as catalysts for the conversion of N2 into NH3 under ambient conditions.
- Published
- 2020
87. Cycling between Molybdenum-Dinitrogen and -Nitride Complexes to Support the Reaction Pathway for Catalytic Formation of Ammonia from Dinitrogen
- Author
-
Yoshiaki Nishibayashi, Kazunari Yoshizawa, Hiromasa Tanaka, and Kazuya Arashiba
- Subjects
010405 organic chemistry ,Chemistry ,Organic Chemistry ,chemistry.chemical_element ,General Chemistry ,Nitride ,010402 general chemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Ammonia ,chemistry.chemical_compound ,Front cover ,Chemical engineering ,Molybdenum ,Roulette wheel ,Nitrogen fixation ,Cycling - Abstract
Cycling between molybdenum(I)-dinitrogen and molybdenum(IV)-nitride complexes was investigated under ambient reaction conditions. A kinetic study of the second-order reaction rate for the conversion of the molybdenum-dinitrogen complex into the molybdenum-nitride complex indicates that the formation of the dinitrogen-bridged dimolybdenum complex is involved in the rate-determining step. DFT calculations indicate that the molybdenum-dinitrogen complex transforms into the molybdenum-nitride complex via direct cleavage of the nitrogen-nitrogen triple bond of the bridging dinitrogen ligand of the dinitrogen-bridged dimolybdenum complex. The corresponding reaction of the molybdenum-nitride complex transforming into the molybdenum-dinitrogen complex proceeds via the ligand exchange of ammonia for dinitrogen at the dinitrogen-bridged dimolybdenum complexes. A new modified reaction pathway has been proposed based on the findings of our experimental and theoretical results.
- Published
- 2020
88. Ammonia Formation Catalyzed by Dinitrogen-Bridged Dirhenium Complex Bearing PNP-Pincer Ligands under Mild Reaction Conditions
- Author
-
Yoshiaki Nishibayashi, Kazunari Yoshizawa, Akihito Egi, Hiromasa Tanaka, Shogo Kuriyama, and Fanqiang Meng
- Abstract
A series of rhenium complexes bearing a pyridine-based PNP-type pincer ligand are synthesized from rhenium phosphine complexes as precursors. A dinitrogen-bridged dirhenium complex bearing the PNP-type pincer ligands catalytically converts dinitrogen into ammonia in the reaction with KC8 as a reductant and [HPCy3]BArF4 (Cy = cyclohexyl, ArF = 3,5-(CF3)2C6H3) as a proton source at –78 °C to afford 8.4 equiv of ammonia based on the rhenium atom of the catalyst. The rhenium-dinitrogen complex also catalyzes silylation of dinitrogen in the reaction with KC8 as a reductant and Me3SiCl as a silylating reagent under ambient reaction conditions to afford 11.3 equiv of tris(trimethylsilyl)amine based on the rhenium atom of the catalyst. These results demonstrate the first successful example of catalytic nitrogen fixation under mild reaction conditions by using rhenium-dinitrogen complexes as catalysts.
- Published
- 2020
89. Non-thermal plasma-activated lactate solution kills U251SP glioblastoma cells in an innate reductive manner with altered metabolism
- Author
-
Hiroaki Kajiyama, Yugo Hosoi, Shinya Toyokuni, Fumitaka Kikkawa, Kenji Ishikawa, Masaru Hori, Hiromasa Tanaka, Masaaki Mizuno, Li Jiang, and Kae Nakamura
- Subjects
0301 basic medicine ,Ringer's Lactate ,Plasma Gases ,Cell Survival ,Biophysics ,Antineoplastic Agents ,Apoptosis ,Oxidative phosphorylation ,medicine.disease_cause ,Biochemistry ,03 medical and health sciences ,chemistry.chemical_compound ,Cell Line, Tumor ,medicine ,Humans ,Metabolomics ,Asparagine ,Molecular Biology ,Alanine ,030102 biochemistry & molecular biology ,Chemistry ,Lipid metabolism ,Glutathione ,humanities ,030104 developmental biology ,Cell culture ,Metabolome ,Oxidation-Reduction ,Oxidative stress ,Intracellular - Abstract
Ringer's lactate solution irradiated by non-thermal plasma, comprised of radicals, electrons, and ions, is defined as plasma-activated lactate (PAL). PAL exhibited antitumor effects in glioblastoma U251SP cells, which we termed PAL-specific regulated cell death. In contrast to the oxidative stress condition typical of cells incubated in plasma-activated medium (PAM), U251SP cells treated with Ringer's lactate solution or PAL exhibited changes in intracellular metabolites that were reductive in the redox state, as measured by the ratio of oxidative/reductive glutathione concentrations. In the metabolomic profiles of PAL-treated cells, the generation of acetyl-CoA increased for lipid metabolism from alanine and asparagine. PAL thus induces regulated death of U251SP glioblastoma cells in more innate microenvironments than PAM.
