2,167 results on '"Borsoi A"'
Search Results
452. Influence of surface treatments and coupling agents on the thermal and thermo‐mechanical properties of yerba mate/post‐consumer polypropylene composites
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André Luis Catto, Betina Hansen, Marcos Aurélio Dahlem Júnior, Ademir J. Zattera, Ruan Ezequiel Gemmer, and Cleide Borsoi
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Materials science ,Polymers and Plastics ,Polypropylene composites ,General Chemistry ,Silane ,food.food ,Coupling (electronics) ,chemistry.chemical_compound ,food ,chemistry ,Yerba-mate ,Thermal ,Materials Chemistry ,Ceramics and Composites ,Composite material ,Thermo mechanical - Published
- 2021
453. Establishing a national HTA program for medical devices in Italy: Overhauling a fragmented system to ensure value and equal access to new medical technologies
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Carlo Federici, Giuditta Callea, Aleksandra Torbica, Francesco Costa, Helen Banks, Patrizio Armeni, Marcella Marletta, Rosanna Tarricone, Oriana Ciani, Fabio Amatucci, and Ludovica Borsoi
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MEDICAL DEVICES ,Technology Assessment, Biomedical ,Process management ,Emerging technologies ,Scientific evidence ,03 medical and health sciences ,0302 clinical medicine ,Procurement ,Humans ,media_common.cataloged_instance ,European Union ,030212 general & internal medicine ,European union ,Competence (human resources) ,Reimbursement ,media_common ,030503 health policy & services ,Health Policy ,Corporate governance ,HTA ,GOVERNANCE ,COVERAGE ,Italy ,Dynamic pricing ,PROCUREMENT ,Business ,COVERAGE, GOVERNANCE, HTA, ITALY, MEDICAL DEVICES, PROCUREMENT ,0305 other medical science ,Delivery of Health Care - Abstract
Differing contexts have greatly influenced HTA development in various countries, with considerable effort recently made by international HTA networks (e.g., EUnetHTA) and the European Union (EU) to make HTA a more coherent, equal, and efficient process. Medical devices (MDs) present particular challenges for HTA because of frequent, rapid innovation, outcomes influenced by end-user competence, dynamic pricing and often low-quality scientific evidence. Our objective is to describe the development, structure and governance of a National HTA Program for MDs (PNHTADM) in Italy, a highly participatory, stakeholder-engaged, evidence-based process to reform a fragmented system of appraisal and approval. Based largely on EUnetHTA methods, the resulting process delineates a standardized system for proposing MDs by any stakeholders, accrediting HTA producers, setting criteria for prioritization and appraisals, and innovatively linking recommendations with coverage, reimbursement and procurement of MDs. Expected benefits include reduced disparities in pricing and reimbursement policies and improved access to new technologies across 21 regional healthcare systems in Italy's decentralized, universal system, complete with provisions to require additional evidence collection and centrally monitor diffusion. Though devised for Italy, the design, resources and underlying analysis provide a framework for other nations seeking to consolidate HTA initiatives, particularly in light of new EU regulation.
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- 2021
454. Platonic Tensegrities: dynamic aspects and characterization
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Castro Arenas, C., primary, Ghersi, I., additional, Borsoi, P. D., additional, and Miralles, M., additional
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- 2017
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455. Force Plate Calibration and Setup for Assessments of Human Balance
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Ghersi, I., primary, Castro Arenas, C. F., additional, Borsoi, P. D., additional, and Miralles, M. T., additional
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- 2017
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456. Nanomedicine Activities in the United States and Worldwide
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Borsoi, Carlotta, primary, Wolfram, Joy, additional, and Ferrari, Mauro, additional
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- 2016
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457. CELLULOSE NANOFIBER FROM YERBA MATE STICKS: SURVEY OF MORPHOLOGICAL, CHEMICAL AND THERMAL PROPERTIES.
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GEMMER, RUAN EZEQUIEL, BORSOI, CLEIDE, HANSEN, BETINA, FRANCISQUETTI, EDSON LUIZ, ORNAGHI JR., HEITOR LUIZ, ZATTERA, ADEMIR JOSÉ, and CATTO, ANDRÉ LUIS
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CELLULOSE , *NANOFIBERS , *MATE plant , *PLANT residues , *LIGNOCELLULOSE - Abstract
This study aims to evaluate different process conditions for obtaining cellulose nanofibers (CNFs) from yerba mate residues. This includes chemical (bleaching and/or TEMPO-oxidation), physical (steam explosion), and mechanical treatments (ultrafine grinding). All treatments demonstrated to be efficient in obtaining CNFs, as observed from a morphological analysis by transmission electronic microscopy (TEM). A reduction of hemicelluloses and an increase in cellulose content was observed from the Fourier-transform infrared spectroscopy (FTIR) results, after all the treatments. The yerba mate sample that underwent physical/chemical/mechanical treatments showed a higher thermal degradation temperature peak at 333 °C, with a degradation of 50% of the initial mass. The activation energy (Ea) increased from 33% to 64%, when the CNFs were obtained using the derivative Friedman method for all the samples, and this method presented a greater proximity to the experimental results. These results demonstrate that CNFs can be obtained from yerba mate residues, to valorize this lignocellulosic biomass. [ABSTRACT FROM AUTHOR]
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- 2023
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458. Nanostructured lime-based materials for the conservation of calcareous substrates
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Giovanni Borsoi
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nanolimes ,nanolime consolidation ,calcereous substrates ,Architecture ,NA1-9428 - Abstract
Nanolimes, i.e. dispersions of lime (Ca(OH)2)nanoparticles in alcohol, have been extensively investigated over the last two decades as consolidation products for calcareous substrates. The use of nanolimes for consolidation of mural paintings arises from the lack of effective and compatible consolidants for this type of substrates; the use of nanolimes was later extended also to limestone and lime-based mortars, as an alternative for silica-precursor consolidants (e.g. tetraethoxysilan - TEOS), which had shown to have a limited effectiveness and compatibility with calcareous substrates. Nanolime dispersions are characterized by a very small size of the lime particles, which should provide a proper penetration within the porous network of most building materials. In fact, a homogeneous and in-depth penetration of the consolidant is a crucial requirement when dealing with decayed stones and plasters/renders. The effectiveness of nanolime dispersions reported in literature appears controversial. Some authors observed a proper penetration and moderate consolidating action, whereas others report poor penetration, poor consolidation action and sometimes the formation of a white haze on the treated surface. There is no agreement concerning the factors affecting the transport and deposition of the lime nanoparticles within a porous network, and the causes of the observed drawbacks are not well understood. Therefore, the main research question is: Is nanolime a suitable alternative to silica-precursor consolidants (e.g. TEOS) for the consolidation of calcareous substrates? More specifically, the following research questions can be formulated: – How and up to which extent can the effectiveness and compatibility of nanolime be improved? How can deposition of nanolime in depth be improved and the appearance of a white haze on the surface avoided? – How can nanolime properties be fine-tuned to improve the effectiveness and compatibility of the treatment? – What is the effect of different application methods on the effectiveness of nanolime consolidation? This research investigates and elucidates the behaviour of nanolime products for consolidation of calcareous substrates. Based on the developed knowledge, it proposes and validates a methodology (including solvent modification and application protocol) for improving the consolidation effectiveness of nanolime dispersions, making these a suitable alternative for TEOS products. Firstly, an experimental campaign was carried out in order to understand the penetration and deposition of commercial nanolimes on coarse porous calcareous substrates (Maastricht limestone). The main cause of the poor nanolime deposition in-depth was identified in the back-transport of the nanoparticles towards the drying surface, as a consequence of the high volatility and low kinetic stability of the dispersions. The modification of the nanolime properties, through the optimization of the solvent, appears thus a feasible strategy to improve the in-depth deposition of the lime nanoparticles. New nanolimes were synthetized and dispersed in a selection of solvents conferring different stability and drying rate to the obtained nanolime dispersions. A conceptual model, correlating the properties (i.e. drying rate and kinetic stability) of nanolimes dispersed in different solvents, to the moisture transport behaviour of the substrates to be treated, was conceived. The model was experimentally validated on coarse porous (Maastricht) and fine-porous (Migné) limestones. Experimental results confirmed the predictions of the model that nanolimes dispersed in solvent with lower volatility and stability (e.g. water or butanol) have a good in-depth deposition within coarse porous networks. On the other hand, solvents with higher volatility and guaranteeing higher kinetic stability (e.g. ethanol or isopropanol) to the relative dispersions, should be preferred for substrates with fine porous networks. Fine-tuning the properties of the nanolime dispersion (by modification of the solvent) to the moisture transport behaviour of the substrate, is shown to be a successful strategy for improving in-depth deposition of lime nanoparticles. On the basis of the obtained results, the solvent mixture was further fine-tuned using ethanol-water mixtures. Results proved that ethanol-based nanolime, mixed with a minor amount of water (5%), can provide better nanoparticles in-depth deposition within coarse porous substrates (e.g. Maastricht limestone), when compared to dispersions in pure ethanol. The application procedure of nanolime dispersions was also studied and optimized, this step being a crucial aspect for a successful consolidation; nanolimes were applied both by capillary absorption (method commonly used for laboratory tests) or by nebulization (method widely used in situ) on a coarse porous limestone and a mortar. The research showed that results obtained by application through capillary absorption do not always correspond to those obtained by nebulization. The effectiveness and compatibility of nanolimes with improved properties and a fine-tuned application protocol were finally verified. Fresh and weathered Maastricht limestone, as well as lime-based mortars, were treated. Results showed that nanolime dispersions can guarantee an in-depth consolidation both in laboratory mortar specimens and weathered limestone, with only a moderate alteration of the total porosity and of the moisture transport properties of the investigated substrates. Therefore, nanolime dispersions, provided that they are properly formulated and applied, can be a suitable and compatible alternative to TEOS for the consolidation of coarse porous substrates. This dissertation contributes to define guidelines to support restorers and professionals in the choice and application of nanolime dispersions for consolidation of calcareous substrates.
