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The B(C6F5)3-Catalyzed Tandem Meinwald Rearrangement–Reductive Amination
- Source :
- Organic Letters, 18(15), 3714. American Chemical Society : Division of Carbohydrate Chemistry
- Publication Year :
- 2016
- Publisher :
- American Chemical Society (ACS), 2016.
-
Abstract
- A system of three coupled catalytic cycles enabling the one-pot transformation of epoxides to amines via Meinwald rearrangement, imine condensation, and imine reduction is described. This assisted tandem catalysis is catalyzed by B(C6F5)3 resulting in the first tandem Meinwald rearrangement-reductive amination protocol. The reaction proceeds in nondried solvents and yields β-functionalized amines. In particular, β-diarylamines are obtained in high yields.
- Subjects :
- Tandem
010405 organic chemistry
Organic Chemistry
Imine
010402 general chemistry
01 natural sciences
Biochemistry
Combinatorial chemistry
Reductive amination
0104 chemical sciences
Catalysis
chemistry.chemical_compound
chemistry
Taverne
Organic chemistry
Physical and Theoretical Chemistry
Amination
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....26e647efbae1687b49fe7dc9980eca53