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A report by DelveInsight provides insights into the treatment and market for Congenital Adrenal Hyperplasia (CAH). The report states that the CAH market size in the 7MM (United States, EU4, and Japan) was approximately USD 21 million in 2021 and is expected to grow from 2023 to 2032. The report also highlights the leading companies developing novel CAH drugs, such as Crinetics Pharmaceuticals Inc. and Diurnal Limited. Additionally, it mentions promising therapies in the pipeline, including CRN04894 and Chronocort. The report provides an overview of CAH, its genetic causes, and diagnostic methods. It also mentions that the United States has the highest number of CAH cases, with an expected increase by 2032. [Extracted from the article]

This section presents news briefs on issues related to ecology. 33 percent of male fish in English rivers are changing sex due to gender-bending chemicals in the water. Meanwhile, 314 million metric tons is the amount of carbon dioxide emitted annually by cars and trucks in the U.S., nearly eight times more than the largest U.S. electricity generator, American Electric Power, which has emissions of 41 million metric tons. Moreover, £10 billion is the value of the illegal trade in wild plants and animals. Furthermore, the United Nations has moved one step closer to adopting a declaration on indigenous people's rights.

This document provides information about a pilot feasibility study being conducted in the United States on a novel non-invasive device called the Anemia Diagnostic Assistant (ADA). The study aims to determine the hemoglobin and end-tidal carbon monoxide (ETCO) concentration in healthy volunteers using the ADA. The device utilizes diffused reflectance spectroscopy to measure hemoglobin levels and a non-invasive probe to measure ETCO as a proxy for hemolysis. The study is currently in the recruitment phase and is expected to be completed by December 2024. It is open to healthy adults aged 18-70 and will compare the results obtained from the ADA with those obtained using standard devices. [Extracted from the article]

A clinical trial, NCT06140784, is currently underway to examine the effects of four different toothpastes on gingivitis and plaque after 12 weeks of use. The main goal of the trial is to determine the impact of the toothpastes on gingivitis, while also evaluating their effects on plaque and the composition of the oral microbiome. The trial is being conducted by Procter and Gamble and is expected to be finished on December 10, 2023. The document provides details about the trial, including the use of a 0.454% Stannous Fluoride Dentifrice for brushing the entire mouth twice daily. The trial is active but not recruiting participants, and it is open to individuals who are at least 18 years old, in good general health, and have mild to moderate gingivitis. The trial is taking place in the United States and is sponsored by Procter and Gamble. The document also includes administrative information such as the NCT number and responsible party. [Extracted from the article]

Solid Biosciences Inc. is conducting a clinical trial, NCT06138639, to investigate the safety and effectiveness of SGT-003, a drug for Duchenne Muscular Dystrophy (DMD), in ambulant males. The trial will have two cohorts, one for children aged 4 to under 6 years and another for children aged 6 to under 8 years. Participants will receive a single intravenous dose of SGT-003 and will be followed up for 5 years. The trial aims to assess adverse events, changes in microdystrophin protein levels, and changes in muscle function and ambulatory performance. The trial is open to male participants in the United States and is expected to be completed by January 15, 2030. [Extracted from the article]

Criticizes August 1999 United States mass media coverage of possible danger from synthetic chemicals that act as human endocrine disrupters. Information about the National Research Council report behind the stories; Comment on U.S. Vice President Albert Gore's statements on the dangers; Thesis of "Our Stolen Future," and impact on public concern; Objections to the endocrine-disrupter theory.

Discusses a United States Environmental Protection Agency (EPA) 1998 plan to test industrial chemicals for harmful hormonal effects. Probable cost to test the most suspicious industrial chemicals; Basis of the scare about their effects in a report in `Science' magazine, whose authors officially withdrew their findings; Impact on consumers; Background of the concern about endocrine disrupters, and the `Science' article.

The article presents information on a pioneering international agreement signed on September 15, 1987 by representatives of twenty-four nations and the European Economic Community, to regulate the production of chlorofluorocarbons (CFCs) and halons, the industrial chemicals that menace the earth's ozone layer. The U.S. delegation played a major role in fashioning the agreement. In April 1987, during negotiations preceding the meeting in which the agreement was signed, the European Economic Community and Japan vetoed a much tougher U.S. proposal for an immediate CFC and halon production freeze to be followed by a draconian 95 percent cutback.

If every disaster is unique, or disastrous in its own way, the three recent ones, at Bhopal in India, Chernobyl in the Soviet Union and aboard the Challenger spacecraft, have at least this much in common, they all suggest that people need to revise the generalizations about Catastrophes. Energy, chemicals and military power are basic state and corporate obligations in the United States and in the Soviet Union, those dangerous systems responsible for the production of energy, chemicals and military power will always be declared essential and supported by numerous organizations and interests.

The article focuses on the development of chemical compounds that have contributed positively to medicine, but are classified as hazardous by the U.S. Environmental Protection Agency (EPA). It states how chemical wastes degrade land and underground reservoirs. The EPA estimates that 77 billion lbs of hazardous waste is generated in the country every year. As mentioned, the ground water, once contaminated, becomes impossible to treat, as it is not exposed to any natural purification system.

