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25 results on '"E. Thervet"'

1. [Involvement of endoplasmic reticulum stress in solid organ transplantation].

Author

Pallet N, Bouvier N, Beaune P, Legendre C, Anglicheau D, and Thervet E

Subjects
Animals, Apoptosis, Cyclosporine adverse effects, Diabetes Mellitus, Type 2 chemically induced, Diabetes Mellitus, Type 2 etiology, Drug Delivery Systems, Endoplasmic Reticulum drug effects, Graft Survival, Humans, Insulin Resistance, Islets of Langerhans drug effects, Kidney Transplantation, Liver Transplantation, Mice, Organ Preservation, Postoperative Complications pathology, Postoperative Complications prevention & control, Reperfusion Injury pathology, Tacrolimus adverse effects, Transplantation, Homologous pathology, Unfolded Protein Response drug effects, Endoplasmic Reticulum physiology, Transplantation, Unfolded Protein Response physiology
Abstract

Endoplasmic reticulum (ER) stress is a situation caused by the accumulation of unfolded proteins in the endoplasmic reticulum, triggering an evolutionary conserved adaptive response termed the unfolded protein response. When adaptation fails, excessive and prolonged ER stress triggers cell suicide. Important roles for ER-initiated cell death pathways have been recognized for several diseases, including diabetes, hypoxia, ischemia/reperfusion injury, neurodegenerative and heart diseases. The implication of the ER stress is not well recognized in solid organ transplantation, but increasing evidence suggests its implication in mediating allograft injury. The purpose of this review is to summarize the mechanisms of ER stress and to discuss its implication during tissue injury in solid organ transplantation. The possible implications of the ER stress in the modifications of cell functional properties and phenotypic changes are also discussed beyond the scope of adaptation and cell death. Increasing the understanding of the cellular and molecular mechanisms of acute and chronic allograft damages could lead to the development of new biomarkers and to the discovery of new therapeutic strategies to prevent the initiation of graft dysfunction or to promote the tissue regeneration after injury.

Published
2010
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2. Endoplasmic reticulum stress: an unrecognized actor in solid organ transplantation.

Author

Pallet N, Fougeray S, Beaune P, Legendre C, Thervet E, and Anglicheau D

Subjects
Animals, Calcineurin Inhibitors, Chronic Disease, Humans, Kidney pathology, Models, Biological, Protein Denaturation, Protein Folding, Regeneration, Reperfusion Injury, Stress, Physiological, Transplantation, Homologous methods, Endoplasmic Reticulum metabolism, Transplantation methods
Abstract

Endoplasmic reticulum (ER) stress is an adaptive response to the accumulation of misfolded proteins within the ER, which can trigger cell dedifferentiation and cell suicide. Increasing evidences suggest its implication in mediating allograft injury. Herein, we summarize the mechanisms of ER stress and discuss its implication in allograft injury. Increasing our understanding of the cellular and molecular mechanisms of acute and chronic allograft damages could lead to the development of new biomarkers and to the discovery of new therapeutic strategies to prevent the initiation of graft dysfunction or to promote the tissue regeneration after injury.

Published
2009
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4. 5% topical imiquimod tolerance in transplant recipients.

Author

Ben M'barek L, Mebazaa A, Euvrard S, Frances C, Thervet E, Morel P, Menasché S, Legendre C, and Lebbe C

Subjects
Adjuvants, Immunologic adverse effects, Administration, Topical, Adult, Aged, Aminoquinolines adverse effects, Drug Administration Schedule, Female, Humans, Imiquimod, Keratosis etiology, Male, Middle Aged, Retrospective Studies, Skin pathology, Skin Neoplasms etiology, Treatment Outcome, Ultraviolet Rays adverse effects, Warts etiology, Adjuvants, Immunologic therapeutic use, Aminoquinolines therapeutic use, Immunocompromised Host, Keratosis drug therapy, Skin Neoplasms drug therapy, Transplantation adverse effects, Warts drug therapy
Abstract

Background: Topical imiquimod is a new immunomodulator agent approved for genital warts, actinic keratosis (AK) or carcinoma, occurring in immunocompetent patients., Objectives: This study aimed to assess the safety and efficacy of imiquimod for the treatment of warts, AK and bowenoid papulosis (BP) in transplant patients., Methods: 24 transplant patients (18 kidney, 4 kidney-pancreas and 2 heart) were included in this retrospective study conducted between June 2000 and February 2003 at the department of dermatology of 3 hospitals. Imiquimod cream was applied 3 times a week over a median period of 9 weeks., Results: Graft function was not altered under therapy. Local tolerance was excellent. Complete responses were observed in 1 patient (1/12) with cutaneous warts and 1 (1/6) with AK. Two patients of 3 with BP had total clearance of their lesions. Partial responses were observed in 3 of the 6 AK-treated patients, 5 of 12 patients with cutaneous warts and 1 of 2 patients with anogenital warts., Conclusions: Imiquimod 5% cream is a promising, well-tolerated therapy for warts, AK and BP in transplant recipients., (Copyright (c) 2007 S. Karger AG, Basel.)

Published
2007
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5. Predictive Modeling of Tacrolimus Dose Requirement Based on High-Throughput Genetic Screening

Author

Pierre Laurent-Puig, L. Toullec, Isabelle Etienne, Gabriel Choukroun, Cécile Vigneau, B. Hurault de Ligny, Mathias Büchler, Anne-Elisabeth Heng, Jean-François Subra, Antoine Thierry, E. Thervet, Anastasia Yartseva, Bruno Moulin, Cécilia Damon, C. Legendre, Dany Anglicheau, A. Monnot, Marie-Anne Loriot, Nicolas Pallet, P Beaune, Mathilde Bateson, Margaux Luck, Génétique, Reproduction et Développement (GReD ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Service de néphrologie et immunologie clinique [CHRU Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours (UT), Service de Néphrologie-Dialyse-Transplantation rénale [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Mécanismes physiologiques et conséquences des calcifications cardiovasculaires: rôle des remodelages cardiovasculaires et osseux, Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Centre hospitalier universitaire de Poitiers (CHU Poitiers), CHU Pontchaillou [Rennes], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de Néphrologie - Hémodialyses [CHU Clermont-Ferrand], Pôle RHEUNNIRS [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Service de Néphrologie [Angers], Université d'Angers (UA)-Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), aucun, AGAETIS, Service de Transplantation Rénale, affiliation inconnue, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Service de néphrologie et immunologie clinique, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Université de Tours, Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Domaines Océaniques (LDO), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Observatoire des Sciences de l'Univers-Institut d'écologie et environnement-Centre National de la Recherche Scientifique (CNRS), Génétique, Reproduction et Développement - Clermont Auvergne (GReD ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Science et Technologie du Lait et de l'Oeuf (STLO), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de Néphrologie, Hôpital Gabriel Montpied, CHU de Clermont-Ferrand, Clermont-Ferrand, France, Centre National de la Recherche Scientifique (CNRS)-Institut d'écologie et environnement-Observatoire des Sciences de l'Univers-Université de Brest (UBO)-Institut national des sciences de l'Univers (INSU - CNRS), and Université de Tours-Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)

Subjects
Genetic Markers, Graft Rejection, 0301 basic medicine, Genotype, translational research/science, immunosuppression/immune modulation, Biology, clinical research/practice, Bioinformatics, Polymorphism, Single Nucleotide, 030226 pharmacology & pharmacy, Tacrolimus, ABCC8, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, genomics, Humans, Immunology and Allergy, genetics, Pharmacology (medical), Genetic Testing, Gene, Transplantation, Models, Statistical, Transporter, Kidney Transplantation, Transplant Recipients, High-Throughput Screening Assays, 3. Good health, immunosuppressive regimens, Molecular network, 030104 developmental biology, [SDV.TOX]Life Sciences [q-bio]/Toxicology, biology.protein, Tacrolimus Dose, pharmacology, Immunosuppressive Agents, Drug metabolism
Abstract

International audience; Any biochemical reaction underlying drug metabolism depends on individual gene-drug interactions and on groups of genes interacting together. Based on a high-throughput genetic approach, we sought to identify a set of covariant single-nucleotide polymorphisms predictive of interindividual tacrolimus (Tac) dose requirement variability. Tac blood concentrations (Tac C0 ) of 229 kidney transplant recipients were repeatedly monitored after transplantation over 3 mo. Given the high dimension of the genomic data in comparison to the low number of observations and the high multicolinearity among the variables (gene variants), we developed an original predictive approach that integrates an ensemble variable-selection strategy to reinforce the stability of the variable-selection process and multivariate modeling. Our predictive models explained up to 70% of total variability in Tac C0 per dose with a maximum of 44 gene variants (p-value