- Published
- 2020
90. Plasma-Activated Solution in Cancer Treatment
- Author
-
Masaru Hori, Mounir Laroussi, Sander Bekeschus, Hiromasa Tanaka, Dayun Yan, and Michael Keidar
- Subjects
chemistry.chemical_classification ,Reactive oxygen species ,In vitro ,Cell biology ,chemistry.chemical_compound ,stomatognathic system ,chemistry ,In vivo ,parasitic diseases ,Cancer cell ,Signal transduction ,Reactive nitrogen species ,Function (biology) ,Intracellular - Abstract
Cold plasma-activated solution (PAS), particularly the cold plasma-activated medium (PAM), is a type of chemotherapy used in the cold plasma-based cancer treatment. Compared with the direct cold plasma treatment, PAM can be stored for a long time and can then be used without dependence on cold plasma sources or devices. Many in vitro and in vivo experiments have demonstrated anti-tumor effects of PAM against a variety of cancer cells. PAM contains a variety of reactive oxygen species (ROS), reactive nitrogen species (RNS), other cold plasma-activated species, and the generated compounds. These species either interact with the cellular membrane or the intracellular function to activate signal pathways and the expression of many genes. Several important signaling pathways are affected by PAM. The effectiveness of PAM has been demonstrated in animal studies using peritoneal metastasis model mice.
- Published
- 2020
91. Measurement of the charged-current electron (anti-)neutrino inclusive cross-sections at the T2K off-axis near detector ND280
- Author
-
M. Gonin, Lars Eklund, C. Bronner, T. Vladisavljevic, E. Rondio, N. McCauley, C. M. Nantais, Thorsten Lux, K. Porwit, A. Eguchi, C. Touramanis, M. Jiang, Antonio Ereditato, N. Yershov, M. McCarthy, T. Lindner, T. Kikawa, Kevin Scott McFarland, S. Suvorov, R. P. Litchfield, S. Ban, M. Barbi, P. Hamacher-Baumann, L. Molina Bueno, B. Radics, B. Bourguille, A. Mefodiev, Vladimir Volkov, S. R. Johnson, J. Morrison, J. McElwee, C. E. R. Naseby, Lester D.R. Thompson, M. Mezzetto, N. Dokania, S. M. Oser, G. Pintaudi, Y. Ashida, A. Gorin, M. Ikeda, K. Nakayoshi, Kimihiro Okumura, M. J. Wilking, C. Alt, N. Teshima, A. T. Suzuki, Y. Nagai, Y. Fukuda, G. Christodoulou, P. B. Jurj, G. Zarnecki, M. Buizza Avanzini, F. Iacob, L. Berns, T. Towstego, S. Murphy, S. Bolognesi, C. K. Jung, B. Quilain, J. Kameda, T. Okusawa, Alexander N. Smirnov, K. Nakamura, K. Sakashita, M. Kuze, G.D. Barr, K. Niewczas, M. M. Khabibullin, R. Wendell, Y. Tanihara, Th. A. Mueller, N. Kukita, M. Licciardi, T. Feusels, T. Hayashino, R. Fukuda, C. Wilkinson, C. Giganti, S. Kuribayashi, R. Akutsu, M. Vagins, M. Yu, T. Kobata, S. Mine, D. Brailsford, T. Radermacher, A. Bubak, K. Iwamoto, A. Knox, T. Arihara, Y. Hayato, L. Ludovici, S. Parsa, J. Steinmann, T. Honjo, Y. Nakajima, G. Fiorillo, Hiroyuki Sekiya, F. Nova, Y. Oyama, Hyun-Chul Kim, V. Paolone, P. Novella, Jaroslaw Pasternak, K. Mavrokoridis, Y. Fujii, A. Konaka, J. L. Palomino, R. Fujita, D. Karlen, L. Pickering, C. Ruggles, G. Santucci, S. L. Liu, Z. Vallari, K. Wood, Masayuki Nakahata, C. Pidcott, Y. Uchida, E. D. Zimmerman, E. Mazzucato, A. Takeda, J. C. Nugent, Keigo Nakamura, C. Vilela, Kendall Mahn, A. Rychter, C. Checchia, A. Longhin, M. Friend, A. Shaykina, J. Lagoda, S. R. Dennis, Yoshihiro Suzuki, K. M. Tsui, C. M. Schloesser, Robert Wilson, C. Barry, A. Hiramoto, R.P. Kurjata, Marco Laveder, S. King, A. Izmaylov, A. C. Kaboth, S. P. Kasetti, J. Zalipska, R. Shah, T. Kobayashi, M. G. Catanesi, T. Hasegawa, A. Blondel, D. Sgalaberna, C. Jesús-Valls, Alexander Finch, L. N. Machado, J. Holeczek, Michelangelo Pari, Shuji Tanaka, G. De