Discusses the environmental devastation caused by the use of defoliants, herbicides, and anti-personnel gases during the Vietnam War. Chemicals sprayed by the U.S. Air Force on 500,000 acres of Vietnamese croplands; Composition of chemicals known as agents Orange, Blue and White that have been sprinkled on these croplands; Concern toward the defoliation and crop denial program in Vietnam shown by botanists and ecologists; Possibility of these chemicals causing abnormalities and birth defects; View that the United States must begin to grasp the concept that belligerents in hostilities share a responsibility for preserving the potential productivity of the area of conflict.

The article focuses on the preservation of wood in the U.S. The structural use of wood was made possible with the use of preservatives and fire-retarding chemicals are finding increased use on wood in industrial installations. The most frequently used method of wood treatment is impregnation under pressure. According to the American Wood Preservers Association, treatment saves around 10.8 billion board feet a year. The elimination of conditions favorable to the growth of fungi is the basic idea behind preservation.

The article focuses on the U.S. rubber industry's critical materials shortages. Cited is the fact that synthetic rubber production involves chemicals such as butadiene, styrene, and isobutylene that are already in high demand for hundreds of other industries. While natural rubber production has been at an all-time high, it has resulted in neither increased supply nor a drop in prices. Reasons given for this are delayed rubber shipments and Soviet purchasers' competing for the stuff. The resulting price increases have caused users to shift to synthetics.

The article discusses the advantages and disadvantages of the development and proliferation of the use of the dichloro-diphenyl-trichloroethane (DDT) chemical as an insecticide in the U.S. in the 1940s. Many people in the country are afraid that the use of this insecticide for agricultural purposes can affect all pollinating insects which are important to the balance of nature. It states that despite the toxic properties of this product, men have nothing to worry because it is not harmful to humans. According to the author, DDT is still used in some farms because it helps increase the production of milk by around eight to 20 per cent.

The article surveys pricing trends of typical industrial chemicals in the United States. The chemicals discussed fall into three categories; inorganic chemicals, coal-tar compounds, and non-coal-tar organic chemicals. The common usages of each chemical are presented, as well as graphs depicting pricing movements. Technological advances in production methods affecting price are discussed. Pricing fluctuations caused by World War I and the years following are analyzed. Annual production rates for each chemical group are also presented.

The article reports on the complex mathematical formula developed by American Alcolac Corp. president Vova Blinoff to guide its U.S. business in March 1956. It says that the chief executives of Alcolac had to select wisely if they were to choose the items that would give them the largest profit potential from a broad range of practically similar products. The author adds that the company has gone in for quick diversification and now offers a wide range of industrial chemicals. The move of American Alcolac from France to the U.S. is also discussed.

The article discusses the potential of silicones in the U.S. market. According to technicians, this family of chemical synthetics can be modified precisely to fit industrial requirements. The price of silicones will reportedly depend on manufacturing skill and public demand. The heat-resistant, oil-resistant and chemically inert lacquer for mass-production products is one market for silicone resins being considered by General Electric Co. (G. E.) and Dow Corning.

The article offers a summary of U.S. federal regulations that affect priorities, price control and transportation as of February 19, 1944. Some of the federal regulations relate to increased civilian supply, relaxation of priorities and imported goods. They also include automobiles, natural gas, chemicals, commercial sales, food processing machinery, green coffee, new tires and tubes, construction materials, private-formula drugs, pickled sheepskins, tissue paper products and tungsten and molybdenum.

This article looks at farmworkers who are being sickened by pesticides and seem to have no recourse. Each summer as the grapes clinging to their vines turn the purple of a deep bruise, Juan Rios feels like he is being poisoned. A farmworker who moved to this agricultural valley from Mexico, Rios sprays pesticides at a winery from 3 AM to 3: 30 PM, five days a week. While relatively little has been done to study the long-term effects of pesticides, the research that does exist suggests that farmworkers and their children are vulnerable to a painful array of illnesses. California farmworkers have elevated levels of leukemia and stomach, uterine and brain cancer, according to a study published by the American Journal of Industrial Medicine in 2001. But most farmworkers have few options for other employment. The vast majority are recent, non-English speaking immigrants. Since more than half are undocumented, and a slim slice are unionized, relatively few complain to state or federal agencies for fear of losing their job or being deported, according to a 2000 General Accounting Office report. Adam Sharp, associate assistant administrator in the Office of Prevention, Pesticides and Toxic Substances, previously worked for the American Farm Bureau Federation, where he criticized EPA efforts to assess pesticide risks, specifically the application of an extra tenfold safety margin for children. In 1939 there were thirty-two pesticide products registered in the United States; there are now more than 20,000, and farmers use an estimated 1.2 billion pounds of pesticides annually. This industry is big business with large political clout: Agricultural chemical companies made more than $1.6 million in campaign contributions in 2001-02. The average farmworker made $8,750 in 1999-2000.

