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C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease.
- Source :
-
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2007 Feb 01; Vol. 175 (3), pp. 250-5. Date of Electronic Publication: 2006 Oct 19. - Publication Year :
- 2007
-
Abstract
- Rationale: Patients with chronic obstructive pulmonary disease (COPD) have an ongoing systemic inflammation, which can be assessed by measuring serum C-reactive protein (CRP).<br />Objective: To determine whether increased serum CRP in individuals with airway obstruction predicts future hospitalization and death from COPD.<br />Methods: We performed a cohort study with a median of 8-yr follow-up of 1,302 individuals with airway obstruction selected from the ongoing Copenhagen City Heart Study.<br />Measurements and Main Results: We measured serum CRP at baseline, and recorded COPD admissions and deaths as outcomes. During follow-up, 185 (14%) individuals were hospitalized due to COPD and 83 (6%) died of COPD. Incidences of COPD hospitalization and COPD death were increased in individuals with baseline CRP > 3 mg/L versus < or = 3 mg/L (log rank: p < 0.001). After adjusting for sex, age, FEV(1)% predicted, tobacco consumption, and ischemic heart disease, the hazard ratios for hospitalization and death due to COPD were increased at 1.4 (95% confidence interval, 1.0-2.0) and 2.2 (1.2-3.9) in individuals with baseline CRP > 3 mg/L versus < or = 3 mg/L. After close matching for FEV(1)% predicted and adjusting for potential confounders, baseline CRP was, on average, increased by 1.2 mg/L (analysis of variance: p = 0.002) and 4.1 mg/L (p = 0.001) in those who were subsequently hospitalized or died of COPD, respectively. The absolute 10-yr risks for COPD hospitalization and death in individuals with CRP above 3 mg/L were 54 and 57%, respectively, among those older than 70 yr with a tobacco consumption above 15 g/d and an FEV(1)% predicted of less than 50.<br />Conclusions: CRP is a strong and independent predictor of future COPD outcomes in individuals with airway obstruction.
- Subjects :
- Aged
Biomarkers blood
Cohort Studies
Female
Hospitalization
Humans
Male
Middle Aged
Outcome Assessment, Health Care
Prognosis
Pulmonary Disease, Chronic Obstructive blood
Risk
C-Reactive Protein analysis
Pulmonary Disease, Chronic Obstructive diagnosis
Pulmonary Disease, Chronic Obstructive mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1073-449X
- Volume :
- 175
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of respiratory and critical care medicine
- Publication Type :
- Academic Journal
- Accession number :
- 17053205
- Full Text :
- https://doi.org/10.1164/rccm.200605-713OC