Rosa, J. G. Walsh, Y. Takeuchi, R. A. Owen, X. Junjie, H. Kikutani, A. Cervera, K. Yamamoto, D. R. Hadley, L. Marti-Magro, F. Bench, K. Zaremba, J. T. Haigh, O. Drapier, S. Yen, D. Cherdack, Y. Kato, S. Valder, A. Pritchard, T. Campbell, Y. Kataoka, M. Batkiewicz-Kwasniak, E. T. Atkin, K. Yasutome, V. A. Matveev, C. Metelko, C. Wret, T. Nakadaira, N. Akhlaq, T. Kajita, M. Lawe, T. Wachala, L. Maret, M. Tani, T. Sekiguchi, Stephanie Bron, C. Riccio, T. Dealtry, K. Abe, C. McGrew, M. Pavin, S. J. Jenkins, L. Koch, M. Guigue, T. Tsukamoto, Akitaka Ariga, D. Coplowe, A. Beloshapkin, M. Miura, F. Di Lodovico, A. A. Sztuc, Federico Sanchez, E. S. Pinzon Guerra, M. Tada, Vincenzo Berardi, G. A. Fiorentini, P. Paudyal, A. Bravar, M. Kabirnezhad, C. Andreopoulos, A. Zykova, W. Toki, Y. Awataguchi, D. Barrow, T. Ishii, P. N. Ratoff, Yu. G. Kudenko, Etam Noah, F. J. P. Soler, T. Kutter, S. L. Cartwright, T. Bonus, N. C. Hastings, D. G. Payne, H. Kubo, A. Nakamura, S. Nakayama, J. Calcutt, Y. Asada, Hiromasa Tanaka, P. Jonsson, Ahmed Ali, M. Hogan, Shigeki Aoki, G. C. Penn, L. Labarga, Alan Cosimo Ruggeri, Y. Nishimura, Gareth J. Barker, M. B. Smy, A. Knight, Y. Seiya, L. Munteanu, H. Sobel, T. Ishida, T. Odagawa, Xiao-yan Li, T. S. Nonnenmacher, S. Bienstock, M. Tajima, Yusuke Koshio, Teppei Katori, L. L. Kormos, H. M. O'Keeffe, E. Radicioni, M. Lamoureux, Y. Sonoda, J. P. Coleman, Laura Gutermuth Anthony, K. Kowalik, S. Zsoldos, S. Roth, C. Pistillo, A. Dabrowska, F. Shaker, T. Matsubara, D. L. Wark, G. Vasseur, V. Palladino, Patrick Dunne, N. Chikuma, J. A. Nowak, W. C. Parker, M. O. Wascko, A. Chappell, E. Kearns, Sy Suzuki, A. N. Khotjantsev, A. K. Ichikawa, J. F. Martin, M. Tzanov, M. Jakkapu, J. R. Wilson, M. Ishitsuka, W. Shorrock, J. Kisiel, Yuuki Nakano, S. Manly, P. F. Denner, A. Minamino, T. Yano, M. Antonova, K. Matsushita, A. D. Marino, R. Okada, T. Ogawa, Y. Katayama, S. Emery-Schrenk, M. Malek, S. Moriyama, Samira Hassani, T. A. Doyle, Jan T. Sobczyk, S. Dolan, C. Densham, A. Cudd, T. Koga, Oleg Mineev, C. Francois, M. Ziembicki, Yufeng Wang, M. Zito, Hidekazu Kakuno, Y. Yamada, G. Yang, S. B. Boyd, N. Izumi, B. A. Popov, B. Jamieson, A. Zalewska, T. Golan, A. Shvartsman, K. Fusshoeller, D. Bravo Berguño, Pablo Fernandez, Kate Scholberg, H. K. Tanaka, D. Vargas, A. C. Weber, J. Dumarchez, J. Schwehr, M. Posiadala-Zezula, G. Collazuol, Mark Scott, T. Yoshida, M. Cicerchia, W. G. S. Vinning, T. Maruyama, T. V. Ngoc, A. Shaikhiev, E. Reinherz-Aronis, K. Nishikawa, Masashi Yokoyama, N. T. Hong Van, J. Walker, Tsuyoshi Nakaya, C. Mauger, Masato Shiozawa, A. Kostin, D. Fukuda, S. Bhadra, L. Cook, L. O'Sullivan, Xianguo Lu, M. Hartz, André Rubbia, L. Magaletti, C. Yanagisawa, S. V. Cao, Ministerio de Economía y Competitividad (España), Abe, K., Akutsu, R., Ali, A., Alt, C., Andreopoulos, C., Anthony, L., Antonova, M., Aoki, S., Ariga, A., Ashida, Y., Atkin, E. T., Awataguchi, Y., Ban, S., Barbi, M., Barker, G. J., Barr, G., Barry, C., Batkiewicz-Kwasniak, M., Beloshapkin, A., Bench, F., Berardi, V., Berkman, S., Berns, L., Bhadra, S., Bienstock, S., Blondel, A., Bolognesi, S., Bourguille, B., Boyd, S. B., Brailsford, D., Bravar, A., Berguno, D. Bravo, Bronner, C., Bubak, A., Avanzini, M. Buizza, Calcutt, J., Campbell, T., Cao, S., Cartwright, S. L., Catanesi, M. G., Cervera, A., Chappell, A., Checchia, C., Cherdack, D., Chikuma, N., Christodoulou, G., Coleman, J., Collazuol, G., Cook, L., Coplowe, D., Cudd, A., Dabrowska, A., De Rosa, G., Dealtry, T., Denner, P. F., Dennis, S. R., Densham, C., Di