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Text-matching software (TMS) is a standard part of efforts to prevent and detect plagiarism in upper secondary and higher education. While there are many studies on the potential benefits of using this technology, few studies look into potential unintended side effects. These side effects include students worrying about being accused of plagiarism due to TMS output, even though they did not intentionally plagiarise. Although such worries are frequently mentioned in the literature, little is known about how prevalent they are, why they occur and how students react to them. This paper aims to fill this knowledge gap. The data for the study comprise 36 interviews with upper secondary and Bachelor students from three European countries combined with survey data from 3,424 students from seven European countries representing a broad range of disciplines. The study found that a substantial proportion of the two groups of students -- 47% of upper secondary and 55% of Bachelor students -- had experienced TMS-related worries during their current studies. Furthermore, there were substantial differences across countries. Students worry partly because they have a poor understanding of how TMS is used in their institution, and partly because they know that plagiarism is taken very seriously. The study shows that TMS-related worries can lead students to become very focused on not being caught plagiarising, to such an extent that some adopt citation practices that they believe are suboptimal. The paper concludes that institutions using TMS should always combine it with training for students and teachers. Students should be clearly informed about how TMS is used and should develop an understanding of plagiarism and good citation practice that goes beyond the narrow focus on any overlap between texts elicited by the software.

In this paper, we introduce "Integrity Games" (https://integgame.eu/)--a freely available, gamified online teaching tool on academic integrity. In addition, we present results from a randomized controlled experiment measuring the learning outcomes from playing "Integrity Games." "Integrity Games" engages students in reflections on realistic and relevant academic integrity issues that lie in the grey zone between good practice and misconduct. Thereby, it aims to (1) motivate students to learn more about academic integrity, (2) increase their awareness of the grey-zone issues, and (3) increase their awareness of misconduct. To achieve these aims, the tool presents four gamified cases that lead students through an engaging narrative. The experiment to measure learning outcomes was conducted in three European countries, and included N = 257 participants from across natural science, social science and the humanities. We show that the participants enjoyed playing "Integrity Games," and that it increased their sensitivity to grey-zone issues and misconduct. However, the increases identified were similar to those achieved by the participants in the control group reading a non-gamified text. We end by discussing the value of gamification in online academic integrity training in light of these results.

Calls continue for the decolonisation of higher education (HE). Based on internationalisation debates, a research team from Africa, Europe and Latin America reviewed published decolonisation voices. Using bibliometric analysis and a conceptual review of abstracts, the authors examined the drivers framing decolonisation in HE and identified the voices in those debates which involved the historically oppressed and those wishing to elicit change in these debates. The paper recognises the importance for decolonisation in education as the tensions explored by the authors often intersect through HE into other domains of the political, social, economic and culturally important areas for replication and change in society.

Wildfires directly emit 2.1 Pg carbon (C) to the atmosphere annually. The net effect of wildfires on the C cycle, however, involves many interacting source and sink processes beyond these emissions from combustion. Among those, the role of post‐fire enhanced soil organic carbon (SOC) erosion as a C sink mechanism remains essentially unquantified. Wildfires can greatly enhance soil erosion due to the loss of protective vegetation cover and changes to soil structure and wettability. Post‐fire SOC erosion acts as a C sink when off‐site burial and stabilization of C eroded after a fire, together with the on‐site recovery of SOC content, exceed the C losses during its post‐fire transport. Here we synthesize published data on post‐fire SOC erosion and evaluate its overall potential to act as longer‐term C sink. To explore its quantitative importance, we also model its magnitude at continental scale using the 2017 wildfire season in Europe. Our estimations show that the C sink ability of SOC water erosion during the first post‐fire year could account for around 13% of the C emissions produced by wildland fires. This indicates that post‐fire SOC erosion is a quantitatively important process in the overall C balance of fires and highlights the need for more field data to further validate this initial assessment. [ABSTRACT FROM AUTHOR]

Objectives: The current European crisis in human resources in health has opened the debate about working conditions and fair wages. This is the case with Resident doctors, which have faced challenges throughout Europe. In Portugal, they account for about a third of the doctors in the Portuguese National Health Service. No studies to date objectively demonstrate the working conditions and responsibilities undertaken. This study aims to quantify the residents' workload and working conditions. Methods: Observational, retrospective cross-sectional study which involved a survey on the clinical and training activity of Portuguese residents, actively working in September 2020. The survey was distributed through e-mail to residents' representatives and directly to those affiliated with the Independent Union of Portuguese Doctors. The descriptive analysis assessed current workload, and logistic regression models analyzed associations with geographical location and residency seniority. Results: There were a total of 2,012 participants (19.6% of invited residents). Of the residents giving consultations, 85.3% do so with full autonomy. In the emergency department, 32.1% of the residents work 24 h shifts and 25.1% work shifts without a specialist doctor present. Regarding medical training, 40.8% invest over EUR 1,500 annually. Autonomy in consultations was associated with being a Family Medicine resident (OR 4.219, p < 0.001), being a senior resident (OR 5.143, p < 0.001), and working in the Center (OR 1.685, p = 0.009) and South regions (OR 2.172, p < 0.001). Seniority was also associated with investing over EUR 1,500 in training annually (OR 1.235, p = 0.021). Conclusion: Residents work far more than the contracted 40 h week, often on an unpaid basis. They present a high degree of autonomy in their practice, make a very significant personal and financial investment in medical training, with almost no time dedicated to studying during working hours. There is a need to provide better working conditions for health professionals, including residents, for the sake of the sustainability of health systems across Europe. [ABSTRACT FROM AUTHOR]

Portugal is one of the major fish consumers in Europe and the World. According to the FAO and the WHO, fish consumption should be increasingly recommended in a healthy and sustainable diet, not only for the diversity of species but also for its health benefits to consumers. Fish is an essential source of nutrients, as it is low in fat content and high level of protein, vitamins, and minerals. In recent decades, this food group's consumption has increased and become available to consumers far from coastal areas. This study aimed to compare Atlantic Bonito samples captured in two seasons (Spring and Autumn) to characterise the seasonality of this specie regarding nutritional, chemical and sensorial properties. Parameters such as pH, water activity, moisture, protein, lipids, carbohydrates, chlorides, fibre, and ash were determined using the fish's muscular tissue. A quantitative descriptive analysis (QDA®) was carried out with six semi-trained panellists. The fish attributes evaluated by the panellists were: characteristic colour, odour, and flavour; superficial shine; chipping; off-odour; ammoniacal and sea odour; hardness; juiciness; fibrousness; acid, bitter and sea/algae taste; and off-flavour. In order to compare not only seasonality but also the effect of the time during cooking, samples were divided into two batches: 5 and 10 min of cooking time. Results showed no significant differences in water activity, carbohydrates, chlorides, and fibre between fish fillets' capture in Spring and Autumn (p>0.05). On the contrary, significant differences were found for moisture, protein, and ash between the fish fillets' capture in Spring and Autumn (p>0.05). Regarding lipids content, Autumn fish samples were 6.32-fold higher than Spring fish samples (p<0.05). As for sensory analysis, panellists noticed some differences between Spring and Autumn samples regarding the following characteristics: superficial shine, chipping, characteristic odour, sea odour, hardness, juiciness, fibrousness, characteristic flavour, and acid taste. These differences were more pronounced on 10 min batch samples, regardless of the seasonality. The sensory analysis results showed that cooking time is the most important factor for the overall sensory evaluation regardless of the season. However, 5 min cooked fish fillets captured in Spring scored higher points than fish samples captured in Autumn. It can be concluded that the Atlantic Bonito seasonality influences sensory characteristics and nutritional properties, mainly the lipid content. [ABSTRACT FROM AUTHOR]

