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Non-Heme Iron Catalysts with a Rigid Bis-Isoindoline Backbone and Their Use in Selective Aliphatic C−H Oxidation
- Source :
- Advanced Synthesis and Catalysis, 359(15), 2590. Wiley-VCH Verlag
- Publication Year :
- 2017
-
Abstract
- Iron complexes derived from a bis-isoindoline-bis-pyridine ligand platform based on the BPBP ligand (BPBP = N,N′-bis(2-picolyl)-2,2′-bis-pyrrolidine) have been synthesized and applied in selective aliphatic C–H oxidation with hydrogen peroxide under mild conditions. The introduction of benzene moieties on the bis-pyrrolidine backbone leads to an increased preference of tertiary over secondary C–H bond oxidation (3°/2° ratio up to 33). On the other hand, substituting the meta-position of the pyridines with bulky silyl groups affords enhanced secondary C–H oxidation selectivity and generally leads to higher product yields and mass balances.
- Subjects :
- Silylation
product selectivity
010405 organic chemistry
Ligand
CH oxidation
hydrogen peroxide
General Chemistry
Isoindoline
bioinspired catalysis
010402 general chemistry
01 natural sciences
Medicinal chemistry
0104 chemical sciences
Catalysis
chemistry.chemical_compound
iron
chemistry
Taverne
Organic chemistry
Non heme iron
Hydrogen peroxide
Selectivity
Benzene
Subjects
Details
- Language :
- English
- ISSN :
- 16154150
- Database :
- OpenAIRE
- Journal :
- Advanced Synthesis and Catalysis, 359(15), 2590. Wiley-VCH Verlag
- Accession number :
- edsair.doi.dedup.....13acc79b5a2939e8d02cfe07706c2a00