Lodovico, F., Dokania, N., Dolan, S., Drapier, O., Dumarchez, J., Dunne, P., Eklund, L., Emery-Schrenk, S., Ereditato, A., Fernandez, P., Feusels, T., Finch, A. J., Fiorentini, G. A., Fiorillo, G., Francois, C., Friend, M., Fujii, Y., Fujita, R., Fukuda, D., Fukuda, R., Fukuda, Y., Gameil, K., Giganti, C., Golan, T., Gonin, M., Gorin, A., Guigue, M., Hadley, D. R., Haigh, J. T., Hamacher-Baumann, P., Hartz, M., Hasegawa, T., Hastings, N. C., Hayashino, T., Hayato, Y., Hiramoto, A., Hogan, M., Holeczek, J., Hong Van, N. T., Iacob, F., Ichikawa, A. K., Ikeda, M., Ishida, T., Ishii, T., Ishitsuka, M., Iwamoto, K., Izmaylov, A., Jamieson, B., Jenkins, S. J., Jesus-Valls, C., Jiang, M., Johnson, S., Jonsson, P., Jung, C. K., Kabirnezhad, M., Kaboth, A. C., Kajita, T., Kakuno, H., Kameda, J., Karlen, D., Kasetti, S. P., Kataoka, Y., Katori, T., Kato, Y., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kim, H., Kim, J., King, S., Kisiel, J., Knight, A., Knox, A., Kobayashi, T., Koch, L., Koga, T., Konaka, A., Kormos, L. L., Koshio, Y., Kowalik, K., Kubo, H., Kudenko, Y., Kukita, N., Kuribayashi, S., Kurjata, R., Kutter, T., Kuze, M., Labarga, L., Lagoda, J., Lamoureux, M., Laveder, M., Lawe, M., Licciardi, M., Lindner, T., Litchfield, R. P., Liu, S. L., Li, X., Longhin, A., Ludovici, L., Lu, X., Lux, T., Nascimento Machado, L., Magaletti, L., Mahn, K., Malek, M., Manly, S., Maret, L., Marino, A. D., Martin, J. F., Maruyama, T., Matsubara, T., Matsushita, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., Mccarthy, M., Mccauley, N., Mcfarland, K. S., Mcgrew, C., Mefodiev, A., Metelko, C., Mezzetto, M., Minamino, A., Mineev, O., Mine, S., Miura, M., Bueno, L. Molina, Moriyama, S., Morrison, J., Mueller, Th. A., Munteanu, L., Murphy, S., Nagai, Y., Nakadaira, T., Nakahata, M., Nakajima, Y., Nakamura, A., Nakamura, K. G., Nakamura, K., Nakayama, S., Nakaya, T., Nakayoshi, K., Nantais, C., Ngoc, T. V., Niewczas, K., Nishikawa, K., Nishimura, Y., Nonnenmacher, T. S., Nova, F., Novella, P., Nowak, J., Nugent, J. C., O'Keeffe, H. M., O'Sullivan, L., Odagawa, T., Okumura, K., Okusawa, T., Oser, S. M., Owen, R. A., Oyama, Y., Palladino, V., Palomino, J. L., Paolone, V., Parker, W. C., Paudyal, P., Pavin, M., Payne, D., Penn, G. C., Pickering, L., Pidcott, C., Guerra, E. S. Pinzon, Pistillo, C., Popov, B., Porwit, K., Posiadala-Zezula, M., Pritchard, A., Quilain, B., Radermacher, T., Radicioni, E., Radics, B., Ratoff, P. N., Reinherz-Aronis, E., Riccio, C., Rondio, E., Roth, S., Rubbia, A., Ruggeri, A. C., Rychter, A., Sakashita, K., Sanchez, F., Schloesser, C. M., Scholberg, K., Schwehr, J., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Sgalaberna, D., Shah, R., Shaikhiev, A., Shaker, F., Shaykina, A., Shiozawa, M., Shorrock, W., Shvartsman, A., Smirnov, A., Smy, M., Sobczyk, J. T., Sobel, H., Soler, F. J. P., Sonoda, Y., Steinmann, J., Suvorov, S., Suzuki, A., Suzuki, S. Y., Suzuki, Y., Sztuc, A. A., Tada, M., Tajima, M., Takeda, A., Takeuchi, Y., Tanaka, H. K., Tanaka, H. A., Tanaka, S., Thompson, L. F., Toki, W., Touramanis, C., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Uno, W., Vagins, M., Valder, S., Vallari, Z., Vargas, D., Vasseur, G., Vilela, C., Vinning, W. G. S., Vladisavljevic, T., Volkov, V. V., Wachala, T., Walker, J., Walsh, J. G., Wang, Y., Wark, D., Wascko, M. O., Weber, A., Wendell, R., Wilking, M. J., Wilkinson, C., Wilson, J. R., Wilson, R. J., Wood, K., Wret, C., Yamada, Y., Yamamoto, K., Yanagisawa, C., Yang, G., Yano, T., Yasutome, K., Yen, S., Yershov, N., Yokoyama, M., Yoshida, T., Yu, M., Zalewska, A., Zalipska, J., Zaremba, K., Zarnecki, G., Ziembicki, M., Zimmerman, E. D., Zito, M., Zsoldos, S., Zykova, A., Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), T2K, Science and Technology Facilities Council (STFC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), and ANR-19-CE31-0001,SUNCORE,Incertitudes systématiques dans les combinaisons de résultats d'oscillations de neutrinos(2019)
