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6. Antibiotic treatment for 6 weeks versus 12 weeks in patients with pyogenic vertebral osteomyelitis: an open-label, non-inferiority, randomised, controlled trial

Author

Bernard, Louis, Dinh, Aurélien, Ghout, Idir, Simo, David, Zeller, Valerie, Issartel, Bertrand, Le Moing, Vincent, Belmatoug, Nadia, Lesprit, Philippe, Bru, Jean-Pierre, Therby, Audrey, Bouhour, Damien, Dénes, Eric, Debard, Alexa, Chirouze, Catherine, Fèvre, Karine, Dupon, Michel, Aegerter, Philippe, and Mulleman, Denis

Published
2015
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7. Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018)

Author

Bretagne, Stéphane, Sitbon, Karine, Desnos-Ollivier, Marie, Garcia-Hermoso, Dea, Letscher-Bru, Valérie, Cassaing, Sophie, Millon, Laurence, Morio, Florent, Gangneux, Jean-Pierre, Hasseine, Lilia, Favennec, Loïc, Cateau, Estelle, Bailly, Eric, Moniot, Maxime, Bonhomme, Julie, Desbois-Nogard, Nicole, Chouaki, Taieb, Paugam, André, Bouteille, Bernard, Pihet, Marc, Dalle, Frédéric, Eloy, Odile, Sasso, Milène, Demar, Magalie, Mariani-Kurkdjian, Patricia, Robert, Vincent, Lortholary, Olivier, Dromer, Françoise, French Mycoses Study Group, The, Damiani, Céline, Dupont, Hervé, Maizel, Julien, Totet, Anne, Bouchara, Jean-Philippe, Bellanger, Anne Pauline, Berceanu, Ana, Navellou, Jean Christophe, Scherer, Emeline, Abboud, Philippe, Aznar, Christine, Blanchet, Denis, Djossou, Félix, Cayot, Sophie, Garrouste, Cyril, Lesens, Olivier, Moluçon, Cécile, Nourrisson, Céline, Poirier, Philippe, Bailly, Éloïse, Basmaciyan, Louise, Belaid, Bouhemad, Blot, Mathieu, Caillot, Denis, Charles, Pierre-Emmanuel, Quenot, Jean Pierre, Amazan, Emmanuelle, Baubion, Emilie, Cabie, André, Chabartier, Cyrille, Deligny, Christophe, Emal, Violaine, Flechelle, Olivier, Hatchuel, Yves, Le Govic, Yohann, Merle, Harold, Miossec, Charline, Turmel, Jean-Marie, Valentino, Ruddy, Durieux, Marie-Fleur, Turlure, Pascal, Mercier, Victor, Gari-Toussaint, Martine, Risso, Karine, Simon, Loïc, Bretonnière, Cedric, Boutoille, David, Gastinne, Thomas, Lakhal, Karim, Launay, Elise, Lepoivre, Thierry, Peterlin, Pierre, Rialland, Fanny, Le Pape, Patrice, Canoui, Etienne, Dahane, Naima, Kerneis, Solène, Angebault, Cécile, Bougnoux, Marie-Elisabethh, Guennouni, Nadia, Lanternier, Fanny, Neven, Bennedicte, Oualha, Mehdi, Scemla, Anne, Sitterlé, Emilie, Suarez, Felipe, Toubiana, Julie, Bonacorci, Stéphane, Alanio, Alexandre, Bergeron, Anne, Denis, Blandine, Gits-Muselli, Maud, Hamane, Samia, Touratier, Sophie, Chaumeil, Christine, Merabet, Lilia, Claudéon, Joelle, Curlier, Elodie, Galantine, Valérie, Gallois, Jean Claude, Markowicz, Samuel, Nicolas, Muriel, Musson, Pascal, Schepers, Kinda, Minoza, Alida, Kauffmann-Lacroix, Catherine, Guégan, Hélène, Costa, Damien, Dehais, Marion, Gargala, Gilles, Bajolet, Odile, Banisadr, Firouze, Cousson, Joel, Himberlin, Chantal, Huguenin, Antoine, Toubas, Dominique, Flori, Pierre, Mahinc, Caroline, Raberin, Hélène, Denis, Julie, Herbrecht, Raoul, Mertes, Paul-Michel, Meziani, Fehrat, Sabou, Marcela, Schneider, Francis, Bertozzi, Anne-Isabelle, Chauvin, Pamela, Charpentier, Elena, Cointault, Olivier, Cottrel, Claire, Delavigne, Karen, Faguer, Stanislas, Fillaux, Judith, Guemas, Emilie, Iriart, Xavier, Lelièvre, Lucie, Ruiz, Jean, Bastides, Frédéric, Chesnay, Adélaïde, Desoubeaux, Guillaume, Therby, Audrey, Chachaty, Elisabeth, Gachot, Bertrand, Westerdijk Fungal Biodiversity Institute, Westerdijk Fungal Biodiversity Institute - Software and Databasing, Mycologie moléculaire - Molecular Mycology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals (CNRMA), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Dynamique des interactions hôte pathogène (DIHP), Université de Strasbourg (UNISTRA), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Nantes Université (Nantes Univ), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Universitaire de Nice (CHU Nice), CHU Rouen, Normandie Université (NU), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Ecologie et biologie des interactions (EBI), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHU Clermont-Ferrand, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), CHU de la Martinique [Fort de France], CHU Amiens-Picardie, Hôpital Cochin [AP-HP], CHU Limoges, SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques (ICAT), Université d'Angers (UA), Laboratoire de Parasitologie-Mycologie (CHU d'Angers), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Infections Respiratoires Fongiques (IRF), Université d'Angers (UA)-Université de Brest (UBO), Procédés Alimentaires et Microbiologiques [Dijon] (PAM), Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Centre Hospitalier de Versailles André Mignot (CHV), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Hôpital Robert Debré Paris, Hôpital Robert Debré, Westerdijk Fungal Biodiversity Institute [Utrecht] (WI), Royal Netherlands Academy of Arts and Sciences (KNAW), Service des Maladies infectieuses et tropicales [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 (AGIR ), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Simplification des soins chez les patients complexes - UR UPJV 7518 (SSPC), Université de Picardie Jules Verne (UPJV), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Laboratoire de Parasitologie-Mycologie [CHU Angers], Hôpital Bretonneau, Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by recurrent financial support from Santé Publique France and Institut Pasteur. The funders had no role in study design, data collection, analysis, interpretation of data, or the decision to submit the work for publication., We thank Didier Che (Direction des Maladies Infectieuses, Santé Publique France) for his continuous support and interest in invasive fungal infections and Etienne Sevin (EpiConcept, Paris, France) for his contribution in the development of the RESSIF website using the VOOZANOO platform. We are thankful for the technical help of Catherine Blanc, Anne Boullié, Cécile Gautier, Virginie Geolier, and Damien Hoinard (Institut Pasteur) for the characterization of the isolates received at the NRCMA., The French Mycoses Study Group includes collaborators who contributed to these data by their involvement in the management of patients, expertise in diagnostic tools, and/or characterization of fungal isolates. They are listed in alphabetical order of a city in France and for each center, in alphabetical order of the last names: in Amiens, Céline Damiani, Hervé Dupont, Julien Maizel, and Anne Totet, in Angers, Jean-Philippe Bouchara, in Besançon, Anne Pauline Bellanger, Ana Berceanu, Jean Christophe Navellou, and Emeline Scherer, in Cayenne, Philippe Abboud, Christine Aznar, Denis Blanchet, and Félix Djossou, in Clermont-Ferrand, Sophie Cayot, Cyril Garrouste, Olivier Lesens, Cécile Moluçon, Céline Nourrisson, and Philippe Poirier, in Dijon, Éloïse Bailly, Louise Basmaciyan, Bouhemad Belaid, Mathieu Blot, Denis Caillot, Pierre-Emmanuel Charles, and Jean Pierre Quenot, in Fort de France, Emmanuelle Amazan, Emilie Baubion, André Cabie, Cyrille Chabartier, Christophe Deligny, Violaine Emal, Olivier Flechelle, Yves Hatchuel, Yohann Le Govic, Harold Merle, Charline Miossec, Jean-Marie Turmel, and Ruddy Valentino, in Limoges, Marie-Fleur Durieux and Pascal Turlure, in Nîmes, Victor Mercier, in Nice, Martine Gari-Toussaint, Karine Risso, and Loïc Simon, in Nantes, Cedric Bretonnière, David Boutoille, Thomas Gastinne, Karim Lakhal, Elise Launay, Thierry Lepoivre, Pierre Peterlin, Fanny Rialland, and Patrice Le Pape, in Paris, in Hôpital Cochin, Etienne Canoui, Naima Dahane, and Solène Kerneis, in Hôpital Necker-Enfants Malades, Cécile Angebault, Marie-Elisabethh Bougnoux, Nadia Guennouni, Fanny Lanternier, Bennedicte Neven, Mehdi Oualha, Anne Scemla, Emilie Sitterlé, Felipe Suarez, and Julie Toubiana, in Hôpital Robert-Debré, Stéphane Bonacorci, in Hôpital Saint-Louis, Alexandre Alanio, Anne Bergeron, Blandine Denis, Maud Gits-Muselli, Samia Hamane, and Sophie Touratier, in hôpital des XV-XX, Christine Chaumeil and Lilia Merabet, in Pointe-à-Pitre, Joelle Claudéon, Elodie Curlier, Valérie Galantine, Jean Claude Gallois, Samuel Markowicz, Muriel Nicolas, Pascal Musson, and Kinda Schepers, in Poitiers, Alida Minoza and Catherine Kauffmann-Lacroix, in Rennes, Hélène Guégan, in Rouen, Damien Costa, Marion Dehais, and Gilles Gargala, in Reims, Odile Bajolet, Firouze Banisadr, Joel Cousson, Chantal Himberlin, Antoine Huguenin, and Dominique Toubas, in Saint Etienne, Pierre Flori, Caroline Mahinc, and Hélène Raberin, in Strabourg, Julie Denis, Raoul Herbrecht, Paul-Michel Mertes, Fehrat Meziani, Marcela Sabou, and Francis Schneider, in Toulouse, Anne-Isabelle Bertozzi, Pamela Chauvin, Elena Charpentier, Olivier Cointault, Claire Cottrel, Karen Delavigne, Stanislas Faguer, Judith Fillaux, Emilie Guemas, Xavier Iriart, Lucie Lelièvre, and Jean Ruiz, in Tours, Frédéric Bastides, Adélaïde Chesnay, and Guillaume Desoubeaux, in Versailles, Audrey Therby, and in Villejuif, Elisabeth Chachaty and Bertrand Gachot., and CLEMENT, Nathalie

Subjects
Antifungal Agents, pneumocytosis, invasive fungal infections, Pneumonia, Pneumocystis, [SDV]Life Sciences [q-bio], candidemia, Microbiology, [SDV.MP.MYC] Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, mucormycosis, [SDV] Life Sciences [q-bio], [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Virology, Humans, aspergillosis, epidemiology, Watchful Waiting, Fungemia, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, Aged
Abstract