Published
2017

6. PRIMARY AND SECONDARY GLOMERULONEPHRITIDES 2

Author

D. Monova, S. Monov, T. Todorov, D. Soderberg, T. Kurz, M. Weiner, P. Eriksson, M. Segelmark, K. Jakuszko, A. Sebastian, Z. Bednarz, M. Krajewska, P. Wiland, K. Madziarska, W. Weyde, M. Klinger, J. Naidoo, N. Wearne, E. Jones, C. Swanepoel, B. Rayner, I. Okpechi, N. Endo, N. Tsuboi, K. Furuhashi, S. Matsuo, S. Maruyama, M. Clerte, C. Levi, M. Touzot, F. Fakhouri, C. Monge, C. Lebas, I. Abboud, A. Huart, P. Durieux, E. Charlin, E. Thervet, A. Karras, K. Smykal-Jankowiak, Z. I. Niemir, M. Polcyn-Adamczak, S. Whatmough, N. Sweeney, S. Fernandez, M. Hussain, A. Dhaygude, K. Gniewek, L. Manenti, M. L. Urban, A. Vaglio, E. Gintoli, M. Galletti, C. Buzio, T. Argirova, I. Wong, F. H. Ibrahim, B. L. Goh, T. S. Lim, M. W. Chan, R. Hiramtasu, Y. Ubara, J. Hoshino, K. Takaichi, V. Ghafoor, M. Sahay, J. Soma, I. Nakaya, N. Sasaki, K. Yoshikawa, H. Sato, V. Kaminskyy, M. ZAbi Ska, K. Ko Cielska-Kasprzak, Z. Niemir, K. Wozniczka, A. Swierzko, M. Cedzynski, A. Sokolowska, A. Szala, A. Arjunan, A. Mikhail, R. Shrivastava, C. Parker, S. Aithal, M. Gursu, M. Ozari, E. Yucetas, A. Sumnu, B. Doner, E. Cebeci, O. Ozkan, M. B. Aktuglu, Z. Karaali, M. Koldas, S. Ozturk, H. Marco, M. Picazo, I. Da Silva, A. Gonzalez, Y. Arce, S. Gracia, M. Corica, J. Llobet, M. Diaz, J. Ballarin, U. Schonermarck, H. Hagele, A. Baumgartner, M. Fischereder, S. Muller, C. B. L. Oliveira, A. S. A. Oliveira, C. J. B. Carvalho, C. T. B. C. Pessoa, L. H. B. C. Sette, G. V. Fernandes, M. A. G. M. Cavalcante, L. M. Valente, Q. Wan, H. Hu, Y. He, T. Li, N. Aazair, Z. Houmaid, A. Rhair, N. Bennani, A. Demin, O. Petrova, O. Kotova, L. Demina, D. Roccatello, S. Sciascia, D. Rossi, C. Naretto, S. Baldovino, M. Alpa, I. Salussola, V. Modena, E. V. Zakharova, O. V. Vinogradova, E. S. Stolyarevich, D. Y. H. Yap, T. M. Chan, V. Thanaraj, A. Ponnusamy, S. Pillai, L. Argentiero, A. Schena, M. Rossini, C. Manno, G. Castellano, M. Martino, A. Mitrotti, M. Giliberti, C. Digiorgio, A. M. Di Palma, M. Battaglia, P. Ditonno, G. Grandaliano, L. Gesualdo, N. Neprintseva, N. Tchebotareva, I. Bobkova, L. Kozlovskaya, V. Rabrenovi, Z. Kova Evi, D. Jovanovi, M. Rabrenovi, S. Anti, L. Ignjatovi, M. Petrovi, S. Longhi, L. Del Vecchio, S. Vigano, D. Casartelli, M. C. Bigi, M. Corti, M. Limardo, F. Tentori, G. Pontoriero, A. A. Zeraati, Z. Shariati Sarabi, A. Davoudabadi Farahani, Z. Mirfeizi, and E. Bae

Subjects
Transplantation, medicine.medical_specialty, Primary (chemistry), Nephrology, business.industry, Internal medicine, medicine, business
Published
2014

7. TRANSPLANTATION BASIC SCIENCE, ALLOGENIC AND XENOGENIC TOLERANCE

Author

L. Berthelot, T. Robert, T. Tabary, V. Vuiblet, M. Drame, O. Toupance, P. Rieu, R. C. Monteiro, F. Toure, S. Ferrario, V. Cantaluppi, M. De Lena, S. Dellepiane, S. Beltramo, M. Rossetti, A. M. Manzione, M. Messina, M. Gai, C. Dolla, L. Biancone, G. Camussi, P. Pontrelli, A. R. Oranger, M. Accetturo, F. Rascio, M. Gigante, G. Castellano, A. Schena, M. Fiorentino, A. Zito, G. Zaza, G. Stallone, L. Gesualdo, G. Grandaliano, E. F. Pattonieri, M. Gregorini, V. Corradetti, C. Rocca, S. Milanesi, A. Peloso, J. Ferrario, M. Cannone, F. Bosio, N. Maggi, M. A. Avanzini, P. Minutillo, M. Paulli, M. Maestri, T. Rampino, A. Dal Canton, K. S. T. Wu, O. Coxall, Y. Luque, S. Candon, M. Rabant, L.-H. Noel, E. Thervet, L. Chatenoud, R. Snanoudj, D. Anglicheau, C. Legendre, J. Zuber, P. Hruba, I. Brabcova, E. Krepsova, J. Slatinska, A. Sekerkova, I. Striz, R. Zachoval, O. Viklicky, T. M. Scholbach, H.-K. Wang, C.-C. Loong, A.-H. Yang, T.-H. Wu, H. Guberina, V. Rebmann, P. Dziallas, S. Dolff, J. Wohlschlaeger, F. M. Heinemann, O. Witzke, Y. M. Zoet, F. H. J. Claas, P. A. Horn, A. Kribben, I. I. N. Doxiadis, N. Prasad, B. Yadav, V. Agarwal, A. Jaiswal, M. Rai, C. M. Hope, P. T. Coates, P. S. Heeger, R. Carroll, V. Masola, M. F. Secchi, M. Onisto, G. Gambaro, A. Lupo, M. Matsuyama, T. Kobayashi, Y. Yoneda, J. Chargui, J. L. Touraine, R. Yoshimura, D. Vizza, A. Perri, S. Lupinacci, G. Toteda, D. Lofaro, F. Leone, P. Gigliotti, A. La Russa, T. Papalia, R. Bonofilgio, A. Sentis Fuster, J. Kers, U. Yapici, N. Claessen, F. J. Bemelman, I. J. M. Ten Berge, S. Florquin, D. Glotz, L. Rostaing, J.-P. Squifflet, P. Merville, C. Belmokhtar, G. Le Ny, Y. Lebranchu, D. A. Papazova, M. Friederich-Persson, M. P. Koeners, J. A. Joles, M. C. Verhaar, H. L. Trivedi, A. V. Vanikar, S. D. Dave, B. Suarez Alvarez, S. Garcia Melendreras, R. Carvajal Palao, C. Diaz Corte, M. Ruiz Ortega, C. Lopez-Larrea, A. K. Yadav, D. Bansal, V. Kumar, M. Minz, V. Jha, D. Kaminska, K. Koscielska-Kasprzak, P. Chudoba, O. Mazanowska, M. Banasik, M. Zabinska, M. Boratynska, A. Lepiesza, K. Korta, M. Klinger, R. Csohany, A. Prokai, D. Pap, N. Balicza-Himer, A. Vannay, A. Fekete, K. Kis-Petik, J. Peti-Peterdi, A. Szabo, A. Masajtis-Zagajewska, K. Muras, M. Niewodniczy, M. Nowicki, J. Pascual, T. R. Srinivas, S. Chadban, F. Citterio, M. Henry, F. Oppenheimer, P.-C. Lee, H. Tedesco-Silva, M. Zeier, Y. Watarai, G. Dong, M. Hexham, P. Bernhardt, F. Vincenti, M. T. Rocchetti, J. Su owicz, A. Wojas-Pelc, E. Ignacak, K. Janda, M. Krzanowski, W. Su owicz, M. Mitsuhashi, T. Murakami, A. Benso, D. Leuning, M. Reinders, E. Lievers, J. Duijs, A. J. Van Zonneveld, C. Van Kooten, M. Engelse, T. Rabelink, A. Assounga, S. Omarjee, Z. Ngema, A. Ersoy, A. Gultepe, E. Isiktas Sayilar, H. Akalin, F. Coskun, M. Oner Torlak, Y. Ayar, M. Riegersperger, M. Plischke, C. Steinhauser, A. Jallitsch-Halper, G. Sengoelge, W. C. Winkelmayer, G. Sunder-Plassmann, M. Foedinger, M. Kaziuk, M. Kuz'Niewski, A. B Tkowska- Prokop, K. Pa Ka, P. Dumnicka, W. Kolber, and W. Su Owicz