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- 2017
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459. Is Forced Swimming Immobility a Good Endpoint for Modeling Negative Symptoms of Schizophrenia? - Study of Sub-Anesthetic Ketamine Repeated Administration Effects
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GILDA NEVES, MILENE BORSOI, CAMILA B. ANTONIO, MARIANA A. PRANKE, ANDRESA H. BETTI, and STELA M.K. RATES
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antidepressant-like effect ,immobility behavior ,locomotor activity ,memory negative symptoms ,Science - Abstract
ABSTRACT Immobility time in the forced swimming has been described as analogous to emotional blunting or apathy and has been used for characterizing schizophrenia animal models. Several clinical studies support the use of NMDA receptor antagonists to model schizophrenia in rodents. Some works describe the effects of ketamine on immobility behavior but there is variability in the experimental design used leading to controversial results. In this study, we evaluated the effects of repeated administration of ketamine sub-anesthetic doses in forced swimming, locomotion in response to novelty and novel object recognition, aiming a broader evaluation of the usefulness of this experimental approach for modeling schizophrenia in mice. Ketamine (30 mg/kg/day i.p. for 14 days) induced a not persistent decrease in immobility time, detected 24h but not 72h after treatment. This same administration protocol induced a deficit in novel object recognition. No change was observed in mice locomotion. Our results confirm that repeated administration of sub-anesthetic doses of ketamine is useful in modeling schizophrenia-related behavioral changes in mice. However, the immobility time during forced swimming does not seem to be a good endpoint to evaluate the modeling of negative symptoms in NMDAR antagonist animal models of schizophrenia.
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- 2017
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460. Tolerância ao frio e características silviculturais do cedro-australiano no sul do Brasil
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Marcio Carlos Navroski, Mariane de Oliveira Pereira, Geedre Adriano Borsoi, Antonio Nascim Kalil Filho, Bruno Nascimento, and Diego Pereira da Rosa
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Toona ciliata ,Resistência a geada ,Plantio misto ,Forestry ,SD1-669.5 - Abstract
O cedro australiano (Toona ciliata M. Roem) é uma espécie difundida no Sudeste, Centro-Oeste e Nordeste do Brasil, onde alcança boa produtividade. Possui madeira de excelente qualidade para finalidades nobres. Entretanto, na região Sul do Brasil apresenta problemas de adaptação devido à ocorrência de geadas. O objetivo deste estudo foi verificar a tolerância ao frio e o potencial silvicultural de cedro-australiano em dois locais no Sul do Brasil. Os tratamentos consistiram de plantio puro de cedro-australiano e misto, com Mimosa scabrella e Eucalyptus benthamii em Lages, SC, e puro e sob Pinus taeda em Ibiam, SC. Durante dois anos após a implantação avaliou-se sobrevivência, danos por geada, bifurcação/brotação, altura total e diâmetro do colo. O cedro-australiano apresentou sérios danos pela geada no município de Lages, reduzindo drasticamente a sobrevivência e prejudicando as características silviculturais. O plantio do cedro-australiano sob pínus em Ibiam apresentou baixa taxa de mortalidade devido a geadas. O plantio puro nesta mesma região também apresentou baixa mortalidade, contudo, os efeitos das geadas foram consideráveis. O plantio de cedro-australiano não é indicado para as regiões com geadas intensas, contudo, em locais com geadas menos severas, o plantio sob pínus é uma alternativa potencial.
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- 2017
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461. Hydrocephalus and arthrogryposis in an immunocompetent mouse model of ZIKA teratogeny: A developmental study.
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Jose Xavier-Neto, Murilo Carvalho, Bruno Dos Santos Pascoalino, Alisson Campos Cardoso, Ângela Maria Sousa Costa, Ana Helena Macedo Pereira, Luana Nunes Santos, Ângela Saito, Rafael Elias Marques, Juliana Helena Costa Smetana, Silvio Roberto Consonni, Carla Bandeira, Vivian Vasconcelos Costa, Marcio Chaim Bajgelman, Paulo Sérgio Lopes de Oliveira, Marli Tenorio Cordeiro, Laura Helena Vega Gonzales Gil, Bianca Alves Pauletti, Daniela Campos Granato, Adriana Franco Paes Leme, Lucio Freitas-Junior, Carolina Borsoi Moraes Holanda de Freitas, Mauro Martins Teixeira, Estela Bevilacqua, and Kleber Franchini
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Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Abstract
The teratogenic mechanisms triggered by ZIKV are still obscure due to the lack of a suitable animal model. Here we present a mouse model of developmental disruption induced by ZIKV hematogenic infection. The model utilizes immunocompetent animals from wild-type FVB/NJ and C57BL/6J strains, providing a better analogy to the human condition than approaches involving immunodeficient, genetically modified animals, or direct ZIKV injection into the brain. When injected via the jugular vein into the blood of pregnant females harboring conceptuses from early gastrulation to organogenesis stages, akin to the human second and fifth week of pregnancy, ZIKV infects maternal tissues, placentas and embryos/fetuses. Early exposure to ZIKV at developmental day 5 (second week in humans) produced complex manifestations of anterior and posterior dysraphia and hydrocephalus, as well as severe malformations and delayed development in 10.5 days post-coitum (dpc) embryos. Exposure to the virus at 7.5-9.5 dpc induces intra-amniotic hemorrhage, widespread edema, and vascular rarefaction, often prominent in the cephalic region. At these stages, most affected embryos/fetuses displayed gross malformations and/or intrauterine growth restriction (IUGR), rather than isolated microcephaly. Disrupted conceptuses failed to achieve normal developmental landmarks and died in utero. Importantly, this is the only model so far to display dysraphia and hydrocephalus, the harbinger of microcephaly in humans, as well as arthrogryposis, a set of abnormal joint postures observed in the human setting. Late exposure to ZIKV at 12.5 dpc failed to produce noticeable malformations. We have thus characterized a developmental window of opportunity for ZIKV-induced teratogenesis encompassing early gastrulation, neurulation and early organogenesis stages. This should not, however, be interpreted as evidence for any safe developmental windows for ZIKV exposure. Late developmental abnormalities correlated with damage to the placenta, particularly to the labyrinthine layer, suggesting that circulatory changes are integral to the altered phenotypes.
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- 2017
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462. Identification of potential inhibitors of Mycobacterium tuberculosis shikimate kinase: molecular docking, in silico toxicity and in vitro experiments
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Talita Freitas de Freitas, Candida Deves Roth, Bruno Lopes Abbadi, Fernanda Souza Macchi Hopf, Marcia Alberton Perelló, Alexia de Matos Czeczot, Eduardo Vieira de Souza, Ana Flávia Borsoi, Pablo Machado, Cristiano Valim Bizarro, Luiz Augusto Basso, and Luis Fernando Saraiva Macedo Timmers
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Drug Discovery ,Physical and Theoretical Chemistry ,Computer Science Applications - Abstract
Tuberculosis (TB) is one of the main causes of death from a single pathological agent, Mycobacterium tuberculosis (Mtb). In addition, the emergence of drug-resistant TB strains has exacerbated even further the treatment outcome of TB patients. It is thus needed the search for new therapeutic strategies to improve the current treatment and to circumvent the resistance mechanisms of Mtb. The shikimate kinase (SK) is the fifth enzyme of the shikimate pathway, which is essential for the survival of Mtb. The shikimate pathway is absent in humans, thereby indicating SK as an attractive target for the development of anti-TB drugs. In this work, a combination of in silico and in vitro techniques was used to identify potential inhibitors for SK from Mtb (MtSK). All compounds of our in-house database (Centro de Pesquisas em Biologia Molecular e Funcional, CPBMF) were submitted to in silico toxicity analysis to evaluate the risk of hepatotoxicity. Docking experiments were performed to identify the potential inhibitors of MtSK according to the predicted binding energy. In vitro inhibitory activity of MtSK-catalyzed chemical reaction at a single compound concentration was assessed. Minimum inhibitory concentration values for in vitro growth of pan-sensitive Mtb H37Rv strain were also determined. The mixed approach implemented in this work was able to identify five compounds that inhibit both MtSK and the in vitro growth of Mtb.
