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Hydrogel membranes based on genipin-cross-linked chitosan blends for corneal epithelium tissue engineering.
- Source :
- Journal of Materials Science: Materials in Medicine; Aug2012, Vol. 23 Issue 8, p1991-2000, 10p, 2 Color Photographs, 1 Diagram, 4 Charts, 2 Graphs
- Publication Year :
- 2012
-
Abstract
- Novel polymeric hydrogel scaffolds for corneal epithelium cell culturing based on blends of chitosan with some other biopolymers such as hydroxypropylcellulose, collagen and elastin crosslinked with genipin, a natural substance, were prepared. Physicochemical and biomechanical properties of these materials were determined. The in vitro cell culture experiments with corneal epithelium cells have indicated that a membrane prepared from chitosan-collagen blend (Ch-Col) provided the regular stratified growth of the epithelium cells, good surface covering and increased number of the cell layers. Ch-Col membranes are therefore the most promising material among those studied. The performance of Ch-Col membranes is comparable with that of the amniotic membrane which is currently recommended for clinical applications. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09574530
- Volume :
- 23
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Journal of Materials Science: Materials in Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 77908482
- Full Text :
- https://doi.org/10.1007/s10856-012-4666-7