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Basic science, medicine, Intensive care medicine, business
Published
2014

8. Treating diabetes with islet transplantation: Lessons from the past decade in Lille

Author

M.-C. Vantyghem, F. Defrance, D. Quintin, C. Leroy, V. Raverdi, G. Prévost, R. Caiazzo, J. Kerr-Conte, F. Glowacki, M. Hazzan, C. Noel, F. Pattou, A.S. Balavoine, R. Bresson, M.F. Bourdelle-Hego, M. Cazaubiel, M. Cordonnier, D. Delefosse, F. Dorey, A. Fayard, C. Fermon, P. Fontaine, C. Gillot, S. Haye, A.C. Le Guillou, W. Karrouz, C. Lemaire, M. Lepeut, R. Leroy, B. Mycinski, E. Parent, C. Siame, A. Sterkers, F. Torres, O. Verier-Mine, E. Verlet, R. Desailloud, A. Dürrbach, M. Godin, J.D. Lalau, C. Lukas-Croisier, E. Thervet, O. Toupance, Y. Reznik, and P.F. Westeel

Subjects
Blood Glucose, Male, medicine.medical_specialty, endocrine system diseases, Edmonton protocol, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Islets of Langerhans Transplantation, Risk Assessment, Endocrinology, Insulin resistance, Insulin-Secreting Cells, Diabetes mellitus, Internal Medicine, medicine, Humans, Intensive care medicine, Glycated Hemoglobin, Type 1 diabetes, geography, geography.geographical_feature_category, business.industry, Patient Selection, Microangiopathy, Reproducibility of Results, General Medicine, Prognosis, medicine.disease, Islet, Surgery, Transplantation, Regimen, C-Reactive Protein, Diabetes Mellitus, Type 1, Treatment Outcome, Practice Guidelines as Topic, Quality of Life, Female, business, Immunosuppressive Agents
Abstract

Type 1 diabetes (T1D) is due to the loss of both beta-cell insulin secretion and glucose sensing, leading to glucose variability and a lack of predictability, a daily issue for patients. Guidelines for the treatment of T1D have become stricter as results from the Diabetes Control and Complications Trial (DCCT) demonstrated the close relationship between microangiopathy and HbA1c levels. In this regard, glucometers, ambulatory continuous glucose monitoring, and subcutaneous and intraperitoneal pumps have been major developments in the management of glucose imbalance. Besides this technological approach, islet transplantation (IT) has emerged as an acceptable safe procedure with results that continue to improve. Research in the last decade of the 20th century focused on the feasibility of islet isolation and transplantation and, since 2000, the success and reproducibility of the Edmonton protocol have been proven, and the mid-term (5-year) benefit-risk ratio evaluated. Currently, a 5-year 50% rate of insulin independence can be expected, with stabilization of microangiopathy and macroangiopathy, but the possible side-effects of immunosuppressants, limited availability of islets and still limited duration of insulin independence restrict the procedure to cases of brittle diabetes in patients who are not overweight or have no associated insulin resistance. However, various prognostic factors have been identified that may extend islet graft survival and reduce the number of islet injections required; these include graft quality, autoimmunity, immunosuppressant regimen and non-specific inflammatory reactions. Finally, alternative injection sites and unlimited sources of islets are likely to make IT a routine procedure in the future.

Published
2014

9. Renal histopathology

Author

E. J. Kim, J. H. Han, H. M. Koo, F. M. Doh, C. H. Kim, K. I. Ko, M. J. Lee, H. J. Oh, T.-H. Yoo, S.-W. Kang, K. H. Choi, S. H. Han, S. Assady, M. Tchirkov, R. Nasser, T. Mashiach, O. Ben Izhak, P. Housset, R. Guillemain, D. Nochy, M. Roland, C. Amrein, A. Karras, V. Boussaud, V. Pezzela, E. Thervet, S. P. Simic Ogrizovic, G. Basta Jovanovic, S. Radojevic, S. Bojic, R. Naumovic, Z. Karim, K. Cyrine, G. Rim, A. Ezzeddine, H. Hafedh, K. Hayet, B. Soumaya, O. Mondher, B. H. Fethi, E. Y. Fethi, B. A. Taieb, B. M. Hedi, B. M. Fatma, K. Adel, M. Penescu, E. Mandache, A. Zumrutdal, R. Ozelsancak, T. Canpolat, S. Barbouch, I. Mami, M. Mayara, M. Jerbi, A. Harzallah, R. Goucha, H. Ben Maiz, A. Kedher, N. Comi, P. Cianfrone, V. Piraina, R. Talarico, K. Giannakakis, G. Fuiano, G. Lucisano, K. Konat, M. Szotowska, H. Karkoszka, M. Adamczak, A. Wiecek, K. Kwiecien, O. Jercan, L. Mogoanta, I. Miller, X. Pan, J. Xu, H. Ren, W. Zhang, Y. Xu, P. Shen, X. Chen, X. Feng, and N. Chen

Subjects
Transplantation, Nephrology
Published
2013

10. Long-term clinical impact of adaptation of initial tacrolimus dosing to CYP3A5 genotype

Author

B. Moulin, Cécile Vigneau, Mathias Büchler, B. Hurault de Ligny, Y. Le Meur, Isabelle Etienne, E. Thervet, Marie-Anne Loriot, Gabriel Choukroun, E. Bailly, Anne-Elisabeth Heng, Antoine Thierry, Philippe Beaune, Charlotte Colosio, Nicolas Pallet, C. Legendre, Médecine Personnalisée, Pharmacogénomique, Optimisation Thérapeutique (MEPPOT - U1147), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), CHU Rouen, Normandie Université (NU), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), CHU Amiens-Picardie, Mécanismes physiologiques et conséquences des calcifications cardiovasculaires: rôle des remodelages cardiovasculaires et osseux, Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Centre Hospitalier Universitaire de Reims (CHU Reims), Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques ( IRTOMIT), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de néphrologie - hémodialyse et transplantation rénale, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de néphrologie [Rennes], Université de Rennes (UR)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Service de Néphrologie et Transplantation, CHU Strasbourg, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, Service de néphrologie adultes [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Jonchère, Laurent, Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre hospitalier universitaire d'Amiens (CHU Amiens-Picardie), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de néphrologie, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], Médecine Personnalisée, Pharmacogénomique, Optimisation Thérapeutique ( MEPPOT - U1147 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Hôpital Européen Georges Pompidou [APHP] ( HEGP ), CHRU Tours, Centre hospitalier universitaire d'Amiens ( CHU Amiens-Picardie ), Université de Picardie Jules Verne ( UPJV ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre Hospitalier Universitaire de Reims ( CHU Reims ), Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques ( IRTOMIT ), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Poitiers-Centre hospitalier universitaire de Poitiers ( CHU Poitiers ), Institut de Génétique et Développement de Rennes ( IGDR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest ), and Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP]

Subjects
[ SDV.MHEP.UN ] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Graft Rejection, Male, immunosuppressant, [SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery, translational research/science, kidney transplantation/nephrology, immunosuppression/immune modulation, Pharmacology, Kidney Function Tests, 030226 pharmacology & pharmacy, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, 0302 clinical medicine, Risk Factors, Cytochrome P-450 CYP3A, Immunology and Allergy, Medicine, Tissue Distribution, Pharmacology (medical), genetics, Prospective Studies, [ SDV.MHEP.CHI ] Life Sciences [q-bio]/Human health and pathology/Surgery, Prospective cohort study, Kidney transplantation, Incidence (epidemiology), Graft Survival, Middle Aged, Prognosis, 3. Good health, surgical procedures, operative, 030220 oncology & carcinogenesis, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Female, pharmacokinetics/pharmacodynamics, Immunosuppressive Agents, Glomerular Filtration Rate, medicine.medical_specialty, Genotype, Renal function, chemical and pharmacologic phenomena, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, clinical research/practice, Tacrolimus, calcineurin inhibitor: tacrolimus, 03 medical and health sciences, patient survival, Internal medicine, Humans, Dosing, CYP3A5, Transplantation, Dose-Response Relationship, Drug, business.industry, [ SDV.SP.PHARMA ] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, medicine.disease, Kidney Transplantation, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Pharmacogenetics, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Kidney Failure, Chronic, business, Follow-Up Studies
Abstract

