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Stimulation through the interleukin-1 receptor (IL-1R) and some Toll-like receptors (TLRs) induces ubiquitination of TRAF6 and IRAK-1, signaling components required for NF-κB and mitogen-activated protein kinase activation. Here we show that although TRAF6 and IRAK-1 acquired Lys63 (K63)-linked polyubiquitin chains upon IL-1 stimulation, only ubiquitinated IRAK-1 bound NEMO, the regulatory subunit of IκB kinase (IKK). The sites of IRAK-1 ubiquitination were mapped to Lys134 and Lys180, and arginine substitution of these residues impaired IL-1R/TLR-mediated IRAK-1 ubiquitination, NEMO binding, and NF-κB activation. K63-linked ubiquitination of IRAK-1 required enzymatically active TRAF6, indicating that it is the physiologically relevant E3. Thus, K63-linked polyubiquitination of proximal signaling proteins is a common mechanism used by diverse innate immune receptors for recruiting IKK and activating NF-κB. [ABSTRACT FROM AUTHOR]

In this publication, experimental results for the radial multiphase thermal conductivity and the wall heat transfer coefficient of different ceramic sponges as column internals for trickle beds are presented. The experiments were performed in co-current mode with the fluids water and air. The material, porosity and cell density of the sponges were varied. A strong influence of the superficial liquid velocity and of the cell density on the radial multiphase thermal conductivity is found. Dimensionless correlations of the experimental data are given. [ABSTRACT FROM AUTHOR]

Experimental results for the two-phase thermal conductivity (often called “effective thermal conductivity”) with stagnant fluid at temperatures up to 1200 K for different ceramic sponges (variation of material, porosity and cell density) are presented in this publication. A two-plate test facility was used for the experiments. Samples investigated have porosities higher than 75% and cell densities in the range of 10–45 ppi (pores per linear inch). They are made of alumina, mullite and oxidic-bonded silicon carbide. The two-phase thermal conductivity is strongly dependent on temperature, porosity and cell sizes of the sponge sample. A model based on the superposition of the two heat transfer mechanisms, thermal conduction and thermal radiation is used to predict the two-phase thermal conductivity of ceramic sponges. A model based on combination of thermal resistances is suggested for predicting the thermal conductivity. The so-called Rosseland equation is used as an initial model for predicting the part of thermal radiation on the two-phase thermal conductivity. Measurements of material properties are included in this work as model implementation requires an exact knowledge of sponge data. [ABSTRACT FROM AUTHOR]

Unilateral cerebral ischemia of the hippocampus is very rare. This paper reviews the literature and presents the case of a 59-year-old woman with an amnestic syndrome due to a left hippocampal stroke. The patient suffered from retrograde amnesia which was most severe over the 2 days prior to presenting and a slight anterograde amnesia. In addition, a verbal memory disorder was confirmed 1 week after admission by neurological tests. As risk factors, arterial hypertension and a relative hyper-beta lipoproteinemia were found. This case shows that unilateral amnestic stroke, e.g. in the hippocampus region, may be the cause of an amnestic syndrome and should be included in the differential diagnostics. [ABSTRACT FROM AUTHOR]

In this publication, experimental results for the radial two-phase thermal conductivity and the wall heat transfer coefficient of different ceramic sponges (variation of material, porosity and pore size) are presented, revealing a strong influence of the superficial air velocity and of the porosity of the ceramic sponges on both the radial two-phase thermal conductivity and the wall heat transfer coefficient. The experimental data are correlated in dimensionless form to offer a “universal” correlation for estimating the radial two-phase thermal conductivity and the wall heat transfer coefficient of sponges in the future. [ABSTRACT FROM AUTHOR]

This paper presents an implementation of an integrated Ultra-wideband (UWB), Binary-Phase Shift Keying (BPSK) Gaussian modulated pulse generator. VCO, multiplier and passive Gaussian filter are the key components. The VCO provides the carrier frequency of 4.1 GHz, the LC Gaussian filter is responsible for the pulse shaping in the baseband. Multiplying the baseband pulse and the VCO frequency shifts the pulse to the desired center frequency. The generated Gaussian pulse ocupppies the frequency range from 3.1 to 5.1 GHz with the center frequency at 4.1 GHz. Simulations and measured results show that this spectrum fulfills the mask for indoor communication systems given by the FCC (Federal Communications Commission, 2002). The total power consumption is 55mW using a supply voltage of 2.5V. Circuits are realized using the IHP 0.25µm SiGe:C BiCMOS technology. [ABSTRACT FROM AUTHOR]

En este número no se incluyeron resúmenes ni palabras clave.

En este número no se incluyeron resúmenes ni palabras clave.

Le XVIIIe siècle allemand est l’époque des transferts ou des adaptations d’œuvres littéraires espagnoles par l’intermédiaire de traductions françaises. Dans le domaine du comportement politico-moral, l’autorité de Gracián remplace celle d’Antonio de Guevara aux XVIe et XVIIe siècles. La transformation de l’homo politicus en galant homme se produit en bonne partie sous l’influence de Gracián. Son prestige et l’interprétation de ses idées dans la philosophie politique des Lumières se fondent sur la version française de l’Oráculo manual par Amelot de la Houssaie.

