1. Addressing the Osteoporosis Problem-Multifunctional Injectable Hybrid Materials for Controlling Local Bone Tissue Remodeling.
- Author
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Gilarska A, Hinz A, Bzowska M, Dyduch G, Kamiński K, Nowakowska M, and Lewandowska-Łańcucka J
- Subjects
- Amines administration & dosage, Amines chemistry, Amines pharmacology, Animals, Biocompatible Materials administration & dosage, Biocompatible Materials chemistry, Bone Regeneration drug effects, Cell Line, Chitosan administration & dosage, Chitosan chemistry, Chitosan pharmacology, Collagen administration & dosage, Collagen chemistry, Collagen pharmacology, Drug Liberation, Humans, Hyaluronic Acid administration & dosage, Hyaluronic Acid chemistry, Hyaluronic Acid pharmacology, Injections, Subcutaneous, Materials Testing, Mice, Mice, Inbred C57BL, Osteoporosis pathology, Particle Size, Silicon Dioxide administration & dosage, Silicon Dioxide chemistry, Silicon Dioxide pharmacology, Biocompatible Materials pharmacology, Osteoporosis drug therapy, Tissue Engineering, Tissue Scaffolds chemistry
- Abstract
Novel multifunctional biomimetic injectable hybrid systems were synthesized. The physicochemical as well as biological in vitro and in vivo tests demonstrated that they are promising candidates for bone tissue regeneration. The hybrids are composed of a biopolymeric collagen/chitosan/hyaluronic acid matrix and amine group-functionalized silica particles decorated with apatite to which the alendronate molecules were coordinated. The components of these systems were integrated and stabilized by cross-linking with genipin, a compound of natural origin. They can be precisely injected into the diseased tissue in the form of a viscous sol or a partially cross-linked hydrogel, where they can serve as scaffolds for locally controlled bone tissue regeneration/remodeling by supporting the osteoblast formation/proliferation and maintaining the optimal osteoclast level. These materials lack systemic toxicity. They can be particularly useful for the repair of small osteoporotic bone defects.
- Published
- 2021
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