Intra-Annual Density Fluctuations (IADFs) are an important wood functional trait that determine trees' ability to adapt to climatic changes. Here, we use a large tree-ring database of 11 species from 89 sites across eight European countries, covering a climatic gradient from the Mediterranean to northern Europe, to analyze how climate variations drive IADF formation. We found that IADF occurrence increases nonlinearly with ring width in both gymnosperms and angiosperms and decreases with altitude and age. Recently recorded higher mean annual temperatures facilitate the formation of IADFs in almost all the studied species. Precipitation plays a significant role in inducing IADFs in species that exhibit drought tolerance capability, and a growth pattern known as bimodal growth. Our findings suggest that species with bimodal growth patterns growing in western and southern Europe will form IADFs more frequently, as an adaptation to increasing temperatures and droughts. [ABSTRACT FROM AUTHOR]

Culture and identity are dynamic realities. Therefore, the essentialist view of culture and identity does not explain the process of integration of minorities in a context of acculturation, and leads to policies of "ghettoisation". This text focuses on what we describe as "cultural transfusion". By means of this process, we analyse two tendencies in personal identity: the first tendency, among professionals, integrates the culture of origin into the emerging cultural identity; the second denies the culture of origin and idealises the target culture as its aim in life. The most representative minorities in Portugal originate from the former colonies, Angola, Cabo Verde, Mozambique, East Timor, Macaw, Brazil and St. Tome, and the immigrants from Eastern Europe that came to Portugal in the 1980s. We also describe the cultural and ethnic diversity of Portuguese society and show how nationalist ideology, imperialist ideals and the "Luso-tropical" theory of Gilberto Freyre shaped the "soft-racism" of the Portuguese. Furthermore, we give account of the recent trends of migration from Eastern Europe to Portugal, and try to explain Portuguese policy towards immigration after joining the European Union. (Contains 1 note and 4 figures.)

To explore optometric practices and attitudes in the management of keratoconus patients in LatinAmerica and how they are influenced by eye-care technology will help to minimise disease progression and their impact on patients' quality of life in Latin America. Keratoconus is a progressive, bilateral and asymmetric corneal disorder that requires a multidisciplinary approach, the use of different eye assessment technology, and different management approaches; mainly contact lenses and surgery. Self-reported answers to an online survey (adapted to primary eye care) distributed via a newsletter emailed by various professional organisations across 15 Latin American countries were assessed and compared with those previously reported in three European countries. Answers from 977 eye care practitioners (60%) with >10 years of experience (396 in Latin America and 581 in Europe) were assessed. A total of 65.9% of Latin American responders prescribed rigid corneal lenses (RCL), although more than half of the respondents (54.0%) would fit more RCL if they underwent further training in RCL fitting. A majority of Latin American practitioners (74.0%) considered that RCL fitting is more difficult in keratoconus, requiring more diagnostic lenses (4.6 ± 2.7; median 4; range 1-10) than are necessary for healthy eyes. Low availability of corneal topography was reported in Latin America (23%), although practitioners with topographers are more likely to prescribe RCL (92.3%) and detect more new patients with keratoconus per year (83.5%). A minority of respondents referred keratoconus patients to another optometrist (25.8%) or (40.4%) participated in comanagement with ophthalmologists. This study provides initial evidence regarding keratoconus management in Latin America and suggests that actions are necessary to improve RCL training, facilitate eye-care technology accessibility and encourage comanagement between eye care practitioners to minimise disease progression and their impact on patients' quality of life in Latin America. [ABSTRACT FROM AUTHOR]

The use of anaesthetic agents has been increasing to address the welfare needs of different fish species in scientific and aquaculture practices. MS‐222 is the most used synthetic anaesthetic but some limitations and side effects have been reported. Natural substances have been used as potential substitutes with clove oil playing an important role due to its eugenol content. Yet, other monoterpenes have shown anaesthetic properties in different fish species. As such, a quantitative assessment has been conducted to explicitly relate and summarise the use of monoterpenes with described anaesthetic properties in fish. A combined PubMed, Web of Science, Scopus, PubMed Central and Europe PMC electronic database search was performed, from January 2002 to August 2022, following the PRISMA guidelines. Out of 1555 articles retrieved from the literature search, 30 English reports met the criteria for inclusion in the meta‐analysis through a generic inverse‐variance method (random‐effects model) and according to the fish age. The findings show a total of 10 different monoterpenes with high homogeneity and effectiveness in inducing anaesthesia and recovery according to the fish anaesthetic criteria. Further subgroup analysis showed these effects were independent of fish age. Meta‐regression of the included studies revealed an inverse linear association between anaesthesia induction and recovery time and water bath temperature while no further correlation was found with other confounding factors (body weight, water pH and dissolved oxygen levels). Although further studies will be required, this meta‐analysis provides robust evidence that different monoterpenes serve as an attractive and effective alternative for fish anaesthesia although water bath temperature also played an important role in anaesthesia outcome. [ABSTRACT FROM AUTHOR]

Objectives: This study investigates causes, characteristics and temporal trends of paediatric major trauma over a 10-year period and assesses potential preventive areas. Methods: Single-centre retrospective study of paediatric trauma patients admitted to a Paediatric Intensive Care Unit (PICU) in a tertiary university hospital in Europe with a level 1 paediatric trauma centre, from 2009 to 2019. Paediatric major trauma patients were defined as patients aged < 18 years with Injury Severity Score > 12, admitted for intensive care for more than 24 h following trauma. Demographic, social and clinical information, including place and mechanism of trauma, injury pattern, pre-hospital and in-hospital procedures, and length of stay in PICU was extracted from PICU medical records. Results: Total 358 patients included (age 11 ± 4,9 years; 67% male); 75% were involved in road traffic accidents: 30% motor vehicle collision, 25% pedestrian, 10% motorcycle and bicycle each. Falls from height injured 19% of children, 4% during sports activities. Main injuries were to head/neck (73%) and extremities (42%). The incidence of major trauma was highest in teenagers and did not show a decreasing trend during the study years. All fatalities (1,7%; n = 6) were related to head/neck injuries. Motor vehicle collisions resulted in higher need for blood transfusion (9 vs. 2 mL/kg, p = 0,006) and the highest ICU-mortality (83%; n = 5). Children in motorcycle accidents had longer ICU length-of-stay (6,4 vs. 4,2 days, p = 0,036). Pedestrians had 25% higher risk of head/neck injuries (RR 1,25; 1,07 − 1,46; p = 0,004), and higher incidence of severe brain injury (46% vs. 34%, p = 0,042). Most children in motor-vehicle/bicycle accidents were not using restraints/protective devices (45%) or were using them inappropriately (13%). Conclusions: Over the last decade, the absolute numbers of paediatric major trauma did not decrease. Road traffic accidents remain the leading cause of injury and death. Teenagers are at highest risk for severe trauma. Appropriate use of child restraints and protective equipment remain key for prevention. [ABSTRACT FROM AUTHOR]