International audience; The French National Reference Center for Invasive Mycoses and Antifungals leads an active and sustained nationwide surveillance program on probable and proven invasive fungal diseases (IFDs) to determine their epidemiology in France. Between 2012 and 2018, a total of 10,886 IFDs were recorded. The incidence increased slightly over time (2.16 to 2.36/10,000 hospitalization days, P = 0.0562) in relation with an increase of fungemia incidence (1.03 to 1.19/10,000, P = 0.0023), while that of other IFDs remained stable. The proportion of ≥65-year-old patients increased from 38.4% to 45.3% (P < 0.0001). Yeast fungemia (n = 5,444) was due mainly to Candida albicans (55.6%) with stable proportions of species over time. Echinocandins became the main drug prescribed (46.7% to 61.8%), but global mortality rate remained unchanged (36.3% at 1 month). Pneumocystis jirovecii pneumonia (n = 2,106) was diagnosed mostly in HIV-negative patients (80.7%) with a significantly higher mortality than in HIV-positive patients (21.9% versus 5.4% at 1 month, P < 0.0001). Invasive aspergillosis (n = 1,661) and mucormycosis (n = 314) were diagnosed mostly in hematology (>60% of the cases) with a global mortality rate of 42.5% and 59.3%, respectively, at 3 months and significant changes in diagnosis procedure over time. More concurrent infections were also diagnosed over time (from 5.4% to 9.4% for mold IFDs, P = 0.0115). In conclusion, we observed an aging of patients with IFD with a significant increase in incidence only for yeast fungemia, a trend toward more concurrent infections, which raises diagnostic and therapeutic issues. Overall, global survival associated with IFDs has not improved despite updated guidelines and new diagnostic tools.IMPORTANCE The epidemiology of invasive fungal diseases (IFDs) is hard to delineate given the difficulties in ascertaining the diagnosis that is often based on the confrontation of clinical and microbiological criteria. The present report underlines the interest of active surveillance involving mycologists and clinicians to describe the global incidence and that of the main IFDs. Globally, although the incidence of Pneumocystis pneumonia, invasive aspergillosis, and mucormycosis remained stable over the study period (2012 to 2018), that of yeast fungemia increased slightly. We also show here that IFDs seem to affect older people more frequently. The most worrisome observation is the lack of improvement in the global survival rate associated with IFDs despite the increasing use of more sensitive diagnostic tools, the availability of new antifungal drugs very active in clinical trials, and a still low/marginal rate of acquired in vitro resistance in France. Therefore, other tracks of improvement should be investigated actively.

Published
2022
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8. Les urgences infectieuses en urologie

Author

A. Therby, C. Le Goux, F. Bruyère, Maxime Vallée, Romain Boissier, P.H. Savoie, A. Dihn, E. Seizilles de Mazancourt, Albert Sotto, and J.-A. Long

Subjects
Gynecology, medicine.medical_specialty, business.industry, Urology, medicine, business
Abstract

Resume Objectif Rapporter la nature, les strategies diagnostiques et therapeutiques des urgences infectieuses en urologie. Materiel et methode Recherche bibliographique a partir de Pubmed, Embase et Google Scholar en juillet 2021. Synthese des recommandations nationales du comite d’infectiologie de l’AFU (CIAFU) et de la Societe de Pathologies Infectieuses de Langue Francaise (SPILF). Resultats L’urosepsis et sepsis urinaire grave repondent a des criteres diagnostiques stricts. La prise en charge infectieuse diagnostique et therapeutique des pyelonephrites graves, infections urinaires masculines graves, infections urinaires associees aux soins, candiduries symptomatiques et infections urinaires chez la personne âgee sont decrites. L’antibiotherapie doit etre adaptee a la gravite, l’ecologie bacterienne, aux particularites du patient et au site d’infection. Conclusion Les infections urinaires peuvent etre graves et necessitent une prise en charge en urgence. La connaissance des recommandations et des strategies diagnostiques et therapeutiques adaptees aux diverses presentations permet une optimisation de la prise en charge qui doit etre la plus rapide possible, et collegiale.

Published
2021
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9. FUrTIHF: French urinary tract infections in healthcare facilities – five-year historic cohort (2014–2018)

Author

Leslie Grammatico-Guillon, A. Therby, S. de Lafforest, Maxime Vallée, F. Bruyère, C. Le Goux, Fabien Saint, E. Bey, A. Magnier, Jean-Ralph Zahar, and Albert Sotto

Subjects
Adult, Male, Microbiology (medical), Pediatrics, medicine.medical_specialty, Urinary system, Prostatitis, urologic and male genital diseases, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Health care, medicine, Humans, Acute Cystitis, 030212 general & internal medicine, 0303 health sciences, Pyelonephritis, 030306 microbiology, business.industry, Incidence (epidemiology), Gold standard, Infant, General Medicine, medicine.disease, female genital diseases and pregnancy complications, Confidence interval, 3. Good health, Hospitalization, Infectious Diseases, Urinary Tract Infections, Cohort, Female, business, Delivery of Health Care
Abstract

Summary Background Urinary tract infections (UTIs) are common and diverse. Even when not severe, UTIs regularly lead to hospitalization, but their hospital burden remains unknown. This study aimed to estimate the national incidence of hospitalized UTIs in France. Methods A historic five-year cohort of adult patients hospitalized with UTIs in France was extracted from the medico-administrative databases using an ICD-10 code algorithm built by a multidisciplinary team. The performance parameters were estimated blindly, by reviewing 1122 cases, using medical reports as the gold standard, giving a global predictive positive value of 70.4% (95% confidence interval 66.6–74.1). The national incidence of UTIs was then estimated. Results A total of 2,083,973 patients with UTIs were hospitalized over the period, giving an adjusted incidence rate of ∼900 cases/100,000 inhabitants, stable over the period, higher in females and increasing with age; 1.2% were device-associated UTIs. Unspecific acute cystitis represented almost two-thirds of cases (63.5%); followed by pyelonephritis (23.6%) and prostatitis (12.4%). More than three-quarters of patients had at least one comorbid condition (76.8%). Conclusions This national cohort study is the first to date to estimate the incidence of UTI-related hospitalizations in France. UTIs represent a substantial burden of care. Further analysis will provide data for more informed goal-of-care discussions targeting each type of UTI, their management and outcomes.

Published
2021
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11. Correction to: Imported falciparum malaria in adults: host- and parasite-related factors associated with severity. The French prospective multicenter PALUREA cohort study

Author

Bruneel, Fabrice, Tubach, Florence, Mira, Jean-Paul, Houze, Sandrine, Gibot, Sebastien, Huisse, Marie-Genevieve, Megarbane, Bruno, Choquet, Christophe, Corne, Philippe, Peytel, Eric, Villers, Daniel, Camus, Christophe, Bouchaud, Olivier, Caumes, Eric, Girard, Pierre-Marie, Simon, Fabrice, Kalloumeh, Antoine, Roy, Carine, Durand, Remy, Le Bras, Jacques, Matheron, Sophie, Wolff, Michel, Mourvillier, B., Aubron, C., Bouadma, L., Regnier, B., d’Ortenzio, E., Matra, R., Bouvet, E., Tourret, J., Dorchies, J., Males, S., Rioux, C., Flicoteaux, R., Yeni, P., Spingler, F., Kargougou, E., Casalino, E., Ollivier, V., Grandchamp, B., Miri, Y., Fresnoy, E., Grelon, F., Asfar, P., Kouatchet, A., Mercat, A., Joly-Guillou, M. L., Kempf, M., Eveillard, M., Daoudal, P., Royer, A., Runge, I., Mathonnet, A., Boulain, T., Bret, L., Hocqueloux, L., Segalin, J. M., Mille, C., Niang, M., Prazuck, T., Fortin, M., Schortgen, F., Brun Buisson, C., Botterel, F., Bretagne, S., Leroy, O., Georges, H., Meybeck, A., Guery, B., Patoz, P., Dhennain, C., Chakarian, D., Azougagh, K., Bonmarchand, G., Abboud, P., Favennec, L., Lemeland, J. F., Petrognani, R., Nau, A., Puidupin, A., Carpentier, J. P., Garnotel, E., Moalic, J. L., Tual, L., Amathieu, R., Dhonneur, G., N’Diaye, M., Jeantils, V., Chassaignon, C., Guillerm, A. L., Riche, D., Javaud, N., Pevirieri, F., Benkel, J., Luis, D., Bon, M. C., Lenoir, G., Bernot, B., Collignon, A., Bemba, D., Poilane, I., Trouillet, J. L., Luyt, C. E., Mirabel, M., Chastre, J., Hochedez, P., Perignon, A., Thellier, M., Danis, M., Faussart, A., Nafziger, J., Gastinne, H., Pichon, N., Ajzenberg, D., Darde, M. L., Jacobs, F., Brivet, F., Veyradier, A., Marfaing-Koka, A., Timsit, J. F., Hammer, L., Maubon, D., Pelloux, H., Pene, F., Charpentier, J., Marque, S., Rousseau, C., Guezennec, P., Troche, G., Bedos, J. P., Eloy, O., Palette, C., Therby, A., Monnier, S., Greder-Bellan, A., Cougot, P., Kuteifan, K., Mootien, Y., Guiot, P., Delarbre, J. M., Kiefer, M. H., Page, B., Vieillard Baron, A., Dunand, J., Loubieres, Y., Ricome, J. L., Peltier, J. Y., Giudicelli, Y., Pelletier, C., Rousseau, J. M., Imbert, P., Rapp, C., Mechai, F., Barruet, R., Debord, T., Pilo, J. E., Cavallo, J. D., Angles, O., Genestal, M., Bretonnière, C., Nicolet, L., Jalin, L., Talarmin, J. P., Grossi, O., Raffi, F., Gay-Andrieu, F., Bompoil, T., Gros, A., Le Tulzo, Y., Revest, M., Fily, F., Chapplain, J. M., Tattevin, P., Michelet, C., Chevrier, S., Guigen, C., Baud, F., Launay, J. M., Gourmel, C., Derouin, F., de Miranda, S., Thiery, G., Legriel, S., Azoulay, E., Schlemmer, B., Colin de Verdieres, N., Lagrange-Xelot, M., Gallien, S., De Castro, N., Pavie, J., Lafaurie, M., Molina, J. M., Sarfati, C., Derouin, F., Jonquet, P., Schved, J. F., Biron, C., Bret, C., Klouche, K., Beraud, P., Cristol, J. P., Gruson, D., Herpe, B., Delacre, M., Castaing, Y., Fialon, P., Vincendeau, P., Vincent, F., Karoubi, P., Cohen, Y., Cordel, H., Prendki, V., Cailhol, J., Abgrall, S., Gros, H., Fantinato, C., Cymbalista, F., Senghor, Y., Memain, N., Thuong, M., Adrie, C., Darques, L., Moret, G., Fraisse, F., Godineau, N., Chaplain, C., Prevel, M., Mary, R. J., Plantefeve, G., Bleichner, G., Mentec, H., Leturdu, F., Hyvernat, H., Bernardin, G., Delaunay, P., Marty, P., Baudel, J. L., Maury, E., Offenstadt, G., Meynard, J. L., Pacanowski, J., Ouazene, Z., Bollens, D., Meyohas, M. C., Fonquerine, L., Belkadi, G., Magne, D., Roux, P., Rusel, L., Ricard, J. D., Dreyfuss, D., Mortier, E., Vinceneux, P., Bloch, M., Galeazzi, G., Charbonneau, P., Duhamel, C., Leclercq, R., Delassus, J. L., Malbec, D., Lusina, D., Broutier, H., Charlier, C., Lanternier, F., Coignard, H., Lortholary, O., Bougnoux, M. E., Consigny, P. H., Simons de Fanti, A., Leguern, A. S., Massin, F., and The PALUREA Study Group

Published
2017
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12. Pyogenic vertebral osteomyelitis of the elderly: Characteristics and outcomes.