- Published
- 2022
463. Dietary polyphenols and their relationship to the modulation of non-communicable chronic diseases and epigenetic mechanisms: A mini-review
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Felipe Tecchio Borsoi, Iramaia Angélica Neri-Numa, Williara Queiroz de Oliveira, Fabio Fernandes de Araújo, and Glaucia Maria Pastore
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Molecular Biology ,Food Science - Abstract
Chronic Non-Communicable Diseases (NCDs) have been considered a global health problem, characterized as diseases of multiple factors, which are developed throughout life, and regardless of genetics as a risk factor of important relevance, the increase in mortality attributed to the disease to environmental factors and the lifestyle one leads. Although the reactive species (ROS/RNS) are necessary for several physiological processes, their overproduction is directly related to the pathogenesis and aggravation of NCDs. In contrast, dietary polyphenols have been widely associated with minimizing oxidative stress and inflammation. In addition to their antioxidant power, polyphenols have also drawn attention for being able to modulate both gene expression and modify epigenetic alterations, suggesting an essential involvement in the prevention and/or development of some pathologies. Therefore, this review briefly explained the mechanisms in the development of some NCDs, followed by a summary of some evidence related to the interaction of polyphenols in oxidative stress, as well as the modulation of epigenetic mechanisms involved in the management of NCDs.
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- 2022
464. Hard superconducting gap in germanium
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Alberto Tosato, Vukan Levajac, Ji-Yin Wang, Casper J. Boor, Francesco Borsoi, Marc Botifoll, Carla N. Borja, Sara Martí-Sánchez, Jordi Arbiol, Amir Sammak, Menno Veldhorst, and Giordano Scappucci
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Condensed Matter::Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics ,Mechanics of Materials ,Condensed Matter::Superconductivity ,Mesoscale and Nanoscale Physics (cond-mat.mes-hall) ,FOS: Physical sciences ,General Materials Science ,Condensed Matter::Mesoscopic Systems and Quantum Hall Effect - Abstract
The co-integration of spin, superconducting, and topological systems is emerging as an exciting pathway for scalable and high-fidelity quantum information technology. High-mobility planar germanium is a front-runner semiconductor for building quantum processors with spin-qubits, but progress with hybrid superconductor-semiconductor devices is hindered by the difficulty in obtaining a superconducting hard gap, that is, a gap free of subgap states. Here, we address this challenge by developing a low-disorder, oxide-free interface between high-mobility planar germanium and a germanosilicide parent superconductor. This superconducting contact is formed by the thermally-activated solid phase reaction between a metal, platinum, and the Ge/SiGe semiconductor heterostructure. Electrical characterization reveals near-unity transparency in Josephson junctions and, importantly, a hard induced superconducting gap in quantum point contacts. Furthermore, we demonstrate phase control of a Josephson junction and study transport in a gated two-dimensional superconductor-semiconductor array towards scalable architectures. These results expand the quantum technology toolbox in germanium and provide new avenues for exploring monolithic superconductor-semiconductor quantum circuits towards scalable quantum information processing.
- Published
- 2022
465. Antitubercular Activity of Novel 2-(Quinoline-4-yloxy)acetamides with Improved Drug-Like Properties
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Ana Flávia Borsoi, Laura Manzoli Alice, Nathalia Sperotto, Alessandro Silva Ramos, Bruno Lopes Abbadi, Fernanda Souza Macchi Hopf, Adilio da Silva Dadda, Raoní S. Rambo, Rodrigo Braccini Madeira Silva, Josiane Delgado Paz, Kenia Pissinate, Mauro Neves Muniz, Christiano Ev Neves, Luiza Galina, Laura Calle González, Marcia Alberton Perelló, Alexia de Matos Czeczot, Mariana Leyser, Sílvia Dias de Oliveira, Graziela de Araújo Lock, Bibiana Verlindo de Araújo, Teresa Dalla Costa, Cristiano Valim Bizarro, Luiz Augusto Basso, and Pablo Machado
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Organic Chemistry ,Drug Discovery ,Biochemistry - Abstract
Using cycloalkyl and electron-donating groups to decrease the carbonyl electrophilicity, a novel series of 2-(quinoline-4-yloxy)acetamides was synthesized and evaluated as
- Published
- 2022
466. The translational challenge in Chagas disease drug development
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Jadel M Kratz, Karolina R Gonçalves, Lavínia MD Romera, Carolina Borsoi Moraes, Paula Bittencourt-Cunha, Sergio Schenkman, Eric Chatelain, and Sergio Sosa-Estani
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Microbiology (medical) ,pharmacokinetic pharmacodynamic (PK/PD) relationship ,dormancy ,Drug Development ,Trypanosoma cruzi ,animal model ,Drug Discovery ,Humans ,Neglected Diseases ,Chagas Disease ,persisters ,Trypanocidal Agents ,in vitro assay - Abstract
Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new treatments since the currently approved drugs have serious limitations. Drug development for Chagas disease has historically been hampered by the complexity of the disease, critical knowledge gaps, and lack of coordinated R&D efforts. This review covers some of the translational challenges associated with the progression of new chemical entities from preclinical to clinical phases of development, and discusses how recent technological advances might allow the research community to answer key questions relevant to the disease and to overcome hurdles in R&D for Chagas disease.
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- 2022
467. O ensino de história, a redemocratização brasileira, e a música
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Borsoi, Lisiara Guazzelli, Lia, Cristine Fortes, Bilhão, Isabel Aparecida, Luchese, Terciane Angela, and Xerri, Eliana Gasparini
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History - Study and teaching ,Educação ,Music and history ,Música e história ,História - Estudo e ensino ,Music ,Música ,Education - Abstract
A dissertação tem como corpus de pesquisa o Ensino de História através da música composta no período da Redemocratização Brasileira (1974-1985). O trabalho faz parte do Programa de Pós-graduação em História da Universidade de Caxias do Sul - Mestrado Profissional em História, tendo como linha de pesquisa as Linguagens e Cultura no Ensino de História. A temática desta pesquisa surgiu a partir das reflexões sobre o desenvolvimento de uma aprendizagem mais significativa nas salas de aula, sobretudo no ensino de História. Relacionar o passado com o presente tem sido um desafio para os professores dessa área, já que muitos os consideram "professores do passado". O objetivo é refletir, discutir e apresentar uma proposta metodológica com o uso da música em sala de aula, para ensinar o período da Redemocratização Brasileira. Considerando que, além de culturalmente muito explorada, a música é um recurso facilmente encontrado e de uso cotidiano da maioria dos jovens, a proposta busca auxiliar nesse processo de aprendizagem e tornar cada vez mais reflexivo e eficaz o ensino, utilizando-se das vivências dos educandos. A música como instrumento pedagógico, utilizada de forma simultânea ao livro didático ou texto, facilita a comunicação em um tempo em que a utilização de novas tecnologias está presente no cotidiano do professor e do educando, trazendo informações em tempo real e de forma acessível. O recorte temporal foi escolhido devido a sua importante transição de um período ditatorial para a democracia, no qual a sociedade brasileira manifestava-se culturalmente contra o governo e a realidade vivida. Assim, foram produzidas inúmeras canções que contextualizavam o momento, podendo ser utilizadas hoje como um documento histórico. A Redemocratização Brasileira se estende de 1974 a 1985, período no qual a Abertura Política aconteceu através de atos contínuos, devolvendo aos cidadãos brasileiros a democracia que lhes foi privada durante o período da Ditadura Civil Militar, iniciada em 1964. A pesquisa é qualitativa, pois o texto está baseado na revisão bibliográfica em livros, artigos científicos e dissertações que discorrem sobre o tema tratado, ressaltando alguns autores importantes para este trabalho como Napolitano (2010), Gardner (1995), Ferreira (2018), Seffner (2016), Chauí (2012 Por se tratar do Tempo Presente, as músicas selecionadas para relacionar a História à Redemocratização, ainda fazem parte do cotidiano de muitos brasileiros, e ainda convivemos com pessoas que vivenciaram aquele período. Como produto final desta pesquisa, proponho oficinas para professores, que visam auxiliar em suas práticas profissionais. Os resultados obtidos ao final de pesquisa sinalizam para uma constante atualização nos métodos e estratégias de aprendizagem utilizadas em sala de aula. [resumo fornecido pelo autor] The dissertation has as its research corpus the Teaching of History through music composed in the period of Brazilian Redemocratization (1974-1985). The work is part of the Postgraduate Program in History at the University of Caxias do Sul - Professional Masters in History, having as a research line Languages and Culture in History Teaching. The theme of this research emerged from reflections on the development of more meaningful learning in classrooms, especially in the teaching of History. Relating the past to the present has been a challenge for teachers in this area, as many consider them "teachers of the past". The objective is to reflect, discuss and present a methodological proposal with the use of music in the classroom, to teach the period of Brazilian Redemocratization. Considering that, in addition to being culturally very explored, music is a resource easily found and used daily by most young people, the proposal seeks to assist in this learning process and make teaching increasingly reflective and effective, using the experiences of students. Music as a pedagogical instrument, used simultaneously with the textbook or text, facilitates communication at a time when the use of new technologies is present in the daily life of the teacher and the student, bringing information in real time and in an accessible way. The time frame was chosen due to its important transition from a dictatorial period to democracy, in which Brazilian society culturally manifested itself against the government and the lived reality. Thus, countless songs were produced that contextualized the moment and can be used today as a historical document. The Brazilian Redemocratization extends from 1974 to 1985, a period in which the Political Opening took place through continuous acts, returning to Brazilian citizens the democracy that was deprived of them during the period of the Civil Military Dictatorship, which began in 1964. The research is qualitative, as it the text is based on the bibliographic review in books, scientific articles and dissertations that discuss the subject, highlighting some important authors for this work such as Napolitano (2010), Gardner (1995), Ferreira (2018), Seffner (2016), Chauí (2012). Because it is the present time, the songs selected to relate History to Redemocratization are still part of the daily lives of many Brazilians, and we still live with people who lived through that period. As a final product of this research, I propose workshops for teachers, who aim to assist in their professional practices. The results obtained at the end of the research point to a constant update in the methods and learning strategies used in the classroom. [resumo fornecido pelo autor]
