1. The B(C6F5)3-Catalyzed Tandem Meinwald Rearrangement–Reductive Amination
- Author
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Tiddens, Martine R, Klein Gebbink, Robertus J M, Otte, Matthias, Organic Chemistry and Catalysis, and Sub Organic Chemistry and Catalysis
- Subjects
Tandem ,010405 organic chemistry ,Organic Chemistry ,Imine ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Combinatorial chemistry ,Reductive amination ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,chemistry ,Taverne ,Organic chemistry ,Physical and Theoretical Chemistry ,Amination - Abstract
A system of three coupled catalytic cycles enabling the one-pot transformation of epoxides to amines via Meinwald rearrangement, imine condensation, and imine reduction is described. This assisted tandem catalysis is catalyzed by B(C6F5)3 resulting in the first tandem Meinwald rearrangement-reductive amination protocol. The reaction proceeds in nondried solvents and yields β-functionalized amines. In particular, β-diarylamines are obtained in high yields.
- Published
- 2016