Copyright of Portuguese Journal of Dermatology & Venereology is the property of Sociedade Portuguesa de Dermatologia & Venereologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Purpose: This study aimed to perform a systematic review and meta-analysis of the literature on mandibular incisive canal (MIC) studies using cone beam computed tomography (CBCT). Materials and Methods: A PROSPERO-registered systematic review (#42017056619) was conducted following the PRISMA statements to summarize current knowledge on the CBCT aspects of the MIC. A search was performed in PubMed's Medline and Scopus databases, without date or language restrictions, using the algorithm {[(Interforaminal region) OR (mandibular incisive channel) OR (mandibular incisive nerve) OR (mental mandible) OR (anterior mandible) (cone beam computed tomography)]}. Also, the references were crosschecked. The Meta-Analysis of Statistics Assessment and Review Instrument and meta-analysis was used to evaluate the selected studies. Results: A total of 410 articles were found, and 25 studies were selected after a two-step selection process. The CBCT systems differed regarding field of view (FOV) (large, n = 3; medium, n = 2; small, n = 4; not informed, n = 16) and voxel size (0.15 to 0.4 mm). Geographically, the studies were distributed across four continents (South America, North America, Asia, and Europe), and there was a statistical significance of studies from the American and Asian continents (P < .0001). From 3,421 CBCT exams, the number of female patients was slightly higher than male, and the mean age ranged from 29.8 to 59.1 years. The overall mean prevalence of MIC was 89.6% ± 15.08%, and bilateral occurrence was statistically significant (P < .0001). The studies using a voxel size lower than 0.3 mm showed the highest mean prevalence (93.88%) in comparison with voxel size described as ≥ 0.3 mm (89.33%). Diameter (0.45 to 4.12 mm) and length (6.6 to 40.3 mm) showed great variability among the included studies. Conclusion: The results of this systematic review evidenced a high worldwide prevalence of MIC. There was no prevalence of MIC in relation to sex, and its presence was mainly related to adults between the fourth and sixth decades of life. In addition, great heterogeneity of methodologies was observed. [ABSTRACT FROM AUTHOR]

The introduction of non-indigenous species (NIS) is one of the major threats to the integrity of European coastal ecosystems. DNA-based assessments have been increasingly adopted for monitoring NIS. However, the accuracy of DNA-based taxonomic assignments is largely dependent on the completion and reliability of DNA barcode reference libraries. As such, we aimed to compile and audit a DNA barcode reference library for marine invertebrate NIS occurring in Europe. To do so, we compiled a list of NIS using three databases: the European Alien Species Information Network (EASIN), the Information System on Aquatic Non-indigenous and Cryptogenic Species (AquaNIS), and the World Register of Introduced Marine Species (WRiMS). For each species, we retrieved the available cytochrome c oxidase subunit I (COI) mitochondrial gene sequences from the Barcode of Life Data System (BOLD) and used the Barcode, Audit & Grade System (BAGS) to check congruence between morphospecies names and Barcode Index Numbers (BINs). From the 1249 species compiled, approximately 42% had records on BOLD, among which 56% were discordant. We further analyzed these cases to determine the causes of the discordances and attributed additional annotation tags. Of the 622 discordant BINs, after revision, 35% were successfully solved, which increased the number of NIS detected in metabarcoding datasets from 12 to 16. However, a fair number of BINs remained discordant. Reliability of reference barcode records is particularly critical in the case of NIS, where erroneous identification may trigger action or inaction when not required. [ABSTRACT FROM AUTHOR]

Objective: To update the census of immigrant nurses in Brazil. Methods: descriptive and quantitative study on the dimension and characteristics of the census of immigrant nurses, according to the states and regions of destination, countries of origin, age, and sex. Data were obtained from the Federal Nursing Council database and analyzed descriptively. Results: Of the total of 176 immigrants, 145 are women and 31 are men, showing the female prevalence in the nursing profession. Of these, 96 are Peruvians, 126 South Americans, 28 Europeans, 9 Cubans, 5 North Americans, and 8 immigrants from different countries. Conclusion: the census from 1973 to 2021 shows the predominance of Peruvian immigrants, with a high concentration in the north and southeast of Brazil, respectively in the state of Amazonas and São Paulo. [ABSTRACT FROM AUTHOR]

Protected areas (PA) play an important role in minimizing the effects of soil erosion in watersheds. This study evaluated the performance of machine learning models, specifically support vector machine with linear kernel (SVMLinear), support vector machine with polynomial kernel (SVMPoly), and random forest (RF), on identifying indicators of soil erosion in 761 sub-watersheds and PA in northern Portugal, by using soil erosion by water in Europe, according to the revised universal soil loss equation (RUSLE2015), as target variable. The parameters analyzed were: soil erosion by water in Europe according to the revised universal soil loss equation (RUSLE2015), total burned area of the sub-watershed in the period of 1975-2020, fire recurrence, topographic wetness index (TWI), and the morphometric factors, namely area (A), perimeter (P), length (L), width (W), orientation (O), elongation ratio (Re), circularity ratio (Rc), compactness coefficient (Cc), form factor (Ff), shape factor (Sf), DEM, slope, and curvature. The median coefficient of determination (R2) for each model was RF (0.61), SVMpoly (0.68), and SVMLinear (0.54). Regarding the analyzed parameters, those that registered the greatest importance were A, P, L, W, curvature, and burned area, indicating that an analysis which considers morphometric factors, together with soil erosion data affected by water and soil moisture, is an important indicator in the analysis of soil erosion in watersheds. [ABSTRACT FROM AUTHOR]

Copyright of Movimento (0104754X) is the property of Movimento, da Escola de Educacao, Fisica, Fisioterapia e Danca and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In the EU, a post-mortem inspection of finishing pigs comprises visual inspections of the carcass and offal followed by additional examinations, such as palpation and incision of parts, when needed. Moreover, it can include various laboratory tests. Since European meat inspection is regulated by the EU, one may assume that post-mortem inspection is performed in the same way in the Member States. However, previous studies showed that variations exist. This article shows the results of a survey performed in September 2020 on how visual meat inspection of finishing pigs is applied in Europe. By using a questionnaire, palpations, incisions and other procedures for 10 gross pathological findings and laboratory methods applied by official veterinarians to evaluate the fitness of meat for human consumption were assessed. We received 44 responses from 26 European countries. Most respondents reported that visual meat inspection was a generally applied inspection method. The main reason for not applying visual meat inspection was export requirements. The most important reasons for applying palpations and incisions in addition to visual inspection were findings detected in ante- or post-mortem inspection. There was considerable variation in the use of palpations and incisions, other post-mortem procedures and laboratory tests to assess meat fitness for human consumption. The respondents mentioned some country-specific practices, but we also observed variations within the responding official veterinarians that could not be explained by country of origin or years of work experience. Additional detailed studies on the variation are needed before harmonisation of meat inspection procedures are attempted. [ABSTRACT FROM AUTHOR]