We report on Ge selectively grown by chemical vapor deposition on free-standing Si(001) nanostructures for future photonic applications. Si(001) substrate is patterned in the form of 140-nm-high and 150-nm-wide stripes along the <110> crystal direction with sidewalls and trenches covered by a thermal SiO2 mask. The selectivity of Ge deposition is triggered by opening growth windows of uncovered Si on top of each nanopillar. The samples with 15- and 25-nm-thick oxide mask are characterized by Raman spectroscopy and transmission electron microscopy supported by finite element method simulation. The analysis indicates that, although nanopatterned Si is stressed by thermal oxide, the Si structure quality is not affected. Additionally, the epi-Ge crystal grows in a relaxed form and nearly the whole strain energy is released by the nucleation of a misfit dislocation network at the Ge/Si interface. The residual stress is mainly accumulated in the bird's beak region of Ge/Si nanostructures. [ABSTRACT FROM AUTHOR]

Presents a study which investigated the influence of molecular-beam-epitaxy growth conditions on the properties of five monolayers of germanium, embedded in a silicon matrix for a conventional as well as an antimony-mediated growth in the temperature. Raman spectroscopy; Transmission electron microscopy; Conclusion.

Abstract New carbon-bonded alumina filters for steel melt filtration were developed. The carbonaceous matrix was based on a new, environmental friendly binder system based on lactose and tannin. The filter preparation was analogous to the production of conventional foam filters according to the Schwartzwalder process. The processing as well as the rheology of the slurries was investigated. An addition of n -Si increased the carbon yield and the cold crushing strength (CCS) of the samples. Higher values of CCS were obtained after coating of the filters with alumina. The material was characterized by scanning electron microscopy, X-ray diffraction and Raman spectroscopy. The applicability of these new filters was assessed in impingement tests with a steel melt, in which three out of four recipes survived the thermal shock. [ABSTRACT FROM AUTHOR]

Background A phase I open-label dose-escalation study was conducted to define the safety, tolerability, and pharmacokinetics (PK) of PankoMab-GEX, a glyco-optimised humanised IgG1, with high affinity to a novel tumour-specific glycopeptide epitope of MUC1 (TA-MUC1) with excellent preclinical anti-tumour activity. Patients and methods Seventy-four patients with advanced TA-MUC1-positive carcinomas received PankoMab-GEX intravenously every 3 (Q3W), 2 (Q2W), or 1 (QW) week in doses of 1–2200 mg in a three-plus-three dose-escalation design until disease progression ( NCT01222624 ). Results No maximum tolerated dose was reached. Adverse events were mainly mild-to-moderate infusion-related reactions (IRRs) by the first infusion in 45% of patients. Only one dose-limiting toxicity, a grade III IRR, was observed. PankoMab-GEX exhibited linear PK over all doses. Mean terminal half-life was 189 ± 66 h (Q3W), without dose dependency. A target trough level ≥50 μg/mL was reached after one infusion with doses ≥1700 mg Q3W in 80% of patients. Clinical benefit in 60 evaluable patients included one complete response in a patient with ovarian cancer treated 483 d and confirmed disease stabilisation in 19 patients lasting a median (range) of 23 (10–109) weeks. All but two of the patients with clinical benefit had received a compounded total dose ≥700 mg over a 3-week period, including 8 of 12 (67%) patients with ovarian cancer. Conclusion PankoMab-GEX is safe, well tolerated, and showed promising anti-tumour activity in advanced disease. A phase IIb study is ongoing evaluating the efficacy of PankoMab-GEX as a maintenance therapy in advanced ovarian cancer. [ABSTRACT FROM AUTHOR]

Hydrodynamic parameters of ceramic sponges as column internals are investigated using X-ray computed tomography. New qualitative and quantitative insights into multiphase flow in ceramic sponges are gained and a phenomenological study is performed to investigate the flow paths, the hold-up and the effective gas–liquid interfacial area of the trickling liquid inside the sponge packing. The formation of rivulets inside the sponge packing and a redistribution of the liquid at intersections are detected. Additionally, it was observed that the liquid paths inside the sponge start to fluctuate with a higher superficial liquid velocity. A specially designed data processing routine is developed. In the experiments, the test column is operated in co-current (downwards) as well as countercurrent mode with an air–water system. The results are compared to literature data to evaluate the accuracy. The sponges investigated are varied in material, porosity and cell density to obtain knowledge concerning dependencies. The cell density and the superficial liquid velocity turned out to be the significant parameters for the hold-up and the effective gas–liquid interfacial area. [ABSTRACT FROM AUTHOR]

We report the growth of thin ScN layers deposited by plasma-assisted molecular beam epitaxy on Sc2O3/Y2O3/Si(111) substrates. Using x-ray diffraction, Raman spectroscopy, and transmission electron microscopy, we find that ScN films grown at 600 °C are single crystalline, twin-free with rock-salt crystal structure, and exhibit a direct optical band gap of 2.2 eV. A high degree of crystalline perfection and a very good lattice matching between ScN and GaN (misfit<0.1%) makes the ScN/Sc2O3/Y2O3 buffer system a very promising template for the growth of high quality GaN layers on silicon. [ABSTRACT FROM AUTHOR]