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- 2022
468. Optimization of nanolime solvent for the consolidation of coarse porous limestone
- Author
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Borsoi, Giovanni, Lubelli, Barbara, van Hees, Rob, Veiga, Rosário, and Silva, António Santos
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- 2016
- Full Text
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469. USO DAS TECNOLOGIAS NÃO FARMACOLÓGICAS DURANTE O TRABALHO DE PARTO: REVISÃO INTEGRATIVA DA LITERATURA
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Rayssa Oliveira Ferreira Ribeiro Rodrigues, Karina Angélica Alvarenga Ribeiro, Maura Cristiane e Silva Figueira, Mayane Magalhães Santos, and Michele Batiston Borsoi
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- 2022
470. Antiviral activity of Cenostigma pluviosumvar. peltophoroidesextract and fractions against SARS-CoV-2
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Pattaro-Júnior, José Renato, Araújo, Ingrid Garcia, Moraes, Carolina Borsoi, Barbosa, Cecilia Gomes, Philippsen, Gisele Strieder, Freitas-Junior, Lúcio Holanda, Guidi, Ana Carolina, de Mello, João Carlos Palazzo, Peralta, Rosane Marina, Fernandez, Maria Aparecida, Teixeira, Róbson Ricardo, and Seixas, Flavio Augusto Vicente
- Abstract
AbstractFew extracts of plant species from the Brazilian flora have been validated from a pharmacological and clinical point of view, and it is important to determine whether their traditional use is proven by pharmacological effects. Cenostigma pluviosum var. peltophoroidesis one of those plants, which belongs to the Fabaceae family that is widely used in traditional medicine and is very rich in tannins. Due to the lack of effective drugs to treat severe cases of Covid-19, the main protease of SARS-CoV-2 (Mpro) becomes an attractive target in the research for new antivirals since this enzyme is crucial for virus replication and does not have homologs in humans. This study aimed to prospect inhibitor candidates among the compounds from C. pluviosumextract, by virtual screening simulations using SARS-CoV-2 Mproas target. Experimental validation was made by inhibitory proteolytic assays of recombinant Mproand by antiviral activity with infected Vero cells. Docking simulations identify four compounds with potential inhibitory activity of Mpropresent in the extract. The compound pentagalloylglucose showed the best result in proteolytic kinetics experiments, with suppression of recombinant Mproactivity by approximately 60%. However, in experiments with infected cells ethyl acetate fraction and sub-fractions, F2 and F4 of C. pluviosumextract performed better than pentagalloylglucose, reaching close to 100% of antiviral activity. The prominent activity of the extract fractions in infected cells may be a result of a synergistic effect from the different hydrolyzable tannins present, performing simultaneous action on Mproand other targets from SARS-CoV-2 and host.Communicated by Ramaswamy H. Sarma
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- 2023
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471. Cushing's Syndrome in a Morbidly Obese Patient Undergoing Evaluation before Bariatric Surgery
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Livia Borsoi, Bernhard Ludvik, Gerhard Prager, Anton Luger, and Michaela Riedl
- Subjects
Cushing ,Obesity ,Bariatric surgery ,Nutrition. Foods and food supply ,TX341-641 ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Objective: Cushing's syndrome (CS) is extremely rare in morbidly obese patients. To date, no occurrences in obese patients with BMI above 60 kg/m2 have been reported in the literature. Case Report: This case report describes a patient who was admitted to the ward of the Clinical Division of Endocrinology and Metabolism of the Medical University of Vienna in preparation for bariatric surgery. The patient was a 49-year-old female who showed morbid obesity (BMI 61.6 kg/m2), hypertension, and substituted hypothyroidism. Preoperative work-up revealed CS due to an adrenal adenoma. Therefore, the patient underwent unilateral adrenalectomy followed by bariatric surgery 6 months later. Conclusion: Since undiagnosed CS might result in severe perioperative complications in a population already at increased risk, this case report underlines the importance of careful endocrine evaluation of morbidly obese patients. After all, even rare endocrine causes should be excluded.
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- 2014
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472. Occurrence of Myocardial Ischemia in Patients Undergoing Pharmacologic Stress Echocardiography: The Impact of Type-D Personality
- Author
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Rafael Borsoi, Viviane Vidal Sabatoski, Ana Paula Higa Ogawa, Aline Fontana, Liz Andrea Villela Baroncini, Admar Moraes de Souza, and Claudio Pereira da Cunha
- Subjects
Coronary artery disease ,myocardial ischemia ,psychological risk factor ,stress echocardiography ,type-D personality ,Medicine - Abstract
Background: Type-D personality has been identified as a risk factor for general and cardiac mortality in patients with coronary artery disease (CAD). Dobutamine-atropine stress echocardiography (DASE) is an established method for non-invasive evaluation of myocardial ischemia in patients with CAD. The objective of this study was to evaluate the prevalence of type-D personality and its association with the occurrence of myocardial ischemia as assessed by DASE. Methods: This case-control study enrolled 306 patients (61 ± 9.6 years, 57.8% female) who were referred by physicians to assessment of myocardial ischemia. Before undergoing DASE, the patients answered the type-D scale, which identifies type-D personality. Results: Type-D personality was identified in 106 patients (34.6%). DASE was positive for myocardial ischemia in 32.4% (99) of 306 participants there was no significant association between type-D personality and ischemic changes on DASE (P = 0.941; odds ratio: 0.98; confidence interval 95%: 0.57-1.69). Chest pain was the only clinical variable with statistically significant prevalence in type-D personality patients (77.4% vs. 57.0%; P < 0.001). Conclusions: Type-D personality was not a significant risk factor for the presence of ischemic changes on DASE. Patients with type-D personality tended to complain more frequently of chest pain than non-type-D patients.
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- 2014
473. Maturidade fisiológica de sementes de tungue (Aleurites fordii Hemsl.)
- Author
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Paulo Ricardo Lima, Augustinho Borsoi, Paulino Ricardo Ribeiro dos Santos, Joao Alexandre Lopes Dranski, Ubirajara Contro Malavasi, and Marlene de Matos Malavasi
- Subjects
Coloração dos frutos ,maturação ,colheita. ,Agriculture ,Agriculture (General) ,S1-972 ,Veterinary medicine ,SF600-1100 - Abstract
O ensaio objetivou determinar a maturidade fisiológica de sementes de tungue (Aleurites fordii Hemsl.) em função da coloração dos frutos. Frutos de dez árvores com quatro anos de idade foram coletados em Cascavel, PR. O ensaio seguiu o delineamento inteiramente casualizado, com quatro estádios de maturação dos frutos e cinco repetições com 25 sementes cada. Os frutos foram classificados em três classes quanto à coloração do epicarpo e uma coletada diretamente do solo. Para caracterizar a maturidade fisiológica utilizou-se a colorimetria digital e parâmetros biométricos. Nas sementes, determinou-se a massa de matéria seca, o grau de umidade, a germinação, e o índice de velocidade de emergência. As sementes extraídas dos frutos com coloração visual marrom-claro apresentaram maior massa seca, menor teor de água e a porcentagem de germinação e velocidade de emergência, indicando a maturidade fisiológica das sementes. Frutos coletados do chão não são indicados para a coleta de sementes. A colheita dos frutos para obtenção de sementes com maturidade fisiológica é recomendada quando os frutos externarem coloração visual marrom-claro com valores de refratância no espectro visível (RGB) de 96,1, 69,9 e 64,1, respectivamente.
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- 2016
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474. Evaluation of the effectiveness and compatibility of nanolime consolidants with improved properties
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Borsoi, Giovanni, Lubelli, Barbara, van Hees, Rob, Veiga, Rosario, and Silva, Antonio Santos
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Building materials durability -- Analysis ,Building materials -- Mechanical properties -- Analysis ,Business ,Construction and materials industries - Abstract
ABSTRACT Surface consolidation is a common practice in the conservation of the built heritage. However, the effectiveness of consolidation of calcareous materials is often doubtful, due to the lack of [...]