Past molecular studies using mtDNA sequences and alloenzymes signalled the existence of at least two cryptic species within the Hediste diversicolor morphotype, in European coasts. However, to this day, no new species descriptions have been made. In this study, we identified five completely sorted lineages using a multi-locus approach, including the mitochondrial DNA cytochrome oxidase I gene (COI-5P) and the nuclear markers ITS2 rRNA and 28S rRNA. The molecular data were complemented with morphometric measurements examined through multivariate statistical analysis and the incorporation of statistical dissimilarities. Apart from the Baltic Sea, where three of the lineages occur in sympatry, Hediste diversicolor comprises four deeply divergent allopatric lineages in the rest of Europe. They group populations from the NE Atlantic and part of the Western Mediterranean Sea; from the Tyrrhenian Sea; from the Adriatic and Ionian Sea; and, lastly, from the Caspian, Black and the northern Aegean Seas. The lineage from the Ionian Sea revealed low genetic distances compared with the one from the Adriatic Sea and lacked enough specimens for the morphometric analysis, preventing further conclusions about its independent status. Three independent morphometric clusters were identified mainly based on worm size, the distance between the anterior and posterior eyes, parapodia proportions and the length of several prostomial appendages. Two sympatric lineages present in the Baltic Sea, showed evidence of possible hybridization and lacked significant PCA morphometric variation between them. The two remaining lineages were formally described as new species, namely Hediste pontii sp. nov. (Adriatic Sea) and Hediste astae sp. nov. (northern Aegean, Caspian and Black Seas). These new species can now be formally recognized and used in biomonitoring or other relevant ecological studies. Finally, a neotype is defined for H. diversicolor, whose usage is restricted to the NE Atlantic lineage. [ABSTRACT FROM AUTHOR]

As a teaching subject, animal welfare is challenging for educators and learners, as was recently shown in a recent survey on the evolution of animal welfare teaching in Europe. Among several suggestions to overcome the current resistance to implementing animal welfare education, we highlight two. The first is that animal welfare education should be based on learner-centred approaches; the second is that it should encompass both animal welfare science and ethics and law. To the best of our knowledge, there are no learner-centred pedagogical approaches that can simultaneously explore scientific and ethical concepts. Furthermore, when exploring ethical concepts within the educational context, there is the additional challenge of being able to depart from discussion and debate to a systematic organization of knowledge. Our work simultaneously addresses these two challenges, presenting the design and implementation of a novel web-based learner-centred pedagogical platform for farm animal welfare teaching. The platform, named ANIPHI, uses the Delphi method's iterative nature as a learning process to generate both reflection and (online) debate among learners. ANIPHI can be used by educators in an online environment, in a classroom environment, or in a combination of the two environments. ANIPHI was developed within the ERASMUS+ ANICARE project and is an open web-based platform for all educators interested in teaching farm animal welfare. Given ANIPHI's flexible and user-friendly nature, the platform simultaneously exposes learners to ethical and scientific concepts in different educational realities, according to the educator's objectives. Furthermore, videos depicting different husbandry practices across different types of animal production and countries are embedded in the platform. These videos are commented on by the farmer himself and by animal scientists, which enriches the learner's experience. Educators across the ANICARE consortium have already successfully tested the ANIPHI platform for different farm animal welfare topics. We conclude this article by presenting one example of using ANIPHI in a real-life educational context, where we discuss some aspects of the design and use of our pedagogical platform. [ABSTRACT FROM AUTHOR]

Background: Co‐medication is common among patients with allergic rhinitis (AR), but its dimension and patterns are unknown. This is particularly relevant since AR is understood differently across European countries, as reflected by rhinitis‐related search patterns in Google Trends. This study aims to assess AR co‐medication and its regional patterns in Europe, using real‐world data. Methods: We analysed 2015–2020 MASK‐air® European data. We compared days under no medication, monotherapy and co‐medication using the visual analogue scale (VAS) levels for overall allergic symptoms ('VAS Global Symptoms') and impact of AR on work. We assessed the monthly use of different medication schemes, performing separate analyses by region (defined geographically or by Google Trends patterns). We estimated the average number of different drugs reported per patient within 1 year. Results: We analysed 222,024 days (13,122 users), including 63,887 days (28.8%) under monotherapy and 38,315 (17.3%) under co‐medication. The median 'VAS Global Symptoms' was 7 for no medication days, 14 for monotherapy and 21 for co‐medication (p <.001). Medication use peaked during the spring, with similar patterns across different European regions (defined geographically or by Google Trends). Oral H1‐antihistamines were the most common medication in single and co‐medication. Each patient reported using an annual average of 2.7 drugs, with 80% reporting two or more. Conclusions: Allergic rhinitis medication patterns are similar across European regions. One third of treatment days involved co‐medication. These findings suggest that patients treat themselves according to their symptoms (irrespective of how they understand AR) and that co‐medication use is driven by symptom severity. [ABSTRACT FROM AUTHOR]

Purpose: The main objective of this work is to show that the traditional specific characteristics of companies as well as cultural and religious dimensions can influence the leverage of companies in different macro-environmental systems. Design/methodology/approach: To achieve this aim, the authors have used data from 1.568 firms from 7 European countries between 2010 and 2016, and the models were estimated by using panel data methodology, specifically the generalized method of moments (GMM) estimation method by Arellano and Bover (1995) and Blundell and Bond (1998). Findings: Overall, the empirical results point out that the cultural moderating factors are essential in determining companies' capital structure, regardless of the country's legal origin. The study results also show that traditional variables, intrinsic to management, macroeconomic environment and religion, have a central role in capital structure, namely for the civilian countries. Originality/value: As far as the authors know, this is the first work that uses, in addition to the traditional specific characteristics of companies, cultural dimensions and religion, as determinants of debt levels, in different legal systems for Europe. [ABSTRACT FROM AUTHOR]

The extensive use of fossil fuels in recent decades is a well-known cause of the climate crisis. Climate action inevitably requires the strategic reorientation of industries that are part of the fossil fuel regime. International oil companies are central to this regime and possess the incumbent's characteristic power and influence to steer this process. However, European international oil companies continue to invest in fossil fuels, even as they acknowledge the climate crisis imperative. Socio-political and economic dynamics can either reinforce the oil regime or pressure firms to take climate action. We aim to comprehensively analyse the dynamics between external socio-political and economic actors' pressures to climate action on the one side, and the industry response on the other, from 2005 to 2019, using Geels Triple Embeddedness Framework. Drawing on a wide range of qualitative and quantitative longitudinal data (e.g. regulations, oil and renewables market trends, companies' investments in oil, renewables, and low-carbon technologies), we characterised the pressures and responses of the different analytical categories and established three phases. The results indicate that policy pressure on the oil regime in this period lacked constancy and comprehensiveness. The Kyoto Protocol ratification produced an initial momentum that prompted some companies to invest in alternative fuels and renewables, but efforts faded after 2010. Societal calls for a transition from fossil fuels and divestments from oil companies have risen since 2017. Recent socio-economic pressures combined with policy pledges for net-zero emissions have prompted all companies to invest beyond fossil fuels. However, efforts are still marginal and additional advancements in climate policy are necessary to foster the renewables market and to promote the phase-out of oil. Key policy insights Europe lacks a comprehensive policy framework to support the fast deployment of available alternative fuels. Policies need to foster the development and adoption of alternatives to petrochemical products, alongside their reduction and recycling. Apart from supporting renewable energy and other alternatives to oil, policies also need to target the phase-out of oil and send a clear signal to companies. [ABSTRACT FROM AUTHOR]