- Subjects
electron ,Physics::Instrumentation and Detectors ,Monte Carlo method ,far detector ,Electron ,KAMIOKANDE ,antineutrino/mu: secondary beam ,Other experiments ,antineutrino/e: particle identification ,01 natural sciences ,neutrino: flux ,High Energy Physics - Experiment ,charged current ,High Energy Physics - Experiment (hep-ex) ,secondary beam [neutrino/mu] ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,neutrino/e: particle identification ,measured [total cross section] ,detector [neutrino] ,Charged current ,Physics ,0105 Mathematical Physics ,J-PARC Lab ,Detector ,Monte Carlo [numerical calculations] ,Nuclear & Particles Physics ,angular dependence ,neutrino: detector ,0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics ,Neutrino ,numerical calculations: Monte Carlo ,Particle Physics - Experiment ,scattering [neutrino] ,Nuclear and High Energy Physics ,530 Physics ,Astrophysics::High Energy Astrophysical Phenomena ,particle identification [antineutrino/e] ,FOS: Physical sciences ,momentum dependence ,secondary beam [antineutrino/mu] ,Nuclear physics ,Momentum ,differential cross section: measured ,phase space ,near detector ,measured [differential cross section] ,0103 physical sciences ,neutrino: scattering ,ddc:530 ,lcsh:Nuclear and particle physics. Atomic energy. Radioactivity ,010306 general physics ,0206 Quantum Physics ,hep-ex ,010308 nuclear & particles physics ,Scattering ,particle identification [neutrino/e] ,background ,Computer Science::Information Retrieval ,High Energy Physics::Phenomenology ,scintillation counter: target ,flux [neutrino] ,neutrino/mu: secondary beam ,total cross section: measured ,target [scintillation counter] ,lcsh:QC770-798 ,High Energy Physics::Experiment ,Electron neutrino ,experimental results - Abstract
The electron (anti-)neutrino component of the T2K neutrino beam constitutes the largest background in the measurement of electron (anti-)neutrino appearance at the far detector. The electron neutrino scattering is measured directly with the T2K off-axis near detector, ND280. The selection of the electron (anti-)neutrino events in the plastic scintillator target from both neutrino and anti-neutrino mode beams is discussed in this paper. The flux integrated single differential charged-current inclusive electron (anti-)neutrino cross-sections, dσ/dp and dσ/d cos(θ), and the total cross-sections in a limited phase-space in momentum and scattering angle (p > 300 MeV/c and θ ≤ 45°) are measured using a binned maximum likelihood fit and compared to the neutrino Monte Carlo generator predictions, resulting in good agreement., Journal of High Energy Physics, 2020 (10), ISSN:1126-6708, ISSN:1029-8479
- Published
- 2020
- Full Text
- View/download PDF
92. New Hopes for Plasma-Based Cancer Treatment
- Author
-
Kenji Ishikawa, Masaru Hori, Fumitaka Kikkawa, Shinya Toyokuni, Hiroaki Kajiyama, Hiromasa Tanaka, and Masaaki Mizuno
- Subjects
010302 applied physics ,Oncology ,medicine.medical_specialty ,Chemotherapy ,business.industry ,medicine.medical_treatment ,Cancer therapy ,Plasma treatment ,Immunotherapy ,01 natural sciences ,Cancer treatment ,Clinical trial ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,0103 physical sciences ,medicine ,business - Abstract
Non-thermal plasma represents a novel approach in cancer treatment. Both direct and indirect plasma treatments are available, with clinical trials of direct plasma treatment in progress. Indirect treatments involve chemotherapy (i.e., plasma-activated medium) and immunotherapy. Recent studies suggest that integrated plasma treatments could be an extremely effective approach to cancer therapy.