International audience; Pretransplantation adaptation of the daily dose of tacrolimus to CYP3A5 genotype is associated with improved achievement of target trough concentration (C0 ), but whether this improvement affects clinical outcomes is unknown. In the present study, we have evaluated the long-term clinical impact of the adaptation of initial tacrolimus dosing according to CYP3A5 genotype: the transplantation outcomes of the 236 kidney transplant recipients included in the Tactique study were retrospectively investigated over a period of more than 5 years. In the Tactique study, patients were randomly assigned to receive tacrolimus at either a fixed dosage or a dosage determined by their genotype, and the primary efficacy end point was the proportion of patients for whom tacrolimus C0 was within target range (10-15 ng/ml) at day 10. Our results indicate that the incidence of biopsy proven acute rejection and graft survival were similar between the control and the adapted tacrolimus dose groups, as well as between the patients who achieve the tacrolimus C0 target ranges earlier. Parients death, cancer, cardiovascular events and infections were also similar, and renal function did not change. We conclude that optimization of initial tacrolimus dose using pharmacogenetic testing does not improve clinical outcomes.

Published
2016

11. Primary and secondary glomerulonephritis I

Author

N. Miyazaki, J. Matsumoto, F. Alberici, A. Palmisano, F. Maritati, E. Oliva, C. Buzio, A. Vaglio, G. Mjoen, G. E. Norby, B. E. Vikse, E. Svarstad, B. Rune, A. Knut, M. Szymczak, J. Kuzniar, W. Kopec, Z. Marchewka, M. Klinger, P. Arrizabalaga, R. Silvarino, F. Sant, G. Espinosa, M. Sole, R. Cervera, D. Gude, S. Chennamsetty, A. Demin, V. Kozlov, I. Lisukov, O. Kotova, A. Sizikov, V. Sergeevicheva, L. Demina, O. Borjesson, M. Wendt, A. Avik, A. R. Qureshi, J. Bratt, E. J. Miller, I. Gunnarsson, A. Bruchfeld, K. Sugiyama, M. Hasegawa, K. Yamamoto, H. Hayashi, S. Koide, K. Murakami, M. Tomita, S. Yoshida, Y. Yuzawa, S. Yew, D. Jayne, K. Westman, P. Hoglund, O. Flossman, A. Mahr, R. Luqmani, J. Robson, E. Thervet, C. Levi, E. Guiard, M. Roland, D. Nochy, C. Daniliuc, L. Guillevin, L. Mouthon, C. Jacquot, A. Karras, Y. Kimura, H. Morita, H. Debiec, H. Yamada, N. Miura, S. Banno, P. Ronco, H. Imai, D. H. Shin, D. Famee, H. M. Koo, S. H. Han, K. H. Choi, T.-H. Yoo, S.-W. Kang, C. Fofi, L. Scabbia, F. Festuccia, A. Stoppacciaro, P. Mene', A. Shimizu, M. Fukui, A. MII, T. Kaneko, Y. Masuda, Y. Iino, Y. Katayama, Y. Fukuda, A. Kuroki, K. Matsumoto, T. Akizawa, R. Jurubita, G. Ismail, R. Bobeica, E. Rusu, D. Zilisteanu, A. Andronesi, O. Motoi, V. Ditoiu, I. Copaci, M. Voiculescu, M. V. Irazabal, A. Eirin, J. C. Lieske, L. H. Beck, J. J. Dillon, P. H. Nachman, S. Sethi, S. B. Erickson, D. C. Cattran, F. C. Fervenza, B. Svobodova, Z. Hruskova, I. Janatkova, E. Jancova, V. Tesar, M. S. Seo, S. H. Kwon, E. B. Lee, J. Y. You, Y. K. Hyun, S. A. Woo, M. Y. Park, S. J. Choi, J. S. Jeon, H. Noh, J. G. Kim, D. C. Han, S. D. Hwang, T. Y. Choi, S. Y. Jin, E. Loiacono, D. Defedele, M. P. Puccinelli, R. Camilla, R. Gallo, L. Peruzzi, C. Rollino, G. Beltrame, M. Ferro, L. Vergano, F. Campolo, A. Amore, R. Coppo, T. Knoop, L. Bostad, T. Leivestad, R. Bjorneklett, J. Teranishi, R. Yamamoto, Y. Nagasawa, T. Shoji, H. Iwatani, N. Okada, T. Moriyama, A. Yamauchi, Y. Tsubakihara, E. Imai, H. Rakugi, Y. Isaka, F. M. Doh, S. J. Kim, D. S. Han, Y. Suzuki, K. Matsuzaki, H. Suzuki, K. Okazaki, H. Yanagawa, M. Maiguma, M. Muto, T. Sato, S. Horikoshi, J. Novak, O. Hotta, Y. Tomino, E. Gutierrez, I. Zamora, J. Ballarin, Y. Arce, S. Jimenez, C. Quereda, T. Olea, J. Martinez-Ara, A. Segarra, C. Bernis, A. Garcia, M. Goicoechea, S. Garcia de Vinuesa, J. Rojas, M. Praga, V. Ristovska, G. Petrushevska, L. Grcevska, K. Satake, Y. Shimizu, N. Mugitani, S. Honda, K. Shibuya, A. Shibuya, M. Papale, M. T. Rocchetti, S. DI Paolo, I. V. Suriano, A. D'apollo, G. Vocino, E. Montemurno, L. Varraso, G. Grandaliano, L. Gesualdo, A. Huerta, A. S. Bomback, P. A. Canetta, J. Radhakrishnan, L. Herlitz, B. Stokes, V. D'agati, G. Markowitz, G. B. Appel, H. Mouna, B. D. Nasr, I. Mrabet, L. Ahmed, A. Sabra, F. Mohamed Ammeur, E. Mezri, S. Habib, M. Innocenti, A. Pasquariello, G. Pasquariello, P. Mattei, A. Bottai, G. Fumagalli, L. Bozzoli, S. Samoni, A. Cupisti, B. Caldin, J. Hung, L. Repizo, D. M. Malheiros, R. Barros, V. Woronik, C. Giammarresi, L. Bono, A. Ferrantelli, C. Tortorici, G. Licavoli, U. Rotolo, X. Huang, Q. Wang, M. Shi, W. Chen, Z. Liu, R. Scarpioni, L. Cantarini, A. Lazzaro, M. Ricardi, V. Albertazzi, L. Melfa, C. Concesi, D. Vallisa, L. Cavanna, G. Gungor, H. Ataseven, A. Demir, Y. Solak, M. Biyik, B. Ozturk, I. Polat, A. Kiyici, O. Ozer Cakir, H. Polat, I. Castillo, V. Carreno, A. Aguilar, R. Madero, E. Hernandez, J. Bartolome, F. Gea, R. Selgas, H. A. M. El Aggan, H. S. El Banawy, E. Wagdy, N. Tchebotareva, O. LI, I. Bobkova, L. Kozlovskaya, V. Varshavskiy, E. Golicina, Y. Chen, Z. Gong, X. Chen, L. Tang, J. Zhou, X. Cao, R. Wei, E. H. Koo, J. H. Park, H. K. Kim, M. S. Kim, H. R. Jang, J. E. Lee, W. Huh, D. J. Kim, H. Y. Oh, Y.-G. Kim, O. Eskova, M. Shvetsov, E. Golytsina, O. Popova, M. Quaglia, S. Monti, R. Fenoglio, A. Menegotto, A. Airoldi, C. Izzo, M. A. Rizzo, U. Dianzani, P. Stratta, and D. Gianfreda