Religion is one of the strategies used to cope with life stressful events, particularly in cancer patients. This study aimed to translate, adapt and validate the 5-item Duke University Religion Index (DUREL) into European Portuguese. This is a cross-sectional study in a sample of cancer patients receiving chemotherapy. Data were collected in July–October 2018, and the study was approved by the ethics committee of the institution. A sample of 150 participants was included (64.7% female and 35.3% male), aged 35–83 years, and mainly Catholic (86.7%). Participants who were females, older, had lower education and from evangelical religious traditions scored higher on the total score. The Cronbach's alpha was 0.89. Factor analysis revealed a one-factor solution. Convergent validity was achieved between DUREL and BIAC (r = 0.78; p < 0.01). The DUREL European Portuguese version is a valid and reliable tool for measuring religious commitment in cancer patients undergoing chemotherapy. [ABSTRACT FROM AUTHOR]

Previously, we identified a Chlamydia trachomatis lymphogranuloma venereum (LGV) recombinant strain possessing a non-LGV ompA genotype. Here, culture-independent genome sequencing confirms its circulation in Europe, Middle East, and North America, and unveils emergence of antibiotic resistance. Broad surveillance is needed. [ABSTRACT FROM AUTHOR]

Objectives. This study is aimed at identifying the best clinical model to predict poststroke independence at 6 and 18 months, considering sociodemographic and clinical characteristics, and then identifying differences between countries. Methods. Data was retrieved from the International Stroke Trial 3 study. Nine clinical variables (age, gender, severity, rt-PA, living alone, atrial fibrillation, history of transient ischemic attack/stroke, and abilities to lift arms and walk) were measured immediately after the stroke and considered to predict independence at 6 and 18 months poststroke. Independence was measured using the Oxford Handicap Scale. The adequacy, predictive capacity, and discriminative capacity of the models were checked. Countries were added to the final models. Results. At 6 months poststroke, 35.8% (n = 1088) of participants were independent, and at 18 months, this proportion decreased to 29.9% (n = 747). Both 6 and 18 months poststroke predictive models obtained fair discriminatory capacities. Gender, living alone, and rt-PA only reached predictive significance at 18 months. Poststroke patients from Poland and Sweden showed greater chances to achieve independence at 6 months compared to the UK. Poland also achieved greater chances at 18 months. Italy had worse chances than the UK at both follow-ups. Discussion. Six and eight variables predicted poststroke independence at 6 and 18 months, respectively. Some variables only reached significance at 18 months, suggesting a late influence in stroke patients' rehabilitation. Differences found between countries in achieving independence may be related to healthcare system organization or cultural characteristics, a hypothesis that must be addressed in future studies. These results can allow the development of tailored interventions to improve the outcomes. [ABSTRACT FROM AUTHOR]

This article analyses some new questions that have emerged as a result of the transposition of the single economic unit doctrine to the realm of private enforcement. The doctrine, originally developed in the context of public enforcement of EU competition law, allows liability to be attributed to parent companies for infringements committed by their subsidiaries, thereby disregarding the corporate separateness of the legal entities involved in order to reflect their economic unity in the market. As antitrust damages become more common throughout Europe, the single economic unit doctrine requires further clarification. In particular, it is not evident whether the doctrine may also apply in an inverted or horizontal manner: whether subsidiaries might be held liable for antitrust infringements committed by their parent companies or whether companies might be held liable for antitrust infringements committed by other entities controlled by the same parent company. This question has led to divergent decisions by national courts throughout Europe. This article rejects the idea of group company liability for antitrust infringements and argues against the automatic recognition of horizontal or inverted liability, which is believed to amount to a violation of general principles of EU law and which cannot be justified on grounds of deterrence, nor on the principle of effectiveness. [ABSTRACT FROM AUTHOR]

New policy developments have emerged in relation to soil conservation after 2020. The Common Agricultural Policy (CAP) 2023–2027, the proposal for a Soil Monitoring Law and the mission 'A Soil Deal for Europe' have shaped a new policy framework at EU level, which requires updated assessments on soil erosion and land degradation. The EU Soil Observatory (EUSO) successfully organised a scientific workshop on ' Soil erosion for the EU ' in June 2022. The event has seen the participation of more than 330 people from 63 countries, addressing important topics such as (i) management practices, (ii) large scale modelling, (iii) the importance of sediments in nutrient cycle, (vi) the role of landslides and (v) laying the foundations for early career scientists. As a follow up, among the 120 abstracts submitted in the workshop, we received fifteen manuscripts, out of which nine were selected for publication in the present special issue. In this editorial, we summarize the major challenges that the soil erosion research community faces in relation to supporting the increasing role of soils in the EU Green Deal. • The EU Soil Observatory (EUSO) organised the Soil Erosion workshop in June 2023. • The workshop was successful as attended by 333 participants and addressed 8 thematic areas. • We address the main developments of the EU policies in relation to soil under the Green Deal. • The editorial includes a summary of 9 published manuscripts. • We propose the main challenges that erosion community will face in the coming yeas. [ABSTRACT FROM AUTHOR]

Aim: Range size conservatism suggests that closely‐related species maintain geographic ranges of similar extent. However, consensus regarding this suggestion has not been reached. To shed more light on this phenomenon, we studied freshwater plant range size conservatism, range overlap and environmental niche conservatism using congeneric species comparison in two continents. In addition, we investigated whether a phylogenetic signal is found in the range sizes of aquatic plants. Location: Europe and North America. Taxon: Freshwater plants. Methods: Across spatial resolutions (50 km2, 100 km2 and 200 km2), we applied Spearman correlations among 347 and 730 pairs of congeneric species in Europe and North America, respectively, and 63 pairs shared between them. In addition, Spearman correlations were used to evaluate how the degree of spatial overlap influences range sizes and which environmental variables explain variation in range sizes. Brownian evolutionary model was used to assess the phylogenetic signal in species range sizes. Results: We found no evidence of range size conservatism across spatial resolutions for any species and species shared between the continents. In addition, range sizes of more closely related species did not overlap geographically more than those of distantly related ones and no support for environmental niche conservatism was evidenced. Main conclusions: We found that aquatic plants show no range size conservatism in the Northern Hemisphere. This means that it is challenging to define different range sizes of freshwater plants through species traits. Furthermore, we are unable to predict unknown distributions of extant aquatic plant species based on known distributional attributes of closely related species. However, our findings suggest that the interpretations of previous investigations on the range sizes of aquatic plants remain valid due to lack of range size conservatism. These practical implications encourage studying range size conservatism across realms and regions, especially for understudied organismal groups. [ABSTRACT FROM AUTHOR]

Ports have been key elements in Europe's economic development. This situation is even more relevant on islands, which are highly dependent on the maritime sector. Consequently, over the years, ports with diverse functionalities have been established both in mainland Europe and on its outlying islands. This article discusses the environmental impact of leisure marinas on European islands, especially as they are closely linked to economic development through tourism. The aim is to study the environmental impact of these infrastructures by determining the carbon and water footprints of marinas on European islands in the Atlantic and the Mediterranean. The results obtained enable the authors to make recommendations in order to reduce the overall environmental footprint of marinas on islands, considering that these territories are much more vulnerable to climate change than mainland locations in Europe. [ABSTRACT FROM AUTHOR]