- Published
- 2018
93. Catalytic reduction of dinitrogen to tris(trimethylsilyl)amine using rhodium complexes with a pyrrole-based PNP-type pincer ligand
- Author
-
Kazunari Nakajima, Kazunari Yoshizawa, Hiromasa Tanaka, Asuka Konomi, Shogo Kuriyama, Kazuya Arashiba, Ryosuke Kawakami, and Yoshiaki Nishibayashi
- Subjects
Tris ,Trimethylsilyl ,010405 organic chemistry ,Metals and Alloys ,chemistry.chemical_element ,Selective catalytic reduction ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Medicinal chemistry ,Catalysis ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Rhodium ,chemistry.chemical_compound ,chemistry ,Materials Chemistry ,Ceramics and Composites ,Amine gas treating ,Pincer ligand ,Pyrrole - Abstract
Rhodium complexes bearing an anionic pyrrole-based PNP-type pincer ligand are synthesised and found to work as effective catalysts for the transformation of molecular dinitrogen into tris(trimethylsilyl)amine under mild reaction conditions. This is the first successful example of rhodium-catalysed dinitrogen reduction under mild reaction conditions.
- Published
- 2019
94. Suppression of mitochondrial oxygen metabolism mediated by the transcription factor HIF-1 alleviates propofol-induced cell toxicity
- Author
-
Akihisa Okamoto, Teppei Iwai, Chisato Sumi, Hiroshi Harada, Munenori Kusunoki, Hidemasa Bono, Yoshiyuki Matsuo, Hiromasa Tanaka, Kenichiro Nishi, Kiichi Hirota, Takeo Uba, Takehiko Adachi, and Tomohiro Shoji
- Subjects
0301 basic medicine ,Programmed cell death ,Apparent oxygen utilisation ,lcsh:Medicine ,Mitochondrion ,03 medical and health sciences ,Cell Line, Tumor ,Humans ,Glycolysis ,lcsh:Science ,Transcription factor ,Propofol ,chemistry.chemical_classification ,Reactive oxygen species ,Multidisciplinary ,Cytotoxins ,lcsh:R ,Cell biology ,Mitochondria ,Oxygen ,030104 developmental biology ,chemistry ,Cell culture ,Toxicity ,lcsh:Q ,Hypoxia-Inducible Factor 1 ,Reactive Oxygen Species - Abstract
A line of studies strongly suggest that the intravenous anesthetic, propofol, suppresses mitochondrial oxygen metabolism. It is also indicated that propofol induces the cell death in a reactive oxygen species (ROS)-dependent manner. Because hypoxia-inducible factor 1 (HIF-1) is a transcription factor which is involved in cellular metabolic reprogramming by modulating gene expressions of enzymes including glycolysis pathway and oxygen utilization of mitochondria, we examined the functional role of HIF-1 activity in propofol-induced cell death. The role of HIF-1 activity on oxygen and energy metabolisms and propofol-induced cell death and caspase activity was examined in renal cell-derived RCC4 cells: RCC4-EV cells which lack von Hippel-Lindau protein (VHL) protein expression and RCC4-VHL cells, which express exogenous VHL, and in neuronal SH-SY5Y cells. It was demonstrated that HIF-1 is involved in suppressing oxygen consumption and facilitating glycolysis in cells and that the resistance to propofol-induced cell death was established in a HIF-1 activation-dependent manner. It was also demonstrated that HIF-1 activation by treatment with HIFα-hydroxylase inhibitors such as n-propyl gallate and dimethyloxaloylglycine, alleviated the toxic effects of propofol. Thus, the resistance to propofol toxicity was conferred by HIF-1 activation by not only genetic deletion of VHL but also exposure to HIFα-hydroxylase inhibitors.
- Published
- 2018
95. Synaptotagmin XIII expression and peritoneal metastasis in gastric cancer
- Author
-
Daisuke Kobayashi, Hiroyuki Sugimoto, Yasuhiro Kodera, Yukiko Niwa, Hiromasa Tanaka, Tsutomu Fujii, Mitsuro Kanda, Suguru Yamada, Chie Tanaka, Hideki Takami, Masamichi Hayashi, and Dai Shimizu
- Subjects
Male ,0301 basic medicine ,Metastasis ,Transcriptome ,Mice ,Synaptotagmins ,03 medical and health sciences ,0302 clinical medicine ,Peritoneum ,Stomach Neoplasms ,Cell Line, Tumor ,Biomarkers, Tumor ,medicine ,Animals ,Humans ,RNA, Small Interfering ,Peritoneal Neoplasms ,Aged ,Mice, Inbred BALB C ,Messenger RNA ,business.industry ,Computational Biology ,Cancer ,Transfection ,Middle Aged ,medicine.disease ,RNAi Therapeutics ,030104 developmental biology ,medicine.anatomical_structure ,Apoptosis ,Cell culture ,030220 oncology & carcinogenesis ,Cancer research ,Female ,RNA Interference ,Surgery ,business ,Neoplasm Transplantation ,Follow-Up Studies - Abstract
Background Peritoneal metastasis is a frequent cause of death in patients with gastric cancer. The aim of this study was to identify molecules responsible for mediating peritoneal metastasis of gastric cancer. Methods Transcriptome and bioinformatics analyses were conducted to identify molecules associated with peritoneal metastasis. The therapeutic effects of intraperitoneally administered small interfering (si) RNA were evaluated using mouse xenograft models. Expression of mRNA and protein was determined in gastric tissues from patients with gastric cancer. Results Synaptotagmin XIII (SYT13) was expressed at significantly higher levels in patients with peritoneal recurrence, but not in those with hepatic or distant lymph node recurrence. Inhibition of SYT13 expression in a gastric cancer cell line transfected with SYT13-specific siRNA (siSYT13) was associated with decreased invasion and migration ability of the cells, but not with proliferation and apoptosis. Intraperitoneal administration of siSYT13 significantly inhibited the growth of peritoneal nodules and prolonged survival in mice. In an analysis of 200 patients with gastric cancer, SYT13 expression in primary gastric cancer tissues was significantly greater in patients with peritoneal recurrence or metastasis. A high level of SYT13 expression in primary gastric cancer tissues was an independent risk factor for peritoneal recurrence. Conclusion SYT13 expression in gastric cancer is associated with perioneal metatases and is a potential target for treatment.