Author

Johan Courjon, Adrien Lemaignen, Idir Ghout, Audrey Therby, Nadia Belmatoug, Aurélien Dinh, Guillaume Gras, Louis Bernard, and DTS (Duration of Treatment for Spondylodiscitis) study group

Subjects
Medicine, Science
Abstract

The incidence of pyogenic vertebral osteomyelitis (PVO) has increased over the past two decades. One possible cause of this increase is the aging of the population, which results in more comorbidities in high income countries.To better characterize the clinical presentation and outcome of PVO in the elderly.We conducted a post-hoc analysis of a previously published trial that studied treatment duration in PVO and compared the presentation and outcomes according to age.Our analysis included 351 patients among whom 85 (24%) were 75-years-old or more.There were no significant differences in the socio-demographics of the patients. Neoplasia and chronic inflammatory diseases were more common in the older group: 34% vs. 19% (p = 0.021) and 9% versus 1% (p = 0.004), respectively. There were no significant differences in clinical and radiological presentations between the groups in terms of back pain (337/351, 97%), fever (182/351, 52%), PVO localization, neurological signs and epidural abscess. Associated infective endocarditis (IE) was more frequent in the older group (37% vs. 14%, p

Published
2017
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13. Characteristics of SARS-CoV-2 infection in lymphoma/chronic lymphocytic leukemia patients during the Omicron outbreak

Author

Milena Kohn, Tamim Alsuliman, Sylvain Lamure, Morgane Cheminant, Jéremy Delage, Corinne Merle De Boever, Jean Jacques Tudesq, Zora Marjanovic, Zoé Van de Wyngaert, Florent Malard, Eolia Brissot, Sophie Rigaudeau, Stéphanie Marque-Juillet, Audrey Therby, Guillaume Cartron, Philippe Rousselot, Olivier Hermine, Rémy Duléry, and Caroline Besson

Subjects
Cancer Research, Oncology, Lymphoma, SARS-CoV-2, Humans, COVID-19, Hematology, Leukemia, Lymphocytic, Chronic, B-Cell, Disease Outbreaks
Published
2022

15. Characteristics of SARS-CoV-2 infection in lymphoma/chronic lymphocytic leukemia patients during the Omicron outbreak

Author

Kohn, Milena, primary, Alsuliman, Tamim, additional, Lamure, Sylvain, additional, Cheminant, Morgane, additional, Delage, Jéremy, additional, Merle De Boever, Corinne, additional, Tudesq, Jean Jacques, additional, Marjanovic, Zora, additional, Van de Wyngaert, Zoé, additional, Malard, Florent, additional, Brissot, Eolia, additional, Rigaudeau, Sophie, additional, Marque-Juillet, Stéphanie, additional, Therby, Audrey, additional, Cartron, Guillaume, additional, Rousselot, Philippe, additional, Hermine, Olivier, additional, Duléry, Rémy, additional, and Besson, Caroline, additional

Published
2022
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16. Place des aminosides en urologie

Author

Maxime Vallée, F. Bruyère, S. Malavaud, G. Cariou, V. Cattoir, Fabien Saint, Par le Comité d’infectiologie de l’Association française d’urologie, E. Bey, A. Therby, Albert Sotto, C. Le Goux, and P. Arnaud

Subjects
0301 basic medicine, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Urology, 030106 microbiology
Abstract

Resume Les aminosides sont une classe d’antibiotiques que tout urologue doit savoir utiliser dans sa pratique courante. Ils sont a reserver essentiellement aux cas d’infections urinaires severes, d’obstruction de la voie excretrice superieure et aux situations d’allergies notamment aux β-lactamines. Il est actuellement recommande de privilegier les traitements de courte duree et a posologie elevee. L’objectif est de maintenir leur efficacite liee a leurs caracteristiques pharmacologiques et au faible taux de resistance bacterienne tout en se premunissant de toxicites potentiellement graves pour le patient.

Published
2020
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17. Les auteurs

Author

Alexandra Benachi, Dominique Luton, Laurent Mandelbrot, Olivier Picone, Hélène Affres, Nadine Ajzenberg, Laurence Amar, Pascale Amate, Djillali Annane, Rana Aoun, Elie Azria, Rakiba Belkhir, Ivan Berlin, Jacques Bernuau, Emmanuel Boleslawski, Claire Bonneau, Marie Bornes, Yoram Bouhnik, Corinne Bouteloup, Elisabeth Bouvet, Dominique Brémond-Gignac, Arnaud Bresset, Florence Bretelle, Léopoldine Bricaire, Marie Bruyère, Julie Carrara, Pierre-François Ceccaldi, Philippe Chanson, Sophie Chauvet, Bernard Clair, Élodie Clouqueur, Sarah Cohen, Chloé Comarmond-Ortoli, Jacqueline Conard, Sophie Conquy, Henri Copin, Anne-Gaël Cordier, Sophie Cordiez, Sarah Coscas, Nathalie Costedoat-Chalumeau, Emile Daraï, Amélie Delabaere, Philippe Deruelle, Marc Dommergues, Anne-Sophie Ducloy-Bouthors, Caroline Dubertret, Hubert Ducou Le Pointe, Bénédicte Dumont, Lise Duranteau, Elisabeth Elefant, Nejla Essafi, Hervé Fernandez, Julia Filippova, Renato Fior, Michael Frank, Jean-Baptiste de Fréminville, Diane Friedman, Frédéric Galacteros, Denis Gallot, Gilles Garcia, Jean-Yves Gauvrit, Anne Gervais, Robert Girot, Bertrand Godeau, Gilles Grangé, Dominique Grenet, Lionel Groussin-Rouiller, Gaëlle Guettrot-Imbert, Stéphanie Guillet, Anoosha Habibi, Smail Hadj-Rabia, Olivier Hermine, Véronique Houfflin-Debarge, Marie Houllier, Lucile Houyel, Marc Humbert, Laurence Iserin, Bernard Iung, Xavier Jaïs, Bérangère Joly, Guillaume Jondeau, Jean-Emmanuel Kahn, Gilles Kayem, Hawa Keita, Valentin Keller, Magalie Ladouceur, Cécile Lavenu-Bombled, Hélène Legardeur, Véronique Le Guern, Claude Lejeune, Claire Le Jeunne, null Lous, null Ray, Aurélien Lorthioir, Lynda Manamani-Bererhi, Isabelle Marie, Grégoire Martin de Frémont, Sophie Matheron, Amandine Maulard, Nadia Merbai, Emmanuel Messas, Sandra de Miranda, Anna Molto, Stéphanie Morgant, Simon Msika, Sophie Nebout, Jacky Nizard, Roseline d'Oiron, Violaine Ozenne, Gabriel Perlemuter, Sandrine Perol, Franck Perrotin, Brigitte Perrouin-Verbe, Edith Peynaud-Debayle, Violaine Peyronnet, Henri-Jean Philippe, Clément Picard, Geneviève Plu-Bureau, Laura Polivka, Brigitte Raccah-Tebeka, Emmanuelle de Raucourt, Jean-Antoine Ribeil, Thomas Ronzière, Valérie Roussel-Robert, Aude Rossi, Lucia Rugeri, David Saadoun, Lise Selleret, Pierre Sellier, Marie-Victoire Sénat, Raphaèle Seror, Damien Subtil, Camille Taillé, Sarah Tebeka, Denis Therby, Ngoc-Tram Tô, Bertrand de Toffol, Nathalie Trillot, Vassilis Tsatsaris, Géraud Tuyeras, Mathieu Uzzan, Morgane Valentin, David Vandendriessche, Roxane Vanspranghels-Gibert, Eric Verspyck, Aurélie Vincent-Rohfritsch, Sandra Vukusic, Bernard Wechsler, Norbert Winer, and Jacques-François Young

Published
2022
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18. Mineral nutrient signaling controls photosynthesis: focus on iron deficiency-induced chlorosis

Author

Laurent Nussaume, Seung Y. Rhee, Rebecca Therby-Vale, Hatem Rouached, Benoît Lacombe, Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) (BIAM), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Signalisation de l'Adaptation des Végétaux à l'Environnement (SAVE), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Biologie végétale et microbiologie environnementale - UMR7265 (BVME), Biochimie et Physiologie Moléculaire des Plantes (BPMP), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Plant Biology [Carnegie] (DPB), Carnegie Institution for Science, Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Plant Environmental Physiology and Stress Signaling (PEPSS), Plant Resilience Institute, Michigan State University [East Lansing], Michigan State University System, Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Carnegie Institution for Science [Washington], and Department of Plant, Soil, and Microbial Sciences

Subjects
0106 biological sciences, Chlorophyll, chlorosis, Iron, [SDV]Life Sciences [q-bio], chemistry.chemical_element, Plant Science, Manganese, Biology, Photosynthesis, 01 natural sciences, 03 medical and health sciences, iron deficiency, Nutrient, Botany, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Iron deficiency (plant disorder), ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 2. Zero hunger, 0303 health sciences, Anemia, Hypochromic, Minerals, mineral nutrition, nutrient signaling crosstalk, Chlorosis, hormones, Phosphorus, food and beverages, Iron Deficiencies, Nutrients, 15. Life on land, Micronutrient, Chloroplast, Plant Leaves, antioxidants, chlorophyll content, chemistry, 010606 plant biology & botany
Abstract

International audience; Photosynthetic organisms convert light energy into chemical energy stored in carbohydrates. To perform this process, an adequate supply of essential mineral elements, such as iron, is required in the chloroplast. Because iron plays a crucial role during electron transport and chlorophyll formation, iron deficiency alters photosynthesis and promotes chlorosis, or the yellowing of leaves. Intriguingly, iron deficiency-induced chlorosis can be reverted by the depletion of other micronutrients [i.e., manganese (Mn)] or macronutrients [i.e., sulfur (S) or phosphorus (P)], raising the question of how plants integrate nutrient status to control photosynthesis. Here, we review how improving our understanding of the complex relationship between nutrient homeostasis and photosynthesis has great potential for crop improvement.