The article presents news related to the Internet as of October 1, 1998. According to a General Accounting Office Report, based on a six month long investigation that ended in May 1998, a surplus of the U.S. military equipment sold around the world often contains technology that should have been removed. According to a study conducted by Nielson Media Research and CommerceNet, roughly 70 million men and women over the age of 16 and living in the U.S. use Internet. The article reports on a breakthrough method to replace corrosive chemicals used to etch circuits on silicon chips is being tested at the Los Alamos National Laboratory in New Mexico, reports New Scientist. A computer system that determines the severity of sewage spills and which beaches they will affect has been installed in the New York, tri-state region.

Reports on developments in the field of science as of September 1999. Research into a vaccine against Alzheimer's disease by Elan Pharmaceuticals; The drawback of allowing infants to sleep on their backs; Endorsement by a government panel of scientists in the United States on a nonanimal method of testing the safety of chemicals.

The article discusses the role of temporary cooling solutions such as cooling towers, chillers and air conditioners in avoiding project delays and costly commitments on short and mid-term needs of the process heating. It mentions an increase in chemical production in the U.S. in 2016 according to the American Chemistry Council (ACC). It also mentions expected increase in the refinery production through 2040 according to U.S. Energy Information Administration.

Last month defense ministers of the North Atlantic Treaty Organization (NATO) endorsed the U.S. plans to add nerve gas to the alliance arsenal, thus, according to U.S. President Ronald Reagan administration, fulfilling the condition of NATO acceptance that Congress had set before it would appropriate money for manufacturing weapons. In 1969, in the face of rising criticism about the American use of chemicals in Vietnam, President Richard Nixon declared a moratorium on the production of lethal chemicals and unilaterally renounced the use of biological warfare.

Reports that new scientific research suggests that the average male sperm count has fallen by almost a half in the past 50 years. Dozens of ubiquitous pollutants which may be to blame; Reference to the book `Our Stolen Future'; Compilation of growing list of chemicals with hormonelike properties; Impact of environmental hormones on fertility; Research on animals.

Focuses on issues stemming from the increasing occupational cancers in the U.S. Estimates on the annual number of work-related cancer cases per year; Citations of chemicals with potential health hazards; Response of the Food and Drug Administration to the issue; Information that the total budget for the National Institute of Occupational Safety and Health (NIOSH), the federal agency charged with research to protect worker safety, is under $30 million; Lack of epidemiologists in the NIOSH staff.

Provides information on the regulation of toxic chemicals in the United States. Comments on the chemical regulation; Information on the Toxic Substances Control Act (TSCA) passed in 1976; Provisions of TSCA.

Focuses on toulene diisocyanate (TDI), a toxic chemical and its harmful effects. Percentage of TDI consumption in American plastics industry; Products made from polyurethane, a plastic compound that contains TDI; Occupational disease caused by TDI; Information on how TDI disrupts body functions.

Discusses the use of chemicals against forested and agricultural lands in Vietnam, as part of U.S. military strategy and tactics, as of November 1967. Purpose of using herbicides, as stated by Assistant Secretary of State Dixon Donnelley; Problem with herbicides affecting a susceptible link in an important food chain; Toxicity of the herbicides used; Details of the defoliation and crop destruction process.

The article focuses on the impact of the ruling of the U.S. Supreme Court of antitrust law to E.I. du Pont de Nemours & Co. and General Motors (GM) Corp. to the business enterprise in the U.S. According to Justice Harold H. Burton the ruling has disregards the statute purpose and language as well as the administrative practice in 40 years. It adds that the hearing for the final disposition will take for six months, according to Federal judge Walter Labuy.

The article focuses on the efforts of the Chemical Construction Corp. (Chemico) to keep ahead of competition by bringing out new developments. Chemico will be the first company to make metals by chemical treatment in the U.S. Chemico has tried to keep competition at arm's length by specializing in fertilizer, chemicals and metals. The metals process will also give Chemico a chance to broaden its market in the ammonia plants.

The article reports on the investigations by the U.S. Senate Small Business Committee about the effects of battery additive AD-X2 on lead acid battery. AD-X2 was developed by K. J. Laidler of Catholic University and Professor H. C. Weber of the Massachusetts Institute of Technology (M.I.T.). It is opined that the recent attacks on the U.S. National Bureau of Standards (NBS), by the promoters of the product to get their product approved has evolved into a controversy in the scientific arena. Although NBS has found the product useless, the M.I.T. continues to defend its product.

The article discusses the return of stock buyers to depressed cyclical and growth stocks that would profit from a business upturn in the U.S. According to investors, business and profit margins will recover and only by putting money in common stock can they keep pace with deterioration in the dollar. The Standard & Poor's utility index showed that utility stocks have increased 8.7%, while industrials jumped 1.5%. The decline in prices of chemical shares indicates a decline in industrial activity.

The article focuses on United States Steel Corp., considered the biggest steel firm in the U.S., as one of the country's 10 biggest chemical concerns. U.S. Steel is facing the dilemma on whether to process raw chemicals or to continue to sell them crude. The author believes the decision is a difficult one because of two main problems. The author claims that if raw chemicals go into refining, it will mean a huge plant-construction program. Also, the chemical processing units need to operate at a high rate to be economical once the plants are built.