- Published
- 2018
96. Catalytic Reduction of Molecular Dinitrogen to Ammonia and Hydrazine Using Vanadium Complexes
- Author
-
Aya Eizawa, Yoshiya Sekiguchi, Kazunari Nakajima, Kazunari Yoshizawa, Kazuya Arashiba, Hiromasa Tanaka, and Yoshiaki Nishibayashi
- Subjects
010405 organic chemistry ,Hydrazine ,Vanadium ,chemistry.chemical_element ,Selective catalytic reduction ,General Medicine ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Pincer movement ,chemistry.chemical_compound ,Ammonia ,chemistry ,Polymer chemistry ,Pincer ligand ,Pyrrole - Abstract
Newly designed and prepared vanadium complexes bearing anionic pyrrole-based PNP-type pincer and aryloxy ligands were found to work as effective catalysts for the direct conversion of molecular dinitrogen into ammonia and hydrazine under mild reaction conditions. This is the first successful example of vanadium-catalyzed dinitrogen reduction under mild reaction conditions.
- Published
- 2018
97. Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Medium
- Author
-
Fumi Utsumi, Yasumasa Okazaki, Masaru Hori, Fumitaka Kikkawa, Hiroshi Hashizume, Hiroaki Kajiyama, Keigo Takeda, Kae Nakamura, Masaaki Mizuno, Shinichi Akiyama, Shinya Toyokuni, Shoichi Maruyama, Hiromasa Tanaka, and Kenji Ishikawa
- Subjects
chemistry.chemical_classification ,Programmed cell death ,Chemotherapy ,Reactive oxygen species ,Antioxidant ,medicine.medical_treatment ,Cancer ,Biology ,medicine.disease ,Atomic and Molecular Physics, and Optics ,stomatognathic system ,chemistry ,Cell culture ,Apoptosis ,embryonic structures ,parasitic diseases ,Cancer cell ,Immunology ,medicine ,Cancer research ,Radiology, Nuclear Medicine and imaging ,Instrumentation ,reproductive and urinary physiology - Abstract
Plasma-activated medium (PAM) is a novel chemotherapy that induces reactive oxygen species (ROS) and cell death in a wide range of cancer cell types, suggesting that PAM may be a promising therapeutic option for cancer treatment. However, dose response experiments suggest that PAM sensitivity is cell line specific. We examined the sensitivities of three glioblastoma cell lines to PAM, and found a wide variation in cell killing that was linked to differences in PAM induced ROS and apoptosis. These results indicate that the PAM sensitivity of glioblastoma cells, and potentially cancer cells more generally, is heterogeneous and likely to be dependent on the regulation of apoptosis and antioxidant pathways in target cells.
