Search

Your search keyword '"FUkumoto, H."' showing total 531 results
Start Over Author "FUkumoto, H."
531 results on '"FUkumoto, H."'

72. Anti-tumour activities of a new benzo[c]phenanthridine agent, 2,3-(methylenedioxy)-5-methyl-7-hydroxy-8-methoxybenzo[c]phenanthridinium hydrogensulphate dihydrate (NK109), against several drug-resistant human tumour cell lines

Author

Kanzawa, F, primary, Nishio, K, additional, Ishida, T, additional, Fukuda, M, additional, Kurokawa, H, additional, Fukumoto, H, additional, Nomoto, Y, additional, Fukuoka, K, additional, Bojanowski, K, additional, and Saijo, N, additional

Published
1997
Full Text
View/download PDF

73. 556 Ectopic p16INK4 expression enhances the susceptibility of human non-small cell lung cancer (NSCLC) cells to CPT-11-induced apoptosis

Author

Fukuoka, K., primary, Nishio, K., additional, Adachi, J., additional, Arioka, H., additional, Kurokawa, H., additional, Fukumoto, H., additional, Ishida, T., additional, Nomoto, T., additional, Yokote, H., additional, Tomonari, A., additional, Iwamoto, Y., additional, Suzuki, T., additional, Usuda, J., additional, Yokota, J., additional, and Saijo, N., additional

Published
1997
Full Text
View/download PDF

87. Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype.

Author

Blom ES, Giedraitis V, Zetterberg H, Fukumoto H, Blennow K, Hyman BT, Irizarry MC, Wahlund LO, Lannfelt L, and Ingelsson M

Abstract

BACKGROUND/AIMS: Increased cerebrospinal fluid (CSF) tau, decreased CSF amyloid-beta42 (Abeta42) and the apolipoprotein E gene (APOE) epsilon4 allele predict progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Here, we investigated these markers to assess their predictive value and influence on the rate of disease progression. METHODS: Using ELISA, we measured the CSF biomarkers in 47 AD patients, 58 patients with MCI and 35 healthy control subjects. Twenty-eight MCI patients revisited the clinic and half of them progressed to AD during a period of 3-12 years. RESULTS: The expected changes in CSF total (T)-tau, phosphorylated (P)-tau and Abeta42 levels were found in AD, confirming the diagnostic value of these biomarkers. We were also able to corroborate an increased risk for progression from MCI to AD with elevated CSF T-tau and P-tau and with the presence of the APOE epsilon4/epsilon4 genotype, but not with decreased Abeta42. Finally, for the first time we demonstrated that MCI subjects with high CSF T-tau or P-tau and APOE epsilon4 homozygosity progressed faster from MCI to AD. CONCLUSIONS: CSF T-tau and P-tau as well as the APOE epsilon4/epsilon4 genotype are robust predictors of AD and are also associated with a more rapid progression from MCI to AD. [ABSTRACT FROM AUTHOR]

Published
2009
Full Text
View/download PDF

94. Al-impurity-doped transparent conductive oxide films of In2O3-ZnO system

Author

Tominaga, K., Fukumoto, H., Kondou, K., Hayashi, Y., Murai, K., Moriga, T., and Nakabayashi, I.

Subjects
*FILMSTRIPS, *ELECTRONS, *ATOMS, *CHEMICAL processes
Abstract

The effects of Al2O3 dopings in pseudobinary (In2O3)1-δ(2ZnO)δ films were investigated, and carrier generation mechanism was discussed. Here the δ value is the ratio of Zn/(Zn+In). For Al2O3 doping below 2 wt%, low-resitivity amorphous films in 2–4×10-4 Ω cm were deposited over a narrow range of δ=Zn/(Zn+In) (0.2⩽δ⩽0.4). At Al2O3=2 wt% doping, the resistivity was improved in the same narrow range of δ. Using a ZnO:Al target with 3 wt% Al2O3, film resistivities of 2–4×10-4 Ω cm were attained over a relatively wide range of δ in the amorphous phase (0.2⩽δ⩽0.6). This result was due to the increase in carrier concentration at δ=0.3–0.6. The Al2O3 doping also influenced on optical band gap: band gap shrinkage for Al2O3=2 wt% and band gap widening for Al2O3=3 wt%. For homologous crystalline films, Al2O3 doping decreased carrier concentration, independent of the level of Al2O3 doping. The Al2O3 doping increased linearly optical band gap energy. These results indicate that the Al atoms are impurities that distort the lattice in homologous film. [Copyright &y& Elsevier]

Published
2004
Full Text
View/download PDF

99. Chain Distortion of m-Linked Aromatic Polymers:  Poly(m-phenylene) and Poly(m-pyridine)

Author

Kobayashi, N., Sasaki, S., Abe, M., Watanabe, S., Fukumoto, H., and Yamamoto, T.

Abstract

The crystal structures of poly(m-phenylene) (PMP) and poly(m-pyridine) [poly(pyridine-2,6-diyl)] (PMPy) have been analyzed by the linked-atom Rietveld method for X-ray powder diffraction profiles in order to demonstrate the effect of hydrogen repulsion on the planarity of aromatic polymer chains. Chain conformation of PMP is a slowly winding helix with a five-ring structural repeat, in which the neighboring aromatic rings are rotated owing to the hydrogen repulsion by torsion angles of average value 42°, in contrast to the alternately twisted conformation of poly(p-phenylene). The four helices are packed in a tetragonal unit cell with dimensions a = b = 13.45 Å and c = 11.30 Å (space group:  P41212 or P43212), and they engage with one another. The helical structure, isomorphous to that of m-deciphenyl determined by single-crystal X-ray analysis, is stabilized by the interchain interactions. The PMPy chain assumes the anticoplanar conformation relieved from hydrogen repulsion. The two chains are contained in an orthorhombic unit cell with dimensions a = 12.23 Å, b = 3.92 Å, and c = 7.06 Å (space group:  Pnam) in a manner similar to orthorhombic polyethylene.

Published
2004

Catalog

Books, media, physical & digital resources
See catalog results