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[Involvement of endoplasmic reticulum stress in solid organ transplantation].
- Source :
-
Medecine sciences : M/S [Med Sci (Paris)] 2010 Apr; Vol. 26 (4), pp. 397-403. - Publication Year :
- 2010
-
Abstract
- Endoplasmic reticulum (ER) stress is a situation caused by the accumulation of unfolded proteins in the endoplasmic reticulum, triggering an evolutionary conserved adaptive response termed the unfolded protein response. When adaptation fails, excessive and prolonged ER stress triggers cell suicide. Important roles for ER-initiated cell death pathways have been recognized for several diseases, including diabetes, hypoxia, ischemia/reperfusion injury, neurodegenerative and heart diseases. The implication of the ER stress is not well recognized in solid organ transplantation, but increasing evidence suggests its implication in mediating allograft injury. The purpose of this review is to summarize the mechanisms of ER stress and to discuss its implication during tissue injury in solid organ transplantation. The possible implications of the ER stress in the modifications of cell functional properties and phenotypic changes are also discussed beyond the scope of adaptation and cell death. Increasing the understanding of the cellular and molecular mechanisms of acute and chronic allograft damages could lead to the development of new biomarkers and to the discovery of new therapeutic strategies to prevent the initiation of graft dysfunction or to promote the tissue regeneration after injury.
- Subjects :
- Animals
Apoptosis
Cyclosporine adverse effects
Diabetes Mellitus, Type 2 chemically induced
Diabetes Mellitus, Type 2 etiology
Drug Delivery Systems
Endoplasmic Reticulum drug effects
Graft Survival
Humans
Insulin Resistance
Islets of Langerhans drug effects
Kidney Transplantation
Liver Transplantation
Mice
Organ Preservation
Postoperative Complications pathology
Postoperative Complications prevention & control
Reperfusion Injury pathology
Tacrolimus adverse effects
Transplantation, Homologous pathology
Unfolded Protein Response drug effects
Endoplasmic Reticulum physiology
Transplantation
Unfolded Protein Response physiology
Subjects
Details
- Language :
- French
- ISSN :
- 0767-0974
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Medecine sciences : M/S
- Publication Type :
- Academic Journal
- Accession number :
- 20412745
- Full Text :
- https://doi.org/10.1051/medsci/2010264397