- Published
- 2018
98. Clinical experience with cold plasma in the treatment of locally advanced head and neck cancer
- Author
-
Kristian Wende, Eun Ha Choi, Alexander Fridman, Kai Masur, Klaus-Dieter Weltmann, Christian Seebauer, Torsten Gerling, Jean-Michel Pouvesle, Hans-Robert Metelmann, Vandana Miller, David B. Graves, Hiromasa Tanaka, Sander Bekeschus, Daniel D. Von Hoff, Masaru Hori, Sybille Hasse, Georg Bauer, Thomas von Woedtke, Philine Metelmann, Matthias Schuster, Rico Rutkowski, Cranio-Maxillo-Facial Surgery, Universität Greifswald - University of Greifswald, Groupe de recherches sur l'énergétique des milieux ionisés (GREMI), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Leibniz Institute for Plasma Science and Technology (INP), Leibniz Association, and INP Greifswald
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,Locally advanced ,Connective tissue ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Dermatology ,01 natural sciences ,03 medical and health sciences ,[PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph] ,Internal medicine ,0103 physical sciences ,medicine ,Clinical significance ,010302 applied physics ,Tumor microenvironment ,business.industry ,Head and neck cancer ,Cancer ,medicine.disease ,3. Good health ,Surgery ,030104 developmental biology ,medicine.anatomical_structure ,Apoptosis ,Immunogenic cell death ,business - Abstract
Purpose Cold atmospheric pressure plasma (CAP) is well known for inactivating microbial pathogens and stimulation of tissue regeneration in chronic wounds. Several authors have reported the effectiveness against cancer in different cell lines and animal models. This is the first report of patients with real clinical benefit following application of CAP, not just visible change of the tumor surface but lasting partial remission. The authors discuss the CAP treatment approach and the efficacy for inoperable head and neck cancer patients. Methods The trial enrolled six patients with locally advanced (pT4) squamous cell carcinoma of the oropharynx suffering from open infected ulcerations. Patients were treated with a jet plasma source (kINPen MED, neoplas tools GmbH, Greifswald, Germany) in cycles of 3 single applications (1 min/cm2 from a distance of 8 mm) within 1 week, each followed by an intermittence of 1 week. Results CAP treatment resulted in a reduction in odor and pain medication requirements, in improvement in social function and a positive emotional affect. Further observance revealed partial remission in two patients for at least nine month. Incisional biopsies at remission demonstrate a moderate amount of apoptotic tumor cells and a desmoplastic reaction of the connective tissue. Conclusion The trial demonstrates the clinical relevance of CAP in cancer treatment. There are three approaches for discussion of tumor remission: (i) the role of myeloid cells, (ii) the ROS/RNS model of cellular impact and (iii) the immunogenic cell death model of cancer treatment, and there is a reflection on non-sustainable tumor response due to adapted tumor microenvironment.
- Published
- 2018
99. Enhancement of ethanol production and cell growth in budding yeast by direct irradiation of low-temperature plasma
- Author
-
Kae Nakamura, Masafumi Ito, Hiromasa Tanaka, Kenji Ishikawa, Kinji Ohno, Mikako Ito, Masaaki Mizuno, Fumitaka Kikkawa, Hiroaki Kajiyama, Yasumasa Okazaki, Hiroshi Hashizume, Shogo Matsumura, Masaru Hori, and Shinya Toyokuni
- Subjects
Physics and Astronomy (miscellaneous) ,Cell growth ,Chemistry ,General Engineering ,Extracellular ,Biophysics ,General Physics and Astronomy ,Ethanol fuel ,Low temperature plasma ,Glycolysis ,Irradiation ,Budding yeast ,Flux (metabolism) - Abstract
Ethanol production by budding yeast was compared between direct and indirect plasma irradiation. We observed enhancement of ethanol production and cell growth not by indirect plasma irradiation but by direct plasma irradiation. Glucose consumption was increased in budding yeast by direct plasma irradiation. Extracellular flux analysis revealed that glycolytic activity in the budding yeast was elevated by direct plasma irradiation. These results suggest that direct plasma irradiation enhances ethanol production in budding yeast by elevating the glycolytic activity.
- Published
- 2021
100. Plasma-activated medium (PAM) kills human cancer-initiating cells
- Author
-
Yuzuru Ikehara, Jun-ichiro Ikeda, Kenji Ishikawa, Hiromasa Tanaka, Hajime Sakakita, and Masaru Hori
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,Aldehyde dehydrogenase ,01 natural sciences ,Pathology and Forensic Medicine ,03 medical and health sciences ,parasitic diseases ,0103 physical sciences ,Carcinoma ,medicine ,Mouse tumor ,010302 applied physics ,Cisplatin ,biology ,Chemistry ,Cancer ,General Medicine ,medicine.disease ,Apoptotic death ,030104 developmental biology ,Cancer cell ,biology.protein ,Cancer research ,Human cancer ,medicine.drug - Abstract
Medical non-thermal plasma (NTP) treatments for various types of cancers have been reported. Cells with tumorigenic potential (cancer-initiating cells; CICs) are few in number in many types of tumors. CICs efficiently eliminate anti-cancer chemicals and exhibit high-level aldehyde dehydrogenase (ALDH) activity. We previously examined the effects of direct irradiation via NTP on cancer cells; even though we targeted CICs expressing high levels of ALDH, such treatment affected both non-CICs and CICs. Recent studies have shown that plasma-activated medium (PAM) (culture medium irradiated by NTP) selectively induces apoptotic death of cancer but not normal cells. Therefore, we explored the anti-cancer effects of PAM on CICs among endometrioid carcinoma and gastric cancer cells. PAM reduced the viability of cells expressing both low and high levels of ALDH. Combined PAM/cisplatin appeared to kill cancer cells more efficiently than did PAM or cisplatin alone. In a mouse tumor xenograft model, PAM exerted an anti-cancer effect on CICs. Thus, our results suggest that PAM effectively kills both non-CICs and CICs, as does NTP. Therefore, PAM may be a useful new anti-cancer therapy, targeting various cancer cells including CICs.
- Published
- 2017
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.