Subjects
Transplantation, Nephrology
Published
2012

12. Genetic diseases

Author

T. Inazu, T. Kawahara, H. Endou, N. Anzai, I. Sebesta, B. Stiburkova, K. Ichida, M. Hosoyamada, A. Testa, D. Leonardis, F. Catalano, A. Pisano, A. Mafrica, B. Spoto, M. C. Sanguedolce, R. M. Parlongo, G. Tripepi, M. Postorino, G. Enia, C. Zoccali, F. Mallamaci, M. Working Group, A. Luque de Pablos, V. Garcia-Nieto, J. C. Lopez-Menchero, E. Ramos-Trujillo, H. Gonzalez-Acosta, F. Claverie-Martin, M. Arsali, P. Demosthenous, L. Papazachariou, Y. Athanasiou, K. Voskarides, C. Deltas, A. Pierides, S. Lee, K. H. Jeong, C. Ihm, T. W. Lee, S. H. Lee, J. Y. Moon, J. G. Wi, H. J. Lee, E. Y. Kim, K. Rogacev, A. Friedrich, B. Hummel, J. Berg, A. Zawada, D. Fliser, J. Geisel, G. H. Heine, I. Brabcova, S. Dusilova-Sulkova, Z. Krejcik, V. Stranecky, K. Lipar, T. Marada, J. Stepankova, O. Viklicky, M. Buraczynska, P. Zukowski, W. Zaluska, A. Kuczmaszewska, A. Ksiazek, M. Gaggl, S. Weidner, M. Hofer, J. Kleinert, G. Fauler, M. Wallner, P. Kotanko, G. Sunder-Plassmann, E. Paschke, R. Heguilen, L. Albarracin, J. Politei, A. A. Liste, A. Bernasconi, E. Kusano, R. Russo, A. Pisani, G. Messalli, M. Imbriaco, L. Prikhodina, O. Ryzhkova, V. Polyakov, K. Lipkowska, D. Ostalska-Nowicka, M. Smiech, M. Jaroniec, K. Zaorska, W. Szaflarski, M. Nowicki, J. Zachwieja, G. D'arrigo, J. Moskowitz, S. Piret, A. Tashman, E. Velez, K. Lhotta, R. Thakker, J. Cox, J. Kingswood, J. Mbundi, G. Attard, U. Patel, A. Saggar, F. Elmslie, T. Doyle, A. Jansen, S. Jozwiak, E. Belousova, M. Frost, R. Kuperman, M. Bebin, B. Korf, R. Flamini, M. Kohrman, S. Sparagana, J. Wu, J. Ford, G. Shah, D. Franz, B. Zonnenberg, W. Cheung, S. Urva, J. Wang, C. Kingswood, K. Budde, T. Kofman, C. Narjoz, Q. Raimbourg, M. Roland, M.-A. Loriot, A. Karras, G. S. Hill, C. Jacquot, D. Nochy, E. Thervet, P. Jagodzinski, M. Mostowska, A. Oko, N. Nicolaou, S. Kevelam, M. Lilien, M. Oosterveld, R. Goldschmeding, A. Van Eerde, R. Pfundt, A. Sonnenberg, P. Ter Hal, N. Knoers, K. Renkema, T. Storm, R. Nielsen, E. Christensen, C. Frykholm, L. Tranebjaerg, H. Birn, P. Verroust, T. Neveus, B. Sundelin, J. M. Hertz, G. Holmstrom, K. Ericson, A. Fabris, D. Cremasco, A. Zambon, E. Muraro, M. Alessi, A. D'angelo, F. Anglani, D. Del Prete, A. Alkmim Teixeira, B. M. Quinto, C. Jose Rodrigues, A. Beltrame Ribeiro, M. Batista, A. Kerti, R. Csohany, A. Szabo, O. Arkossy, P. Sallai, V. Moriniere, V. Vega-Warner, O. Lakatos, T. Szabo, G. Reusz, K. Tory, M. Addis, E. Tosetto, C. Meloni, M. Ceol, R. Cristofaro, M. A. Melis, P. Vercelloni, G. Marra, S. Kaniuka, M. Nagel, W. Wolyniec, L. Obolonczyk, R. Swiatkowska-Stodulska, K. Sworczak, B. Rutkowski, C. Chen, L. Jiang, L. Chen, L. Fang, M. Mozes M., M. Boosi, L. Rosivall, G. Kokeny, R. Diana, O. Gross, T. Johanna, G. Rainer, C. Ayse, H. Henrik, M. Gerhard-Anton, M. Nabil, E. Intissar, H. Belge, J. Bloch, K. Dahan, Y. Pirson, P. Vanhille, and N. Demoulin

Subjects
Transplantation, Nephrology
Published
2012

13. Renal histopathology

Author

F. Marie-Lucile, N. Laure-Helene, C. Yosr, M. Anne, F. Fadi, C. Levi, V. Meas-Yedid, C. Daniliuc, A. Karras, J. C. Olivo-Marin, L. Mouthon, E. Guiard, M. Roland, L. Guillevin, C. Jacquot, D. Nochy, E. Thervet, Q. Chen, C. Skerka, B. Uzonyi, S. Lindner, C. Licht, B. Hoppe, M. Riedl, M. Kirschfink, S. Habbich, G. Wolf, L. Strain, T. H. Goodship, P. F. Zipfel, H. Kfoury, A. Alsuwaida, K. Alsaad, F. Alhejaili, M. Alghonaim, J. Alwakeel, S. Husain, N. Aloudah, L. Besso, M. Tamagnone, G. Daidola, M. Burdese, L. Repetto, G. Pasquale, L. Colla, L. Biancone, P. Stratta, G. P. Segoloni, J. Bacalja, A. M. Bauer Segvic, S. Bulimbasic, A. Pacic, M. Knotek, M. Sabljar Matovinovic, K. Galesic, D. Galesic Ljubanovic, E. Zakharova, E. Stolyarevich, O. Vorobjova, H. Tamouza, J. M. Chemouny, M. Flamant, L. Raskova Kafkova, M. Demion, M. Laurent, F. Walker, B. A. Julian, E. Tissandie, M. K. Tiwari, J. Novak, N. O. Camara, M. Benhamou, F. Vrtovsnik, R. C. Monteiro, I. C. Moura, S. Samavat, P. Ahmadpoor, P. Torbati, R. Ghaderi, F. Poorrezagholi, F. Samadian, M. Nafar, A. MII, A. Shimizu, T. Kaneko, F. Yasuda, M. Fukui, Y. Masuda, Y. Iino, Y. Katayama, C. Muller, J. Markovic-Lipkovski, S. Simic-Ogrizovic, R. Naumovic, S. Cirovic, D. Mitrovic, G. Muller, A. Wozniak, M. Janicka-Jedynska, J. Zurawski, E. Kaczmarek, J. Zachwieja, S. Khilji, T. Dorman, P. O'kelly, L. Lampty, K. Leung, A. Shadivan, C. Varghese, J. Walshe, T. Saito, M. Kawano, T. Saeki, I. Mizushima, Y. Yamaguchi, N. Imai, H. Nakashima, H. Umehara, M. Shvetsov, O. Popova, N. Chebotareva, A. Ivanov, I. Bobkova, D. Cremasco, M. Ceol, L. Peruzzi, G. Mazzucco, M. Giuseppina, G. Vezzoli, R. Cristofaro, A. D'angelo, F. Anglani, D. Del Prete, G. Coppolino, N. Comi, D. Bolignano, V. Piraina, R. Talarico, A. Colombo, G. Lucisano, G. Fuiano, P. Bernich, A. Lupo, T. R. Of Renal Biopsies, M. P. Rastaldi, O. C. Jercan, P. Messa, D. Alexandru, L. Mogoanta, and V. Uribe Villegas