Gynaecological cancers, namely breast and cervical cancer represent a high burden in women's health. It is well established that cervical and breast cancer screening programmes are effective in reducing morbidity and mortality. It is of the most importance to define strategies to provide a universal access to screening. In European countries, significant progress has been made over the past years concerning screening strategies, namely the choice of screening test, its frequency as well as the age to start and stop the screening. Introduction of Human Papillomavirus vaccination programmes is also making a measurable impact to reduce cervical cancer prevalence and mortality. Our survey has shown a variation among European countries in delivery of cervical and breast cancer screening programmes. These variations can be due to organizational, economic or cultural reasons. The European Board and College of Obstetrics and Gynaecology calls for an implementation of a unified policy of prevention, screening and early detection of cervical and breast cancer across Europe to optimize clinical outcomes and reduce variations. [ABSTRACT FROM AUTHOR]

Cocaine is still one of the most commonly used illicit substances worldwide, with an estimated 4 million users in Europe in the last year. Hair samples have been widely used for the determination of episodic or repeated consumption of this substance, but the use of miniaturized techniques for hair sample clean-up has been challenging due to the sample complexity. Despite hair's complex matrix, MEPS provides a method that is fast, reduces the volume of extraction solvents used, and offers low-cost options (since extraction beds may be reused several times). Microextraction by packed sorbent using a mixed-mode sorbent was optimized for hair sample clean-up in order to determine cocaine, benzoylecgonine, ecgonine methyl ester, norcocaine, cocaethylene and anhydroecgonine methyl ester by gas chromatography coupled to tandem mass spectrometry. The method was fully validated according to internationally accepted criteria, presenting good linearity between the limits of quantification (0.01–0.15) and 5 ng/mg. Precision and accuracy resulted in coefficients of variation typically lower than 15%, with mean relative errors within ±15% for all compounds, except for the limit of quantification (±20%). The present work describes the first application of microextraction by packed sorbent for the concentration of cocaine and metabolites extracted from hair samples. [ABSTRACT FROM AUTHOR]

Objectives To assess the impact of 'patient's minus evaluator's global assessment of disease activity' (ΔPEG) at treatment initiation on retention and remission rates of TNF inhibitors (TNFi) in psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) patients across Europe. Methods Real-life data from PsA and axSpA patients starting their first TNFi from 11 countries in the European Spondyloarthritis Research Collaboration Network were pooled. Retention rates were compared by Kaplan–Meier analyses with log-rank test and by Cox regression, and remission rates by χ2 test and by logistic regression across quartiles of baseline ΔPEG, separately in female and male PsA and axSpA patients. Results We included 14 868 spondyloarthritis (5855 PsA, 9013 axSpA) patients. Baseline ΔPEG was negatively associated with 6/12/24-months' TNFi retention rates in female and male PsA and axSpA patients (P  <0.001), with 6/12/24-months' BASDAI < 2 (P  ≤0.002) and ASDAS < 1.3 (P  ≤0.005) in axSpA patients, and with DAS28CRP(4)<2.6 (P  ≤0.04) and DAPSA28 ≤ 4 (P  ≤0.01), but not DAS28CRP(3)<2.6 (P  ≥0.13) in PsA patients, with few exceptions on remission rates. Retention and remission rates were overall lower in female than male patients. Conclusion High baseline patient's compared with evaluator's global assessment was associated with lower 6/12/24-months' remission as well as retention rates of first TNFi in both PsA and axSpA patients. These results highlight the importance of discordance between patient's and evaluator's perspective on disease outcomes. [ABSTRACT FROM AUTHOR]

This paper presents the formal description of Impagidinium obscurum sp. nov. from the Thanetian strata of northwest Europe. The palaeogeographic distribution of this species covers a wide area, ranging from the North Sea to the Barents Sea. Palynologists working in the region have long referred to Impagidinium obscurum sp. nov. as Leptodinium? 'obscurum' and used it as an important intra-Paleocene marker species. The informal specific name was with reference to the incompletely defined tabulation of the cyst. However, although the tabulation is often obscured by the dense folding of the walls, the cyst tabulation formula has been partly deciphered in this work, based on the organisation of sutural crests in exceptionally well-preserved specimens, which allows confident attribution to the genus Impagidinium. This species is restricted to the 'early' Thanetian and is associated with diverse dinoflagellate cyst assemblages which include Alisocysta margarita and Areoligera gippingensis. [ABSTRACT FROM AUTHOR]

No official data exist on the status of musculoskeletal (MSK) radiology in Europe. The Committee for National Societies conducted an international survey to understand the status of training, subspecialization, and local practice among the European Society of Musculoskeletal Radiology (ESSR) partner societies. This article reports the results of that survey. An online questionnaire was distributed to all 26 European national associations that act as official partner societies of the ESSR. The 24 questions were subdivided into six sections: society structure, relationship with the national radiological society, subspecialization, present radiology practice, MSK interventional procedures, and MSK ultrasound. The findings of our study show a lack of standardized training and/or accreditation methods in the field of MSK radiology at a national level. The European diploma in musculoskeletal radiology is directed to partly overcome this problem; however, this certification is still underrecognized. Using certification methods, a more homogeneous European landscape could be created in the future with a view to subspecialist training. MSK ultrasound and MSK interventional procedures should be performed by a health professional with a solid knowledge of the relevant imaging modalities and sufficient training in MSK radiology. Recognition of MSK radiology as an official subspecialty would make the field more attractive for younger colleagues as well as attracting the brightest and best, an important key to further development of both clinical and academic radiology. KEY POINTS: · Standardized training and/or accreditation methods in the field of MSK radiology is lacking at a national level.. · With certification methods, such as the European diploma in musculoskeletal radiology, a more homogeneous European landscape could be created in the future with a view to subspecialist training.. · Recognition of MSK radiology as an official subspecialty would make the field more attractive for younger colleagues as well as attracting the brightest and best, an important key to further development of both clinical and academic radiology.. [ABSTRACT FROM AUTHOR]

The article focuses on the Federation of European Nutrition Societies (FENS) and their efforts to improve the credibility and trustworthiness of nutrition science. Topics include the development of guidance for writing and reviewing the lack of standardized approaches in disseminating nutrition research, and the need for accurate communication to the public; and FENS Working Group has identified the press release as a source of inaccuracy and exaggeration in nutrition science communication.

Exposure to excessively high noise levels is a relevant health problem in Europe and road traffic noise is the most widespread noise source. When considering cold climate countries, the available scientific literature on noise emission properties of winter tyres is still very limited. In order to contribute into filling this knowledge gap, this paper investigates the acoustical performance of different types of tyres, with focus on winter tyres, on different road surfaces, at different speeds, and with different states of wear. The results indicate that studded winter tyres have, indeed, an increased noise level at frequencies between 315 Hz and 10 kHz, having a significantly different response especially at frequencies higher than 4 kHz. The acoustical response also depends on the tyre type when comparing different road surfaces, as a result of conflicting vibrational and aerodynamic noise generation mechanisms. Additionally, the relationship between labelled and measured values was explored, however, no statistically significant relationship was found between them (and labelling is not applied for studded tyres). A frequency spectrum correction was attempted based on previous measurements on an ISO track, which reduced the difference between measured and labelled values, however, further investigation is still required to properly understand differences between label and road measurements, where the label is determined on a test track with a special, smooth surface. [ABSTRACT FROM AUTHOR]

Copyright of Ekstasis: Revista de Hermenêutica e Fenomenologia is the property of Editora da Universidade do Estado do Rio de Janeiro (EdUERJ) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