Published
2021
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19. Les urgences infectieuses en urologie

Author

E, Seizilles de Mazancourt, M, Vallée, A, Sotto, C, Le Goux, A, Dihn, A, Therby, R, Boissier, P H, Savoie, J A, Long, F, Bruyere, Hospices Civils de Lyon (HCL), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Virulence bactérienne et maladies infectieuses (VBMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Service d'urologie [CH René Dubos Pontoise], Centre Hospitalier René Dubos [Pontoise], CIT-IT Garches, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Raymond Poincaré [AP-HP]-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier de Versailles André Mignot (CHV), Aix Marseille Université (AMU), Assistance Publique - Hôpitaux de Marseille (APHM), Hopital d'instruction des armées Sainte-Anne [Toulon] (HIA), Service d'urologie [CHU Grenoble], Centre Hospitalier Universitaire [Grenoble] (CHU), Service d'urologie [Tours], and Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau

Subjects
Male, Pyélonéphrite, Urology, MESH: Urinary Tract Infections, Urgence, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Infection urinaire, MESH: Emergencies, MESH: Anti-Bacterial Agents, Humans, MESH: Ecosystem, Infections urinaires associées aux soins, Ecosystem, Aged, Infection urinaire masculine, MESH: Aged, Bacterial prostatitis, Urinary tract infection, MESH: Humans, Pyelonephritis, Candidurie, MESH: Urology, MESH: Male, Anti-Bacterial Agents, Urosepsis, Sepsis urinaire, Health related urinary infection, Urinary Tract Infections, Emergency, Candiduria, Emergencies
Abstract

International audience; Objective: To report the nature, diagnosis and therapeutic strategy of infectious emergencies in urology.Material and methods: Bibliographic research from Pubmed, Embase, and Google scholar in July 2021. A synthesis of the guidelines of national infectious diseases societies.Results: Urosepsis and complicated urinary tract infection have a standardized definition. Diagnosis and therapeutic strategy are presented for upper tract urinary infection, male urinary infection, healthcare associated urinary infection, symptomatic canduria and urinary infections of the elderly. Appropriate antibiotherapy should be tailored to the degree of severity, bacterial ecosystem, patient characteristics et localization of the infection.Conclusion: Urinary infections can be critical and require immediate care. Knowledge of the guidelines and of appropriate diagnosis and therapeutics strategy improve care which should be rapidly applied, and collegial.; ObjectifRapporter la nature, les stratégies diagnostiques et thérapeutiques des urgences infectieuses en urologie.Matériel et méthodeRecherche bibliographique à partir de Pubmed, Embase et Google Scholar en juillet 2021. Synthèse des recommandations nationales du comité d’infectiologie de l’AFU (CIAFU) et de la Société de Pathologies Infectieuses de Langue Française (SPILF).RésultatsL’urosepsis et sepsis urinaire grave répondent à des critères diagnostiques stricts. La prise en charge infectieuse diagnostique et thérapeutique des pyélonéphrites graves, infections urinaires masculines graves, infections urinaires associées aux soins, candiduries symptomatiques et infections urinaires chez la personne âgée sont décrites. L’antibiothérapie doit être adaptée à la gravité, l’écologie bactérienne, aux particularités du patient et au site d’infection.ConclusionLes infections urinaires peuvent être graves et nécessitent une prise en charge en urgence. La connaissance des recommandations et des stratégies diagnostiques et thérapeutiques adaptées aux diverses présentations permet une optimisation de la prise en charge qui doit être la plus rapide possible, et collégiale.

Published
2021
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20. Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission

Author

Chéret, Antoine, Bacchus-Souffan, Charline, Avettand-Fenoël, Veronique, Mélard, Adeline, Nembot, Georges, Blanc, Catherine, Samri, Assia, Sáez-Cirión, Asier, Hocqueloux, Laurent, Lascoux-Combe, Caroline, Allavena, Clotilde, Goujard, Cécile, Valantin, Marc Antoine, Leplatois, Anne, Meyer, Laurence, Rouzioux, Christine, Autran, Brigitte, Hoen, B., Bourdeaux, C., Delfraissy, J. F., Goujard, C., Amri, I., Fourn, E., Quertainmont, Y., Môle, M., Rami, A., Durel, A., Diemer, M., Parrinello, M., Allègre, T., Lafeuillade, A., Hittinger, G., Lambry, V., Carrerre, M., Philip, G., Duvivier, C., Consigny, P. H., Charlier, C., Shoai, M., Touam, F., Pialoux, G., Slama, L., LʼYavanc, T., Mathurin, P., Adda, A., Berrebi, V., Salmon, D., Chakvetadze, E., Tassadit, T., Ousseima, E., Pietri, M. P., Levy, Y., Lascaux, A. S., Lelievre, J. D., Giovanna, M., Dominguez, S., Dumont, C., Katlama, C., Valentin, M. A., Seang, S., Schneider, L., Kiorza, N., Chermak, A., Ben Abdallah, S., Simon, A., Pichon, F., Pauchard, M., Molina, J. M., Lascoux, C., Ponscarme, D., Colin De Verdiere, N., Scemla, A., De Castro, N., Rachline, A., Garrait, V., Rozenbaum, W., Ferret, S., Balkan, S., Clavel, F., Tourdjman, M., Lafaurie, M., Aslan, A., Goguel, J., Thierry, S. M., De Lastours, V., Gallien, S., Pavie, J., Delgado, J., Mededji, C., Veron, R., Abel, S., Pierre-François, S., Baringhton, C., Chennebault, J. M., Vandamme, Y. M., Fialaire, P., Rehaiem, S., Rabier, V., Abgueguen, P., Morlat, P., Vandenhende, M. A., Bernard, N., Lacoste, D., Michaux, C., Paccalin, F., Receveur, M. C., Caldato, S., Delaune, J., Ragnaud, J. M., Neau, D., Lacaze-Buzy, L., Livrozet, J. M., Jeanblanc, F., Makhloufi, D., Brunel Dalmas, F., Jourdain, J. J., Chiarello, P., Yeni, P., Phung, B., Rioux, C., Godard, C., Louni, F., El Alami Talbi, N., Catalano, G., Guiroy, F., Reynes, J., Jacquet, J. M., Fauchere, V., Merle, C., Lemoine, V., Loriette, M., Morquin, D., Makinson, A., Atoui, N., Tramoni, C., Raffi, F., Allavena, C., Bonnet, B., Bouchez, S., Feuillebois, N., Brunet-François, C., Reliquet, V., Mounoury, O., Morineau-Le-Houssine, P., Billaud, E., Brosseau, D., Hüe, H., Dellamonica, P., Vassallo, M., Leplatois, A., Durant, J., Naqvi, A., Joulié, A., Souala, F., Michelet, C., Arvieux, C., Tattevin, P., Leroy, H., Revest, M., Fily, F., Chapplain, J. M., Ratajczak, C. M., Gras, G., Bernard, L., Dailloux, J. F., Laplantine, V., Cuzin, L., Marchou, B., Larrigue, S., Chauveau, M., Balsarin, F., Obadia, M., Chéret, A., Bonne, S., Huleux, T., Ajana, F., Alcaraz, I., Baclet, V., Melliez, H., Viget, N., De La Tribonniere, X., Aissi, E., Poissy, J., Ravaux, I., Vallon, A., Varan, M., May, T., Letranchant, L., Burty, C., Briaud, A., Wassoumbou, S., Stenzel, M., Bouillon, M. P., Debab, Y., Caron, F., Gueit, I., Chapuzet, C., Borsa Lebas, F., Etienne, M., Miailhes, P., Perpoint, T., Senechal, A., Schlienger, I., Cotte, L., Augustin Normand, C., Boibieux, A., Ferry, T., Corsini, N., Braun, E., Lippran, J., Biron, F., Chidiac, C., Pailhes, S., Lipman, J., Braun, E., Koffi, J., Thoirain, V., Brochier, C., Greder Belan, A., Therby, A., Monnier, S., Ruquet, M., Garrait, V., Richier, L., Prevoteau Du Clary, F., Philibert, P., Chapus, C., Cabié, A., and Abel, S.

Published
2015
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21. FUrTIHF: French Urinary Tract Infections in Healthcare Facilities French Urinary Tract Infections in Healthcare Facilities: 5-year historic cohort 2014-2018

Author

de Lafforest, Sixtine, Magnier, Alexandre, Vallée, Maxime, Bey, Elsa, Le Goux, Constance, Saint, Fabien, Therby, Audrey, Zahar, Jean Ralph, Sotto, Albert, Bruyere, Franck, Grammatico-Guillon, Leslie, and Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021
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23. Liste des collaborateurs

Author

Affres, Hélène, primary, Amar, Laurence, additional, Amate, Pascale, additional, Annane, Djillali, additional, Azria, Elie, additional, Benachi, Alexandra, additional, Berlin, Ivan, additional, Bernuau, Jacques, additional, Bobrie, Guillaume, additional, Boleslawski, Emmanel, additional, Bonneau, Claire, additional, Bornes, Marie, additional, Bouhnik, Yoram, additional, Bouteloup, Corinne, additional, Bouvet, Elisabeth, additional, Brémond-Gignac, Dominique, additional, Bresset, Arnaud, additional, Bretelle, Florence, additional, Bricaire, Léopoldine, additional, Bruyere, Marie, additional, Ceccaldi, Pierre-François, additional, Chanson, Philippe, additional, Chauvet, Sophie, additional, Clair, Bernard, additional, Clouqueur, Élodie, additional, Cohen, Sarah, additional, Conard, Jacqueline, additional, Comarmond, Cloé, additional, Conquy, Sophie, additional, Copin, Henri, additional, Cordier, Anne-Gaël, additional, Cordiez, Sophie, additional, Costedoat-Chalumeau, Nathalie, additional, Daraï, Emile, additional, Delabaere, Amélie, additional, Deruelle, Philippe, additional, Dommergues, Marc, additional, Dreyfus, Marie, additional, Dubertret, Caroline, additional, Du-Boutin, Lê Thi Huong, additional, Ducarme, Guillaume, additional, Ducloy-Bouthors, Anne-Sophie, additional, Le Pointe, Hubert Ducou, additional, Duranteau, Lise, additional, Fakhouri, Fadi, additional, Fernandez, Hervé, additional, Ferrand, Hélène, additional, Filippova, Julia, additional, Fior, Renato, additional, Frank, Michael, additional, Friedman, Diane, additional, Galacteros, Frédéric, additional, Gallot, Denis, additional, Garcia, Gilles, additional, Gauvrit, Jean-Yves, additional, Gervais, Anne, additional, Girot, Robert, additional, Godeau, Bertrand, additional, Grangé, Gilles, additional, Grenet, Dominique, additional, Groussin, Lionel, additional, Guettrot-Imbert, Gaëlle, additional, Habibi, Anoosha, additional, Hadj-Rabia, Smail, additional, Hermine, Olivier, additional, Houfflin-Debarge, Véronique, additional, Houyel, Lucile, additional, Hugon-Rodin, Justine, additional, Humbert, Marc, additional, Iserin, Laurence, additional, Iung, Bernard, additional, Jaïs, Xavier, additional, Joly, Bérangère, additional, Jondeau, Guillaume, additional, Kahn, Jean-Emmanuel, additional, Kayem, Gilles, additional, Keita, Hawa, additional, Keller, Valentin, additional, Ladouceur, Magalie, additional, Legardeur, Hélène, additional, Le Guern, Véronique, additional, Lejeune, Claude, additional, Le Jeunne, Claire, additional, Le Ray, Camille, additional, Luton, Dominique, additional, Manamani-Bererhi, Lynda, additional, Mandelbrot, Laurent, additional, Marie, Isabelle, additional, Matheron, Sophie, additional, Maulard, Amandine, additional, Merbai, Nadia, additional, Messas, Emmanuel, additional, De Miranda, Sandra, additional, Morgant, Stéphanie, additional, Msika, Simon, additional, Nebout, Sophie, additional, Nedellec, Sophie, additional, Nizard, Jacky, additional, d'Oiron, Roseline, additional, Ozenne, Violaine, additional, Perlemuter, Gabriel, additional, Perrouin-Verbe, Brigitte, additional, Perrotin, Franck, additional, Peynaud-Debayle, Edith, additional, Philippe, Henri-Jean, additional, Picard, Clément, additional, Picone, Olivier, additional, Pigeyre, Marie, additional, Plouin, Pierre-François, additional, Plu-Bureau, Geneviève, additional, Polivka, Laura, additional, Poulain, Patrice, additional, de Pradier, Marie, additional, Raccah-Tebeka, Brigitte, additional, Ribeil, Jean-Antoine, additional, Rouzier, Roman, additional, Ronziere, Thomas, additional, Rossi, Aude, additional, Saadoun, David, additional, Selleret, Lise, additional, Sellier, Pierre, additional, Sénat, Marie-Victoire, additional, Subtil, Damine, additional, Taillé, Camille, additional, Therby, Denis, additional, Tô, Ngoc-Tram, additional, de Toffol, Bertrand, additional, Trillot, Nathalie, additional, Tsatsaris, Vassilis, additional, Tuyeras, Géraud, additional, Valentin, Morgane, additional, Vambergue, Anne, additional, Vandendriessche, David, additional, Verspyck, Eric, additional, Vincent-Rohfritsch, Aurélie, additional, Voltzenlogel, Marie-Catherine, additional, Vukusic, Sandra, additional, Wechsler, Bernard, additional, Winer, Norbert, additional, and Young, Jacques-François, additional