Subjects
Transplantation, Nephrology
Published
2012

14. Transplantation - clinical I

Author

M. Bonani, J. Brockmann, C. D. Cohen, T. Fehr, A. Nocito, M. Schiesser, A. L. Serra, M. Blum, M. Struker, D. F. Frey, R. P. Wuthrich, Y. W. Kim, S. J. Park, T. H. Kim, Y.-H. Kim, S. W. Kang, L. Webb, A. Casula, C. Tomson, Y. Ben-Shlomo, H. Mansour, A. Akl, E. Wafa, M. El Shahawy, R. Palma, S. Swaminathan, A. B. Irish, A. Kolonko, J. Chudek, A. Wiecek, Y. Vanrenterghem, D. Kuypers, D. V. Katrien, P. Evenepoel, K. Claes, B. Bammens, B. Meijers, M. Naesens, S. Lo, C.-K. Chan, D. Yong, P.-N. Wong, T.-H. Kwan, Y.-L. Cheng, K.-S. Fung, B.-Y. Choy, K.-F. Chau, C.-B. Leung, J. Ebben, J. Liu, S.-C. Chen, A. Collins, Y.-W. Ho, M. Abelli, A. Ferrario DI Torvajana, E. Ticozzelli, B. Maiga, A. Patane, P. Albrizio, M. Gregorini, C. Libetta, T. Rampino, P. Geraci, A. Dal Canton, M.-T. Rotter, J. Jacobi, K. Pressmar, K. Amann, K.-U. Eckardt, A. Weidemann, K. Muller, M. Stein, C. Diezemann, A. Sefrin, N. Babel, P. Reinke, T. Schachtner, C. Costa, G. A. Touscoz, F. Sidoti, F. Sinesi, S. Mantovani, S. Simeone, C. Balloco, E. Piasentin Alessio, M. Messina, G. Segoloni, R. Cavallo, R. .K. Sharma, D. A. Kaul, R. K. Gupta, A. Gupta, N. Prasad, D. Bhadhuria, K. J. Suresh, S. Benaboud, D. Prie, E. Thervet, S. Urien, C. Legendre, J.-C. Souberbielle, D. Hirt, G. Friedlander, J.-M. Treluyer, M. Courbebaisse, M. Arias, J. Campistol, J. Pascual, J. M. Grinyo, D. Hernandez, J. M. Morales, L. M. Pallardo, D. Seron, L. Senecal, A. Boucher, R. Dandavino, S. Colette, M. Vallee, J.-P. Lafrance, Y. Tung-Min, W. Min-Ju, C. Cheng-Hsu, C. Chi-Hung, S. Kuo-Hsiung, W. Mei-Chin, S. Direkze, M. Khorsavi, S. Stuart, A. Goode, G. Jones, C. Massimetti, I. Napoletano, G. Imperato, M. T. Muratore, S. Fazio, G. Pessina, F. Brescia, S. Feriozzi, K. Tanaka, K. Sakai, A. Futaki, Y. Hyoudo, M. Muramatsu, T. Kawamura, S. Shishido, S. Hara, A. Kushiyama, A. Aikawa, K. Jankowski, J. Gozdowska, D. Lewandowska, A. Kwiatkowski, M. Durlik, P. Pruszczyk, Y. Obi, N. Ichimaru, T. Kato, M. Okumi, J. Kaimori, K. Yazawa, N. Nonomura, Y. Isaka, S. Takahara, M. Aimele, R. Christophe, D. Geraldine, R. Eric, H. Alexandre, I. Masson, M. Nicolas, T. Ivan, J. Acil, T. Lise, H.-A. Aoumeur, D. Laurence, D. Pierre, C. Etienne, R. Lionel, K. Nassim, M. Emmanuel, A. Eric, M. Christophe, K. Alexandre, B. Pierre, H. Jean-Philippe, P. Dominique, L. Christophe, G. Alexei, D. Michel, P. Shah, V. B. Kute, A. Vanikar, M. Gumber, P. Modi, H. Trivedi, J. GoIebiewska, A. Debska-Slizien, B. Rutkowski, L. Domanski, G. Dutkiewicz, K. Kloda, A. Pawlik, A. Ciechanowicz, A. Binczak-Kuleta, J. Rozanski, M. Myslak, K. Safranow, K. Ciechanowski, C. S. Aline, T. Basset, X. Delavenne, E. Alamartine, C. Mariat, K. Bobrek-Lesiakowska, M. Wisniewska, M. Romanowski, M. Kurzawski, M. De Borst, L. Baia, G. Navis, S. Bakker, A. Ranghino, G. Tognarelli, E. Basso, A. M. Manzione, G. Daidola, G. P. Segoloni, T. Kimura, T. Yagisawa, N. Ishikawa, Y. Sakuma, T. Hujiwara, A. Nukui, M. Yashi, J. H. Kim, S.-S. Kim, D. J. Han, S.-K. Park, G. Randhawa, H. Patel, S. Taheri, O. Goker-Alpan, J. Ibrahim, K. Nedd, S. Shankar, H. Lein, B. Barshop, E. Boyd, M. Holida, R. Hillman, R. Mardach, N. Wienreb, B. Rever, R. Forte, A. Desai, A. Wijatyk, P. Chang, and R. Martin

Subjects
Transplantation, Nephrology
Published
2012

15. Kidney Transplant Recipients Carrying the CYP3A4*22 Allelic Variant Have Reduced Tacrolimus Clearance and Often Reach Supratherapeutic Tacrolimus Concentrations

Author

Isabelle Etienne, Mathias Büchler, P. Beaune, Marie-Anne Loriot, Y. Le Meur, M. El Bahri, Anne-Elisabeth Heng, Cécile Vigneau, Antoine Thierry, Charlotte Colosio, Jean-François Subra, B. H. de Ligny, Gabriel Choukroun, Nicolas Pallet, B. Moulin, A.-S. Jannot, C. Legendre, Corinne Alberti, E. Thervet, Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Service de Néphrologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Mécanismes physiologiques et conséquences des calcifications cardiovasculaires: rôle des remodelages cardiovasculaires et osseux, Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, LabEX IGO Immunothérapie Grand Ouest, Nantes Université (Nantes Univ), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Service de Néphrologie [Angers], Université d'Angers (UA)-Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Médecine Personnalisée, Pharmacogénomique, Optimisation Thérapeutique (MEPPOT - U1147), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Transplantation Rénale, affiliation inconnue, Université Grenoble Alpes (UGA), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Clermont Université-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Recherche Agronomique (INRA), Université Grenoble Alpes - UFR Médecine ( UGA UFRM ), Université Grenoble Alpes ( UGA ), CHU Rouen-Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ), Université de Picardie Jules Verne ( UPJV ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut de Génétique et Développement de Rennes ( IGDR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Immunologie et Pathologie ( EA2216 ), Université de Brest ( UBO ) -IFR148, Unité de Nutrition Humaine ( UNH ), Institut National de la Recherche Agronomique ( INRA ) -Université d'Auvergne - Clermont-Ferrand I ( UdA ) -Clermont Université, Université d'Angers ( UA ) -CHU Angers, Section clinique, Université Paris 8 Vincennes-Saint-Denis ( UP8 ), Médecine Personnalisée, Pharmacogénomique, Optimisation Thérapeutique ( MEPPOT - U1147 ), and Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM )

Subjects
Adult, Male, medicine.medical_specialty, immunosuppressant, [SDV]Life Sciences [q-bio], Population, nephrology, kidney transplantation, Pharmacology, Gastroenterology, Tacrolimus, Clinical research, calcineurin inhibitor: tacrolimus, Polymorphism (computer science), Internal medicine, Genotype, medicine, pharmacodynamics, Immunology and Allergy, Cytochrome P-450 CYP3A, Humans, Pharmacology (medical), genetics, Allele, education, Allele frequency, Alleles, ComputingMilieux_MISCELLANEOUS, Transplantation, education.field_of_study, immune modulation, immunosuppression, CYP3A4, [ SDV ] Life Sciences [q-bio], business.industry, Middle Aged, practice, Female, pharmacology, business, pharmacokinetics, Immunosuppressive Agents
Abstract

International audience; CYP3A4*22 is an allelic variant of the cytochrome P450 3A4 associated with a decreased activity. Carriers of this polymorphism may require reduced tacrolimus (Tac) doses to reach the target residual concentrations (Co). We tested this hypothesis in a population of kidney transplant recipients extracted from a multicenter, prospective and randomized study. Among the 186 kidney transplant recipients included, 9.3% (18 patients) were heterozygous for the CYP3A4*22 genotype and none were homozygous (allele frequency of 4.8%). Ten days after transplantation (3 days after starting treatment with Tac), 11% of the CYP3A4*22 carriers were within the target range of Tac Co (10–15 ng/mL), whereas among the CYP3A4*1/*1 carriers, 40% were within the target range (p = 0.02, OR = 0.19 [0.03; 0.69]). The mean Tac Co at day 10 in the CYP3A4*1/*22 group was 23.5 ng/mL (16.6–30.9) compared with 15.1 ng/mL (14–16.3) in the CYP3A4*1/*1 group, p

Published
2015

16. PATHOLOGY

Author

R. Inagi, S. Motonishi, M. Nangaku, E. M. Buhl, S. Djudjaj, B. M. Klinkhammer, U. Eriksson, J. Floege, P. Boor, R. Kramann, S. Fleig, S. Fabian, D. Dirocco, B. D. Humphreys, M. Jasiek, A. Karras, B. Terrier, R. Mesbah, S. Faguer, N. Jourde, P. Remy, P. Ronco, X. Mariette, R. Seror, E. Thervet, V. Le Guern, H. Francois, I. Grgic, M. Krautzberger, A. Hofmeister, M. Lalli, J. Liu, J. S. Duffield, A. P. McMahon, and B. Aronow

Subjects
Transplantation, Nephrology
Published
2014

17. Quantification of interstitial fibrosis by image analysis on routine renal biopsy 1 year after transplantation in patients managed by C2 monitoring of cyclosporine microemulsion

