1. Anti-inflammatory Steroids from the South China Sea Sponge Spongia officinalis.
- Author
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Liu J, Liu ZY, Fu Y, Gu YC, Li SW, Zhang HY, and Guo YW
- Subjects
- Animals, Mice, China, Microglia drug effects, Microglia metabolism, Microglia cytology, Cell Line, Molecular Conformation, Molecular Structure, Porifera chemistry, Steroids chemistry, Steroids isolation & purification, Steroids pharmacology, Lipopolysaccharides pharmacology, Lipopolysaccharides antagonists & inhibitors, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents chemistry, Anti-Inflammatory Agents isolation & purification
- Abstract
One new highly degraded steroid, namely 21-nor-4-ene-chaxine A (1) furnishing a 5/6/5-tricyclic, along with one known related analogue (2), were isolated from the South China Sea sponge Spongia officinalis. Their structures including absolute configurations were established by extensive spectroscopic data analysis, TDDFT-ECD calculation, and comparison with the spectral data previously reported in the literature. Compound 1 represent the new member of incisterols family with a highly degradation in ring B. In vitro bioassays revealed compound 2 exhibited significant anti-microglial inflammatory effect on lipopolysaccharide (LPS)-induced inflammation in BV-2 microglial cells., (© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
- Published
- 2024
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