We studied a commensal colistin-resistant Escherichia coli isolated from a swine cecum sample collected at a slaughter, in Portugal. Antimicrobial susceptibility phenotype of E. coli LV23529 showed resistance to colistin at a minimum inhibitory concentration of 4 mg/L. Whole genome of E. coli LV23529 was sequenced using a MiSeq system and the assembled contigs were analyzed for the presence of antibiotic resistance and plasmid replicon types using bioinformatics tools. We report a novel mcr-1 gene variant (mcr-1.9), carried by an IncX4 plasmid, where one-point mutation at nucleotide T1238C leads to Val413Ala substitution. The mcr-1.9 genetic context was characterized by an IS 26 element upstream of the mcr-pap2 element and by the absence of IS Apl1. Bioinformatic analysis also revealed genes conferring resistance to β-lactams, sulphamethoxazole, trimethoprim, chloramphenicol and colistin, corresponding to the phenotype noticed. Moreover, we highlight the presence of mcr-1.9 plus bla CTX-M-8, a bla ESBL gene rarely detected in Europe in isolates of animal origin; these two genes were located on different plasmids with 33,303 and 89,458 bp, respectively. MCR-1.9-harboring plasmid showed high identity to other X4-type mcr-1 -harboring plasmids characterized worldwide, which strongly suggests that the presence of PMCR-encoding genes in food-producing animals, such as MCR-1.9, represent a potential threat to humans, as it is located in mobile genetic elements that have the potential to spread horizontally. [ABSTRACT FROM AUTHOR]

Copyright of Revista Caatinga is the property of Revista Caatinga and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Madeira, like many mountainous volcanic islands, is susceptible to flash floods. Throughout its history, about 40 large events resulted in more than 1200 victims and countless damages. Recently, urban areas expanded greatly, leading to a higher exposure of the population to flash floods. In order to analyse ways to reduce vulnerability and decrease hazard in the urbanised, flash flood prone watershed of the Machico River, the construction of detention basins (DB) is simulated. A hydrological and hydraulic model was performed to determine if they would be a viable option to protect downstream populations. Modelling suggests that two 12 m high outlet structures, and a storage capacity of 111 298 m³ (DB1) and 121 095 m³ (DB2), would reduce peak discharge by 72%, from a precipitation event with a return period of 100 years. Two identified sensitive Sections (S) had their fill rates reduced from 130.6% to 79.6% (S1) and from 128.6% to 33.4% (S2), thus preventing channel overflow. A concise economic analysis was made in terms of implementation and maintenance costs, as well as a SWOT analysis highlighting that DB should be regarded as a viable engineering solution to reduce vulnerability to flash floods hazards in volcanic islands with small, steep, and urbanised watersheds. [ABSTRACT FROM AUTHOR]

Purpose This paper aims to examine the relationship between board of directors’ characteristics and performance in family businesses. It offers evidence to the question of whether a family firm (FF) differs from a non-family firm and looks at the possibility of asymmetrical effects between periods of stability and economic adversity.Design/methodology/approach A panel data approach was applied to a sample of Portuguese firms listed the on Euronext Lisbon exchange between 2002 and 2013.Findings The results show that FFs are likely to have a lower proportion of independent members and higher gender diversity on their boards than non-family firms. FF performance is positively related to ownership concentration and gender diversity. There are performance premiums for family businesses, which have more gender diversity than their counterparts. These effects also depend on whether the economy is in recession. The evidence suggests that the presence of women on the board and the leverage and size of the FFs have a more significant impact on the performance in periods of economic adversity.Research limitations/implications One limitation of this study is the small size of the sample as it was drawn from the Euronext Lisbon exchange, a small stock exchange market.Originality/value This study provides input into the academic discussion on corporate governance and FF, an area which is in need of research. In addition, the authors examine this issue in conjunction with generalised economic adversity, focusing on the possible asymmetrical effects that the nature of the board of directors may have on performance in periods of stability and those of economic adversity. The role of board of directors is crucial to the understanding of corporate behaviour and the setting of the policy that regulates corporate activities. [ABSTRACT FROM AUTHOR]

Based on field and petrographic observations, mineralogical, geochemical (whole-rock by ICP-MS, ICP-OES, ISE and PGNAA) and geochronological (Ar Ar on mica and U Pb on columbite) data, ten pegmatite types and one type of cassiterite-rich quartz hydrothermal veins have been distinguished in the Fregeneda-Almendra field (FA) (Central Iberian Zone), some of them highly enriched in Li (included in petalite, spodumene and Li-rich mica). The pegmatites and the veins mostly intrude Neoproterozoic to Cambrian rocks from the Schist-Greywacke Complex. Felsic igneous magmatism during syn - to late-D 3 stages (≈ 320–295 Ma) of the Variscan orogeny was important and nearly continuous in the area, with the overlap of different granitic units of highly peraluminous S-type composition. The most important in outcrop corresponds to the Mêda-Escalhão-Penedono-Lumbrales granitic complex (MEPL), which belongs to a two-mica leucogranitic series. The other granitic units (Saucelle, Feli and East-MEPL granites) are younger and belong to a P-rich, Ca-poor monzogranitic series. Spatial relationships, together with chemical, mineralogical and geochronological data, indicate that all the pegmatite types and the cassiterite-rich quartz hydrothermal veins are not cogenetic, being related to three different magmatic events: (i) (≈ 319–313 Ma) includes the syn -D 3 MEPL granite and three types of barren pegmatites (intragranitic, quartz+andalusite layers and simple concordant pegmatites); (ii) (≈ 305–300 Ma) corresponds to the late to post-D 3 Feli granite, related to a group of cassiterite-rich quartz veins; and, (iii) (≈ 300–298 Ma) represents the late- to post-D 3 East-MEPL and Saucelle granites, likely parental of some barren aplitic-pegmatitic apophyses and the discordant intermediate and Li-rich pegmatites. These latter form part of a general granite-pegmatite fractionation trend. • Different pegmatite generations coexist in the FA field and one of them is Li-rich. • A petrogenetic model based on geochemical and geochronological data is made for them. • The FA Li-rich aplite-pegmatites have a magmatic affiliation. • They formed by extreme fractionation of P-rich, Ca-poor peraluminous granitic melts. • This model may be applied to other Variscan Li-rich aplite-pegmatites from Europe. [ABSTRACT FROM AUTHOR]

Important gaps remain in our understanding of the spread of farming into Europe, due partly to apparent contradictions between studies of contemporary genetic variation and ancient DNA. It seems clear that farming was introduced into central, northern, and eastern Europe from the south by pioneer colonization. It is often argued that these dispersals originated in the Near East, where the potential source genetic pool resembles that of the early European farmers, but clear ancient DNA evidence from Mediterranean Europe is lacking, and there are suggestions that Mediterranean Europe may have resembled the Near East more than the rest of Europe in the Mesolithic. Here, we test this proposal by dating mitogenome founder lineages from the Near East in different regions of Europe. We find that whereas the lineages date mainly to the Neolithic in central Europe and Iberia, they largely date to the Late Glacial period in central/eastern Mediterranean Europe. This supports a scenario in which the genetic pool of Mediterranean Europe was partly a result of Late Glacial expansions from a Near Eastern refuge, and that this formed an important source pool for subsequent Neolithic expansions into the rest of Europe. [ABSTRACT FROM AUTHOR]