Author

Vannary Meas-Yedid, Jean-Christophe Olivo-Marin, E. Morelon, E. Thervet, Aude Servais, and M. Buchler

Subjects
Adult, Male, medicine.medical_specialty, Biopsy, chemistry.chemical_compound, Chronic allograft nephropathy, Multicenter trial, medicine, Image Processing, Computer-Assisted, Humans, Kidney transplantation, Monitoring, Physiologic, Transplantation, Creatinine, medicine.diagnostic_test, Surrogate endpoint, business.industry, Histocompatibility Testing, Middle Aged, medicine.disease, Fibrosis, Kidney Transplantation, Surgery, chemistry, Cyclosporine, Emulsions, Female, Renal biopsy, Radiology, business, Immunosuppressive Agents, Follow-Up Studies
Abstract

Background Renal interstitial fibrosis (IF), the main histopathologic feature of chronic allograft nephropathy (CAN), may be an important surrogate endpoint for patient follow-up. IF is currently assessed by semiquantitative analysis, but automatic color image analysis may be a more reliable, reproducible method to evaluate IF. We performed a retrospective analysis to calculate IF on routine renal biopsies 1 year after transplantation. Methods Data were obtained from MO2ART, a prospective multicenter trial in which the cyclosporine microemulsion dose was adjusted based on C2 levels. We included 26 patients in whom routine renal biopsy at 1 year was available from two centers. For each biopsy, a section was analyzed by a program of color segmentation image that automatically extracted green-colored areas characteristic of IF. Results were expressed as percent IF and grade namely grade I, 50%. The results were compared according to clinical and biological data. Results The 26 patients had a mean IF score of 0.35 ± 0.04. We observed 34.6% CAN grade I; 46.1%, grade II; and 19.2%, grade III. Serum creatinine at 3 years was greater in the higher grade of automated IF by repeated ANOVA. Conclusion Automatic quantification of IF on routine biopsy at 1 year after transplantation was predictive of renal outcome. This technique may provide an interesting tool for the early diagnosis of CAN after renal transplantation.

Published
2007

18. Successful organ transplantation after treatment of fatal cyanide poisoning with hydroxocobalamin

Author

J L Fortin, S Ferlicot, M Ruttimann, G Capellier, E Thervet, and A Bigorie

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Antidotes, Liver transplantation, Toxicology, Organ transplantation, Hydroxocobalamin, Medicine, Humans, Kidney transplantation, Heart transplantation, Cyanides, business.industry, General Medicine, Middle Aged, medicine.disease, Kidney Transplantation, Tissue Donors, Surgery, Heart Arrest, Liver Transplantation, Transplantation, B vitamins, Anesthesia, Cyanide poisoning, Heart Transplantation, Female, business, medicine.drug
Abstract

Background. Cyanide-poisoned patients are potential organ donors provided that organs are not damaged by the poison or by antidotal treatment. Case study. A patient with third-degree burns and smoke inhalation-associated cyanide poisoning confirmed by measurements of whole blood cyanide was found in cardiac arrest and administered epinephrine and hydroxocobalamin (5 g + 5 g). Cardiac activity resumed, but the patient was declared brain dead on the third day of hospitalization when coma deteriorated to a shock state with refractory hypoxemia. Kidneys, heart, and liver were removed and transplanted into four patients. Gross pre-transplantation inspection of the donor organs and renal histology showed no evidence that hydroxocobalamin caused organ toxicity. Donor organs functioned normally through follow-up periods of several months. Conclusion. Anoxic cardiac arrest following acute cyanide poisoning treated with hydroxocobalamin (5 g + 5 g) was not a contraindication to organ transplantation after confirmed...

Published
2007

19. Lowering immunosuppression is safe and effective to treat altered pattern of CMV infection in renal transplant recipients on valaciclovir prophylaxis

Author

F Martinez, Christophe Legendre, F Morinet, C Scieux, A Lautrette, E Thervet, D Anglicheau, and M. Flamant

Subjects
Human cytomegalovirus, medicine.medical_specialty, Opportunistic infection, medicine.medical_treatment, Acyclovir, Gastroenterology, Antiviral Agents, Betaherpesvirinae, Internal medicine, medicine, Humans, Prodrugs, Antigens, Viral, Kidney transplantation, Immunosuppression Therapy, Transplantation, Kidney, biology, Dose-Response Relationship, Drug, business.industry, Immunosuppression, Valine, medicine.disease, biology.organism_classification, Kidney Transplantation, Valaciclovir, medicine.anatomical_structure, Valacyclovir, Immunology, Cytomegalovirus Infections, Surgery, Drug Therapy, Combination, business, Immunosuppressive Agents, medicine.drug
Published
2002

20. Histologic evolution of kidney graft after combined pancreas-kidney transplantation

Author

Dominique Nochy, J.P Rerolle, P Passa, J Bedrossian, E. Thervet, François Desgrandchamps, S. Fornairon, C. Legendre, and Anne Janin

Subjects
Adult, Graft Rejection, medicine.medical_specialty, Time Factors, Biopsy, MEDLINE, Renal function, medicine, Humans, Observer Variation, Transplantation, Kidney, medicine.diagnostic_test, business.industry, Graft Survival, Kidney Transplantation, Surgery, Pancreas kidney transplantation, medicine.anatomical_structure, Creatinine, Histopathology, Pancreas Transplantation, Pancreas, business
Published
2000

21. Placebo-controlled study of a humanized anti-TAC monoclonal antibody in dual therapy for prevention of acute rejection after renal transplantation

Author

B Charpentier and E Thervet

Subjects
Graft Rejection, medicine.medical_specialty, Daclizumab, medicine.drug_class, Placebo-controlled study, Monoclonal antibody, Antibodies, Monoclonal, Humanized, Gastroenterology, Placebos, Double-Blind Method, Adrenal Cortex Hormones, Internal medicine, medicine, Cadaver, Humans, Transplantation, Kidney, business.industry, Antibodies, Monoclonal, Ciclosporin, Kidney Transplantation, Tissue Donors, Clinical trial, medicine.anatomical_structure, Immunoglobulin G, Chemoprophylaxis, Immunology, Acute Disease, Cyclosporine, Surgery, business, Immunosuppressive Agents, medicine.drug
Published
1998