- Published
- 2017
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475. Coupled Tensor Decomposition for Hyperspectral and Multispectral Image Fusion With Inter-Image Variability
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David Brie, Ricardo Augusto Borsoi, Jose C. M. Bermudez, Cedric Richard, Clémence Prévost, Konstantin Usevich, Universidade Federal de Santa Catarina = Federal University of Santa Catarina [Florianópolis] (UFSC), Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Automatique de Nancy (CRAN), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), and ANR-19-CE23-0021,LeaFleT,Apprentissage des réseaux de neurones avec des fonctions d'activation flexibles par les méthodes tensorielles(2019)
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Signal Processing (eess.SP) ,Computational complexity theory ,Computer science ,Multispectral image ,multispectral data ,super-resolution ,Hyperspectral data ,02 engineering and technology ,image fusion ,Matrix decomposition ,tensor decomposition ,[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing ,FOS: Electrical engineering, electronic engineering, information engineering ,0202 electrical engineering, electronic engineering, information engineering ,Electrical Engineering and Systems Science - Signal Processing ,inter-image variability ,Electrical and Electronic Engineering ,Image resolution ,Image fusion ,Image and Video Processing (eess.IV) ,Hyperspectral imaging ,020206 networking & telecommunications ,Electrical Engineering and Systems Science - Image and Video Processing ,Signal Processing ,Identifiability ,Algorithm ,Tucker decomposition - Abstract
International audience; Coupled tensor approximation has recently emerged as a promising approach for the fusion of hyperspectral and multispectral images, reconciling state of the art performance with strong theoretical guarantees. However, tensor-based approaches previously proposed assume that the different observed images are acquired under exactly the same conditions. A recent work proposed to accommodate inter-image spectral variability in the image fusion problem using a matrix factorization-based formulation, but did not account for spatially-localized variations. Moreover, it lacks theoretical guarantees and has a high associated computational complexity. In this paper, we consider the image fusion problem while accounting for both spatially and spectrally localized changes in an additive model. We first study how the general identifiability of the model is impacted by the presence of such changes. Then, assuming that the high-resolution image and the variation factors admit a Tucker decomposition, two new algorithms are proposed-one purely algebraic, and another based on an optimization procedure. Theoretical guarantees for the exact recovery of the high-resolution image are provided for both algorithms. Experimental results show that the proposed method outperforms state-of-the-art methods in the presence of spectral and spatial variations between the images, at a smaller computational cost.
- Published
- 2021
476. Cama de aves de corral un factor importante en la seguridad alimentaria
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Lina-Maria Peñuela-Sierra, Maria-Alejandra Ospina-Barrero, Anderlise Borsoi, and Maryeimy Varon-Lopez
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General Engineering - Abstract
La cama es un componente esencial en la producción de aves de corral, ya que habitan sobre este material la mayor parte de su ciclo productivo, por consiguiente, en ella se puede encontrar heces, bacterias entéricas, patógenos de importancia zoonótica y/o de transmisión alimentaria, plaguicidas y antimicrobianos, los cuales pueden afectar la sanidad de las aves. Después del ciclo de producción avícola, la cama es comúnmente utilizada como fertilizante orgánico para mejorar la calidad de los suelos y los cultivos. A pesar de su amplio uso en la avicultura y agricultura, se conoce poco acerca de su importancia en la seguridad alimentaria, por lo cual, la presente revisión discute acerca de los patógenos y contaminantes presentes en la cama y sus riesgos para la seguridad alimentaria, además las prácticas de manejo y tratamientos más adecuados. Información que será útil para maximizar los usos de la cama y los desechos avícolas, para que estos no representen un peligro para las personas, animales y el medio ambiente.
- Published
- 2021
477. Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection
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Caio Haddad Franco, Laura Maria Alcântara, Eric Chatelain, Lucio Freitas-Junior, and Carolina Borsoi Moraes
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Trypanosoma cruzi ,high content screening ,phenotypic screening ,chagas disease drug discovery ,host cells ,host-parasite interactions ,Medicine - Abstract
Cell-based screening has become the major compound interrogation strategy in Chagas disease drug discovery. Several different cell lines have been deployed as host cells in screening assays. However, host cell characteristics and host-parasite interactions may play an important role when assessing anti-T. cruzi compound activity, ultimately impacting on hit discovery. To verify this hypothesis, four distinct mammalian cell lines (U2OS, THP-1, Vero and L6) were used as T. cruzi host cells in High Content Screening assays. Rates of infection varied greatly between different host cells. Susceptibility to benznidazole also varied, depending on the host cell and parasite strain. A library of 1,280 compounds was screened against the four different cell lines infected with T. cruzi, resulting in the selection of a total of 82 distinct compounds as hits. From these, only two hits were common to all four cell lines assays (2.4%) and 51 were exclusively selected from a single assay (62.2%). Infected U2OS cells were the most sensitive assay, as 55 compounds in total were identified as hits; infected THP-1 yielded the lowest hit rates, with only 16 hit compounds. Of the selected hits, compound FPL64176 presented selective anti-T. cruzi activity and could serve as a starting point for the discovery of new anti-chagasic drugs.
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- 2019
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478. Morphological abnormality in larvae of Amblyomma oblongoguttatum (Acari: Ixodidae)
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Camila Flávia Gomes Azzi, Cesarino Junior Lima Aprígio, Rosemira Vidal de Souza, Ana Beatriz Pais Borsoi, Karla Bitencourth, Ademar Ferreira, Marinete Amorim, Stefan Vilges de Oliveira, and Gilberto Salles Gazeta
- Subjects
Veterinary medicine ,SF600-1100 - Abstract
Amblyomma oblongoguttatum is a tick that is a parasite of mammals and its preferred hosts are the wild pigs, tapirs and small rodents, being collected also parasitizing domestic dogs and eventually humans. An Amblyomma oblongoguttatum larva with morphological abnormality was collected along with other specimens (larvae and females) of this species and with morphologically normal Amblyomma naponense nymphs in a wild pig - Pecari tacaju - in a rural area of the state of Rondônia / Brazil, during research of tick-borne disease environments. The morphologically abnormal specimen showed a bifurcation of the posterior region of the opisthosoma, without other altered morphological characters. This is the first record of morphological abnormality at the larval stage of Amblyomma oblongoguttatum.
- Published
- 2019
479. Antitubercular Activity of Novel 2-(Quinoline-4-yloxy)acetamides with Improved Drug-Like Properties
- Author
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Borsoi, Ana Flávia, primary, Alice, Laura Manzoli, additional, Sperotto, Nathalia, additional, Ramos, Alessandro Silva, additional, Abbadi, Bruno Lopes, additional, Macchi Hopf, Fernanda Souza, additional, Silva Dadda, Adilio da, additional, Rambo, Raoní S., additional, Madeira Silva, Rodrigo Braccini, additional, Paz, Josiane Delgado, additional, Pissinate, Kenia, additional, Muniz, Mauro Neves, additional, Neves, Christiano Ev, additional, Galina, Luiza, additional, González, Laura Calle, additional, Perelló, Marcia Alberton, additional, de Matos Czeczot, Alexia, additional, Leyser, Mariana, additional, de Oliveira, Sílvia Dias, additional, de Araújo Lock, Graziela, additional, de Araújo, Bibiana Verlindo, additional, Costa, Teresa Dalla, additional, Bizarro, Cristiano Valim, additional, Basso, Luiz Augusto, additional, and Machado, Pablo, additional
- Published
- 2022
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480. Spin‐Mixing Enhanced Proximity Effect in Aluminum‐Based Superconductor–Semiconductor Hybrids
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Mazur, Grzegorz P., primary, van Loo, Nick, additional, Wang, Ji‐Yin, additional, Dvir, Tom, additional, Wang, Guanzhong, additional, Khindanov, Aleksei, additional, Korneychuk, Svetlana, additional, Borsoi, Francesco, additional, Dekker, Robin C., additional, Badawy, Ghada, additional, Vinke, Peter, additional, Gazibegovic, Sasa, additional, Bakkers, Erik P. A. M., additional, Pérez, Marina Quintero‐, additional, Heedt, Sebastian, additional, and Kouwenhoven, Leo P., additional
- Published
- 2022
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- View/download PDF
481. The invisible costs of obstructive sleep apnea (OSA): Systematic review and cost-of-illness analysis
- Author
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Borsoi, Ludovica, primary, Armeni, Patrizio, additional, Donin, Gleb, additional, Costa, Francesco, additional, and Ferini-Strambi, Luigi, additional
- Published
- 2022
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482. Detection of virulence-associated genes in Salmonella Enteritidis isolates from chicken in South of Brazil
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Karen A. Borges, Thales Q. Furian, Anderlise Borsoi, Hamilton L.S. Moraes, Carlos T.P. Salle, and Vladimir P. Nascimento
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Salmonella Enteritidis ,PCR ,perfil de virulência ,frangos ,Veterinary medicine ,SF600-1100 - Abstract
Salmonella spp. are considered the main agents of foodborne disease and Salmonella Enteritidis is one of the most frequently isolated serovars worldwide. The virulence of Salmonella spp. and their interaction with the host are complex processes involving virulence factors to overcome host defenses. The purpose of this study was to detect virulence genes in S. Enteritidis isolates from poultry in the South of Brazil. PCR-based assays were developed in order to detect nine genes (lpfA, agfA, sefA, invA, hilA, avrA, sopE, sivH and spvC) associated with the virulence in eighty-four isolates of S. Enteritidis isolated from poultry. The invA, hilA, sivH, sefA and avrA genes were present in 100% of the isolates; lpfA and sopE were present in 99%; agfA was present in 96%; and the spvC gene was present in 92%. It was possible to characterize the isolates with four different genetic profiles (P1, P2, P3 and P4), as it follows: P1, positive for all genes; P2, negative only for spvC; P3, negative for agfA; and P4, negative for lpfA, spvC and sopE. The most prevalent profile was P1, which was present in 88% of the isolates. Although all isolates belong to the same serovar, it was possible to observe variations in the presence of these virulence-associated genes between different isolates. The characterization of the mechanisms of virulence circulating in the population of Salmonella Enteritidis is important for a better understanding of its biology and pathogenicity. The frequency of these genes and the establishment of genetic profiles can be used to determine patterns of virulence. These patterns, associated with in vivo studies, may help develop tools to predict the ability of virulence of different strains.
