1. Chronic Cough in Individuals With COPD: A Population-Based Cohort Study.
- Author
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Landt E, Çolak Y, Lange P, Laursen LC, Nordestgaard BG, and Dahl M
- Subjects
- Aged, Chronic Disease, Cough epidemiology, Denmark epidemiology, Female, Follow-Up Studies, Forced Expiratory Volume physiology, Humans, Incidence, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive diagnosis, Pulmonary Disease, Chronic Obstructive physiopathology, Retrospective Studies, Severity of Illness Index, Surveys and Questionnaires, Cough etiology, Lung physiopathology, Population Surveillance, Pulmonary Disease, Chronic Obstructive complications
- Abstract
Background: The role and impact of chronic cough in individuals with COPD have not been described in the general population. This study hypothesized that comorbid chronic cough is a marker of disease severity in individuals with COPD., Methods: This study identified individuals with COPD and chronic cough, and recorded respiratory symptoms, health-care utilizations, lung function, and inflammatory biomarkers in blood in a nested cohort of 43,271 adults from the Copenhagen General Population Study (CGPS)., Results: Among 43,271 individuals from the general population, 8,181 (19%) experienced COPD, of whom 796 (10%) had chronic cough. Individuals with COPD and chronic cough had a Leicester Cough Questionnaire median (25th-75th percentiles) total score of 17.7 (16.0-18.9), corresponding to 5.9 (5.3-6.3) for the physical domain, 5.6 (4.9-6.3) for the psychological domain, and 6.3 (5.8-6.8) for the social domain. Among individuals with COPD, those with chronic cough vs those without chronic cough more often experienced sputum production (60% vs 8%), wheezing (46% vs 14%), dyspnea (66% vs 38%), chest pain/tightness (9% vs 4%), nighttime dyspnea (8% vs 3%), episodes of acute bronchitis/pneumonias in the last 10 years (45% vs 25%), and ≥ 3 general practitioner visits in the past 12 months (53% vs 37%). Furthermore, these individuals had lower FEV
1 % predicted (81% vs 89%) and FEV1 /FVC (0.64 vs 0.66), as well as higher levels of high-sensitivity C-reactive protein, fibrinogen, leukocytes, neutrophils, eosinophils, and IgE in blood., Conclusions: Comorbid chronic cough in individuals with COPD is associated with a more severe disease in terms of more respiratory symptoms and health-care utilizations, lower lung function, and increased inflammation in blood., (Copyright © 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.)- Published
- 2020
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