Published
2014
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26. Place des aminosides en urologie

Author

Arnaud, P., primary, Malavaud, S., additional, Therby, A., additional, Le Goux, C., additional, Bey, E., additional, Cariou, G., additional, Cattoir, V., additional, Saint, F., additional, Sotto, A., additional, Vallée, M., additional, and Bruyere, F., additional

Published
2020
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27. Cutaneous Melioidosis in Adolescent Returning from Guadeloupe

Author

Roderich Meckenstock, Audrey Therby, Stephanie Marque-Juillet, Sebastian Monnier, David Khau, Beatrice Pangon, and Alix Greder-Belan

Subjects
melioidosis, Guadeloupe, Burkholderia pseudomallei, bacteria, primary cutaneous melioidosis, Caribbean, Medicine, Infectious and parasitic diseases, RC109-216
Published
2012
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32. Immediate and delayed affects of antenatal corticosteroids on fetal heart rate: a randomized trial that compares betamethasone acetate and phosphate, betamethasone phosphate, and dexamethasone

Author

Subtil, Damien, Timerghien, Pauline, Therby, Denis, Leclerc, Gilles, Vaast, Pascal, Puech, Francis, and Devos, Patrick

Subjects
Acetates -- Physiological aspects, Phosphates -- Physiological aspects, Betamethasone -- Physiological aspects, Dexamethasone -- Physiological aspects, Clinical trials -- Analysis, Heart beat -- Health aspects, Fetus -- Health aspects, Adrenocortical hormones -- Physiological aspects, Adrenocortical hormones -- Genetic aspects, Adrenocortical hormones -- Comparative analysis, Adrenocortical hormones -- Dosage and administration, Obstetrics -- Research, Health
Abstract

The auhors have investigated the role of formulations and administration kinetics of antenatal corticosteroid therapy on fetal heart rate. Results demonstrate that that antenatal corticotherapy is applicable for fetal heart rate modifications which is not affected by the dosage regiment.

Published
2003

33. Simplified Bishop score including parity predicts successful induction of labor

Author

Patrick Devos, Joanna Ivars, Damien Subtil, Charles Garabedian, Philippe Deruelle, Denis Therby, and Sabine Carlier

Subjects
Adult, medicine.medical_specialty, Multivariate analysis, medicine.medical_treatment, Population, Bishop score, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, medicine, Humans, Labor, Induced, 030212 general & internal medicine, education, Retrospective Studies, education.field_of_study, 030219 obstetrics & reproductive medicine, Receiver operating characteristic, Vaginal delivery, Obstetrics, business.industry, Obstetrics and Gynecology, Delivery, Obstetric, Cervical effacement, Parity, Reproductive Medicine, Labor induction, Female, business, Parity (mathematics), Cervical Ripening
Abstract

Our objectives were to confirm the predictiveness of parity for successful labor induction and propose an improvement in the Bishop's score to take parity into account and simultaneously simplify the original Bishop score.Retrospective study of 326 deliveries induced by oxytocin and amniotomy before prostaglandins between January 1, 1987, and June 30, 1988. We conducted a univariate and then a multivariate analysis of the relation between successful labor induction - defined by vaginal delivery- and the components of Bishop's score and parity.Nulliparous accounted for 38% of the studied population. The mean Bishop at induction was 5.75±1.4. Fetal station, cervical effacement, and parity were the only factors associated with the success of induction in this study. Removing the cervical position and consistency from the score as well as adding parity significantly improved the prediction of success (ROC curves, AUC 0.88 vs 0.68, p0.001). By taking 5% as the maximum risk of induction failure, a cutoff point of 4 for the new score makes it possible to induce labor in 90% of the women that were considered in the study (vs 26% or 60%, according to whether the cutoff point of the original Bishop's score is set, respectively, at 7 or 6, p0.001).Cervical position and consistency are not necessary for predicting successful labor induction by oxytocin and amniotomy. We confirmed the usefulness of a simplified Bishop score that considers parity.

Published
2016
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34. Les auteurs

Author

Benachi, Alexandra, Luton, Dominique, Mandelbrot, Laurent, Picone, Olivier, Affres, Hélène, Ajzenberg, Nadine, Amar, Laurence, Amate, Pascale, Annane, Djillali, Aoun, Rana, Azria, Elie, Belkhir, Rakiba, Berlin, Ivan, Bernuau, Jacques, Boleslawski, Emmanuel, Bonneau, Claire, Bornes, Marie, Bouhnik, Yoram, Bouteloup, Corinne, Bouvet, Elisabeth, Brémond-Gignac, Dominique, Bresset, Arnaud, Bretelle, Florence, Bricaire, Léopoldine, Bruyère, Marie, Carrara, Julie, Ceccaldi, Pierre-François, Chanson, Philippe, Chauvet, Sophie, Clair, Bernard, Clouqueur, Élodie, Cohen, Sarah, Comarmond-Ortoli, Chloé, Conard, Jacqueline, Conquy, Sophie, Copin, Henri, Cordier, Anne-Gaël, Cordiez, Sophie, Coscas, Sarah, Costedoat-Chalumeau, Nathalie, Daraï, Emile, Delabaere, Amélie, Deruelle, Philippe, Dommergues, Marc, Ducloy-Bouthors, Anne-Sophie, Dubertret, Caroline, Le Pointe, Hubert Ducou, Dumont, Bénédicte, Duranteau, Lise, Elefant, Elisabeth, Essafi, Nejla, Fernandez, Hervé, Filippova, Julia, Fior, Renato, Frank, Michael, de Fréminville, Jean-Baptiste, Friedman, Diane, Galacteros, Frédéric, Gallot, Denis, Garcia, Gilles, Gauvrit, Jean-Yves, Gervais, Anne, Girot, Robert, Godeau, Bertrand, Grangé, Gilles, Grenet, Dominique, Groussin-Rouiller, Lionel, Guettrot-Imbert, Gaëlle, Guillet, Stéphanie, Habibi, Anoosha, Hadj-Rabia, Smail, Hermine, Olivier, Houfflin-Debarge, Véronique, Houllier, Marie, Houyel, Lucile, Humbert, Marc, Iserin, Laurence, Iung, Bernard, Jaïs, Xavier, Joly, Bérangère, Jondeau, Guillaume, Kahn, Jean-Emmanuel, Kayem, Gilles, Keita, Hawa, Keller, Valentin, Ladouceur, Magalie, Lavenu-Bombled, Cécile, Legardeur, Hélène, Le Guern, Véronique, Lejeune, Claude, Le Jeunne, Claire, Lous, Ray, Lorthioir, Aurélien, Manamani-Bererhi, Lynda, Marie, Isabelle, de Frémont, Grégoire Martin, Matheron, Sophie, Maulard, Amandine, Merbai, Nadia, Messas, Emmanuel, de Miranda, Sandra, Molto, Anna, Morgant, Stéphanie, Msika, Simon, Nebout, Sophie, Nizard, Jacky, d'Oiron, Roseline, Ozenne, Violaine, Perlemuter, Gabriel, Perol, Sandrine, Perrotin, Franck, Perrouin-Verbe, Brigitte, Peynaud-Debayle, Edith, Peyronnet, Violaine, Philippe, Henri-Jean, Picard, Clément, Plu-Bureau, Geneviève, Polivka, Laura, Raccah-Tebeka, Brigitte, de Raucourt, Emmanuelle, Ribeil, Jean-Antoine, Ronzière, Thomas, Roussel-Robert, Valérie, Rossi, Aude, Rugeri, Lucia, Saadoun, David, Selleret, Lise, Sellier, Pierre, Sénat, Marie-Victoire, Seror, Raphaèle, Subtil, Damien, Taillé, Camille, Tebeka, Sarah, Therby, Denis, Tô, Ngoc-Tram, de Toffol, Bertrand, Trillot, Nathalie, Tsatsaris, Vassilis, Tuyeras, Géraud, Uzzan, Mathieu, Valentin, Morgane, Vandendriessche, David, Vanspranghels-Gibert, Roxane, Verspyck, Eric, Vincent-Rohfritsch, Aurélie, Vukusic, Sandra, Wechsler, Bernard, Winer, Norbert, and Young, Jacques-François

Published
2022
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35. Decreased darunavir concentrations during once-daily co-administration with maraviroc and raltegravir: OPTIPRIM-ANRS 147 trial