- Published
- 2013
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483. Double continuous injection preparation method of cyclodextrin inclusion compounds by spray drying
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Passos, Joel J., De Sousa, Frederico B., Mundim, Iram M., Bonfim, Ricardo R., Melo, Robson, Viana, Alice F., Stolz, Eveline D., Borsoi, Milene, Rates, Stela M.K., and Sinisterra, Rubén D.
- Published
- 2013
- Full Text
- View/download PDF
484. Cost-Effectiveness and Net Monetary Benefit of Olaparib Maintenance Therapy Versus No Maintenance Therapy After First-line Platinum-based Chemotherapy in Newly Diagnosed Advanced BRCA1/2-mutated Ovarian Cancer in the Italian National Health Service
- Author
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Armeni, P, Borsoi, L, Fornaro, G, Jommi, C, Colombo, N, Costa, F, Armeni P., Borsoi L., Fornaro G., Jommi C., Colombo N., Costa F., Armeni, P, Borsoi, L, Fornaro, G, Jommi, C, Colombo, N, Costa, F, Armeni P., Borsoi L., Fornaro G., Jommi C., Colombo N., and Costa F.
- Abstract
Purpose: The aim of this study was to evaluate the cost-effectiveness and net monetary benefit of olaparib maintenance therapy compared with no maintenance therapy after first-line platinum-based chemotherapy in newly diagnosed advanced BRCA1/2-mutated ovarian cancer from the Italian National Health Service (NHS) perspective. Methods: We developed a lifetime Markov model in which a cohort of patients with newly diagnosed advanced BRCA1/2-mutated ovarian cancer was assigned to receive either olaparib maintenance therapy or active surveillance (Italian standard of care) after first-line platinum-based chemotherapy to compare cost-effectiveness and net monetary benefit of the 2 strategies. Data on clinical outcomes were obtained from related clinical trial literature and extrapolated using parametric survival analyses. Data on costs were derived from Italian official sources and relevant real-world studies. The incremental cost-effectiveness ratio (ICER), incremental cost-utility ratio (ICUR), and incremental net monetary benefit (INMB) were computed and compared against an incremental cost per quality-adjusted life-year (QALY) gained of €16,372 willingness-to-pay (WTP) threshold. We used deterministic sensitivity analysis (DSA) and probabilistic sensitivity analysis (PSA) to assess how uncertainty affects results; we also performed scenario analyses to compare results under different pricing settings. Findings: In the base-case scenario, during a 50-year time horizon, the total costs for patients treated with olaparib therapy and active surveillance were €124,359 and €97,043, respectively, and QALYs gained were 7.29 and 4.88, respectively, with an ICER of €9,515 per life-year gained, an ICUR of €11,345 per QALY gained, and an INMB of €12,104. In scenario analyses, considering maximum selling prices for all other drugs, ICUR decreased to €11,311 per QALY and €7,498 per QALY when a 10% and 20% discount, respectively, was applied to the olaparib official price, and the I
- Published
- 2020
485. The Boom in Nanomaterials for Built Heritage Conservation: Why Does Size Matter?
- Author
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Jorge Otero, Giovanni Borsoi, and Luis Monasterio-Guillot
- Subjects
Nanoscience ,Cultural heritage conservation ,Nanotechnology ,General Materials Science ,Nanolime ,Nanomaterials - Abstract
There is no doubt that nanotechnology and nanoscience open new doors to new applications and products that can potentially revolutionize the practice field and how we conserve built heritage materials. However, we are living at the beginning of this era and the potential benefits of nanotechnology to specific conservation practice needs are not always fully understood. This opinion/review paper aims to present reflections and answer a question that we are often asked when working directly with stone field conservators: why should we use a nanomaterial instead of a conventional product? Why does size matter? To answer this question, we revise the basic concepts of nanoscience with implications for the built heritage conservation field.
- Published
- 2023
486. Scientific Advances in the Last Decade on the Recovery, Characterization, and Functionality of Bioactive Compounds from the Araticum Fruit (Annona crassiflora Mart.)
- Author
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Henrique Silvano Arruda, Felipe Tecchio Borsoi, Amanda Cristina Andrade, Glaucia Maria Pastore, and Mario Roberto Marostica Junior
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Ecology ,Plant Science ,Ecology, Evolution, Behavior and Systematics - Abstract
Araticum (Annona crassiflora Mart.) is a native and endemic species to Brazilian Cerrado whose fruits have high sensorial, nutritional, bioactive, and economic potential. Its use in local folk medicine, associated with recent scientific findings, has attracted growing interest from different industrial sectors. Therefore, understanding the scientific advances achieved so far and identifying gaps to be filled is essential to direct future studies and transform accumulated knowledge into innovative technologies and products. In this review, we summarize the phytochemical composition, bioactivities, and food products from araticum fruit that have been reported in the scientific literature over the past 10 years. The compiled data showed that araticum fruit parts contain a wide range of bioactive compounds, particularly phenolic compounds, alkaloids, annonaceous acetogenins, carotenoids, phytosterols, and tocols. These phytochemicals contribute to different biological activities verified in araticum fruit extracts/fractions, including antioxidant, anti-inflammatory, anti-Alzheimer, anticancer, antidiabetic, anti-obesity, antidyslipidemic, antinociceptive, hepatoprotective, healing of the cutaneous wound, antibacterial, and insecticide effects. Despite the promising findings, further studies—particularly toxicological (especially, with byproducts), pre-clinical, and clinical trials—must be conducted to confirm these biological effects in humans and assure the safety and well-being of consumers.
- Published
- 2023
487. GIBERELINA NA EMERGÊNCIA DE PLÂNTULAS DE MAMOEIRO CV. GOLDEN COM SEMENTES DE DIFERENTES IDADES
- Author
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Tiago Souza Savacini, Virgínia Campos De Oliveira, Antônio Carlos Borsoi Neto, Vitória Evangelista dos Santos, and Marcus Vinicius Sandoval Paixão
- Subjects
Fuel Technology ,Energy Engineering and Power Technology - Abstract
As sementes em geral possuem um período determinado para germinação e após este tempo passam a não serem viáveis para plantio. A giberelina é um hormônio que atua estimulando a germinação em sementes que apresentem algum bloqueio para germinar. Objetivou-se avaliar o efeito da giberelina na emergência e desenvolvimento inicial de plântulas de mamoeiro cultivar golden, com sementes de diferentes idades. Os tratamentos foram sementes com um ano, dois anos e 3 anos, armazenadas em geladeira (10°C). Duzentas sementes de cada idade foram imersas durante 60 minutos em solução de Giberelina ( , na dosagem de 2000 mg.L-1, e 200 de cada idade em água pura como testemunha, e semeadas em bandejas com substrato comercial. Após trinta dias do início da emergência, foi avaliado a porcentagem de emergência, o índice de velocidade de emergência e o tempo médio de emergência. Sessenta dias após o início da emergência foram avaliadas a altura da planta, número de folhas, diâmetro do coleto, comprimento da raiz, massa verde e seca das folhas e das raízes. Sementes de mamão armazenadas por até três anos germinam normalmente e possuem potencial para emergência quando submetidas a tratamento pré germinativo com giberelina.
