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Elevated ACE activity is not associated with asthma, COPD, and COPD co-morbidity.
- Source :
-
Respiratory medicine [Respir Med] 2009 Sep; Vol. 103 (9), pp. 1286-92. Date of Electronic Publication: 2009 May 06. - Publication Year :
- 2009
-
Abstract
- The angiotensin-converting enzyme (ACE) gene is a potential candidate gene for risk of asthma, COPD, and COPD co-morbidity. In 9034 Danish adults, we determined whether individuals homozygous or heterozygous for the ACE D allele are at greater risk of asthma, COPD, or COPD co-morbidity compared with ACE II homozygous individuals. In the general population, serum ACE activity increased with the number of D alleles (Kruskal-Wallis ANOVA: II vs. ID, p<0.001; ID vs. DD, p<0.001); however, this did not translate into altered risk of asthma or COPD. In the general population, the odds ratio (95% confidence interval) for asthma was 1.2 (0.9-1.4) for ID individuals and 1.2 (0.9-1.5) for DD individuals compared with II individuals. In the general population, the odds ratio for COPD was 0.9 (0.8-1.1) for ID individuals and 1.0 (0.8-1.2) for DD individuals compared with II individuals. Among patients with COPD, the odds ratio for ischemic heart disease was 1.1 (0.8-1.6) for ID individuals and 1.2 (0.8-1.7) for DD individuals compared with II individuals; corresponding odds ratios for hypertension were 1.1 (0.7-1.5) and 0.8 (0.5-1.2), and for low physical activity 0.9 (0.5-1.4) and 0.7 (0.4-1.2). The results were similar upon adjustment for sex, age, smoking status, body mass index, total cholesterol, and ACE inhibitor/angiotensin II type 1 receptor blocker use. These data suggest that lifelong genetically elevated ACE activity is not a major risk factor for asthma or COPD, or for ischemic heart disease, hypertension, and low physical activity in COPD patients.
- Subjects :
- Adult
Aged
Aged, 80 and over
Asthma enzymology
Denmark
Exercise
Female
Gene Frequency
Genotype
Humans
Male
Middle Aged
Odds Ratio
Peptidyl-Dipeptidase A metabolism
Pulmonary Disease, Chronic Obstructive enzymology
Risk Assessment
Young Adult
Asthma genetics
Genetic Predisposition to Disease genetics
Peptidyl-Dipeptidase A genetics
Pulmonary Disease, Chronic Obstructive genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1532-3064
- Volume :
- 103
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Respiratory medicine
- Publication Type :
- Academic Journal
- Accession number :
- 19423314
- Full Text :
- https://doi.org/10.1016/j.rmed.2009.04.003