Author

Pressiat, Claire, Hirt, Déborah, Treluyer, Jean-Marc, Zheng, Yi, Morlat, Philippe, Naqvi, Alice, Tran, Laurent, Viard, Jean-Paul, Avettand-Fenoel, Véronique, Rouzioux, Christine, Meyer, Laurence, Cheret, Antoine, Hoen, B, Bourdeaux, C, Delfraissy, J, Goujard, C, Amri, I, Fourn, E, Quertainmont, Y, Môle, M, Rami, A, Durel, A, Diemer, M, Parrinello, M, Allègre, T, Lafeuillade, A, Hittinger, G, Lambry, V, Carrerre, M, Philip, G, Duvivier, C, Consigny, P, Charlier, C, Shoai, M, Touam, F, Pialoux, G, Slama, L, l'Yavanc, T, Mathurin, P, Adda, A, Berrebi, V, Salmon, D, Chakvetadze, E, Tassadit, T, Ousseima, E, Pietri, M, Levy, Y, Lascaux, A, Lelievre, J, Giovanna, M, Dominguez, S, Dumont, C, Katlama, C, Valentin, M, Seang, S, Schneider, L, Kiorza, N, Chermak, A, Ben Abdallah, S, Simon, A, Pichon, F, Pauchard, M, Molina, J, Lascoux, C, Ponscarme, D, Colin de Verdiere, N, Scemla, A, de Castro, N, Rachline, A, Garrait, V, Rozenbaum, W, Ferret, S, Balkan, S, Clavel, F, Tourdjman, M, Lafaurie, M, Aslan, A, Goguel, J, Thierry, S, de Lastours, V, Gallien, S, Pavie, J, Delgado, J, Mededji, C, Veron, R, Abel, S, Pierre-François, S, Baringhton, C, Chennebault, J, Vandamme, Y, Fialaire, P, Rehaiem, S, Rabier, V, Abgueguen, P, Vandenhende, M, Bernard, N, Lacoste, D, Michaux, C, Paccalin, F, Receveur, M, Caldato, S, Delaune, J, Ragnaud, J, Neau, D, Lacaze-Buzy, L, Livrozet, J, Jeanblanc, F, Makhloufi, D, Brunel Dalmas, F, Jourdain, J, Chiarello, P, Yeni, P, Phung, B, Rioux, C, Godard, C, Louni, F, El Alami Talbi, N, Catalano, G, Guiroy, F, Reynes, J, Jacquet, J, Fauchere, V, Merle, C, Lemoine, V, Loriette, M, Morquin, D, Makinson, A, Atoui, N, Tramoni, C, Raffi, F, Allavena, C, Bonnet, B, Bouchez, S, Feuillebois, N, Brunet-François, C, Reliquet, V, Mounoury, O, Morineau-Le-Houssine, P, Billaud, E, Brosseau, D, Hüe, H, Dellamonica, P, Vassallo, M, Leplatois, A, Durant, J, Joulié, A, Souala, F, Michelet, C, Arvieux, C, Tattevin, P, Leroy, H, Revest, M, Fily, F, Chapplain, J, Ratajczak, C, Gras, G, Bernard, L, Dailloux, J, Laplantine, V, Cuzin, L, Marchou, B, Larrigue, S, Chauveau, M, Balsarin, F, Obadia, M, Bonne, S, Huleux, T, Ajana, F, Alcaraz, I, Baclet, V, Melliez, H, Viget, N, de la Tribonniere, X, Aissi, E, Poissy, J, Ravaux, I, Vallon, A, Varan, M, May, T, Letranchant, L, Burty, C, Briaud, A, Wassoumbou, S, Stenzel, M, Bouillon, M, Debab, Y, Caron, F, Gueit, I, Chapuzet, C, Borsa Lebas, F, Etienne, M, Miailhes, P, Perpoint, T, Senechal, A, Schlienger, I, Cotte, L, Augustin Normand, C, Boibieux, A, Ferry, T, Corsini, N, Braun, E, Lippran, J, Biron, F, Chidiac, C, Pailhes, S, Lipman, J, Koffi, J, Thoirain, V, Brochier, C, Greder Belan, A, Therby, A, Monnier, S, Ruquet, M, Richier, L, Prevoteau Du Clary, F, Evaluation thérapeutique et pharmacologie périnatale et pédiatrique (EA_7323), Université Paris Descartes - Paris 5 (UPD5), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de médecine interne et maladies infectieuses [Bordeaux], CHU Bordeaux [Bordeaux]-Groupe hospitalier Saint-André, Service de Maladies Infectieuses [CHU Nice], Hôpital l'Archet - CHU de Nice, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Diagnostic et de Thérapeutique, Hôpital de l’Hôtel-Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Infection à VIH, réservoirs, diversité génétique et résistance aux antirétroviraux (ARV) (EA 7327), Laboratoire de Virologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Service de Médecine Interne - Immunologie Clinique [AP-HP Bicêtre], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Stratégies thérapeutiques contre l'infection VIH et les maladies virales associées [iPLesp] (THERAVIR), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and CHU Pontchaillou [Rennes]

Subjects
Male, 0301 basic medicine, MESH: Raltegravir Potassium, [SDV]Life Sciences [q-bio], HIV Infections, Pharmacology, Maraviroc, MESH: HIV-1, Plasma, chemistry.chemical_compound, Pharmacology (medical), MESH: Anti-HIV Agents, MESH: Maraviroc, Darunavir, MESH: Darunavir, education.field_of_study, MESH: Middle Aged, MESH: HIV Infections, Middle Aged, Viral Load, Infectious Diseases, MESH: Young Adult, Female, MESH: Viral Load, Viral load, medicine.drug, Adult, Microbiology (medical), Anti-HIV Agents, 030106 microbiology, Population, Emtricitabine, Young Adult, 03 medical and health sciences, Pharmacokinetics, Raltegravir Potassium, medicine, Humans, education, MESH: Plasma, Models, Statistical, Ritonavir, MESH: Humans, business.industry, MESH: Adult, Raltegravir, MESH: Male, 030104 developmental biology, chemistry, HIV-1, MESH: Ritonavir, business, MESH: Female, MESH: Models, Statistical
Abstract

International audience; BackgroundThe OPTIPRIM-ANRS 147 trial compared intensive combination ART (darunavir/ritonavir, tenofovir disoproxil fumarate/emtricitabine, raltegravir and maraviroc) started early during primary HIV-1 infection with standard tritherapy with darunavir/ritonavir, tenofovir disoproxil fumarate and emtricitabine. From month 6 to 18, the percentage of viral load values

Published
2018
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36. Efficacy of cefoxitin versus carbapenem in febrile male urinary tract infections caused by extended spectrum beta-lactamase–producing Escherichia coli: a multicenter retrospective cohort study with propensity score analysis

Author

Senard, O., primary, Lafaurie, M., additional, Lesprit, P., additional, Nguyen, Y., additional, Lescure, X., additional, Therby, A., additional, Fihman, V., additional, Oubaya, N., additional, and Lepeule, R., additional

Published
2019
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37. Prevalence of mixed cryoglobulins in relation to CD4 cell count among patients coinfected with HIV and hepatitis C virus

Author

Aaron, Laurent, Lebray, Pascal, Alyanakian, Marie-Alexandra, Roudiere, Laurent, Therby, Audrey, Chaix, Marie-Laure, Dupont, Bertrand, Pol, Stanislas, and Viard, Jean-Paul

Subjects
Hepatitis C virus -- Risk factors, Hepatitis C virus -- Care and treatment, HIV infection -- Risk factors, HIV infection -- Care and treatment, Cryoglobulinemia -- Risk factors, Cryoglobulinemia -- Research, Health, Health care industry
Published
2005

38. Modifications de l’immunité dans l’obésité : impact sur le risque infectieux

Author

R Meckenstock and A Therby

Subjects
medicine.medical_specialty, business.industry, Public health, Gastroenterology, Adipose tissue, Cancer, Inflammation, medicine.disease, Obesity, Clinical trial, Immune system, Immunology, Internal Medicine, medicine, Risk factor, medicine.symptom, business
Abstract

Incidence of obesity is constantly rising all over the world; obesity has developed into an important problem of public health. Clinical experience, supported by many clinical trials, shows that obesity constitutes a risk factor for numerous cardiovascular, metabolic, cancer and even infectious diseases. In this revue we summarize the present knowledge on immunological properties and functions of adipose tissue and their modifications in obese subjects, with a bending to a potentially deleterious chronic inflammatory state. We will discuss the negative impact of this chronic inflammation on physiological acute inflammatory reaction during infectious episodes. However, the modifications of anti-infectious immune response in obese subjects are not well known at present and need further investigations.

Published
2015
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39. Dépistage des situations de vulnérabilité psychosociale et toxicologique pendant la grossesse : évaluation d’un auto-questionnaire par comparaison aux données du dossier médical

Author

J. Gaugue, D. Therby, M.-H. Fline-Barthes, Damien Subtil, D. Vandendriessche, and L. Urso

Subjects
Reproductive Medicine, Obstetrics and Gynecology, General Medicine
Abstract

Resume But Evaluer la performance d’un auto-questionnaire dans le depistage des situations a risque medico-psycho-sociales (tabagisme, consommation d’alcool, de toxiques, depression, violence, isolement social) pendant la grossesse, par rapport aux donnees d’un dossier medical structure. Materiel et methodes Un auto-questionnaire a ete elabore a partir de tests valides (Fagerstrom/HSI, T-ACE, EPDS, SSQ6) et propose a 1977 femmes enceintes avant leur premiere consultation prenatale et compare aux donnees recueillies par le dossier medical classique. Resultats Au total, 1676 patientes ont rempli l’auto-questionnaire propose (89,4 %). Les deux questions du HSI indiquaient que 20,7 % de patientes etaient fumeuses. Le T-ACE a depiste beaucoup plus de consommations d’alcool a risque que le seul dossier medical (4,0 % vs 0,1 %, Conclusion Un auto-questionnaire realise a partir de tests valides pourrait permettre de mieux depister les situations de vulnerabilite des femmes enceintes en pratique obstetricale courante.

Published
2015
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40. Signs, symptoms and complications of complete and partial uterine ruptures during pregnancy and delivery

Author

Denis Therby, F. LeGoueff, Philippe Deruelle, E. Closset, Damien Subtil, and M. Guiliano

Subjects
Adult, medicine.medical_specialty, Uterus, Asymptomatic, Uterine Rupture, Pregnancy, Risk Factors, Infant Mortality, medicine, Humans, Sign/symptom, Vaginal bleeding, Retrospective Studies, Obstetrics, business.industry, Infant, Newborn, Infant, Obstetrics and Gynecology, Retrospective cohort study, Delivery, Obstetric, medicine.disease, Vaginal Birth after Cesarean, Surgery, Uterine rupture, medicine.anatomical_structure, Reproductive Medicine, Female, medicine.symptom, Complication, business
Abstract

Uterine rupture is a rare but potentially catastrophic complication of pregnancy that requires rapid diagnosis. Classically, its signs and symptoms combine pain, fetal heart rate (FHR) abnormalities, and vaginal bleeding. The purpose of this study is to identify these signs and symptoms as well as the immediate complications of complete and incomplete (partial) ruptures of the uterine wall, whether or not they follow a previous cesarean delivery.Retrospective study of case records from two university hospital maternity units, from 1987 to 2008.In a total of 97,028 births during the study period, we identified 52 uterine ruptures (0.05%): 25 complete and 27 partial. Most (89%) occurred in women with a previous cesarean delivery. In complete ruptures, FHR abnormalities were the most frequent sign (82%), while the complete triad of FHR abnormalities-pain-vaginal bleeding was present in only 9%. The signs and symptoms of partial ruptures were very different; these were asymptomatic in half the cases (48%). Neonatal mortality reached 13.6% among the complete ruptures; 27 and 40% of these newborns had pH6.80 and pH7.0, respectively. Among the incomplete ruptures, only 7.7% of the newborns had a pH7.0 and there were no deaths.Although complete rupture of the uterus has a severe neonatal prognosis, the complete set of standard symptoms is present in less than 10% of cases. FHR abnormalities are by far the most frequent sign.