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- 2023
488. SUBSTRATOS MINERAIS NA EMERGÊNCIA DE PLÂNTULAS DE MAMOEIRO CV ALIANÇA
- Author
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Vitória Evangelista Dos Santos, Antônio Carlos Borsoi Neto, Luiz Antônio Mota, Ednaldo Miranda De Oliveira, and Marcus Vinicius Sandoval Paixão
- Subjects
Fuel Technology ,Energy Engineering and Power Technology - Abstract
O estudo do substrato adequado é de grande importância na produção da muda para implantação de um pomar produtivo, pois fornece condições ideais para a germinação e desenvolvimento. Objetivou-se avaliar o efeito de diferentes substratos minerais na emergência e desenvolvimento inicial de plântulas de mamoeiro cultivar aliança. O experimento foi realizado em delineamento em blocos casualizados, com cinco tratamentos e quatro repetições. Foram utilizadas cinquenta sementes por repetição, e para cada avaliação foram consideradas cinco plantas de cada repetição. Os tratamentos utilizados foram compostos de terra pura, areia, perlita, vermiculita, todos na mistura de 3:1 e substrato comercial como testemunha. Após trinta dias do início da emergência foi avaliado a porcentagem de emergência, índice de velocidade de emergência e tempo médio de emergência. Noventa dias após o início da emergência foram avaliadas altura da planta, número de folhas, diâmetro do coleto, comprimento da raiz, massa verde e seca das folhas e das raízes. O substrato vermiculita apresentou os melhores desempenhos para emergência e desenvolvimento inicial de plântulas de mamoeiro CV aliança.
- Published
- 2023
489. Advances in Nanolime and Other Nanomaterials for Built Heritage Conservation
- Author
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Luis Monasterio-Guillot, Giovanni Borsoi, and Jorge Otero
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General Materials Science - Abstract
This Special Issue examines the synthesis, characterization, and manufacturing of nanoparticles and their potential advantages and applications for the conservation of built cultural heritage materials [...]
- Published
- 2023
490. Kinetic evaluation of tobacco stalk waste exposed to alkaline surface treatment under different conditions
- Author
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Cleide Borsoi, Betina Hansen, Danieli Dallé, Ademir J. Zattera, André Luis Catto, and Edson Luiz Francisquetti
- Subjects
Thermogravimetric analysis ,Polymers and Plastics ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,Crystallinity ,Synthetic fiber ,chemistry ,Chemical engineering ,Sodium hydroxide ,Thermal stability ,Hemicellulose ,Fiber ,Cellulose ,0210 nano-technology - Abstract
Lignocellulosic materials (some natural fibers) have relevant mechanical properties when incorporated in polymeric matrices, being a renewable source to replace synthetic fibers; however, for good adhesion and durability, it is necessary to modify the fibrous surface structure in order to eliminate unwanted compounds. This work aims to evaluate different conditions of alkaline treatment of tobacco stalk waste using 10 and 15 wt% sodium hydroxide (NaOH) during an exposure time of 3 or 5 h. Thermal, chemical, and morphological characterizations as well as kinetic analysis were performed. Through Fourier transform infrared spectroscopy, it was possible to identify the partial removal of compounds such as lignin, hemicellulose, and extractives, increasing the thermal stability, which was proven by thermogravimetric analysis. Furthermore, X-ray diffraction shows a higher crystallinity index from cellulose after the alkaline treatment. Through the kinetic analysis, it is possible to observe that both methods presented similar activation energy values (Ea). In addition, after the alkaline treatment there was a reduction in Ea, the most evident result being observed in the TSW\10\5 sample, which presented an average value of Ea of 223.95 ± 15.79 kJ/mol by the Flynn–Wall–Ozawa method and 218.74 ± 24.69 kJ/mol by the Friedman method. Scanning electron microscopy showed the exposure of the microfibrils and an enhancement of roughness after alkaline treatment. Tobacco stalk wastes has potential application as reinforcing filler in composite materials since surface alkaline modification provides higher fiber/matrix adhesion through the removal of amorphous compounds.
- Published
- 2021
491. Evaluation of the cytotoxic and genotoxic effects of Sida planicaulis Cav extract using human neuroblastoma cell line SH-SY5Y
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Guilherme de Souza, Cleverson Costa Feistel, Johnny Ferraz Dias, Dione Silva Corrêa, Mariana Terezinha Selbach, Juliana da Silva, Ivana Grivicich, Daiana Dalberto, Guilherme Borsoi, Paola Chytry, Amanda Souza Scotti, Alexandre de Barros Falcão Ferraz, Caroline Cardoso Nicolau, and Natália Garcia Dos Santos
- Subjects
0301 basic medicine ,SH-SY5Y ,biology ,Health, Toxicology and Mutagenesis ,Toxicology ,biology.organism_classification ,medicine.disease_cause ,Molecular biology ,Comet assay ,03 medical and health sciences ,Swainsonine ,chemistry.chemical_compound ,030104 developmental biology ,0302 clinical medicine ,chemistry ,medicine ,Cytotoxic T cell ,Sida ,Cytotoxicity ,Weed ,030217 neurology & neurosurgery ,Genotoxicity - Abstract
Sida planicaulis is a weed thought to have originated in Brazil, where it is present in abundant quantities, but also this plant is also found in south-central Florida, Indian Ocean Islands, and th...
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- 2021
492. GALERIA DE ARTE PROEX: UM ESPAÇO DE MUITAS AÇÕES CULTURAIS/ARTÍSTICAS
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Adriana R. SUAREZ, Ana Luiza R. NUNES, and Sandra BORSOI
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General Medicine - Published
- 2021
493. Evaluation of carbon fiber reinforced polymer – CFRP – machining by applying industrial robots
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Ever Grisol de Melo, Jéssica Christina dos Santos Silva, J. Polte, Jefferson de Oliveira Gomes, Eckart Uhlmann, and Tiago Borsoi Klein
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Carbon fiber reinforced polymer ,Machining process ,0209 industrial biotechnology ,Materials science ,02 engineering and technology ,cutting tools ,021001 nanoscience & nanotechnology ,machining process ,law.invention ,Industrial robot ,020901 industrial engineering & automation ,Machining ,law ,milling ,TA401-492 ,Materials Chemistry ,Ceramics and Composites ,Robot ,carbon fiber reinforced polymer ,Composite material ,0210 nano-technology ,Materials of engineering and construction. Mechanics of materials ,industrial robot - Abstract
Carbon fiber reinforced polymer (CFRP) is widely used in high-tech industries because of its interesting characteristics and properties. This material presents good strength and stiffness, relatively low density, high damping ability, good dimensional stability, and good corrosion resistance. However, the machinability of composite materials is complex because of the matrix/fiber interface, being a challenging machining material. The CFRP milling process is still necessary to meet dimensional tolerances, the manufacture of difficult-to-mold features like pockets or complexes advance surfaces, finish the edges of laminated composites, or drill holes for the assembly of the components. Besides, the demand for low-cost, reconfigurable manufacturing systems of the industry demonstrates that the application of industrial robots (IRs) in the CFRP milling process becomes an alternative for providing automation and flexibility. Therefore, the objective of this work is to evaluate the performance of the low payload IR KUKA KR60 HA in a milling experiment of CFRP, which indicates its potential application as an alternative to milling process. Furthermore, the influence of the cutting tool geometry as well as the cutting parameters in the machining behavior with IRs is evaluated.