22. Renal transplantation - clinical studies - 1

Author

Francesca Sidoti, V. Jha, Massimiliano Bergallo, Beom Seok Kim, Jerzy Chudek, Hyunwook Kim, Petar Kes, Nadezda Babenko, Diana C. Grootendorst, Ahmed A. Shokeir, Mohammad Mahdi Sagheb, Erkan Demir, Mohamed A. Ali, Joon Heun Jeong, Malihe Layeghian Javan, Sonja Dzikova, Mariangela Leal Cherchiglia, Reza Hekmat, Maria Emilia Ferreira, Franca Giacchino, Z. Jabbar, M.R. Alam, S.Y. Tan, Oestein Bentdal, Ralf Schindler, Anna Casula, Natalia Polanco, T.C. Keng, Jae Ho Choi, P. Fraile, C. Randoux, Ho Yung Lee, Federica Neve Vigotti, Fatemeh Pour-Reza Gholi, J.M. Tabernero, R.M.V. Ree, Inara Adamsone, Marc A. Seelen, B. Sis, K.S. Famulski, W.Y. Kong, Jelka Masin-Spasovska, R.O.B. Gans, Juan Vanegas, Eric Lechevallier, J. vd Born, Mustafa Balal, Antonino Catalano, Jung Tak Park, E. Kerezsy, Hallvard Holdaas, Jean-Pierre Grünfeld, Chantal Gautreau, Ljupco Lekovski, Maria Elena Terlizzi, Goce Spasovski, Efat Razeghi, Filógenes Aguirre, David Ansell, Zoubeir Skalli, Jaap J. Homan van der Heide, Jong Oh Lee, S. Bunnag, Annie Lahoche, Caroline Suberbielle-Boissel, Magdalena Szotowska, Dominique Charron, Ronald P. Stolk, Valérie Moal, Ana Paula Alvares, Dirk De Bacquer, Yip Boon Chong, Thomas F. Mueller, Budiman David, Dorien M. Zelle, Eva Gavela, I. Ursuleac, Christiane Mousson, Paul Roderick, Wha Rhim Lee, Bulent Tokgoz, Pietro Lampertico, Mehmet Sikgenc, Pavel Jindra, Gerardo Oliveira, Dominique Nochy, Vahid Pourfarziani, Charles R.V. Tomson, Andrzej Wiecek, Kristian Heldal, François Provôt, Wilfried Gwinner, Sharnaz Shahidi, M. Rathi, Jerome Verine, Arbey Aristizabal, Joana Santos, François Glowacki, Ana Maria Manzione, Raymond Vanholder, Philipp Halloran, S.H. Teo, Luís Coentrão, Asia Khanam, Pedram Ahmadpour, Udaya Udayaraj, Hermann Haller, Ghanbarali Raeesjalali, Eun Young Kim, A.E. Heng, Sandro Feriozzi, Myoung Soo Kim, Sun Young Park, P.F. Halloran, Patrick Peeters, Joao Andrade, Tomas Vanecek, Jana Nemcova, Carlos Guzman, Hakim Hamzaoui, Dong Ryeol Lee, Ninoslav Ivanovski, María M. Morales-Suárez-Varela, Harry Abadia, François Buissou, M. Buchler, M. Mengel, Marie Frimat, Wael Nassar, Lama Barakat, P.K. Agarwal, Denis Glotz, I. Sinescu, Willy Aaseboe, Christopher Dudley, L.P. Tan, Karsten Midtvedt, Mohamed Ghonein, Mauro Viganò, Saman Nikeghbalian, Roy Calne, Giovanna Lunghi, J.J. Homan vd Heide, Mahmoud El-Baz, F. Bayle, Ljubica Bubic-Filipi, Anders Hartmann, Alvaro Mena, H.U. Rashid, Chew Ming Wong, Francisco de Assis Acurcio, Pieter Evenepoel, Fabrizio Fop, Khadidheh Makhdomi, Maryam Sharifian, M.S. Islam, Amado Andrés, Bassam Saeed, Zahra Javadi, Lech Cierpka, Dmitry Babarykin, M. Salahuddin, Ivana Jurić, Kathleen Claes, Saime Paydas, E. Thervet, Carmen Lefaucheur, Abeed Pall, Waleska Teixeira Caiaffa, Y. Lebranchu, Gerjan Navis, Dong Ki Kim, Olga Randone, Zivko Popov, Sara Astegiano, Francis Verbeke, G. Einecke, Yu Seun Kim, Stephan J. L. Bakker, Elaine Leandro Machado, Ondrej Hes, Stanislav Kirillov, Henryk Karkoszka, Yvon Berland, G.J. Navis, Christian Coulange, Tatyana Cheprasova, Anke Schwarz, T. Frouget, Fergus Caskey, Seyed Ali Malek-Hosseini, Maria Messina, Beti Dejanova, Elisabetta Mezza, Esther González, H. Rahman, D. Yrrell, Arsen Abovyan, Murat Hayri Sipahioglu, Mohamed A. Bakr, I. Alexiu, Hassan Argani, Cristina Alina Bucsa, S.J.L. Bakker, Hakima Rhou, Cristina Costa, Manuel Pestana, Tarek M. Abbas, Rabia Bayahia, Hyae Ju Oh, Dave Collett, Antonio Lavacca, Motaz Obeidat, Laurent Daniel, Intissar Haddiya, Ana Ávila, Véronique Frémeaux-Bacchi, Eghlim Nemati, Ahad Eshraghian, Tomas Reischig, J. Reeve, D. Tacu, Wim Van Biesen, H. Mazouz, Susana Sampaio, Essam Lotfy, Nadine Zoephel, Boshra Hassanzamani, Yann Neuzillet, Cengiz Utas, Daniele A.C. Szuster, P. Macintyre, P. Halloran, H.S. Kohli, Rafał Zwiech, Anna Varberg Reisæter, Sima Abediazar, Malaka Yehya Fouad, Giuseppe Montagnino, Dinanda de Jager, Eli Iola Gurgel Andrade, P.G. Cosmes, Torbjørn Leivestad, I. Etienne, Roland Hetzer, Byng Chang Kim, Kyu Hun Choi, K.L. Gupta, Ashraf Donia, Rijk O. B. Gans, Jan P. Schouten, Graham A. Stewart, Adel Ghorab, V.G. Bernalt, Ali Bahador, Mohsen Nafar, L. Pallardó, Torbjoern Leivestad, Hamid Tayebi Khosroshahi, Mohammad Kazem Tarzamni, Juliana Álvares, Asunción Sancho, Enrique Morales, Piergiorgio Messa, Nassim Kamar, Behzad Einollahi, Ibrahim Barghouth, Isabel Cristina Gomes, Ahmed F. Hamdy, W.J.V. Son, Gustavo Zuluaga, Fadoua Bouabid, S Behzadi, Giuseppe Paolo Segoloni, Marc Hazzan, Mi Young Jeon, Rutger M. van Ree, F. Allano, Alan Zokoev, O. Toupance, G. Touchard, Urszula Siekiera, JoséF. Crespo, Gary S. Hill, Hans Lehmkuhl, Michael Kaabak, Erik Heyerdahl Stroem, Amir M Elokely, Mohamed A. Ghoneim, José M. Morales, Valerie A. Luyckx, Nikolina Bašić-Jukić, Tae Ik Chang, Vinay Sakhuja, Mohamed Shamrouk, Oscar Leiva, Yoav Ben-Shlomo, Jorge González, Yong Hun Shin, Dirk Kuypers, Catarina Carvalho, N. Simforoosh, Manuela Bustorff, Cibele C Comini, Narges Sobhani, Heshmatollah Salahi, D. Glotz, Jae Hyun Chang, Saffa Elawad, Adriana Aroldi, Mahboob Lessan-Pezeshki, Ulrich Frei, Loubna Benamar, Jamshid Roozbeh, Gordana Petrusevska, Rafail Rozental, Michael Mengel, Ana Hernández, Walter Angel, Yasar Sertdemir, Tae Hyun Yoo, Catalina Ocampo, Manuel Praga, B. Moulin, Roberta Giraudi, Ilaria Napoletano, Mirko Bouda, U. Erken, Feliks Kacprzyk, Soo Kun Lim, Chiara Merlino, Winston W. Bakker, G.S. Jhangri, Joong Kyung Kim, Daniel Kobewka, Maurizio Ferro, Diana Amerika, Heshmatollah Shahbazian, S.A. Khan, Oktay Oymak, Vladislav Treska, Christina Doerje, Naima Ouzeddoun, D. Kayser, Franco Bonello, Nariman Nezami, Catalina Velez, Bert Bammens, Steven Van Laecke, Yves Vanrenterghem, Young Ki Son, J.P Rerolle, Figen Binokay, Aydin Unal, P. Martín, G. Tognarelli, Rachel Johnson, B. Hurault de Ligny, Cemal Kurt, Jan A. Krikken, Ali Ghafari, Shin Wook Kang, Hussein Sheashaa, Dong Hyung Lee, Arnaud Lionet, Mohammad Hossein Nourbala, Inese Folkmane, Carlo Massimetti, Maria Teresa Muratore, Rania Derani, Fatima Zahra Berkchi, Rossana Cavallo, Taeibi Khosroshahi, C. Dobrea, Ehab W. Wafa, Soon Il Kim, Christian Noel, Eduardo Gutiérrez, Theo Borghuis, Feridun Kavuncuoglu, Thomas Rath, and Rafael Díaz

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Medicine, business, Surgery
Published
2009

24. A pilot study of cyclosporine withdrawal in stable renal transplant recipients after azathioprine–mycophenolate mofetil conversion

Author

L Bererhi, C Legendre, Michael J. Mihatsch, S Puget, D. Ducloux, J Bedrossian, J.M Chalopin, E Morelon, L.-H. Noël, E Thervet, Kreis H, and Anne Janin

Subjects
Graft Rejection, medicine.medical_specialty, Time Factors, Urinary system, Urology, Pilot Projects, Azathioprine, Mycophenolate, Drug Administration Schedule, Mycophenolic acid, medicine, Humans, Kidney transplantation, Transplantation, Kidney, business.industry, Mycophenolic Acid, Ciclosporin, medicine.disease, Kidney Transplantation, Surgery, medicine.anatomical_structure, Cyclosporine, business, Immunosuppressive Agents, Follow-Up Studies, medicine.drug
Published
2000

25. La xénotransplantation : une solution à la pénurie d'organe ?

Author

E Thervet

Subjects
Gynecology, Transplantation, medicine.medical_specialty, business.industry, Xenotransplantation, medicine.medical_treatment, medicine, General Medicine, business, General Biochemistry, Genetics and Molecular Biology
Published
1992

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