Background: Long-acting reversible contraceptives, including hormonal levonorgestrel-releasing intrauterine systems, are the most effective methods of reversible contraception. However, unfavorable bleeding, particularly during the first months of use, is one of the most important reasons for discontinuation or avoidance. Minimizing this as early as possible would be highly beneficial. Nonsteroidal anti-inflammatory drugs inhibiting prostaglandin synthesis are known to reduce bleeding and pain at time of menses. A levonorgestrel-releasing intrauterine system has been developed with an additional reservoir containing indomethacin, designed to be released during the initial postplacement period.Objective: This proof-of-concept study aimed to establish whether the addition of indomethacin to the currently available levonorgestrel-releasing intrauterine system (average in vivo levonorgestrel release rate of 8 μg/24 h during the first year of use) reduces the number of bleeding and spotting days during the first 90 days of use compared with the unmodified system. The dose-finding analysis included 3 doses of indomethacin-low (6.5 mg), middle (12.5 mg), and high (15.4 mg)-to determine the ideal dose of indomethacin to reduce bleeding and spotting days with minimal side-effects.Study Design: This was a multicenter, single-blinded, randomized, controlled phase II trial conducted between June 2018 and June 2019 at 6 centers in Europe. Three indomethacin dose-ranging treatment groups (low-, middle-, and high-dose indomethacin/levonorgestrel-releasing intrauterine system) were compared with the unmodified levonorgestrel-releasing intrauterine system group, with participants randomized in a 1:1:1:1 ratio. The primary outcome was the number of uterine bleeding and spotting days over a 90-day reference (treatment) period. Secondary outcomes were the number of women showing endometrial histology expected for intrauterine levonorgestrel application and the frequency of treatment-emergent adverse events. Point estimates and 2-sided 90% credible intervals were calculated for mean and median differences between treatment groups and the levonorgestrel-releasing intrauterine system without indomethacin. Point and interval estimates were determined using a Bayesian analysis.Results: A total of 174 healthy, premenopausal women, aged 18 to 45 years, were randomized, with 160 women eligible for the per-protocol analysis set. Fewer bleeding and spotting days were observed in the 90-day reference period for the 3 indomethacin/levonorgestrel-releasing intrauterine system dose groups than for the levonorgestrel-releasing intrauterine system without indomethacin group. The largest reduction in bleeding and spotting days was achieved with low-dose indomethacin/levonorgestrel-releasing intrauterine system, which demonstrated a point estimate difference of -32% (90% credible interval, -45% to -19%) compared with levonorgestrel-releasing intrauterine system without indomethacin. Differences for high- and middle-dose indomethacin/levonorgestrel-releasing intrauterine system groups relative to levonorgestrel-releasing intrauterine system without indomethacin were -19% and -16%, respectively. Overall, 97 women (58.1%) experienced a treatment-emergent adverse event considered related to the study drug, with similar incidence across all treatment groups including the unmodified levonorgestrel-releasing intrauterine system. These were all mild or moderate in intensity, with 6 leading to discontinuation. Endometrial biopsy findings were consistent with effects expected for the levonorgestrel-releasing intrauterine system.Conclusion: All 3 doses of indomethacin substantially reduced the number of bleeding and spotting days in the first 90 days after placement of the levonorgestrel-releasing intrauterine system, thus providing proof of concept. Adding indomethacin to the levonorgestrel-releasing intrauterine system can reduce the number of bleeding and spotting days in the initial 90 days postplacement, without affecting the safety profile, and potentially improving patient acceptability and satisfaction. [ABSTRACT FROM AUTHOR]

Annually, millions of hectares of land are affected by wildfires worldwide, disrupting ecosystems functioning by affecting on-site vegetation, soil, and above- and belowground biodiversity, but also triggering erosive off-site impacts such as water-bodies contamination or mudflows. Here, we present a soil erosion assessment following the 2017's wildfires at the European scale, including an analysis of vegetation recovery and soil erosion mitigation potential. Results indicate a sharp increase in soil losses with 19.4 million Mg additional erosion in the first post-fire year when compared to unburned conditions. Over five years, 44 million Mg additional soil losses were estimated, and 46% of the burned area presented no signs of full recovery. Post-fire mitigation could attenuate these impacts by 63–77%, reducing soil erosion to background levels by the 4th post-fire year. Our insights may help identifying target policies to reduce land degradation, as identified in the European Union Soil, Forest, and Biodiversity strategies. • Sharp increase in the soil erosion was found after wildfire (11.8-fold). • No full recovery was found after the 5-years assessment. • After 5 years, 46% of the burned area presented vegetation cover lower than the pre-fire. • Post-fire mitigation has the potential to reduce post-fire soil erosion impacts by 63–77%. [ABSTRACT FROM AUTHOR]

Copyright of Educacao e Pesquisa is the property of Faculdade de Educacao da Universidade de Sao Paulo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The ageing of the European population is creating a new demographic mix, increasing the relevance of intergenerational practice (IGP). To date, however, this field lacks an appropriate conceptual framework. This study aims to contribute to such a framework through an integrative review of peer-reviewed papers reporting on IGPs. Fifteen papers were obtained, published over the last 20 years. The main findings suggest that the wealth of IGPs lies in their versatility/diversity. In order to build an appropriate conceptual framework for IGP, it is recommended that IGP be understood as a tool to restructure society: from generations’ segregation to generations’ cooperation. [ABSTRACT FROM AUTHOR]

Background: Screening and brief interventions (SBI) in primary healthcare are cost-effective in risky drinkers, yet they are not offered to all eligible patients. This qualitative study aimed to provide more insight into the factors and mechanisms of and implementation strategies work or do not work why, how, for whom under what circumstances in increasing SBI. Methods: Semi-structured interviews were conducted between February and July 2014 with 40 GPs and 28 nurses in Catalonia, the Netherlands, Poland, and Sweden. Participants were purposefully selected from the European Optimising Delivery of Healthcare Interventions (ODHIN) trial. This randomised controlled trial evaluated the influence of training and support, financial reimbursement and an internet-based method of delivering advice on SBI. Amongst them were 38 providers with a high screening performance and 30 with a low screening performance from different allocation groups. Realist evaluation was combined with the Tailored Implementation for Chronic Diseases framework for identification of implementation determinants to guide the interviews and analysis. Transcripts were analysed thematically with the diagram affinity method. Results: Training and support motivated SBI by improved knowledge, skills and prioritisation. Continuous provision, sufficient time to learn intervention techniques and to tailor to individual experienced barriers, seemed important T&S conditions. Catalan and Polish professionals perceived financial reimbursement to be an additional stimulating factor as well, as effects on SBI were smoothened by personnel levels and salary levels. Structural payment for preventive services rather than a temporary project based payment, might have increased the effects of financial reimbursement. Implementing e-BI seem to require more guidance than was delivered in ODHIN. Despite the allocation, important preconditions for SBI routine seemed frequent exposure of this topic in media and guidelines, SBI facilitating information systems, and having SBI in protocol-led care. Hence, the second order analysis revealed that the applied implementation strategies have high potential on the micro professional level and meso-organisational level, however due to influences from the macro- level such as societal and political culture the effects risks to get nullified. Conclusions: Essential determinants perceived for the implementation of SBI routines were identified, in particular for training and support and financial reimbursement. However, focusing only on the primary healthcare setting seems insufficient and a more integrated SBI culture, together with meso- and macro-focused implementation process is requested. Trial registration: ClinicalTrials.gov. Trial identifier: NCT01501552. [ABSTRACT FROM AUTHOR]