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- 2021
494. Quantificação Semiautomática da Fração de Ejeção e Volumes do Ventrículo Esquerdo ao Ecocardiograma Bidimensional: Comparação com o Ecocardiograma Tridimensional Automático
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Rafael Borsoi, Miguel Morita Fernandes da Silva, Quanta Diagnóstico e Terapia. Curitiba, Pr, Brasil., and Silvio Henrique Barberato
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General Medicine - Abstract
Fundamento: A fração de ejeção do ventrículo esquerdo é um dos parâmetros ecocardiográficos mais utilizados na prática clínica. Sua estimativa pelo método bidimensional manual (método de Simpson) tem reprodutibilidade e acurácia limitadas, e métodos semiautomáticos têm sido propostos. Torna-se necessário comparar o método bidimensional semiautomático com métodos mais acurados de avaliação da fração de ejeção do ventrículo esquerdo, como a medida pela ecocardiografia tridimensional automática. Objetivo: Comparar as estimativas da fração de ejeção do ventrículo esquerdo e dos volumes diastólico final e sistólico final do ventrículo esquerdo pelo método bidimensional semiautomático com as obtidas pelo método tridimensional automático. Método: Estudo observacional transversal, com pacientes em ritmo sinusal, fração de ejeção do ventrículo esquerdo >50% e sem cardiopatia estrutural significativa, submetidos ao ecocardiograma transtorácico. Teste t de Student, coeficiente de Pearson e análise de Bland-Altman foram usados na análise estatística. Resultados: Foram incluídos 40 pacientes, sendo: 53% mulheres, 35% hipertensos, 25% dislipidêmicos, 10% diabéticos, 10% tabagistas e 13% com angioplastia prévia. Os valores médios da fração de ejeção do ventrículo esquerdo aos métodos tri e bidimensionais foram 62,1 ± 5,8% e 61,7 ± 5,9% (p = 0,50), respectivamente. Houve forte correlação da fração de ejeção do ventrículo esquerdo determinada melos métodos bi e tridimensional (r = 0,74; p
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- 2020
495. Phytochemical profiling, antidiabetic, antitumoral and cytotoxic potential of
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Yasmine de Melo, Barradas, Felipe Tecchio, Borsoi, Marina Volpato, Dacoreggio, Liziane Schittler, Moroni, Beatriz da, Silva Rosa Bonadiman, Filomena, Marafon, Clevison Luiz, Giacobbo, Margarete Dulce, Bagatini, and Aniela Pinto, Kempka
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In this study, phytochemical profiling, and antidiabetic, antitumoral and cytotoxic potential of aqueous extracts of leaves of red variety of
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- 2022
496. Online Multi-resolution Fusion of Space-borne Multispectral Images
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Haoqing Li, Bhavya Duvvuri, Ricardo Borsoi, Tales Imbiriba, Edward Beighley, Deniz Erdogmus, and Pau Closas
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Image and Video Processing (eess.IV) ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,FOS: Electrical engineering, electronic engineering, information engineering ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
Satellite imaging has a central role in monitoring, detecting and estimating the intensity of key natural phenomena. One important feature of satellite images is the trade-off between spatial/spectral resolution and their revisiting time, a consequence of design and physical constraints imposed by satellite orbit among other technical limitations. In this paper, we focus on fusing multi-temporal, multi-spectral images where data acquired from different instruments with different spatial resolutions is used. We leverage the spatial relationship between images at multiple modalities to generate high-resolution image sequences at higher revisiting rates. To achieve this goal, we formulate the fusion method as a recursive state estimation problem and study its performance in filtering and smoothing contexts. The proposed strategy clearly outperforms competing methodologies, which is shown in the paper for real data acquired by the Landsat and MODIS instruments., Comment: Published in IEEE AeroConf 2022
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- 2022
497. Medical Students' Knowledge about Alcohol and Drug Problems: Results of the Medical Council of Canada Examination
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Kahan, Meldon, Midmer, Deana, Wilson, Lynn, and Borsoi, Diane
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Purpose: To determine knowledge of a national sample of medical students about substance withdrawal, screening and early intervention, medical and psychiatric complications of addiction, and treatment options. Methods: Based on learning objectives developed by medical faculty, twenty-two questions on addictions were included in the 1998 Canadian licensing examination. Results: The exam was written by 858 medical students. The average score on the addiction questions was 64%. Students showed strong knowledge of the clinical features of medical complications. Specific knowledge gaps were identified for withdrawal treatment protocols, low-risk drinking guidelines, taking an alcohol history, substance-induced psychiatric disorders, and Alcoholics Anonymous. Conclusion: Medical students are knowledge-deficient around key learning objectives in addictions. The deficiencies were in areas of basic knowledge that could be learnt with little difficulty. (Contains 3 tables.)
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- 2006
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498. Spin-Mixing Enhanced Proximity Effect in Aluminum-Based Superconductor–Semiconductor Hybrids
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Mazur, G.P. (author), van Loo, N. (author), Wang, J. (author), Dvir, T. (author), Wang, Guanzhong (author), Korneychuk, S. (author), Borsoi, F. (author), Dekker, R.C. (author), Badawy, G.H.A. (author), Vinke, Peter (author), Quintero Perez, M. (author), Heedt, S. (author), Kouwenhoven, Leo P. (author), Mazur, G.P. (author), van Loo, N. (author), Wang, J. (author), Dvir, T. (author), Wang, Guanzhong (author), Korneychuk, S. (author), Borsoi, F. (author), Dekker, R.C. (author), Badawy, G.H.A. (author), Vinke, Peter (author), Quintero Perez, M. (author), Heedt, S. (author), and Kouwenhoven, Leo P. (author)
- Abstract
In superconducting quantum circuits, aluminum is one of the most widely used materials. It is currently also the superconductor of choice for the development of topological qubits. However, aluminum-based devices suffer from poor magnetic field compatibility. Herein, this limitation is resolved by showing that adatoms of heavy elements (e.g., platinum) increase the critical field of thin aluminum films by more than a factor of two. Using tunnel junctions, it is shown that the increased field resilience originates from spin-orbit scattering introduced by Pt. This property is exploited in the context of the superconducting proximity effect in semiconductor–superconductor hybrids, where it is shown that InSb nanowires strongly coupled to Al/Pt films can maintain superconductivity up to 7 T. The two-electron charging effect is shown to be robust against the presence of heavy adatoms. Additionally, non-local spectroscopy is used in a three-terminal geometry to probe the bulk of hybrid devices, showing that it remains free of sub-gap states. Finally, it is demonstrated that proximitized semiconductor states maintain their ability to Zeeman-split in an applied magnetic field. Combined with the chemical stability and well-known fabrication routes of aluminum, Al/Pt emerges as the natural successor to Al-based systems and is a compelling alternative to other superconductors, whenever high-field resilience is required., QRD/Kouwenhoven Lab, QCD/Veldhorst Lab, QN/Steele Lab, BUS/Quantum Delft, QN/Kouwenhoven Lab
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- 2022
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499. Disability weights for castration-resistant prostate cancer: an empirical investigation
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Borsoi, Ludovica, Ciani, Oriana, De Vivo, Rocco, Russo, Giorgio Ivan, Scarcia, Marcello, De Fino, Chiara, Beccaglia, Patrizia, Luccarini, Irene, Borsoi, Ludovica, Ciani, Oriana, De Vivo, Rocco, Russo, Giorgio Ivan, Scarcia, Marcello, De Fino, Chiara, Beccaglia, Patrizia, and Luccarini, Irene
- Abstract
Introduction: Health state valuation and diagnostic-therapeutic pathways at the junction between non-metastatic and metastatic castration-resistant prostate cancer (CRPC) are not well documented. We aimed at: (i) estimating the disability weights (DWs) for health states across a continuum of disease from asymptomatic non-metastatic (nmCRPC) to symptomatic metastatic state (mCRPC); (ii) mapping the diagnostic-therapeutic pathway of nmCRPC in Italy. Methods: Structured qualitative interviews were performed with clinical experts to gather information on nmCRPC clinical pathway. An online survey was administered to clinical experts to estimate DWs for four CRPC health states defined from interviews and literature review (i.e., nmCRPC, asymptomatic mCRPC, symptomatic mCRPC, mCRPC in progression during or after chemotherapy). Clinicians’ preferences for health states were elicited using the Person-Trade-Off (PTO) and Visual Analogue Scale (VAS) methods. DWs associated with each health state, from 0 (best imaginable health state) and 1 (worst imaginable health state), were estimated. Results: We found that the management of nmCRPC is heterogeneous across Italian regions and hospitals, especially with respect to diagnostic imaging techniques. DWs for PTO ranged from 0.415 (95% confidence interval [CI] 0.208-0.623) in nmCRPC to 0.740 (95% CI 0.560-0.920) in mCRPC, in progression during or after chemotherapy. DWs for VAS ranged between 0.246 (95% CI 0.131-0.361) in nmCRPC to 0.689 (95% CI 0.583-0.795) in mCRPC, in progression during or after chemotherapy. Conclusions: Estimated DWs suggest that delaying transition to a metastatic state might ease the disease burden at both patient and societal levels.
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- 2022
500. Parametric exploration of zero-energy modes in three-terminal InSb-Al nanowire devices
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Wang, Ji Yin (author), van Loo, N. (author), Mazur, G.P. (author), Levajac, V. (author), Malinowski, F.K. (author), Lemang, M.F. (author), Borsoi, F. (author), Badawy, G.H.A. (author), Quintero Perez, M. (author), Heedt, S. (author), Kouwenhoven, Leo P. (author), Wang, Ji Yin (author), van Loo, N. (author), Mazur, G.P. (author), Levajac, V. (author), Malinowski, F.K. (author), Lemang, M.F. (author), Borsoi, F. (author), Badawy, G.H.A. (author), Quintero Perez, M. (author), Heedt, S. (author), and Kouwenhoven, Leo P. (author)
- Abstract
We systematically study three-terminal InSb-Al nanowire devices by using radio-frequency reflectometry. Tunneling spectroscopy measurements on both ends of the hybrid nanowires are performed while systematically varying the chemical potential, magnetic field, and junction transparencies. Identifying the lowest-energy state allows for the construction of the lowest- and zero-energy state diagrams, which show how the states evolve as a function of the aforementioned parameters. Importantly, comparing the diagrams taken for each end of the hybrids enables the identification of states which do not coexist simultaneously, ruling out a significant amount of the parameter space as candidates for a topological phase. Furthermore, altering junction transparencies filters out zero-energy states sensitive to a local gate potential. Such a measurement strategy significantly reduces the time necessary to identify a potential topological phase and minimizes the risk of falsely recognizing trivial bound states as Majorana zero modes., QRD/Kouwenhoven Lab, BUS/Quantum Delft, QN/Afdelingsbureau, QCD/Veldhorst Lab, QN/Kouwenhoven Lab
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- 2022
- Full Text
- View/download PDF
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