Published
2014
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41. Intérêt du dosage de l’antigène galactomannane dans le diagnostic et le suivi de l’histoplasmose disséminée à Histoplasma capsulatum var. duboisii au cours du VIH : enseignement à partir d’un cas clinique

Author

O. Polotzanu, A. Greder Belan, D. Khau, O. Eloy, S. Monnier, and A. Therby

Subjects
Aspergillus, biology, business.industry, Direct examination, chemical and pharmacologic phenomena, bacterial infections and mycoses, biology.organism_classification, medicine.disease, complex mixtures, Virology, Histoplasmosis, Galactomannan, chemistry.chemical_compound, fluids and secretions, Infectious Diseases, chemistry, parasitic diseases, medicine, In patient, African histoplasmosis, Differential diagnosis, business, Histoplasma capsulatum var capsulatum
Abstract

The diagnosis of histoplasmosis due to Histoplasma capsulatum var capsulatum is based on a direct examination identifying encapsulated yeast with narrow-based budding. Galactomannan antigenemia facilitates diagnosis, as well as the monitoring of patients receiving treatment. The case of a HIV-positive patient from Congo-Brazzaville with a disseminated form of African histoplasmosis highlighted the positive galactomannan antigen in this disease due to Histoplasma capsulatum var duboisii. Galactomannan antigenemia remained high with a very slow decrease during antifungal therapy and slow regression of clinical lesions. African histoplasmosis is a rare disease that is difficult to diagnose and rarely described in immunocompromised patients, in whom differential diagnosis can be common. This observation underlines the importance of the galactomannan antigen assay in patients who have travelled to endemic areas. As in the case of Histoplasma capsulatum var capsulatum, the positivity of the Aspergillus galactomannan antigen is very useful in the diagnosis and monitoring of African histoplasmosis.

Published
2014
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42. Efficacy of cefoxitin versus carbapenem in febrile male urinary tract infections caused by extended spectrum beta-lactamase–producing Escherichia coli: a multicenter retrospective cohort study with propensity score analysis.

Author

Senard, O., Lafaurie, M., Lesprit, P., Nguyen, Y., Lescure, X., Therby, A., Fihman, V., Oubaya, N., and Lepeule, R.

Subjects
BETA lactamases, ESCHERICHIA coli, COHORT analysis, URINARY tract infections, CEFOXITIN, TEACHING hospitals, RETROSPECTIVE studies
Abstract

Cefoxitin has demonstrated good in vitro activity against extended spectrum beta-lactamase (ESBL)–producing Escherichia coli (ESBL-Ec) and is regarded as a carbapenem-sparing beta-lactam alternative in urinary tract infections. Its efficacy has never been compared to carbapenems in male UTIs. Our study aimed to compare the clinical and microbiological efficacy of cefoxitin (FOX) and carbapenems (CP) in febrile M-UTI due to ESBL-Ec (F-M-UTI). We conducted a multicenter retrospective cohort study of patients with F-M-UTI treated with FOX or CP as definitive therapy, between January 2013 and June 2015, in six French acute care teaching hospitals. The clinical and microbiological efficacies of FOX and CP were compared using multivariable logistic regression models, adjusting for propensity scores. Of the 66 patients included, 23 patients in FOX group and 27 in CP group had clinical assessment at follow-up. Median follow-up after end of treatment was 63 days (interquartile range 26–114). Clinical success was observed for 17/23 (73.9%) and 22/27 (81.5%) patients and microbiological success for 11/19 (57.9%) and for 6/12 (50.0%) patients in FOX and CP groups respectively. We did not find any significant difference for clinical (OR = 0.90, 95% CI [0.12; 6.70]) neither microbiological (OR = 0.85, 95% CI [0.05; 14.00]) success between CP and FOX groups in univariate and multivariable models. In the FOX group, high dose with use of continuous infusion was associated with clinical success. These results add evidence that FOX is an effective alternative treatment to carbapenems for M-UTI caused by ESBL-Ec, particularly when high doses and continuous infusion are used. [ABSTRACT FROM AUTHOR]

Published
2020
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43. An unusual inguinal hernia

Author

S. Monnier, R. Meckenstock, M Amara, G Chevreau, C. Blanc, E. Bruneel, A. Therby, and A. Greder Belan

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, business.industry, General surgery, 030231 tropical medicine, 030106 microbiology, Hernia, Inguinal, medicine.disease, Diagnosis, Differential, 03 medical and health sciences, Inguinal hernia, Elephantiasis, Filarial, 0302 clinical medicine, Internal Medicine, medicine, Animals, Humans, Wuchereria bancrofti, business
Published
2017
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44. Lupus érythémateux actif disséminé (LEAD) avec vascularité rétinienne sévère

Author

A. Therby, E. Koch, R. Meckenstock, E. Bruneel, S. Monnier, P. Bayle, and A. Greder-Belan

Subjects
03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Gastroenterology, Internal Medicine, 030212 general & internal medicine
Abstract

Introduction L’atteinte ophtalmique du lupus erythemateux dissemine, qui ne fait pas partie des criteres diagnostiques de l’American College of Rhumatology, s’observe dans 3 a 30 % des cas avec environ 20 % de syndrome sec oculaire. Dans environ 30 % des cas, un LEAD s’accompagne d’une retinopathie sous forme d’une micro-angiopathie dysorique, caracterisee par des nodules cotonneux et des hemorragies en flammeche, dont le pronostic fonctionnel est plutot favorable [1] . La vascularite retinienne occlusive du LEAD, par contre, est rare, d’apparition aigue, et liee dans les trois-quarts des cas a la presence d’anticorps anti-phospholipides [2] , [3] . Elle peut etre associee a une vascularite cerebrale et elle est grevee d’un mauvais pronostic fonctionnel et d’une survie globale diminuee, indiquant un LEAD severe [2] , [3] . Observation Homme de 51 ans, d’origine antillaise, ATCD : thrombose veineuse profonde en 1992 et 1995 (avec EP), anticoagulation a vie ; HTA, pneumopathie, cholecystectomie. Hospitalise pour AEG majeure, fievre, amaigrissement de 18 kg en un an, arthralgies diffuses d’allure inflammatoire, eruptions palmaires et flou visuel de l’œil droit. Examen clinique normal hormis adenopathies sous-angulo-maxillaires et eruptions palmaires erythro-purpuriques. Biologie : Hb 11,4 g/dL, leucocytes 3/nL, plaquettes 131/nL, CRP, bilan hepatique, creatinine : normal, VS = 50, LDH = 774 UI/L, ferritine 1770 μg/L, triglycerides 2,3 mmol/L, C 3 0,55 g/L (N > 0,9), C 4 et CH 50 normal. FAN = 1280, anti-ADN natifs 23 U/ml (N Discussion Le diagnostic d’un LEAD severe avec vascularite retinienne occlusive sans syndrome des anti-phospholipides (SAPL) associe a ete pose, avec possible activation macrophagique moderee et probable atteinte renale (biopsie renale prevue). Vu le diagnostic certain d’un LEAD, des diagnostics differentiels tels que malade de Behcet ou retinopathie hypertensive severe (evoques a partir de l’atteinte ophtalmique, mais l’angiographie etant en faveur d’une vascularite), sarcoidose ou tuberculose (malgre l’IDR positif mais ancien) ont ete ecartes. Un traitement immuno-suppresseur lourd (des le diagnostic de la vascularite retinienne) associant des bolus de prednisolone 1 g/jour × 3 relaye par prednisone 1 mg/kg p.o. et cyclophosphamide 0,7 g/m2 i.v. (6 cures) a ete mis en route, apres traitement prealable par ivermectine. Conclusion La vascularite retinienne occlusive est une complication rare du LEAD, en particulier en l’absence d’un SAPL comme dans notre cas, et constitue une veritable urgence therapeutique, necessitant un traitement immuno-suppresseur lourd en analogie avec la vascularite cerebrale qui peut y etre associee (dans le cas de notre patient : possibles signes evocateurs a l’IRM mais absence de signes cliniques). Elle revele une forme severe, multisystemique (notre cas : atteinte renale probable, biopsie en attente), et devrait faire partie des criteres diagnostiques et pronostiques du LE. Par ailleurs, les manifestations retiniennes du LEAD suivent parallelement l’evolution de la maladie systemique et peuvent servir d’indicateur pour evaluer la reponse au traitement.

Published
2017
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45. Évaluation de la quantification du cytomégalovirus dans le sang par le test de PCR en temps réel CMV R-gene®

Author

A. Touzard, C. Fernand-Laurent, S. Marque-Juillet, S. Monnier, M. Harzic, A. Therby, and S. Rigaudeau

Subjects
Gynecology, medicine.medical_specialty, Validation study, business.industry, Blood preservation, virus diseases, Medicine, General Medicine, business, Viral antigens
Abstract

Resume But de l’etude Le diagnostic de maladie a cytomegalovirus (CMV) chez le patient immunodeprime est souvent realise par PCR quantitative (Q-PCR) dans le sang bien que la methode de reference reste l’antigenemie pp65. Objectifs Definir la valeur predictive de la Q-PCR par le test CMV R-gene® pour le diagnostic de maladie a CMV et le suivi de l’efficacite du traitement. Comparer les resultats de la Q-PCR a ceux de l’Ag-pp65 et la faisabilite des deux techniques. Patients et methodes La Q-PCR a ete realisee sur des prelevements de sang total congeles a −80 °C (n = 34) de cinq patients avec un diagnostic de maladie a CMV definie par la presence de signes cliniques evocateurs et une Ag pp65 superieure a deux noyaux. Apres extraction, l’ADN a ete quantifie dans chaque echantillon par la Q-PCR quantitative CMV R-gene® selon les recommandations du fabricant. La detection de l’Ag pp65 CMV avait ete realisee avec le reactif CINAkit® (Argene) lors de la reception du prelevement pour 32 echantillons. Resultats Tous les echantillons positifs en Ag pp65 sont positifs en PCR (n = 16). Six echantillons negatifs en Ag pp65 sont positifs en PCR. Les dix autres echantillons sont negatifs par les deux techniques. Les cinetiques des deux marqueurs sous traitement sont superposables. Conclusion Le test CMV R-gene® a une aussi bonne valeur predictive que l’Ag-pp65 tout en etant une technique rapide, et plus facile d’utilisation. Une etude prospective sur un plus grand nombre de patients est necessaire pour definir le seuil de prediction de maladie a CMV.

Published
2010
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46. An unusual inguinal hernia

Author

Monnier, S, primary, Chevreau, G, additional, Bruneel, E, additional, Blanc, C, additional, Meckenstock, R, additional, Therby, A, additional, Belan, A Greder, additional, and Amara, M, additional

Published
2017
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48. The man with 'milk-shake' urine

Author

Fakhouri, Fadi, Matignon, Marie, Therby, Audrey, Mejean, Arnaud, Correas, Jean-Michel, Challier, Svetlana, and Knebelmann, Bertrand

Published
2004

49. Actinomycose abdominopelvienne révélée par des abcès pariétaux

Author

Géraldine Orazi, Valérie Chevalier-Evain, Anna-Maria Bory, N Mubiayi, and Denis Therby

Subjects
medicine.medical_specialty, Stereotactic biopsy, medicine.diagnostic_test, business.industry, General Medicine, Pelvic cavity, Intrauterine device, medicine.disease, Surgery, medicine.anatomical_structure, medicine, Abdomen, Actinomycosis, Abscess, Ovarian cancer, business, Rare disease
Abstract

Summary Introduction Actinomycosis is a rare disease. It has a highly varied clinical picture and may simulate genital or gastrointestinal neoplasms. Case This 45-year-old woman was referred for suspected ovarian cancer, with secondary lesions of the liver and pelvic wall. Pelvic actinomycosis was first suggested by the presence of an intrauterine device (IUD), which had been in place for several years without any follow-up. The final diagnosis was based upon histological examination of a biopsy sample of the parietal mass. Comments The association of apparent pelvic tumors with infection and inflammation together with the presence of an IUD must suggest genital actinomycosis and lead to the rejection of any immediate surgical resection. The diagnosis is usually histological, with samples obtained either surgically or by percutaneous stereotactic biopsy. The treatment is essentially medical and consists of long-term antibiotics (penicillin). The prognosis is usually good.

Published
2007
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50. A multifaceted intervention designed to improve medical management of moderate to advanced chronic kidney disease in HIV-infected patients: a cluster randomised trial

Author

P Brazille, Johan Chanal, N. de Castro, B. Lefebvre, Sophie Abgrall, N Petit, M Marcou, Pascal Pugliese, A Parrot, F Meier, Yazdan Yazdanpanah, A Signori-Schmuck, Hana Selinger-Leneman, Pierre Delobel, F Touam, A Cros, Claire Rouzaud, Philippe Bossi, J. P. Faller, Jean-Marc Mauboussin, Faiza Ajana, V Perronne, V Chambrin, Olivier Lortholary, Laurent Alric, V. Gendrin, C Sautron, K Benhadj, H Gil, C Lascoux, F Raffi, JE Kahn, Michel Vidal, J. J. Laurichesse, O Ruyer, F Brunel, Pascal Chavanet, J. Durant, J. M. Chapplain, T. Perpoint, D Blanc, S Casanova, Frédéric Méchaï, P Poubeau, M Benomar, David Zucman, P Fischer, H Fischer, V Ronat, D Coban, Elisabeth Rouveix, H. Berthé, E Roveix, Corinne Isnard-Bagnis, Aurélie Fillion, P Loulergue, Jennifer M. Rohan, Isabelle Ravaux, Catherine Michel, C Faudon, Jacques Gilquin, J. M. Livrozet, Christian Chidiac, G Wartel, Patricia Enel, G. Beck-Wirth, I Prade, O. Derradji, Jean-Paul Viard, Cécile Goujard, R Cohen Valensi, M Batard, Jean-Luc Meynard, G Camuset, Jacques Cadranel, Christian Pradier, S Gohier, Jean-François Bergmann, Francis Barin, D. Makhloufi, Philippe Gerhardt, A Canestri, Lionel Piroth, S Greffe, N Biezunski, C Bolliot, L Toko, G Mboungou, Jérôme Moreau, Valérie Potard, H Masson, Eric Rosenthal, Jacques Reynes, André Cabié, Gilles Pialoux, P Granet Brunello, F Durand, Véronique Obry-Roguet, Jade Ghosn, V Walter, P Gazalet, O Boulat, P M Girard, A Ménard, M. Môle, G Martin Blondel, M Hamidi, C Lupin, P Druart, Sophie Matheron, Catherine Chirouze, P. De Truchis, Laurent Cotte, P. Del Giudice, Caroline Dupont, Anne Frésard, C Jung, V Payssan, M Saidani, C. Chesnel, Véronique Joly, S Abgrall, B Wifaq, Bruno Hoen, I Fabre, E Pannier Metzger, M Beyrne, Christian Rabaud, C. Gaud, Pierre Durieux, S Makhloufi, Eric Billaud, Jean-Marc Lacombe, T Akpan, PY Dides, Dominique Mathez, V Delcey, P. Sellier, A Naqvi, Amanda Lopes, Laurent Hustache-Mathieu, C Bartoli, V Marcou, Murielle Mary-Krause, Elisabeth Botelho-Nevers, K Samar, Hervé Tissot-Dupont, M Ruquet, Laurence Weiss, Boue F, Philippe Morand, I Lamaury, L Meddeb, Nadia Valin, M Delestan, N. Jacquemet, N Méaux-Ruault, A Gergely, M. Blanc, M Sordage, L Sutton, Dominique Costagliola, V Thomas, PH Consigny, G Cessot, C Le Jeunne, A Freire Maresca, A Greder Belan, Jean-Pierre Morini, G Astier, D. Martin, Pierre-Marie Roger, E Bourzam, G Melica-Gregoire, Nicolas Vignier, B. Taverne, P. Leclercq, M. Sebire, A Adda, A Meybeck, MG Lebrette, André Boibieux, T. Allegre, Nicolas Dupin, M. Parrinello, S Roussin-Bretagne, Christine Jacomet, Laurence Gérard, Jean Deleuze, A S Ritleng, M Raho-Moussa, Marialuisa Partisani, Daniel Vittecoq, M André, Albert Sotto, Pierre Tattevin, S Marque Juillet, Antolini-Bouvenot, Sylvie Abel, M Guivarch, S Lang, P. Honoré, A Lavolé, C. Majerholc, Gilles Hittinger, Marguerite Guiguet, N Magy-Bertrand, Alain Lafeuillade, Elina Teicher, JM Riou, B Slama, Sophie Grabar, N. Viget, P Genet, Faouzi Souala, X. Duval, Lise Cuzin, B. Marchou, D Bonnabel, O. Faucher, S Stegmann, C Veyssier-Belot, I Perbost, K Bourdic, Cédric Arvieux, V Masse, L Pellissier, Giovanna Melica, S Lariven, S Chebrek, H Zerazhi, G Philip, Hugues Melliez, D Marigot-Outtandy, Mark Bloch, E Fourn, E. Billaud, J. Gerbe, C Dhiver, Benveniste O, Delphine Bonnet, D. Quinsat, V Daneluzzi, E Haustraete, P Guet, Dominique Salmon, Christophe Rioux, E Duvallon, E. Mortier, G Borgherini, P Goubin, D. Costagliola, Renaud Verdon, M J Soavi, A. Simon, F Zeng, Aba Mahamat, Mathieu Nacher, P Colardelle, F Granier, E Hope-Rapp, M. Poupard, V Vanticlke, M P Bouillon, C Clavel, Ml Lucas, P. Chiarello, Fabienne Caby, G Jacques, Juliette Pavie, MP Pietri, Blandine Denis, P. Miailhes, Sylvie Bregigeon, B Mouchet, Marie-Aude Khuong-Josses, P Thibaut, Antoine Rachas, H Laurichesse, Sylvie Dargere, C Godin Collet, Odile Launay, Jacques Gasnault, Clotilde Allavena, C. Dumont, Isabelle Poizot-Martin, M. Ratajczak, A. Maignan, A Brunon-Gagneux, Olivier Epaulard, A Therby, Tristan Ferry, E Reimann, Laurent Boyer, Régine Doncesco, Eric Cua, K Risso, Claudine Duvivier, Leila Adriouch, W. Rozenbaum, Christian Perronne, R Sambuc, I Kansau, J. F. Faucher, Florence Huber, J. M. Ruiz, Ma Khuong, Sandrine Pierre-François, Laurence Lievre, G Breton, J.-M. Molina, C. Tomei, M Guiguet, A Proust, L Fonquernie, D. Bornarel, David Rey, Isabelle Rouanet, C Guglielminotti, Jérôme Tourret, V. Reliquet, A Palacin, C Cheneau, Eric Oksenhendler, P Féret, B Montoya, V Lambry, N Hall, Jean-Daniel Lelièvre, Delphine Croisier, C Ricaud, M Ptak, Pierre Couppié, S Mokhtari, Y Welker, R Rodet, T May, Epidémiologie, stratégies thérapeutiques et virologie cliniques dans l'infection à VIH, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ecologie et Evolution des Microorganismes (EEM), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Nantes (CHU Nantes), Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], Fonction, structure et inactivation d'ARN bactériens, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Epidémiologie, Systèmes d'Information, Modélisation, Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Centre de Recherche des Cordeliers (CRC (UMR_S 872)), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), ANRS, 2009, the French Ministry of Health, Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Ecologie et Evolution des Microorganismes ( EEM ), Université Paris Diderot - Paris 7 ( UPD7 ) -Université Paris 13 ( UP13 ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre hospitalier universitaire de Nantes ( CHU Nantes ), Service des maladies infectieuses et réanimation médicale, Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Hôpital Pontchaillou, Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Pitié-Salpêtrière [APHP], Centre de Recherche des Cordeliers ( CRC (UMR_S 872) ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université Paris Descartes - Paris 5 (UPD5)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou, and Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]

Subjects
Male, Microbiology (medical), Nephrology, medicine.medical_specialty, HIV Infections, urologic and male genital diseases, law.invention, Randomized controlled trial, law, [ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology, Internal medicine, Humans, Medicine, Cluster randomised controlled trial, Aged, business.industry, Guideline, Middle Aged, medicine.disease, HIV infection, Confidence interval, 3. Good health, clinical practice, Clinical trial, Treatment Outcome, Infectious Diseases, Blood pressure, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Practice Guidelines as Topic, Physical therapy, cluster randomized trial, Kidney Failure, Chronic, Female, business, chronic kidney disease, Glomerular Filtration Rate, Kidney disease
Abstract

International audience; Background - Chronic kidney disease (CKD) is frequent in individuals infected with human immunodeficiency virus (HIV). Progression to end-stage renal disease can be slowed by appropriate medical management. Methods - To assess whether active promotion of guidelines improves CKD management, we conducted a cluster randomized controlled trial within the French Hospital Database on HIV (FHDH-ANRS CO4). We randomized 46 centers participating in the FHDH to either simple information on guideline availability or active promotion with a multifaceted and repeated intervention comprising reminders and audit feedback and targeting of local opinion leaders carried out between April 2009 and April 2010. Outcome measure was CKD management adequacy assessed before and 2 years after the beginning of the intervention in HIV-infected patients with moderate to severe CKD. CKD management was considered adequate in case of referral to a nephrologist or if proteinuria, blood pressure, low-density lipoprotein cholesterol level, and glycemia had been measured during the previous year and medications had been prescribed when necessary. Results - Three hundred six patients were enrolled, of whom 238 (78%) completed the 2 years of follow-up. During the study period, the percentage of patients receiving adequate CKD management improved from 64.1% to 70.4% (+6.3%) in the active arm and from 68.3% to 75.6% (+7.3%) in the control arm (adjusted mean difference, -0.7 percentage points [95% confidence interval: -9.2 to 7.9]; P = .95). The biggest impact of active promotion was on the management of proteinuria and blood pressure. Conclusions - Adequate compliance with CKD management guidelines improved slightly between 2009 and 2011, with no difference between the simple information and active promotion arms. Clinical trials registration - CCTIRS 10.150 and CNIL DR-2010-379.

Published
2015
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